http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
PROBING THE INTERMEDIATE-AGE GLOBULAR CLUSTERS IN NGC 5128 FROM ULTRAVIOLET OBSERVATIONS
Rey, Soo-Chang,Sohn, Sangmo T.,Beasley, Michael A.,Lee, Young-Wook,Rich, R. Michael,Yoon, Suk-Jin,Yi, Sukyoung K.,Bianch, Luciana,Kang, Yongbeom,Lee, Kyeongsook,Chung, Chul,Lee, Sang-Yoon,Barlow, Tom IOP Publishing 2009 ASTROPHYSICAL JOURNAL LETTERS - Vol.700 No.1
<P>We explore the age distribution of the globular cluster ( GC) system of the nearby elliptical galaxy NGC 5128 using ultraviolet (UV) photometry from GALEX observations, with UV-optical colors used as the age indicator. Most GCs in NGC 5128 follow the general trends of GCs in M31 and the Milky Way in the UV-optical color color diagram, which indicates that the majority of GCs in NGC 5128 are old similar to the age range of old GCs in M31 and the Milky Way. A large fraction of spectroscopically identified intermediate-age GC (IAGC) candidates with similar to 3-8 Gyr are not detected in the far-UV (FUV) passband. Considering the nature of intermediate-age populations being faint in the FUV passband, we suggest that many of the spectroscopically identified IAGCs may be truly intermediate in age. This is in contrast to the case of M31 where a large fraction of spectroscopically suggested IAGCs are detected in FUV and therefore may not be genuine IAGCs but rather older GCs with developed blue horizontal branch stars. Our UV photometry strengthens the results previously suggesting the presence of GC and stellar subpopulation with intermediate age in NGC 5128. The existence of IAGCs strongly indicates the occurrence of at least one more major star formation episode after a starburst at high redshift.</P>
Electron delocalization and charge mobility as a function of reduction in a metal–organic framework
Aubrey, Michael L.,Wiers, Brian M.,Andrews, Sean C.,Sakurai, Tsuneaki,Reyes-Lillo, Sebastian E.,Hamed, Samia M.,Yu, Chung-Jui,Darago, Lucy E.,Mason, Jarad A.,Baeg, Jin-Ook,Grandjean, Fernande,Long, Ga Nature Publishing Group UK 2018 Nature Materials Vol.17 No.7
<P>Conductive metal-organic frameworks are an emerging class of three-dimensional architectures with degrees of modularity, synthetic flexibility and structural predictability that are unprecedented in other porous materials. However, engendering long-range charge delocalization and establishing synthetic strategies that are broadly applicable to the diverse range of structures encountered for this class of materials remain challenging. Here, we report the synthesis of KxFe2(BDP)(3) (0 <= x <= 2; BDP2- =1,4-benzenedipyrazolate), which exhibits full charge delocalization within the parent framework and charge mobilities comparable to technologically relevant polymers and ceramics. Through a battery of spectroscopic methods, computational techniques and single-microcrystal field-effect transistor measurements, we demonstrate that fractional reduction of Fe-2(BDP)(3) results in a metal-organic framework that displays a nearly 10,000-fold enhancement in conductivity along a single crystallographic axis. The attainment of such properties in a KxFe2(BDP)(3) field-effect transistor represents the realization of a general synthetic strategy for the creation of new porous conductor-based devices.</P>
Nelson, Michael T,Joksovic, Pavle M,Su, Peihan,Kang, Ho-Won,Van Deusen, Amy,Baumgart, Joel P,David, Laurence S,Snutch, Terrance P,Barrett, Paula Q,Lee, Jung-Ha,Zorumski, Charles F,Perez-Reyes, Edward Society for Neuroscience 2007 The Journal of neuroscience Vol.27 No.46
<P>T-type Ca2+ channels (T-channels) are involved in the control of neuronal excitability and their gating can be modulated by a variety of redox agents. Ascorbate is an endogenous redox agent that can function as both an anti- and pro-oxidant. Here, we show that ascorbate selectively inhibits native Ca(v)3.2 T-channels in peripheral and central neurons, as well as recombinant Ca(v)3.2 channels heterologously expressed in human embryonic kidney 293 cells, by initiating the metal-catalyzed oxidation of a specific, metal-binding histidine residue in domain 1 of the channel. Our biophysical experiments indicate that ascorbate reduces the availability of Ca(v)3.2 channels over a wide range of membrane potentials, and inhibits Ca(v)3.2-dependent low-threshold-Ca2+ spikes as well as burst-firing in reticular thalamic neurons at physiologically relevant concentrations. This study represents the first mechanistic demonstration of ion channel modulation by ascorbate, and suggests that ascorbate may function as an endogenous modulator of neuronal excitability.</P>
GALAXY LUMINOSITY FUNCTION OF THE DYNAMICALLY YOUNG ABELL 119 CLUSTER: PROBING THE CLUSTER ASSEMBLY
Lee, Youngdae,Rey, Soo-Chang,Hilker, Michael,Sheen, Yun-Kyeong,Yi, Sukyoung K. American Astronomical Society 2016 The Astrophysical journal Vol.822 No.2
<P>We present the galaxy luminosity function (LF) of the Abell 119 cluster down to M-r similar to -14 mag based on deep images in the u, g, and r. bands taken by using MOSAIC II CCD mounted on the Blanco 4 m telescope at the CTIO. The cluster membership was accurately determined based on the radial velocity information and on the color-magnitude relation for bright galaxies and the scaling relation for faint galaxies. The overall LF exhibits a bimodal behavior with a distinct dip at r similar to 18.5 mag (M-r similar to -17.8 mag), which is more appropriately described by a two-component function. The shape of the LF strongly depends on the clustercentric distance and on the local galaxy density. The LF of galaxies in the outer, low-density region exhibits a steeper slope and more prominent dip compared with that of counterparts in the inner, high-density region. We found evidence for a substructure in the projected galaxy distribution in which several overdense regions in the Abell 119 cluster appear to be closely associated with the surrounding, possible filamentary structure. The combined LF of the overdense regions exhibits a two-component function with a distinct dip, while the LF of the central region is well described by a single Schechter function. We suggest that, in the context of the hierarchical cluster formation scenario, the observed overdense regions are the relics of galaxy groups, retaining their two-component LFs with a dip, which acquired their shapes through a. galaxy merging process in group environments, before they fall into a cluster.</P>
Prevertebrate Local Gene Duplication Facilitated Expansion of the Neuropeptide GPCR Superfamily
Yun, Seongsik,Furlong, Michael,Sim, Mikang,Cho, Minah,Park, Sumi,Cho, Eun Bee,Reyes-Alcaraz, Arfaxad,Hwang, Jong-Ik,Kim, Jaebum,Seong, Jae Young University of Chicago Press 2015 Molecular biology and evolution Vol.32 No.11
<P>In humans, numerous genes encode neuropeptides that comprise a superfamily of more than 70 genes in approximately 30 families and act mainly through rhodopsin-like G protein-coupled receptors (GPCRs). Two rounds of whole-genome duplication (2R WGD) during early vertebrate evolution greatly contributed to proliferation within gene families; however, the mechanisms underlying the initial emergence and diversification of these gene families before 2R WGD are largely unknown. In this study, we analyzed 25 vertebrate rhodopsin-like neuropeptide GPCR families and their cognate peptides using phylogeny, synteny, and localization of these genes on reconstructed vertebrate ancestral chromosomes (<I>VAC</I>s). Based on phylogeny, these GPCR families can be divided into five distinct clades, and members of each clade tend to be located on the same <I>VAC</I>s. Similarly, their neuropeptide gene families also tend to reside on distinct <I>VAC</I>s. Comparison of these GPCR genes with those of invertebrates including <I>Drosophila melanogaster</I>, <I>Caenorhabditis elegans</I>, <I>Branchiostoma floridae</I>, and <I>Ciona intestinalis</I> indicates that these GPCR families emerged through tandem local duplication during metazoan evolution prior to 2R WGD. Our study describes a presumptive evolutionary mechanism and development pathway of the vertebrate rhodopsin-like GPCR and cognate neuropeptide families from the urbilaterian ancestor to modern vertebrates.</P>
( Manalo Jaime Aherrera ),( Lauro Abrahan ),( Anastacio Degayo ),( Michael Agbayani ),( Michael Reyes ),( Wilfred Dee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Synopsis: The Wolff Parkinson White syndrome and mitral stenosis (MS) is a unfortunate combination, with less than 15 patients reported in literature. They are individually associated with supraventricular arrhythmias and their combination may have profound hemodynamic consequences. Our case is a young male presenting with neurologic deficits who was newly diagnosed with the WPW syndrome and mitral stenosis. Case: A 25 year old male sought consult syncope, palpitations, and dizziness. On the day of admission, he experienced persistent palpitations then subsequently lost consciousness. He had a diastolic rumble, right sided hemiparesis, and dysarthria. A cranial CT scan revealed a left basal ganglia infarction. Electrocardiogram showed sinus rhythm and left atrial enlargement, a short PR interval, wide QRS complexes, and delta waves. Holter monitoring showed episodes of atrial fl utter with rapid ventricular rates. QRS complexes were narrow during other episodes of tachycardia. Echocardiogram revealed moderate mitral stenosis and a dilated LA with no thrombus. Diagnosis was WPW syndrome and rheumatic MS manifesting as a stroke in the young. Percutaneous transvenous mitral commissurotomy (PTMC) was done. He is now on regular follow up on chronic anticoagulation and medical therapy for the WPW syndrome. Conclusion: To our knowledge, this is the fi rst case of a WPW syndrome with rheumatic MS presenting as a stroke in the young who was successfully managed with PTMC for MS and anti-arhrythmics for the WPW syndrome. This unfortunate combination may have potentiated the risk for cardioembolic events which emphasizes that detection of these entities is of paramount importance. Though either of the two entities may have caused the stroke, treatment is warranted for both entities as to avoid future episodes of cardioembolic phenomena.
Belen Lopez-Millan,Rafael Diaz de la Guardia,Heleia Roca-Ho,Carmen M García-Herrero,Jessie R Lavoie,Michael Rosu-Myles,Elena Gonzalez-Rey,Francisco O’Valle,Gabriel Criado,Mario Delgado,Pablo Menendez 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide analogs, including lenalidomide and pomalidomide. These are new generation IMiDs that exhibit direct antitumor activity as well as anti-inflammatory/immunomodulatory properties, and are FDA-approved for the treatment of several hematological malignances. Here we investigated the potential therapeutic effects of lenalidomide and pomalidomide in several experimental murine models of autoimmune/inflammatory diseases: 2,4,6-trinitrobenzene sulfonic acid- and dextran sulfate sodium-induced inflammatory bowel disease and type II collagen-induced arthritis. Lenalidomide displayed a strong therapeutic effect in all these models of autoimmune/inflammatory diseases, while the effect of pomalidomide was less pronounced. In vitro experiments confirmed the immunosuppressive effect of both IMiDs on the proliferative response of stimulated human lymphocytes and on the balance of secreted cytokines toward an anti-inflammatory profile. We conclude that lenalidomide may offer a therapeutic opportunity against autoimmune/inflammatory diseases.