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Lee, Hyeong-Mo,Hur, Bock,Kim, Hyeon-Cheol,Woo, Sung-Gwan,Kim, Kwang-Hoon,Son, Kon,Park, Jeong- Kil 대한치과보존학회 2006 Restorative Dentistry & Endodontics Vol.31 No.6
본 연구의 목적은 3차원유한요소분석법을 이용하여 정상 상악 제2소구치의 협측부의 응력분포에 다양한 교합응력이 미치는 영향을 평가하고자 하였다. 상악 제2소구치의 3차원유한요소모델을 형성한 후 형성된 모델에 3종류의 정적인 500N 점하중의 응력조건을 부여하였다. ANSYS 프로그램 (Swanson Analysis Systems, Inc., Houston, USA)으로 최대주응력과 최소주응력을 4개의 수평면 상(CEJ 상방 1mm, CEJ 상방 0.5 mm, CEJ, CEJ 하방 0.5 mm)에서 분석하여 다음 결과를 얻었다. 1. peak stress가 협측 백악법랑경계를 따라 비대칭적인 모습으로 나타났다. 2.압축응력 값은 법랑질의 압축파괴응력 범위 내에 있었지만 인장응력은 법랑질의 인장파괴응력 범위를 넘어섰다. 3. 비우식성치경부병소를 발생시키는 주요인은 설측교두의 협측경사면에 가해지는 교합압에 의한 인장응력이라고 보여진다. The objective of this study was to investigate the effects of various occlusal loads on the stress distribu-tion of the buccal cervical region of a normal maxillary second premolar, using a three dimensional finite element analysis (3D FEA). After 3D FE modeling of maxillary second premolar, a static load of 500N of three load cases was applied. Stress analysis was performed using ANSYS (Swanson Analysis Systems, Inc., Houston, USA). The maxi-mum principal stresses and minimum principal stresses were sampled at thirteen nodal points in the buc-cal cervical enamel for each four horizontal planes 1.0㎜ above CEJ, 0.5 ㎜ above CEJ, CEJ, 0.5 ㎜ under CEJ. The results were as follows 1. The peak stress was seen at the cervical enamel surface of the mesiobuccal line angle area, asymmetri-cally. 2. The values of compressive stresses were within the range of the failure stress of enamel. But the val-ues of tensile stresses exceeded the range of the failure stress of enamel. 3. The tensile stresses from the perpendicular load at the buccal incline of palatal cusp may be shown to be the primary etiological factors of the NCCLs.
The Urate-lowering Efficacy and Safety of Febuxostat in Korean Patients with Gout
( Sung Hwan Park ),( Yeong Wook Song ),( Won Park ),( Eun Mi Koh ),( Bin Yoo ),( Soo Kon Lee ),( Dae Hyun Yoo ),( Yun Jong Lee ),( Hyun Ah Kim ),( Hyo Jin Choi ),( Ho Youn Kim ),( Hyong Gi Jung ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.4
Objective. To compare the urate-lowering efficacy and the safety of febuxostat, allopurinol and placebo in Korean patients with gout for 4 weeks. Methods. Subjects (n=182) with gout were randomized to febuxostat (40, 80, 120 mg), allopurinol 300 mg, or placebo group. The primary end point was the proportion of subjects whose serum urate concentration fell to less than 6.0 mg/dL after the 4-week treatment. Results. The primary end point was reached at 25.7%, 80.0% and 83.3% of patients receiving 40, 80 and 120 mg of febuxostat, respectively, 58.3% of those receiving 300 mg of allopurinol and none of the placebo (p<0.001: each febuxostat dose or allopurinol group versus placebo group, p=0.0484 and p=0.0196: febuxostat 80 and 120 mg compared with allopurinol, respectively). The number and proportion of subjects who developed adverse events (AEs) were 13 subjects (37%), 14 (39%) and 18 (50%) in the febuxostat of 40, 80 and 120 mg group, respectively, 21 (57%) in the allopurinol 300 mg group and 17 (46%) in the placebo group. No statistically significant differences in the incidence rates of adverse events were observed between the groups. There was no significant difference in gout flare-up incidence. Conclusion. Febuxostat, 80 mg or 120 mg, was more effective than allopurinol (300 mg) or placebo, when lowering the serum urate. The safety of febuxostat and allopurinol was comparable.
Lee, Seung-Ho,Yun, Mi-Jin,Kim, Ki-Nam,Seo, Sang-Hui,Sohn, Sung-Hwa,Kim, Yu-Ri,Kim, Hye-Won,Kim, In-Kyoung,Shim, Boo-Im,Lee, Seung-Min,Kim, Meyoung-Kon The Korean Society of Toxicogenomics and Toxicopro 2007 Molecular & cellular toxicology Vol.3 No.3
[ $^{18}F$ ]-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) scan has been found to reflect tumor aggressiveness and prognosis in various types of cancer. In this study, the gene expression profiles of glial tumors were evaluated to determine whether glial tumors with high $^{18}F$-FDG uptake have more aggressive biological potential than with low uptake. Surgical specimens were obtained from the 12 patients with glial tumors (4 males and 8 females, age range 42-68 years). The tumor samples were divided into two groups based on the $^{18}F$-FDG uptake PET scan findings: high $^{18}F$-FDG uptake (n=4) and low $^{18}F$-FDG uptake (n=8). The pathological tumor grade was closely correlated with the $^{18}F$-FDG uptake pattern: Glial tumors with high $^{18}F$-FDG uptake were pathologically Edmondson-Steiner grade III, while those with low uptake were grade II. The total RNA was extracted from the frozen tissues of all glial tumors (n=12), and adjacent non-cancerous tissue (n=3). The gene expression profiles were evaluated using cDNA microarray. The glial tumors with high $^{18}F$-FDG uptake showed increase expression of 15 genes compared to those with low uptake (P<0.005). Nine genes were down-regulated. Gene expression is closely related to cell survival, cell-to-cell adhesion or cell spreading; therefore, glial tumors with high $^{18}F$-FDG uptake appear to have more aggressive biological properties than those with low uptake.
Sang Bae Lee,Kwang Hyun Ryu,Ji Kon Ryu,Hoi Jin Kim,Jin Kwang Lee,Hyun Seung Jeong,Jin Soo Bae 대한내과학회 2003 The Korean Journal of Internal Medicine Vol.18 No.2
Although acute acalculous cholecystitis (AAC) accounts for less than 10% of acute cholecystitis in the adult population, gangrene and perforation are much more frequent compared to the usual cases of acute cholecystitis (calculus cholecystitis). However
Lee, Chan-Joo,Kim, Jae-Young,Lee, Sang-Kon,Ko, Dae-Cheol,Kim, Byung-Min 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1
The purpose of this study is to investigate the effects of process parameters on the joint characteristics of advanced high-strength steel DP780 and Al5052 alloy sheet in mechanical clinching process. The defects in the clinching joint, such as necking of the upper sheet, cracks in the lower sheet, and no interlocking, occur because of the different ductility between advanced high-strength steel and aluminum alloy. In this study, the effect of the process parameters of the clinching process on the joinability of advanced high-strength steel with Al5052 alloy was investigated using finite element (FE) analysis. From the result, the die radius, die depth, and die groove shape were mainly affected by the joinability of advanced high-strength steel with Al5052 alloy. H-type tension test was performed under the same condition as the FE analysis. In addition, the joint strength was determined by interlocking length as well as neck thickness.