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Yoon, Minseok,Kim, Jin Soo,Jo, Jinho,Han, Daeseok,Cho, Suengmok The Korean Society of Fisheries and Aquatic Scienc 2014 Fisheries and Aquatic Sciences Vol.17 No.1
We investigated the effects of Ecklonia cava ethanol extract (ECE) on sleep architecture and sleep profiles. ECE was orally administered at a dose of 100, 250, or 500 mg/kg to C57BL/6N mice and its effects were measured by recording electroencephalogram (EEG) and electromyogram. Administration of ECE (250 and 500 mg/kg) significantly induced non-rapid eye movement sleep (NREMS) without affecting rapid eye movement sleep. The increase in NREMS by ECE (500 mg/kg) was significant (P < 0.05) during the first 2 h after administration. In addition, ECE had no effect on EEG power density (an indicator of sleep quality) in NREMS. These results suggest that ECE induces NREMS in a manner similar to physiological sleep.
Extraction Optimization for Phlorotannin Recovery from the Edible Brown Seaweed Ecklonia Cava
Yoon, Minseok,Kim, Jin-Soo,Um, Min Young,Yang, Hyejin,Kim, Jiyoung,Kim, Yun Tai,Lee, Changho,Kim, Seon-Bong,Kwon, Sangoh,Cho, Suengmok Taylor Francis 2017 JOURNAL OF AQUATIC FOOD PRODUCT TECHNOLOGY Vol.26 No.7
( Minseok Albert Kim ),( Jeong-hoon Lee ),( Sungwon Chung ),( Sun Woong Kim ),( Jun Sik Yoon ),( Young Chang ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung-hwan Yoon ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The seroclearance of hepatitis B virus (HBV) surface antigen (HBsAg) is currently considered as a functional cure of chronic hepatitis B. However, there is still a lack of evidence whether the HBsAg-seroclearance is a reliable and durable indicator of HBV eradication. In this study, we aimed to evaluate the reliability and durability of NA-induced HBsAg-seroclearance. Methods: Among 1,100 patients with chronic hepatitis B, 33 patients who achieved HBsAg-seroclearance with NA treatment between January 2010 and December 2017 at a single referral center were analyzed retrospectively. HBsAg was examined using ELISA kit (ARCHITECT HBsAg Qualitative II; Abbott, Wiesbaden, Germany) and < 1.17 S/Co (~0.02 IU/mL) was defined as a negativity. Results: The median age at NA-induced HBsAg-seroclearance was 59.8 (range, 22.4-74.6) years and median NA treatment duration before seroclearance was 76.1 (range, 11.3-193.5) months. At the time of HBsAg-seroclearance, all patients had undetectable serum HBV DNA (< 20 IU/mL). Among them, 22 patients (66.7%) stopped NAs after HBsAg-seroclearance (the NA-off group) and the remaining 11 patients (33.3%) maintained NAs for median 23.5 (range, 5.0-49.8) months (the NA-maintenance group) after HBsAg-seroclearance. During follow-up period (median, 35.0 months; range, 4.7-89.9), two patients (one in the NA-off group and one in the NA-maintenance group) experienced HBsAg-seroreversion although their serum HBV DNA were not detectable. Of the two patents, a patient who are in the NA-maintenance group developed HBsAg-seroreversion at 19 months after HBsAg-seroclearance and again experienced HBsAg-re-seroclearance 17 months later. Interestingly, both patients experiencing HBsAg-seroreversion had hepatocellular carcinoma. Conclusions: A single time negative-conversion of HBsAg might not be a reliable and durable indicator of HBV eradication since there were a few cases of detectable HBV DNA and HBsAg-seroreversion. Thus, repeated evaluation of both HBsAg and HBV DNA might be necessary to confirm the functional cure of chronic hepatitis B undergoing antiviral treatment.
Yoon, Minseok,Kim, Jin-Soo,Kim, Dongsoo,Jo, Jinho,Cho, Suengmok The Korean Society of Fisheries and Aquatic Scienc 2014 Fisheries and Aquatic Sciences Vol.17 No.2
Surimi (or fish paste) products are one of the most representative processed seafoods in Korea. In a previous study, we evaluated the potential use of rice flour as an agent to replace wheat flour in surimi products. In this study, we optimized the content of rice flour and water in surimi products using response surface methodology. Rice flour content ($X_1$, w/w) and water content ($X_2$, v/w) were chosen as independent variables and gel strength ($Y_1$) and overall acceptance ($Y_2$) as dependent variables. Optimal conditions of $X_1$ and $X_2$ were 14% and 9.1%, respectively, and the predicted values of the multiple response optimal conditions were $Y_1=656.4(g{\cdot}cm)$ and $Y_2=6.34$. Under optimal conditions, the experimental values of $Y_1$ and $Y_2$ were $647.8(g{\cdot}cm)$ and 6.21, respectively, which were similar to the predicted values. Surimi products that are prepared under optimum conditions were similar in gel strength to those of commercial products. However, its sensory evaluation score was higher than that of the commercial products. In conclusion, rice flour can not only be used as an alternative to wheat flour, but it also can be used to improve the quality of surimi products.
( Minseok Yoon ),( Jin Soo Kim ),( Dongsoo Kim ),( Jinho Jo ),( Suengmok Cho ) 한국수산과학회(구 한국수산학회) 2014 Fisheries and Aquatic Sciences Vol.17 No.2
Surimi (or fish paste) products are one of the most representative processed seafoods in Korea. In a previous study, we evaluated the potential use of rice flour as an agent to replace wheat flour in surimi products. In this study, we optimized the content of rice flour and water in surimi products using response surface methodology. Rice flour content (X1, w/w) and water content (X2, v/w) were chosen as independent variables and gel strength (Y1) and overall acceptance (Y2) as dependent variables. Optimal conditions of X1 and X2 were 14% and 9.1%, respectively, and the predicted values of the multiple response optimal conditions were Y1 = 656.4 (g.cm) and Y2 = 6.34. Under optimal conditions, the experimental values of Y1 and Y2 were 647.8 (g.cm) and 6.21, respectively, which were similar to the predicted values. Surimi products that are prepared under optimum conditions were similar in gel strength to those of commercial products. However, its sensory evaluation score was higher than that of the commercial products. In conclusion, rice flour can not only be used as an alternative to wheat flour, but it also can be used to improve the quality of surimi products.
Sleep-promoting effects and possible mechanism of a major marine polyphenol dieckol
Minseok Yoon,Jin-Soo Kim,Sangwoo Seo,Kiwon Lee,Min Young Um,Jaekwang Lee,Jonghoon Jung,Minji Kim,Suengmok Cho 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
We had previously demonstrated that phlorotannins enhance sleep in mice. Dieckol is a major phlorotannin constituent from the brown alga Ecklonia cava. Although phlorotannins are known to exert hypnotic effects, the sleep-promoting effect of dieckol has not yet been determined. We evaluated the effect of dieckol on sleep-wake state of mice by analyzing electroencephalograms (EEG) and electromyograms. Flumazenil, a GABAA-benzodiazepine (BZD) antagonist, was used to investigate the molecular mechanism underlying the effects of dieckol on sleep. Dieckol shortened sleep latency and increased non-rapid eye movement sleep duration. Additionally, sleep quality was evaluated by analyzing the EEG power density, and dieckol was found to not affect sleep intensity while zolpidem was found to reduce it. Finally, we treated mice with dieckol in combination with flumazenil and found the latter to inhibit the sleep-promoting effect of dieckol, thereby indicating that dieckol exerts sleep-promoting effects by activating the GABAA-BZD receptor. These results implied that dieckol can be used as a promising herbal sleep aid with minimal side effects, unlike the existing hypnotics.
( Minseok Albert Kim ),( Heejoon Jang ),( Hyunwoo Oh ),( Joon Yeul Nam ),( Yun Bin Lee ),( Eun Ju Cho ),( Jeong-hoon Lee ),( Su Jong Yu ),( Jung-hwan Yoon ),( Hyo-cheol Kim ),( Jin Wook Chung ),( Yoon 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Locoregional therapies, such as yttrium-90 (Y-90) radioembolization (RE) and conventional chemoembolization (CE) can effectively control localized hepatocellular carcinoma (HCC) in patients who are not amenable to curative resection. However, it has not yet been fully established which modality is more effective. The aim of this study was to compare effectiveness of RE and CE as the first treatment of HCC. Methods: We retrospectively reviewed data of patients who received RE or CE as the first treatment of HCC at Seoul National University Hospital from March 2012 to December 2017. A propensity score matching was performed to reduce selection bias. Overall survival (OS), progression-free survival (PFS), and intrahepatic PFS were compared. Results: A total of 138 patients who were initially treated with RE (n=54) or CE (n=84) was included in this study and baseline characteristics was well-balanced between the two groups. Of 138 patients, median age was 59 and median follow-up period was 22.5 months. RE showed better overall survival than CE (hazard ratio [HR]=0.30, 95% confidence interval [CI]=0.10- 0.90, log-rank P=0.02) and tended toward better intrahepatic PFS than CE (HR=0.52, 95% CI=0.25-1.09, log-rank P=0.08). However, progression-free survival was not significantly different between the two groups (HR=0.67, 95% CI=0.39-1.16, log-rank P=0.15). In multivariable analysis, RE was an independent prognositc factor for overall survival (adjusted HR=0.31, 95% CI=0.11-0.92, P=0.04). Conclusions: RE might be more effective as the initial treatment than CE in patients with HCC.