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Song-lin Zhou,Min Wang,Huan-ge Zhao,Yong-hao Huang,Ying-ying Lin,Guang-hong Tan,Shung-lin Chen 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.12
Two azaphilonidal derivatives [penicilazaphilonesB (1) and C (2)], have been isolated from thefermented products of marine fungus strain Penicilliumsclerotiorum M-22, penicilazaphilones C was a new compound. The compound’s structures were identified by theanalysis of spectroscopic data including 1D and 2D NMRtechniques (1H-NMR, 13C-NMR, COSY, HMQC, andHMBC). Biological evaluation revealed that penicilazaphilonesB and C showed selective cytotoxicity againstmelanoma cells B-16 and human gastric cancer cells SGC-7901 with IC50 values of 0.291, 0.449 and 0.065,0.720 mM, respectively, while exhibiting no significanttoxicity to normal mammary epithelial cells M10 at thesame concentration. Moreover, penicilazaphilones C alsoexhibited strong antibacterial activity against Staphylococcusaureus, Pseudomonas aeruginosa, Klebsiellapneumonia and Escherichia coli with MIC values0.037–0.150 mM, while penicilazaphilones B’s bacteriostaticaction was weaker.
Preparation and properties of Al-Al2O3 metal ceramics via powder metallurgy methods
Jieguang Song,Xiuqin Wang,Lin Chen,Cailiang Pang,Jia Zhang,Weiguo Shi,Songlin Guo,Xianzhong Wang,Ruihua Wang 한양대학교 세라믹연구소 2018 Journal of Ceramic Processing Research Vol.19 No.1
Metal ceramics are outstanding new engineering materials that offer the advantages of both ceramics and metals. In this study,Al-Al2O3 metal ceramics were prepared through powder metallurgy methods, and the densification and properties of theprepared metal ceramics were investigated to gain insights into the preparation of high-performance cermet materials. Resultsrevealed that as the forming pressure was increased, the relative density of the ceramics increased, whereas their electricalresistivity decreased. The relative density increased with increasing sintering temperature up to 700 oC and decreased beyond700 oC, whereas the electrical resistivity exhibited an opposite trend. The relative density increased with increasing Al content,whereas the electrical resistivity displayed an opposite trend. Under optimal technological parameters of 700 oC sinteringtemperature, < 20MPa forming pressure, and 75 wt% Al content, Al-Al2O3 metal ceramics with a high relative density(97.52%) and a low electrical resistivity (101.34 Ω·m) were successfully prepared.
A Novel Control Strategy for Input-Parallel-Output-Series Inverter System
Song, Chun-Wei,Zhao, Rong-Xiang,Lin, Wang-Qing,Zeng, Zheng Journal of International Conference on Electrical 2012 Journal of international Conference on Electrical Vol.1 No.2
This paper presents a topology structure and control method for an input-parallel-output-series(IPOS) inverter system which is suitable for high input current, high output voltage, and high power applications. In order to ensure the normal operation of the IPOS inverter system, the control method should achieve input current sharing(ICS) and output voltage sharing(OVS) among constituent modules. Through the analysis in this paper, ICS is automatically achieved as long as OVS is controlled. The IPOS inverter system is controlled by a three-loop control system which is composed of an outer common-output voltage loop, inner current loops and voltage sharing loops. Simulation results show that this control strategy can achieve low total harmonic distortion(THD) in the system output voltage, fast dynamic response, and good output voltage sharing performance.
Lin Yao,Qian Yang,Jinzhu Song,Chong Tan,Changhong Guo,Li Wang,Lianhai Qu,Yun Wang 한국미생물학회 2013 The journal of microbiology Vol.51 No.2
Trichoderma harzianum 88, a filamentous soil fungus, is an effective biocontrol agent against several plant pathogens. High-throughput sequencing was used here to study the mycoparasitism mechanisms of T. harzianum 88. Plate confrontation tests of T. harzianum 88 against plant pathogens were conducted, and a cDNA library was constructed from T. harzianum 88 mycelia in the presence of plant pathogen cell walls. Randomly selected transcripts from the cDNA library were compared with eukaryotic plant and fungal genomes. Of the 1,386 transcripts sequenced, the most abundant Gene Ontology (GO) classification group was “physiological process”. Differential expression of 19 genes was confirmed by real-time RT-PCR at different mycoparasitism stages against plant pathogens. Gene expression analysis revealed the transcription of various genes involved in mycoparasitism of T. harzianum 88. Our study provides helpful insights into the mechanisms of T. harzianum 88-plant pathogen interactions.
Wang, Zehua,Yang, Bo,Zhang, Min,Guo, Weiwei,Wu, Zhiyuan,Wang, Yue,Jia, Lin,Li, Song,Caesar-Johnson, Samantha J.,Demchok, John A.,Felau, Ina,Kasapi, Melpomeni,Ferguson, Martin L.,Hutter, Carolyn M.,Sof Cell Press 2018 Cancer Cell Vol. No.
<P><B>Summary</B></P> <P>We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. In stark contrast to the CpG island hypermethylation phenotype in cancer, we observed a recurrent hypomethylation of 1,006 lncRNA genes in cancer, including <I>EPIC1</I> (epigenetically-induced lncRNA1). Overexpression of <I>EPIC1</I> is associated with poor prognosis in luminal B breast cancer patients and enhances tumor growth <I>in vitro</I> and <I>in vivo.</I> Mechanistically, <I>EPIC1</I> promotes cell-cycle progression by interacting with MYC through <I>EPIC1</I>'s 129–283 nt region. <I>EPIC1</I> knockdown reduces the occupancy of MYC to its target genes (e.g., <I>CDKN1A</I>, <I>CCNA2</I>, <I>CDC20</I>, and <I>CDC45</I>). MYC depletion abolishes <I>EPIC1</I>'s regulation of MYC target and luminal breast cancer tumorigenesis <I>in vitro</I> and <I>in vivo</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> LncRNAs show a hypomethylation phenotype, in contrast to a CIMP phenotype in cancer </LI> <LI> <I>EPIC1</I> promotes breast tumorigenesis through regulating cancer cell-cycle progression </LI> <LI> <I>EPIC1</I> directly interacts with MYC protein through <I>EPIC1</I>'s 129–283 nt region </LI> <LI> <I>EPIC1</I> regulates MYC targets by enhancing MYC occupancy on its target promoters </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lin Hui,신은석,전은정,백영준,Scot Garg,김태현,손창배,최병주,Liu Kun,Song Lin Yuan,Wang Zhi,Jiang Hao,Shi Zhentao,Tang Qiang 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.12
Purpose: Dissection after plain balloon angioplasty is required to achieve adequate luminal area; however, it is associated with ahigh risk of vascular events. This study aimed to examine the relationship between non-flow limiting coronary dissections andsubsequent lumen loss and long-term clinical outcomes following successful drug-coated balloon (DCB) treatment of de novocoronary lesions. Materials and Methods: A total of 227 patients with good distal flow (Thrombolysis in Myocardial Infarction flow grade 3) followingDCB treatment were retrospectively enrolled and stratified according to the presence or absence of a non-flow limiting dissection. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vesselfailure (TVF, a composite of cardiac death, target vessel myocardial infarction, target vessel revascularization, and target vesselthrombosis). Results: The cohort consisted of 95 patients with and 132 patients without a dissection. There were no between-group differencesin LLL (90.8%) returning for angiography at 6 months (0.05±0.19 mm in non-dissection and 0.05±0.30 mm in dissection group, p=0.886) or in TVF (6.8% in non-dissection and 8.4% in dissection group, p=0.799) at a median follow-up of 3.4 years. In a multivariateanalysis, the presence of dissection and its severity were not associated with LLL or TVF. Almost dissections (93.9%) were completelyhealed, and there was no newly developed dissection at 6-month angiography. Conclusion: The presence of a dissection following successful DCB treatment of a de novo coronary lesion may not be associatedwith an increased risk of LLL or TVF (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).
Linli Hou,Yonghai Song,Fengxiang Lang,Zhenrong Wang,Li Wang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.90 No.-
A luminescent Tb3+-pyromellitic acid (H4L = pyromellitic acid) coordination polymer (Tb-H4L CP, TbL0.5(H2L)0.5(H2O)DMF) was prepared for multiresponsive fluorescence sensor. The Tb-H4L CP exhibits uniform nanospheres with average diameter of 220 20 nm, good crystalline structure, and good dispersion in water. The Tb-H4L CP emitted the characteristic green fluorescence through antenna effect from H4L which was an excellent antenna molecule when excited at 270 nm and could be used to selectively determine Fe3+ and polychlorinated benzenes based on fluorescence quenching effect. The coordination between Fe3+ and carboxylic oxygen of Tb-H4L to damage the antenna effect and polychlorinated benzenes absorb the excitation light to result the inner-filter effect of fluorescence, which quenched the fluorescence of Tb-H4L CP. The linear range for Fe3+ was 2.0–100mM with a detection limit of 0.7mM and for 1,3,5-trichlorobenzene was 0–0.44 103 ppm with a detection limit of 0.087 ppm. The Tb-H4L CP demonstrates excellent fluorescence sensing performances, indicating that it can be used as a multi-response sensor to effectively measure toxic and harmful substances.
Therapeutic Regimens and Prognostic Factors of Brain Metastatic Cancers
Song, Wen-Guang,Wang, Yi-Feng,Wang, Rui-Lin,Qu, Yin-E,Zhang, Zhi,Li, Guo-Zhong,Xiao, Ying,Fang, Fang,Chen, Hong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Objective: This work aims to investigate the therapeutic regimen of brain metastatic cancers and the relationship between clinical features and prognosis. Methods: Clinical data of 184 patients with brain metastatic cancers were collected and analysed for the relationship between survival time and age, gender, primary diseases, quantity of brain metastatic foci, their position, extra cranial lesions, and therapeutic regimens. Results: The average age of onset was 59.1 years old. The median survival time (MST) was 15.0 months, and the patients with breast cancer as the primary disease had the longest survival time. Females had a longer survival time than males. Patients with meningeal metastasis had extremely short survival time. Those with less than 3 brain metastatic foci survived longer than patients with more than 3. The MST of patients receiving radiotherapy only and the patients receiving chemotherapy only were all 10.0 months while the MST of patients receiving combination therapy was 16.0 months. Multiple COX regression analysis demonstrated that gender, primary diseases, and quantity of brain metastatic foci were independent prognostic factors for brain metastatic cancers. Conclusions: Chemotherapy is as important as radiotherapy in the treatment of brain metastatic cancer. Combination therapy is the best treatment mode. Male gender, brain metastatic cancers originating in the gastrointestinal tract, more than 3 metastatic foci, and involvement of meninges indicate a worse prognosis.
Expression and Effects of JMJD2A Histone Demethylase in Endometrial Carcinoma
Wang, Hong-Li,Liu, Mei-Mei,Ma, Xin,Fang, Lei,Zhang, Zong-Feng,Song, Tie-Fang,Gao, Jia-Yin,Kuang, Ye,Jiang, Jing,Li, Lin,Wang, Yang-Yang,Li, Pei-Ling Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Previous studies have demonstrated that JMJD2A is a potential oncogene and is overexpressed in human tumors. However, its role in the endometrial carcinoma remains largely unknown. In this study, we discovered that JMJD2A was overexpressed in endometrial carcinoma, using immunohistochemistry, quantitative realtime polymerase chain reaction, and western blotting. Downregulation of JMJD2A led to reduced endometrial carcinoma RL95-2 and ISK cell proliferation, invasion and metastasis as asessed with cell counting kit-8, cell migration and invasive assays. Collectively, our results support that JMJD2A is a promoter of endometrial carcinoma cell proliferation and survival, and is a potential novel drug target.