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Kim, Min Young,Kim, In-Jung,Im, Soon Jae,Kim, Ji Hye,Heo, Ji-Man,Song, Seung-Yeob,Kim, Jung Hyun,Moon, Seo Hyun,Cho, Seongbeom Taylor Francis Health Sciences 2014 Natural product research Vol.28 No.22
<P>A Satsuma mandarin (Citrus unshiu Marc. cv. Miyagawa) spontaneous mutant, Shinheungri, produces fruit with an abnormal red-coloured peel during ripening. The peel and pulp extracts of Shinheungri fruit were evaluated for polyphenolic contents and antioxidant activities by using various in vitro assays. Compared with those of wild type (WT), Shinheungri exhibited slightly higher total flavonoid content and antioxidant activities. The results of UPLC analyses indicate that the peel and pulp extracts of Shinheungri fruit were rich in mainly hesperidin, and they had different flavonoid composition. The present data on Shinheungri revealed a potential source of powerful flavonoids for further detailed phytochemical investigation.</P>
A new flavonoid glycoside from the root bark of Morus alba L.
Park, Ji-Hae,Jung, Ye-Jin,Jung, Jae-Woo,Shrestha, Sabina,Lim, Dong Wook,Han, Daeseok,Baek, Nam-In Taylor & Francis Health Sciences 2014 NATURAL PRODUCT RESEARCH Vol.28 No.21
<P>A new guibourtinidol glycoside, (2R,3S)-guibourtinidol-3-O-α-d-apiofuranosyl-(1 6)-O-β-D-glucopyranoside (1), and three known compounds, quercetin 7-O-β-D-glucopyranoside (2), syringaresinol-4-O-β-D-glucopyranoside (3) and dehydrodiconiferyl alcohol 4,9'-di-O-β-D-glucopyranoside (4), were isolated from the root bark of Morus alba L. through repeated silica gel, octadecyl silica gel and Sephadex LH-20 column chromatography for the n-BuOH fraction. The chemical structure of the compounds was elucidated based on MS, infrared, 1D and 2D NMR spectroscopic data. Compounds 2-4 were also isolated for the first time from the root bark of M. alba L. in this study.</P>
Taylor Francis Health Sciences 2012 NATURAL PRODUCT RESEARCH Vol.26 No.22
<P>The insecticidal activity of Piper nigrum fruit-derived piperidine alkaloid (piperine) and N-isobutylamide alkaloids (pellitorine, guineensine, pipercide and retrofractamide A) against female adults of Culex pipiens pallens and Aedes aegypti was examined. On the basis of 24-h LD(50) values, the compound most toxic to female C. pipiens pallens was pellitorine (0.4??g/) followed by guineensine (1.9??g/), retrofractamide A (2.4??g/) and pipercide (3.2??g/). LD(50) value of chlorpyrifos was 0.03??g/. Against female A. aegypti, the insecticidal activity was more pronounced in pellitorine (0.17??g/) than in retrofractamide A (1.5??g/), guineensine (1.7??g/), and pipercide (2.0??g/). LD(50) value of chlorpyrifos was 0.0014??g/.</P>
관-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus.
Youn, Kumju,Jeong, Woo-Sik,Jun, Mira Taylor Francis Health Sciences 2013 NATURAL PRODUCT RESEARCH Vol.27 No.16
<P>In the course of searching for anti-dementia agents from natural products, loganin isolated from EtOAc fraction of Corni fructus possessed specific inhibitory activity against 관-secretase (BACE1) with 9.2????????10???? ???M and K(i) value of 5.5????????10???? M. Loganin exhibited less inhibitory activity to 관-secretase (TACE) and other serine proteases exhibiting that it was a relatively specific inhibitor of BACE1. These novel findings suggest that loganin may be used to attenuate the progression and/or prevention of Alzheimer's disease.</P>
Antimicrobial, antileishmanial and cytotoxic compounds from Piper chaba.
Naz, Tarannum,Mosaddik, Ashik,Rahman, Motiur,Muhammad, Ilias,Haque, Ekramul,Cho, Somi Kim Taylor Francis Health Sciences 2012 Natural product research Vol.26 No.11
<P>The petroleum ether and chloroform extracts of the root of Piper chaba showed antimicrobial, antileishmanial and cytotoxic activities. Further bioactivity-guided fractionation led to the isolation of Bornyl piperate (1), piperlonguminine (2) and piperine (3). This is the first report of isolation of compounds (1) and (2) from P. chaba. It was observed that the isolated compounds (1 and 2) showed potent antifungal activity when compared with standard drug Nystatin, and significant cytotoxic activity with the IC?????? values of 0.76 and 0.83???µg???mL???, respectively. These compounds were also found to have weak antibacterial and antileishmanial activities. This is the first report about the antileishmanial activity of Piper isolates.</P>
Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3)
Choi, Sung-Kyu,Oh, Hyun-Mi,Lee, Su-Kyung,Jeong, Dae Gwin,Ryu, Seong Eon,Son, Kwang-Hee,Han, Dong Cho,Sung, Nack-Do,Baek, Nam-In,Kwon, Byoung-Mog Taylor & Francis Health Sciences 2006 NATURAL PRODUCT RESEARCH Vol.20 No.4
<P> Two biflavonoids, ginkgetin (1) and sciadopitysin (2), were isolated from the MeOH extract of the young branches of Taxus cuspidata, which inhibited phosphatase of regenerating liver-3 (PRL-3) with IC50 values of 25.8 and 46.2 μM, respectively. This is the first report on PRL-3 inhibitors, isolated from natural sources.</P>
Kim, Jinmo,Kim, Mi-Yeon,Leem, Kang-Hyun,Moon, Sangkwan,Jamakattel-Pandit, Nirmala,Choi, Hoyoung,Kim, Hocheol,Bu, Youngmin Taylor Francis Health Sciences 2010 NATURAL PRODUCT RESEARCH Vol.24 No.13
<P>Polygonum cuspidatum is a potent anti-oxidant herb that is well known for its various bioactivities. The current study investigates which compound group is most effective, to establish the key compound groups for quality assessment, especially in terms of neuroprotective effects. The roots of P. cuspidatum were extracted with 85% methanol and fractionated with hexane, ethyl acetate, n-butanol and water. Each fraction was applied to an in vitro radical scavenging assay, a lipid peroxidation assay in brain homogenates and an in vivo assay using a transient focal cerebra ischemia model induced by a middle cerebral artery occlusion in a Sprague-Dawley rat. The ethyl acetate fraction was the most effective fraction in both in vitro and in vivo assays, having the highest stilbene and anthraquinone contents. These results suggest that stilbenes and anthraquinones may be key compound groups for the quality assessment of the anti-oxidative and neuroprotective effects of P. cuspidatum.</P>
Li, Wei,Lee, Changyeol,Kim, Young Ho,Ma, Jin Yeul,Shim, Sang Hee Taylor & Francis Health Sciences 2017 NATURAL PRODUCT RESEARCH Vol.31 No.19
<P>A phytochemical investigation of Taraxacum mongolicum led to the isolation of 24 compounds, including six flavonoids (1-6), four sesquiterpenes (7-10), two sphingolipids (11 and 12), six glycerols (13-18) and six triterpenoids and sterols (19-24). The structures of these compounds were identified by spectroscopic methods, and their data compared with those reported in the literature. This is the first report of compounds 11-19 from T. mongolicum and the genus Taraxacum, and compounds 11, 12, 15, 16, 18 and 19 from the Asteraceae family. The chemotaxonomic relationship between T. mongolicum and other Taraxacum species is also discussed.</P>