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      • KCI등재

        Efficiency Optimization Control of an IPMSM Drive System for Electric Vehicles (EVs)

        Qin-Mu Wu,Yu Zhan,Mei Zhang,Xiang-Ping Chen,Wen-Ping Cao 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.8

        Electric vehicles are a key technology to decarbonize the transport sector where interior permanent magnet synchronous motors (IPMSMs) are the best performer at the heart of the electrical drive system. In order to optimize their operational efficiency, the model-based method associated with parameter identification is widely adopted. However, efficiency optimization and parameter identification in the existing methods are implemented independently by different strategies in a sequential execution manner, which does not produce an optimized systemlevel solution. In this paper, the two methods are combined to deal with a constrained optimization problem in an IPMSM drive. Firstly, the problem is converted into a variational problem based on the variational principle and projection dynamic theory. Then, a unified projection dynamic equation (UPDE) is used to estimate the parameters and determine the solution of optimal current (OC) of the IPMSM. Further, a recursive neural network (RNN)corresponding to the UPDE is developed to implement the developed fast efficiency optimization of the IPMSM drive. The results of simulation experiments show the proposed method is effective to identify motor parameters and determine the OC of the drive system rapidly and accurately. Thus, it can rapidly realize efficiency optimization of an IPMSM drive-system. Because the designed RNN can be easily implemented in the hardware, such as a field-programmable gate array (FPGA) or dedicated neural network chip, the method can achieve instantaneousefficiency optimization of the IPMSM drive system and therefore improve the widespread application of IPMSMs in EVs.

      • KCI등재

        Physical and Numerical Investigation of Cavitating Flow-Induced Vibration of a Flexible Hydrofoil

        Qin Wu,Guoyu Wang,Biao Huang 한국유체기계학회 2017 International journal of fluid machinery and syste Vol.10 No.3

        The objective of this paper is to investigate the flow-induced vibration of a flexible hydrofoil in cavitating flows via combined experimental and numerical studies. The experiments are presented for the modified NACA66 hydrofoil made of POM Polyacetate in the closed-loop cavitation tunnel and the numerical investigations are performed using a hybrid coupled fluid structure interaction model. The results showed that with the decreasing of cavitation number, the vibration magnitude increases dramatically for the cloud cavitation and declines for the supercavitation. The cloud cavitation development strongly affects the vibration response, with the main frequency of the vibration being accordance with the cavity shedding frequency and other two frequencies corresponding to the bending and twisting frequencies.

      • KCI등재

        GPH1 is involved in glycerol accumulation in the three-dimensional networks of the nematode-trapping fungus Arthrobotrys oligospora

        Qin-Yi Wu,Yue-Yan Zhu,Cheng-Gang Zou,Ying-Qian Kang,Lian-Ming Liang 한국미생물학회 2016 The journal of microbiology Vol.54 No.11

        Turgor is very important for the invasive growth of fungal pathogens. Glycerol, a highly osmotic solvent, is considered to play an important role in turgor generation. The nematophagous fungus Arthrobotrys oligospora mainly lives as a saprophyte. In the presence of nematodes, A. oligospora enters the parasitic stage by forming three-dimensional networks (traps) to capture nematodes. In A. oligospora, we found that glycerol accumulated during nematode-induced trap formation. We demonstrated that deleting gph1, which encodes glycogen phosphorylase, decreased the glycerol content, compared with that of a wild-type strain. Although the number of traps induced by nematodes was not affected in the Δgph1 mutant, the capture rate was lower. Meanwhile, deleting gph1 also affected the growth rate and conidiation capacity of the fungus. These results indicate that glycerol derived from GPH1 is essential for the full virulence of A. oligospora against nematodes.

      • SCOPUSKCI등재

        Physical and Numerical Investigation of Cavitating Flow-Induced Vibration of a Flexible Hydrofoil

        Wu, Qin,Wang, Guoyu,Huang, Biao Korean Society for Fluid machinery 2017 International journal of fluid machinery and syste Vol.10 No.3

        The objective of this paper is to investigate the flow-induced vibration of a flexible hydrofoil in cavitating flows via combined experimental and numerical studies. The experiments are presented for the modified NACA66 hydrofoil made of POM Polyacetate in the closed-loop cavitation tunnel and the numerical investigations are performed using a hybrid coupled fluid structure interaction model. The results showed that with the decreasing of cavitation number, the vibration magnitude increases dramatically for the cloud cavitation and declines for the supercavitation. The cloud cavitation development strongly affects the vibration response, with the main frequency of the vibration being accordance with the cavity shedding frequency and other two frequencies corresponding to the bending and twisting frequencies.

      • SCISCIESCOPUS

        SMA OBSERVATIONS OF THE W3(OH) COMPLEX: PHYSICAL AND CHEMICAL DIFFERENTIATION BETWEEN W3(H<sub>2</sub>O) AND W3(OH)

        Qin, Sheng-Li,Schilke, Peter,Wu, Jingwen,Wu, Yuefang,Liu, Tie,Liu, Ying,,nchez-Monge, Á,lvaro IOP Publishing 2015 The Astrophysical journal Vol.803 No.1

        <P>We report on the Submillimeter Array (SMA) observations of molecular lines at 270 GHz toward the W3(OH) and W3(H2O) complex. Although previous observations already resolved the W3(H2O) into two or three subcomponents, the physical and chemical properties of the two sources are not well constrained. Our SMA observations clearly resolved the W3(OH) and W3(H2O) continuum cores. Taking advantage of the line fitting tool XCLASS, we identified and modeled a rich molecular spectrum in this complex, including multiple CH3CN and CH3OH transitions in both cores. HDO, C2H5CN, (OCS)-C-13, and vibrationally excited lines of HCN, CH3CN, and CH3OCHO were only detected in W3(H2O). We calculate gas temperatures and column densities for both cores. The results show that W3(H2O) has higher gas temperatures and larger column densities than W3(OH) as previously observed, suggesting physical and chemical differences between the two cores. We compare the molecular abundances in W3(H2O) to those in the Sgr B2(N) hot core, the Orion KL hot core, and the Orion Compact Ridge, and discuss the chemical origin of specific species. An east-west velocity gradient is seen in W3 (H2O), and the extension is consistent with the bipolar outflow orientation traced by water masers and radio jets. A north-south velocity gradient across W3(OH) is also observed. However, with current observations we cannot be assured whether the velocity gradients are caused by rotation, outflow, or radial velocity differences of the subcomponents of W3(OH).</P>

      • T-SPOT.TB for Detection of Tuberculosis Infection among Hematological Malignancy Patients and Hematopoietic Stem Cell Transplant Recipients

        Qin, Li-Li,Wang, Qin-Rong,Wang, Qian,Yao, Hong,Wen, Li-Jun,Wu, Li-Li,Ping, Na-Na,Xie, Jun-Dan,Chen, Mei-Yu,Chen, Su-Ning Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

        The diagnosis of latent Mycobacterium tuberculosis infection (LTBI) is recommended in hematological malignancy patients and before hematopoietic stem cell transplantation (Guidelines for the prevention and management of infectious complications of solid organ transplantation, 2004). Compared to traditional methods such as tuberculin skin test (TST), T-SPOT.TB has been shown to be more specific. In the present study we enrolled 536 patients for whom T-SPOT.TB was performed, among which 295 patients also received the TST test. The agreement (79%) between T-SPOT.TB and TST was poor (x=0.274, P<0.001). The patients with positive T-SPOT.TB results numbered 62 (11.6%), in which only 20 (48.8%) of the 41 receiving the TST test had positive results. A majority of the patients with T-SPOT.TB positive results had some other evidence ofTB, such as TB history, clinical symptoms and an abnormal chest CT scan. Active TB was found in 9 patients, in which 2 had negative TST results. We followed up the patients and no one developed active TB. Our study suggested that the T-SPOT.TB may be more useful for screening LTBI and active TB in hematological malignancy patients and hematopoietic stem cell transplant recipients than the TST test.

      • KCI등재

        Hybrid model for the analysis of the modal properties of a ball screw vibration system

        Qin Wu,Feng-shou Gu,Andrew Ball,Hua Huang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.2

        In accordance with the vibration characteristics of ball screw feed systems, a hybrid modeling method is proposed to study its dynamic behavior. Partially, the ball screw is modeled as a continuous body, and the remaining components are considered lumped masses, allowing for a realistic description of the dynamics of the feed system. The axial, torsional, transverse, and bending vibration models of a ball screw carriage system are established via the Rayleigh-Ritz series method based on the Timoshenko beam assumption. The established model that added the Timoshenko beam assumption obtains the coupling vibration displacement between the transverse and bending vibrations of the lead screw, which is close to real situations. Numerical simulations are conducted to investigate the changes of the natural frequency and modal shapes of ball screw systems with carriage positions. Results show that the carriage position has significant influence on the amplitude and direction of axial and transverse vibrations, substantial influence on the direction of the bending vibration, and minimal influence on the amplitude and direction of torsional vibration. These results indicate that the proposed hybrid model performs well to predict the vibration characteristics of the feed system. Moreover, the carriage position and carriage load also have a remarkable effect on the frequency response of the feed system. These results, along with the modeling approach, provide an important basis for the further study of in-machining monitoring and vibration controller design.

      • KCI등재

        Identification of novel rheumatoid arthritis-associated MiRNA-204-5p from plasma exosomes

        Wu Long-Fei,Zhang Qin,Mo Xing-Bo,Lin Jun,Wu Yang-Lin,Lu Xin,He Pei,Wu Jian,Guo Yu-Fan,Wang Ming-Jun,Ren Wen-Yan,Deng Hong-Wen,Lei Shu-Feng,Deng Fei-Yan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

        Rheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune cells in the synovium. However, the crosstalk of immune cells and synovial fibroblasts is still largely unknown. Here, global miRNA screening in plasma exosomes was carried out with a custom microarray (RA patients vs. healthy controls = 9:9). A total of 14 exosomal miRNAs were abnormally expressed in the RA patients. Then, downregulated expression of exosomal miR-204-5p was confirmed in both the replication (RA patients vs. healthy controls = 30:30) and validation groups (RA patients vs. healthy controls = 56:60). Similar to the findings obtained in humans, a decreased abundance of exosomal miR-204-5p was observed in mice with collagen-induced arthritis (CIA). Furthermore, Spearman correlation analysis indicated that plasma exosomal miR-204-5p expression was inversely correlated with disease parameters of RA patients, such as rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein. In vitro, our data showed that human T lymphocytes released exosomes containing large amounts of miR-204-5p, which can be transferred into synovial fibroblasts, inhibiting cell proliferation. Overexpression of miR-204-5p in synovial fibroblasts suppressed synovial fibroblast activation by targeting genes related to cell proliferation and invasion. In vivo assays found that administration of lentiviruses expressing miR-204-5p markedly alleviated the disease progression of the mice with CIA. Collectively, this study identified a novel RA-associated plasma exosomal miRNA-204-5p that mediates the communication between immune cells and synovial fibroblasts and can be used as a potential biomarker for RA diagnosis and treatment.

      • KCI등재

        Homogenized cross-section generation for pebble-bed type high-temperature gas-cooled reactor using NECP-MCX

        Qin Shuai,Li Yunzhao,He Qingming,Cao Liangzhi,Wang Yongping,Wu Yuxuan,Wu Hongchun 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.9

        In the two-step analysis of Pebble-Bed type High-Temperature Gas-Cooled Reactor (PB-HTGR), the lattice physics calculation for the generation of homogenized cross-sections is based on the fuel pebble. However, the randomly-dispersed fuel particles in the fuel pebble introduce double heterogeneity and randomness. Compared to the deterministic method, the Monte Carlo method which is flexible in geometry modeling provides a high-fidelity treatment. Therefore, the Monte Carlo code NECP-MCX is extended in this study to perform the lattice physics calculation of the PB-HTGR. Firstly, the capability for the simulation of randomly-dispersed media, using the explicit modeling approach, is developed in NECP-MCX. Secondly, the capability for the generation of the homogenized cross-section is also developed in NECP-MCX. Finally, simplified PB-HTGR problems are calculated by a two-step neutronics analysis tool based on Monte Carlo homogenization. For the pebble beds mixed by fuel pebble and graphite pebble, the bias is less than 100 pcm when compared to the high-fidelity model, and the bias is increased to 269 pcm for pebble bed mixed by depleted fuel pebble. Numerical results show that the Monte Carlo lattice physics calculation for the two-step analysis of PB-HTGR is feasible.

      • KCI등재

        Nomogram for predicting overall survival in children with neuroblastoma based on SEER database

        Song-Wu Liang,Gang Chen,Yi-Ge Luo,Peng Chen,Jin-Han Gu,Qiong-Qian Xu,Yi-Wu Dang,Li-Ting Qin,Hui-Ping Lu,Wen-Ting Huang,Zhi-Guang Huang,Li Gao,Jia-Bo Chen 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.2

        Purpose: This study was performed to establish and validate a nomogram for predicting the overall survival in children with neuroblastoma. Methods: The latest clinical data of neuroblastoma in Surveillance, Epidemiology, and End Results (SEER) database was extracted from 2000 to 2016. The cases included were randomly divided into training and validation cohorts. The survival curves were drawn with a Kaplan-Meier estimator to investigate the influences of certain single factors on overall survival. Also, least absolute shrinkage and selection operator regression was applied to further select the prognostic variables for neuroblastoma. Additionally, receiver operating characteristic (ROC) curves and calibration curves were used to evaluate the accuracy of the nomogram. Results: In total, 1,262 patients were collected and 8 independent prognostic factors were achieved, including patients’ age, sex, race, tumor grade, radiotherapy, chemotherapy, tumor site, and tumor size. Then we constructed a nomogram by using the data of the training cohort with 886 cases. Subsequently, the nomogram was validated internally and externally with 886 and 376 cases, respectively. The internal validation revealed that the area under the curves (AUC) of ROC curves of 1-, 3-, and 5-year overall survival were 0.69, 0.78, and 0.81, respectively. Accordingly, the external validation also showed that the AUC of 1-, 3-, and 5-year overall survival were all ≥0.69. Both methods of validation demonstrated that the predictive calibration curves were consistent with standard curves. Conclusion: The nomogram possess the potential to be a new tool in predicting the survival rate of neuroblastoma patients.

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