Temperature Adjustable Tumbler

Rina So(소리나) 한국디자인학회 2019 한국디자인학회 국제초대전도록 Vol.2019 No.6

Cytoplasmic fractions derived from lactic acid bacteria inhibit lipid peroxidation in brain homogenate and attenuate oxidative stress in macrophages

So Young Choi,Ji Yeon Kim,Hyung Joo Lee,Hee Jong Woo,Dae Kyun Chung,Rina Yu 한국식품과학회 1999 한국식품과학회 학술대회 Vol.1999 No.1

Saturated fatty acids enhance osteoclast survival

Oh, So-Ra,Sul, Ok-Joo,Kim, Youn-Young,Kim, Hye-Jin,Yu, Rina,Suh, Jae-Hee,Choi, Hye-Seon American Society for Biochemistry and Molecular Bi 2010 Journal of lipid research Vol.51 No.5

<P>Hyperlipidemia and marrow fat are associated with lowering bone density in vivo, suggesting that lipid contributes to bone loss. Using bone marrow-derived macrophages, we investigated the effect of saturated fatty acids (SFA) on osteoclastogenesis. The level of free fatty acids and adiposity in bone marrow was significantly elevated in obese mice. SFA increased osteoclast (OC) survival by preventing apoptosis. SFA caused the production of MIP-1alpha and led to activation of nuclear factor (NF)-kappaB in the OC. The absence of Toll-like receptor 4 (TLR4) or myeloid differentiation factor 88 (MyD88) abolished the survival effect of SFA on OC.</P>

Effects of aerobic or resistance exercise on body composition and strength in men with obesity

( Bokun Kim ),( Rina So ),( Takehiko Tsujimoto ),( Sechang Oh ),( Jinhong Kim ),( Kiyoji Tanaka ) 대한운동사협회 2017 대한운동사협회 운동사대회자료집 Vol.2017 No.-

Ambient temperature and hospital admissions for acute kidney injury: A time-series analysis

Lim, Youn-Hee,So, Rina,Lee, Choongho,Hong, Yun-Chul,Park, Minseon,Kim, Logyoung,Yoon, Hyung-Jin Elsevier 2018 Science of the Total Environment Vol.616 No.-

<P><B>Abstract</B></P> <P>Some studies have suggested that high ambient temperatures are a risk factor for kidney-related diseases. However, none have examined the association between ambient temperature and acute kidney injury (AKI). This study aimed to examine the association between daily mean temperature and AKI and identify high-risk subgroups in this association. We obtained health insurance claim data from the Health Insurance Review and Assessment Service (HIRA) for 24,800 admitted cases of AKI during the period 2007–2014 in Seoul, Korea. Using a time-series design and piecewise linear regression models, we estimated the percentage change in AKI admissions associated with daily mean temperature after controlling for relevant covariates. Daily mean temperature and AKI admissions displayed an inverse association in the cold season and a nonlinear relationship with a flexion point around 28.8°C in the warm season. AKI admissions increased by 23.3% (95% confidence interval [CI]: 14.3, 33.0) per 1°C increase in mean temperature above the 28.8°C flexion point in the warm season. The estimates were greatest among men with hypertension (55.1%; 95% CI: 25.1, 92.2). However, we did not observe significant increases in AKI admissions associated with ambient temperature in the cold season (0.4% [95% CI: −0.1, 0.9] per 1°C decrease in mean temperature). Our results suggest that hospital admissions for AKI increase in association with high temperature, particularly among men with hypertension in the warm season. Thus, early detection of AKI during heat wave periods is crucial. Our findings also provide evidence for the local government to target populations vulnerable to high ambient temperatures.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High temperature and acute kidney injury have a strong relationship. </LI> <LI> A nonlinear relationship with a flexion point was observed in the warm season. </LI> <LI> Men with hypertension were most vulnerable to high ambient temperatures. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Weight reduction does not induce an undesirable decrease in muscle mass, muscle strength, or physical performance in men with obesity: a pilot study

( Bokun Kim ),( Takehiko Tsujimoto ),( Rina So ),( Xiaoguang Zhao ),( Sechang Oh ),( Kiyoji Tanaka ) 한국운동영양학회 2017 Physical Activity and Nutrition (Phys Act Nutr) Vol.21 No.4

[Purpose] To date, there have been no reports on whether weight reduction causes decreases in muscle mass, muscle strength, or physical performance that could lead to health problems. Thus, in this pilot study, we investigated the appropriateness of the changes in muscle mass, muscle strength and physical performance after weight reduction. [Methods] Obese men who completed a weight reduction program to decrease and maintain a body mass index (BMI) of less than 25 kg/m2 for one year were recruited for the study. One year after the completion of a weight reduction program, the participants’ muscle mass, muscle strength, and physical performance were compared with those in a reference group composed of individuals whose BMI was less than 25 kg/m2. Whole-body scanning was performed using dual-energy X-ray absorptiometry to analyze muscle mass. Handgrip strength and knee extensor strength were measured to evaluate arm and leg muscle strength, respectively. For physical performance, a jump test was employed. [Results] The results showed that the biceps, triceps, subscapular, and suprailiac areas of professional fashion models were significantly thinner than those of women in general (p<.001), and that their waist size was also significantly smaller (p<.001). However, hip circumference showed no significant difference. Body mass index, waist-to-hip ratio, and body fat (%) in professional fashion models were significantly lower than those in women in general (p<.001), while the body density in professional fashion models was significantly greater (p<0.001). [Conclusion] Weight reduction participants showed an average reduction in body weight of -16.47%. Normalized arm muscle mass and handgrip strength were significantly greater in the weight reduction group than in the reference group; however, no significant differences were detected between the two groups with respect to the other variables. After one year, there were no significant differences between the two groups.

Centella asiatica extract prevents visual impairment by promoting the production of rhodopsin in the retina

Dae Won Park,Hyelin Jeon,Rina So,Se Chan Kang 대한지역사회영양학회 2020 Nutrition Research and Practice Vol.14 No.3

BACKGROUND/OBJECTIVE: Centella asiatica, also known as Gotu kola, is a tropical medicinal plant native to Madagascar, Southeast Asia, and South Africa. It is well known to have biological activities, including wound healing, anti-inflammatory, antidiabetic, cytotoxic, and antioxidant effects. The purpose of this study was to determine the efficacy of extracts of C. asiatica against age-related eye degeneration and to examine their physiological activities. MATERIALS/METHODS: To determine the effects of CA-HE50 (C. asiatica 50% EtOH extract) on retinal pigment cells, we assessed the cytotoxicity of CoCl₂ and oxidized-A2E in ARPE-19 cells and observed the protective effects of CA-HE50 against N-methyl-N-nitrosourea (MNU)-induced retinal damage in C57BL/6 mice. In particular, we measured factors related to apoptosis and anti-oxidation and the protein levels of rhodopsin/opsin. We also measured glucose uptake to characterize glucose metabolism, a major factor in cell protection. RESULTS: Induction of cytotoxicity with CoCl₂ and oxidized-A2E inhibited decreases in the viability of ARPE-19 cells when CA-HE50 was administered, and promoted glucose uptake under normal conditions (P < 0.05). In addition, CA-HE50 inhibited degeneration/apoptosis of the retina in the context of MNU-induced toxicity (P < 0.05). In particular, CA-HE50 at 200 mg/kg inhibited the cleavage of pro-caspase-3 and pro-poly (ADP-ribose)-polymerase and maintained the expressions of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 similar to normal control levels. Rhodopsin/opsin expression was maintained at a higher level than in normal controls. CONCLUSION: A series of experiments confirmed that CA-HE50 was effective for inhibiting or preventing age-related eye damage/degeneration. Based on these results, we believe it is worthwhile to develop drugs or functional foods related to age-related eye degeneration using CA-HE50.

Multioside, an active ingredient from <i>adonis amurensis,</i> displays anti-cancer activity through autophagosome formation

Park, Dae Won,Ham, Young Min,Lee, Yeong-Geun,So, Rina,Seo, Young-Jin,Kang, Se Chan Urban und Fischer Verlag 2019 Phytomedicine Vol.65 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P> <I>Adonis amurensis</I> Regel & Radde, commonly found in East Asia, has been traditionally used to treat cardiac insufficiency and edema. Although this plant extract has been shown to regulate cell growth and neovascularization, the anti-cancer mechanism of <I>A. amurensis</I> has not been fully investigated.</P> <P><B>Purpose</B></P> <P>In this study, we aimed to examine the anti-cancer activity of <I>A. amurensis</I> and identify its underlying mechanism.</P> <P><B>Methods</B></P> <P>The growth of cancer cells was evaluated by MTT and hollow fiber assays. A cancer xenograft nude mouse model was used to assess the anti-cancer activities <I>in vivo</I>. Autophagic activity was measured by the detection of autophagosome formation and by performing a monodansylcadaverine (MDC) assay.</P> <P><B>Result</B></P> <P> <I>A. amurensis</I> extract showed potent anti-cancer activity both <I>in vitro</I> and <I>in vivo</I>. Importantly, the treatment of cancer cells with <I>A. amurensis</I> extract dramatically increased the formation of autophagosomes and was involved in the activation of multiple signaling components including AKT, ERK, and MAPK. Furthermore, we isolated an active ingredient, Multioside, which exhibited strong anti-cancer activity through autophagy.</P> <P><B>Conclusion</B></P> <P> <I>A. amurensis</I> displays anti-cancer activity that is mediated by the activation of autophagy, suggesting that <I>A. amurensis</I> could be a useful therapeutic anti-cancer agent.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Nationwide Epidemiologic Study of Abdominal Aortic Aneurysms in Korea: A Cross-Sectional Study Using National Health Insurance Review and Assessment Service Data

최찬중,Sanghyun Ahn,Sang-il Min,안문상,하종원,Hyung-Jin Yoon,Rina So,Sung Hyouk Choi,Seung-Kee Min 대한혈관외과학회 2019 Vascular Specialist International Vol.35 No.4

Purpose: The prevalence and treatment patterns of abdominal aortic aneurysm (AAA) vary according to ethnicity and region. This study analyzed nationwide data on the epidemiology, practice patterns, and mortality rates of AAA in Korea. Materials and Methods: Data from patients treated for AAA from 2012 to 2016 were extracted from the Korean Health Insurance Review and Assessment (HIRA) database. Results: A total of 30,766 patients in Korea had treatment codes for AAA and 2,618 patients were treated for ruptured AAA. Of the 6,356 patients treated surgically, 1,849 and 4,507 underwent open surgical aneurysmal repairs (OSAR) or endovascular aneurysmal repairs (EVAR), respectively. The number of surgical treatments performed annually for AAA increased from 1,129 cases in 2012 to 1,501 cases in 2016. The number of EVAR cases increased from 753 to 1,109 during these five years, while the number of OSAR cases remained similar, at 376 and 392, respectively. The 30-day mortality rates after EVAR and OSAR were 4.2% and 10.6%, respectively. The mortality rates were significantly higher in patients with hypertension, dyslipidemia, chronic renal disease, diabetes mellitus, and congestive heart failure. There were significant differences in the prevalence, proportion of EVAR, and mortality rates according to the regional area. Conclusion: The prevalence of AAA and the proportion of EVAR in Korea increased in the past 5 years, while the rupture rate and the proportion of OSAR remained similar. To minimize mortality and regional discrepancies, nationwide registry and treatment standardization are needed.

Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice

Park Dae Won,Jeon Hyelin,권정은,Lee Young Geun,So Rina,Choe Tae Hwan,Jeong Yong Joon,Kang Se Chan 한국독성학회 2021 Toxicological Research Vol.37 No.2

N-acetyl-p-aminophenol (acetaminophen, APAP) is a well-known component of analgesic and antipyretic monotherapy products. However, exceeding the recommended dose can lead to serious injury to the liver. We conducted this study to determine the potential of Centella asiatica as a natural substance to protect against APAP-induced liver injury. When acute hepatotoxicity was induced in mice by APAP overdose, their liver weight decreased significantly (p < 0.05). However, mice treated with C. asiatica 50% ethanol extract (CA-HE50, 200 mg/kg) for a week before induction of hepatotoxicity by APAP had similar liver weights to those of mice in which hepatotoxicity was not induced. In particular, levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase, which are biomarkers of liver injury, were significantly increased by APAP and dose-dependently decreased by CA-HE50 (p < 0.05). Glutathione and malondialdehyde, indicators of oxidative stress, were significantly changed by APAP and CA-HE50 (p < 0.05). In addition, hepatic necrosis and expression of genes encoding pro-inflammatory cytokines (tumor necrosis factor-α, interleukin (IL)-1β, and IL-4) induced by APAP were inhibited by CA-HE50, and these results were dose-dependent. Through our in vivo studies, we found that CA-HE50 can help prevent APAP-induced hepatic tissue injury in BALB/c mice. Furthermore, CA-HE50 was effective at protecting RAW 264.7 cells from lipopolysaccharide-induced cytotoxicity and inhibiting the release of nitric oxide from these cells; in particular, asiaticoside was found to be a key component of CA-HE50 responsible for these effects. Therefore, we suggest that CA-HE50 has potential applications in functional health foods and drugs.