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Experimental and numerical studies of miniature bar-typed structural fuses with Teflon pads
Sen Yang,Yan Liu,Yu Lin,Dongzhi Guan,Hanbin Ge,Zhengxing Guo,Wenguang Liu 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.41 No.4
Many studies have proved that structural fuses could improve the seismic performance of structures efficiently. A structural fuse named the miniature bar-typed structural fuse (MBSF) has been proposed and investigated by the authors, which consists of a central core bar, a confining tube. To further improve the mechanic performances of the MBSFs under compressive loadings, Teflon pads are introduced to adjust the contact and friction status between the core bar and the confining tube. Three groups of specimens were discussed including the specimen with a single cutting line (SC), the specimen with double cutting lines (DC), and the specimen with triple cutting lines (TC). The results show that the hysteretic performances of the fuses are improved with the help of Teflon pads. The compression strength adjustment factor declines when Teflon pads are appended. Numerical and theoretical analyses are also conducted which expounded the effect of the Teflon pads. Different plastic buckling deformation principles of the core bars are compared by the theoretical analysis. It is shown that Shanley’s theory fits the numerical results well, which is recommended for the theoretical calculation of the proposed MBSFs.
A Social Motivation-aware Mobility Model for Mobile Opportunistic Networks
( Sen Liu ),( Xiaoming Wang ),( Lichen Zhang ),( Peng Li ),( Yaguang Lin ),( Yunhui Yang ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.8
In mobile opportunistic networks (MONs), human-carried mobile devices such as PDAs and smartphones, with the capability of short range wireless communications, could form various intermittent contacts due to the mobility of humans, and then could use the contact opportunity to communicate with each other. The dynamic changes of the network topology are closely related to the human mobility patterns. In this paper, we propose a social motivation-aware mobility model for MONs, which explains the basic laws of human mobility from the psychological point of view. We analyze and model social motivations of human mobility mainly in terms of expectancy value theory and affiliation motivation. Furthermore, we introduce a new concept of geographic functional cells, which not only incorporates the influence of geographical constraints on human mobility but also simplifies the complicated configuration of simulation areas. Lastly, we validate our model by simulating three real scenarios and comparing it with reality traces and other synthetic traces. The simulation results show that our model has a better match in the performance evaluation when applying social-based forwarding protocols like BUBBULE.
Liu, Sen,Su, Mingzhi,Song, Shao-Jiang,Hong, Jongki,Chung, Hae Young,Jung, Jee H. American Chemical Society and American Society of 2018 Journal of natural products Vol.81 No.2
<P>An investigation of the jellyfish-derived fungus <I>Penicillium chrysogenum</I> J08NF-4 led to the isolation of two new meroterpene derivatives, chrysogenester (<B>1</B>) and 5-farnesyl-2-methyl-1-<I>O</I>-methylhydroquinone (<B>2</B>), and four known farnesyl meroterpenes. Docking analysis of <B>1</B> showed that it binds to PPAR-γ in the same manner as the natural PPAR-γ agonist amorfrutin B (<B>7</B>). Compound <B>1</B> activated PPAR-γ in murine Ac2F liver cells and increased nuclear PPAR-γ protein levels in murine RAW 264.7 macrophages. Because one of the main biological functions of PPAR-γ agonists is to suppress inflammatory response, an <I>in vitro</I> study was performed to explore the anti-inflammatory potency of <B>1</B> and the mechanism involved. In RAW 264.7 macrophages, <B>1</B> inhibited phosphorylation of the NF-κB p65 subunit and suppressed the expression of the pro-inflammatory mediators iNOS, NO, COX-2, TNF-α, IL-1β, and IL-6. We propose <B>1</B> suppresses inflammatory responses by activating PPAR-γ and subsequently downregulating the NF-κB signaling pathway, thus reducing the expressions of pro-inflammatory mediators.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2018/jnprdf.2018.81.issue-2/acs.jnatprod.7b00846/production/images/medium/np-2017-008469_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np7b00846'>ACS Electronic Supporting Info</A></P>
Robust Minimum Squared Error Classification Algorithm with Applications to Face Recognition
( Zhonghua Liu ),( Chunlei Yang ),( Jiexin Pu ),( Gang Liu ),( Sen Liu ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.1
Although the face almost always has an axisymmetric structure, it is generally not symmetrical image for the face image. However, the mirror image of the face image can reflect possible variation of the poses and illumination opposite to that of the original face image. A robust minimum squared error classification (RMSEC) algorithm is proposed in this paper. Concretely speaking, the original training samples and the mirror images of the original samples are taken to form a new training set, and the generated training set is used to perform the modified minimum sqreared error classification(MMSEC) algorithm. The extensive experiments show that the accuracy rate of the proposed RMSEC is greatly increased, and the the proposed RMSEC is not sensitive to the variations of the parameters.
Xiong Song,Liangui Nie,Junrong Long,Junxiong Zhao,Xing Liu,Liuyang Wang,Da Liu,Sen Wang,Shengquan Liu,Jun Yang 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.1
Hypothyroidism alone can lead to myocardial fibrosis and result in heart failure, but traditional hormone replacement therapy does not improve the fibrotic situation. Hydrogen sulfide (H2S), a new gas signaling molecule, possesses antiinflammatory, antioxidant, and anti-fibrotic capabilities. Whether H2S could improve hypothyroidism-induced myocardial fibrosis are not yet studied. In our study, H2S could decrease collagen deposition in the myocardial tissue of rats caused by hypothyroidism. Furthermore, in hypothyroidism-induced rats, we found that H2S could enhance cystathionine-gamma-lyase (CSE), not cystathionine β-synthase (CBS), protein expressions. Finally, we noticed that H2S could elevate autophagy levels and inhibit the transforming growth factor-β1 (TGF-β1) signal transduction pathway. In conclusion, our experiments not only suggest that H2S could alleviate hypothyroidism- induced myocardial fibrosis by activating autophagy and suppressing TGF-β1/ SMAD family member 2 (Smad 2) signal transduction pathway, but also show that it can be used as a complementary treatment to conventional hormone therapy.
Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study
Sen Li,Jiaxin Wang,Biao Zhang,Xinyi Li,Yuan Liu 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.3
Background: To investigate whether diabetes contributes to mortality for major types of diseases. Methods: Six National Health and Nutrition Examination Survey data cycles (1999 to 2000, 2001 to 2002, 2003 to 2004, 2005 to 2006, 2007 to 2008, and 2009 to 2010) and their linked mortality files were used. A population of 15,513 participants was included according to the availability of diabetes and mortality status. Results: Participants with diabetes tended to have higher all-cause mortality and mortality due to cardiovascular disease, cancer, chronic lower respiratory diseases, cerebrovascular disease, influenza and pneumonia, and kidney disease. Confounder-adjusted Cox proportional hazard models showed that both diagnosed diabetes category (yes or no) and diabetes status (diabetes, prediabetes, or no diabetes) were associated with all-cause mortality and with mortality due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease. No associations were found for cancer-, accidents-, or Alzheimer’s disease-related mortality. Conclusion: The current study’s findings provide epidemiological evidence that diagnosed diabetes at the baseline is associated with increased mortality risk due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease, but not with cancer or Alzheimer’s disease.
Screening, Gene Cloning, and Characterizations of an Acid-Stable α-Amylase
Liu, Xinyu,Jia, Wei,An, Yi,Cheng, Kun,Wang, Mingdao,Yang, Sen,Chen, Hongge The Korean Society for Microbiology and Biotechnol 2015 Journal of microbiology and biotechnology Vol.25 No.6
Based on its α-amylase activity at pH 5.0 and optimal pH of the crude enzyme, a strain (named B-5) with acid α-amylase production was screened. The B-5 strain was identified as Bacillus amyloliquefaciens through morphological, physiological, and biochemical characteristics analysis, as well as 16S rDNA phylogenetic analysis. Its α-amylase gene of GenBank Accession No. GU318401 was cloned and expressed in Escherichia coli. The purified recombinant α-amylase AMY-Ba showed the optimal pH of 5.0, and was stable at a pH range of 4.0-6.0. When hydrolyzing soluble starch, amylose, and amylopectin, AMY-Ba released glucose and maltose as major end products. The α-amylase AMY-Ba in this work was different from the well-investigated J01542-type α-amylase which also came from B. amyloliquefaciens. AMY-Ba exhibited notable adsorption and hydrolysis ability towards various raw starches. Structure analysis of AMY-Ba suggested the presence of a new starch-binding domain at its C-terminal region.
Liu, Yun-Long,Jing, Li-Ling,Guo, Qi-Sen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Objective: To assess the practical utility of pleural fluid carbonic anhydrase XII (CAXII) quantification for differential diagnosis of effusions. Materials and Methods: Fluid was collected prospectively from fifty patients presenting with lymphocytic pleural effusions for investigation and CAXII was quantified by ELISA. Results: Pleural fluid CAXII concentrations were significantly higher in lung cancer patients (n=30) than in tuberculous controls (n=20). The sensitivity and specificity of this biomarker were 60%and 75%, respectively. CAXII measurement was not inferior to cytological examination in the diagnosis and exclusion of pleural effusions from lung cancer patitents (sensitivity 60% vs. 57%; specificity 75% vs. 100%; positive predictive value 77%; negative predictive value 54%). In patients with negative cytology, it offered a sensitivity of 54%. Conclusions: Pleural fluid CAXII is elevated in pleural effusions from lung cancer patients. Measurement of CAXII may be used in the future as a valuable adjunct to cytology in the diagnostic assessment of patients with pleural effusions related to lung cancer, especially when cytological examination is inconclusive.