HAYMAN T DIRECTIONS OF MEROMORPHIC FUNCTIONS IN SOME ANGULAR DOMAINS

Nan Wu,Zu-Xing Xuan 대한수학회 2015 대한수학회보 Vol.52 No.1

This paper is devoted to investigate the singular directions of meromorphic functions in some angular domains. We will confirm the existence of Hayman T directions in some angular domains. This is a continuous work of Yang [8] and Zheng [10].

Stem Cell-Derived Exosomes: A New Method for Reversing Skin Aging

Wu Jinyan,Wu Sai-Nan,Zhang Li-Ping,Zhao Xiansheng,Li Yue,Yang Quyang,Yuan Ruoyue,Liu Jian-Lan,Mao Hong-Ju,Zhu Ningwen 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.5

Senescence is an inevitable natural life process that involves structural and functional degeneration of tissues and organs. Recently, the process of skin aging has attracted much attention. Determining a means to delay or even reverse skin aging has become a research hotspot in medical cosmetology and anti-aging. Dysfunction in the epidermis and fibroblasts and changes in the composition and content of the extracellular matrix are common pathophysiological manifestations of skin aging. Reactive oxygen species and matrix metalloproteinases play essential roles in this process. Stem cells are pluripotent cells that possess self-replication abilities and can differentiate into multiple functional cells under certain conditions. These cells also possess a strong ability to facilitate tissue repair and regeneration. Stem cell transplantation has the potential for application in anti-aging therapy. Increasing studies have demonstrated that stem cells perform functions through paracrine processes, particularly those involving exosomes. Exosomes are nano-vesicular substances secreted by stem cells that participate in cell-to-cell communication by transporting their contents into target cells. In this chapter, the biological characteristics of exosomes were reviewed, including their effects on extracellular matrix formation, epidermal cell function, fibroblast function and antioxidation. Exosomes derived from stem cells may provide a new means to reverse skin aging.

HAYMAN T DIRECTIONS OF MEROMORPHIC FUNCTIONS IN SOME ANGULAR DOMAINS

Wu, Nan,Xuan, Zu-Xing Korean Mathematical Society 2015 대한수학회보 Vol.52 No.1

This paper is devoted to investigate the singular directions of meromorphic functions in some angular domains. We will confirm the existence of Hayman T directions in some angular domains. This is a continuous work of Yang [8] and Zheng [10].

Decoy receptor 3 is involved in epidermal keratinocyte commitment to terminal differentiation via EGFR and PKC activation

Wu Nan-Lin,Huang Duen-Yi,Hsieh Shie-Liang,Dai Yang-Shia,Lin Wan-Wan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Decoy receptor 3 (DcR3) is a soluble receptor for Fas ligand, LIGHT and TL1A, but it also exerts effector functions. Previously, we found that DcR3 is upregulated in the serum and lesional skin of patients with psoriasis and is upregulated by EGFR activation in proliferating primary human epidermal keratinocytes. However, the functional role of intracellular DcR3 in keratinocyte differentiation is still incompletely defined. Herein, primary cultured human epidermal keratinocytes were differentiated by phorbol 12-myristate 13-acetate (PMA) treatment, calcium treatment and cell confluence, which are three standard in vitro differentiation models. We found that the constitutive expression of the DcR3 gene and protein was progressively suppressed during terminal differentiation of keratinocytes. These changes were correlated with downregulation of EGFR activation during keratinocyte differentiation. EGFR inhibition by gefitinib further decreased confluence-induced suppression of DcR3 mRNA expression, and, vice versa, knocking down DcR3 expression attenuated EGFR and EGFR ligand expression as well as EGFR activation. Under conditions without a change in cell growth, DcR3 silencing reduced the expression of involucrin and transglutaminase 1 but enhanced the induction of the terminal differentiation markers keratin 10 and loricrin. Of note, DcR3 interacted with PKCα and PKCδ and enhanced PKC activity. In keratinocytes with PKCα and PKCδ silencing, differentiation markers were differentially affected. In conclusion, DcR3 expression in keratinocytes is regulated by EGFR and forms a positive feedback loop to orchestrate constitutive EGFR and PKC activity. During differentiation, DcR3 is downregulated and involved in modulating the pattern of terminal differentiation.

Study of forced vibration response of a beam with a breathing crack using iteration method

Nan Wu 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.7

A numerical model is developed to study the forced vibration characteristics of a beam structure with a breathing edge crack. The variablevibration characteristics of the beam induced by the crack breathing are considered in a theoretical model. An iteration numericalmethod is presented to solve the accurate forced vibration of the cracked beam considering its multiple vibration modes and the bilinearity. From numerical simulations, the satisfied iteration step length is obtained to get the accurate crack breathing frequency under asinusoidal periodic excitation. The crack breathing frequency increases linearly when the excitation frequency changes from 0 to firstresonant frequencies of the cracked beam; a non-linear variation of the crack breathing frequency is revealed with the further increasingof the excitation frequency. The proposed numerical model can be used to solve and study the vibration characteristics of beams withbreathing cracks under various excitations.

Dynamic Behavior of Rock Joint Under Different Impact Loads

Nan Wu,Zhen-de Zhu,Cong Zhang,Zhihua Luo 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.2

In order to investigate the influence of the rock joint to rock mass on dynamic loading, the Split Hopkinson Pressure Bar (SHPB) apparatus is used as an effective instrument. Using three different samples of intact (Series A), unfilled joint (Series B), and filled joint (Series C) interfaces, impact tests were performed under different impact speeds. Results showed that the peak strength of series B and C was 55%–75% that of series A. Series C was 10%–20% lower than series B because the former was filled with gypsum in the interface. The attenuation law of the transmission coefficient and failure mode caused by the rock joint was also obtained. To address the problem of classic rock joint constitutive relations being unsuitable under dynamic loading, a new regular expression is proposed by defining two velocity impact factors at respective impact velocities of 3.6 m/s, 6.6 m/s, and 9.6 m/s. Calculation results of this function are tested and verified, and the data are highly consistent.

On the growth of solutions to linear complex differential equations on annuli

Nan Wu,Zu-Xing Xuan 대한수학회 2019 대한수학회보 Vol.56 No.2

In this note, we consider the growth of solutions to second order and higher order linear complex differential equations on annuli instead of the complex plane. We establish several theorems that are analogues of the results in the complex plane.

ON THE GROWTH OF SOLUTIONS TO LINEAR COMPLEX DIFFERENTIAL EQUATIONS ON ANNULI

Wu, Nan,Xuan, Zuxing Korean Mathematical Society 2019 대한수학회보 Vol.56 No.2

In this note, we consider the growth of solutions to second order and higher order linear complex differential equations on annuli instead of the complex plane. We establish several theorems that are analogues of the results in the complex plane.

Development of a Pants Pattern for Chinese Women in Their 20s Using a Virtual Fitting Method

( Nan Wu ),( Chuyeon Suh ) 한국의류학회 2021 한국의류학회지 Vol.45 No.6

This study was conducted to develop a basic pants pattern reflecting the average body shape of Chinese women in their 20s by using a virtual fitting method. A formula for the research pattern was derived by applying the measured value based on the drafting method of existing patterns. The final pattern was presented through two actual fitting processes. The suitability of the final pattern was then verified through a functional evaluation and an appearance evaluation based on an actual fitting and a virtual fitting. As a result of the evaluations, the final pattern reflected the body shape of Chinese women in their 20s and was evaluated as a higher quality pattern compared to existing patterns. The final pattern was based on the omphalion waist circumference. Ease amounts were set to be the omphalion waist circumference + 1.0 cm, hip circumference + 2.0 cm, and the pants length was set to 94 cm.

Review : Alpha-Ketoglutarate: Physiological Functions and Applications

( Nan Wu ),( Mingyao Yang ),( Uma Gaur ),( Huailiang Xu ),( Yongfang Yao ),( Diyan Li ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.1

Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as well. AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles and can be used in clinical applications. In addition to these health benefits, a recent study has shown that AKG can extend the lifespan of adult Caenorhabditis elegans by inhibiting ATP synthase and TOR. AKG not only extends lifespan, but also delays age-related disease. In this review, we will summarize the advances in AKG research field, in the content of its physiological functions and applications.