http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Lijing Deng ) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Simotang Alleviates the Gastrointestinal Side Effects of Chemotherapy by Altering Gut Microbiota
( Lijing Deng ),( Xingyi Zhou ),( Zhifang Lan ),( Kairui Tang ),( Xiaoxu Zhu ),( Xiaowei Mo ),( Zongyao Zhao ),( Zhiqiang Zhao ),( Mansi Wu ) 한국미생물생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.4
Simotang oral liquid (SMT) is a traditional Chinese medicine (TCM) consisting of four natural plants and is used to alleviate gastrointestinal side effects after chemotherapy and functional dyspepsia (FD). However, the mechanism by which SMT helps cure these gastrointestinal diseases is still unknown. Here, we discovered that SMT could alleviate gastrointestinal side effects after chemotherapy by altering gut microbiota. C57BL/6J mice were treated with cisplatin (DDP) and SMT, and biological samples were collected. Pathological changes in the small intestine were observed, and the intestinal injury score was assessed. The expression levels of the inflammatory factors IL-1β and IL-6 and the adhesive factors Occludin and ZO-1 in mouse blood or small intestine tissue were also detected. Moreover, the gut microbiota was analyzed by high-throughput sequencing of 16S rRNA amplicons. SMT was found to effectively reduce gastrointestinal mucositis after DDP injection, which lowered inflammation and tightened the intestinal epithelial cells. Gut microbiota analysis showed that the abundance of the anti-inflammatory microbiota was downregulated and that the inflammatory microbiota was upregulated in DDP-treated mice. SMT upregulated antiinflammatory and anticancer microbiota abundance, while the inflammatory microbiota was downregulated. An antibiotic cocktail (ABX) was also used to delete mice gut microbiota to test the importance of gut microbiota, and we found that SMT could not alleviate gastrointestinal mucositis after DDP injection, showing that gut microbiota might be an important mediator of SMT treatment. Our study provides evidence that SMT might moderate gastrointestinal mucositis after chemotherapy by altering gut microbiota.
-
Diameter Variations of Irregular Fibers under Different Tensions
Deng, Chuanming,Wang, Lijing,Wang, Xungai The Korean Fiber Society 2007 Fibers and polymers Vol.8 No.6
The cross-section area of animal fibers varies along the fiber length, and this geometrical irregularity has a major impact on the mechanical properties of those fibers. In practice fibers are often subjected to tensile stresses during processing and application, which may change fiber cross-section area. It is thus necessary to examine geometrical irregularity of fibers under tension. In this study, scoured animal fibers were subjected to different tensile loading using a Single Fiber Analyzer (SIFAN) instrument. The 3D images of the fiber specimens were first constructed, and then along-fiber diameter irregularities of the specimens were analyzed for different levels of tensile loading. The changes in effective fineness of the fiber specimens were also discussed. The results indicate that for the wool fibers examined, there is considerable discrepancy in the fiber diameter results obtained from the commonly used single scan along fiber length and that from multiple scans at different rotational angles, and that the diameter variation along fiber length increases as fiber tension increases. The results also show that when diameter reduction treatments are applied to wool by stretching, the reduced average fiber diameter is associated with an increase in both within-fiber and between-fiber diameter variations. So in terms of effective fineness, the change is much smaller than the difference between the average diameters of the parent and treated wool. These results have significant implications for improving the accuracy of fiber diameter measurement and evaluation.
-
Liu Lijing,Jia Ling,Xu Li,Deng Lele,Zhao Ping,Zeng Wanli 한국식물생명공학회 2021 Plant biotechnology reports Vol.15 No.2
2, 3-bisphosphoglycerate-independent phosphoglycerate mutase (iPGAM), is a key enzyme that catalyzes the reversible interconversion of 3-phosphoglycerate and 2-phosphoglycerate in glycolysis. iPGAM has been found to be involved in several physiological processes, including stomatal movement, chlorophyll synthesis, pollen production, chloroplast development and photosynthesis in diferent plants. However, the roles iPGAM plays in model plant tobacco are still elusive. In the current study, two copies of the iPGAM gene in Nicotiana tabacum were cloned, NtiPGAMa and NtiPGAMb, from the variety “Honghuadajinyuan”. Expression profles and subcellular localization analyses showed that NtiPGAMa and NtiPGAMb were highly expressed in the anthers and were localized to the nucleus, cytosol and cell membrane. Using the CRISPR/ Cas9 system, three mutant lines with mosaic leaves were obtained by targeting the second exon of the iPGAM gene. Based on Sanger sequencing, the mutant lines were chimeric plants and displayed mutation rates ranging from 82.3% to 92.5%. The iPGAM mutations showed signifcantly decreased photosynthetic pigments, i.e., chlorophyll a, chlorophyll b and carotenoids, thinning or loss of chloroplast thylakoid lamellar structures. RT-PCR analysis showed that the expressions of genes associated with chlorophyll synthesis and photosynthesis were signifcantly down-regulated in the iPGAM mutant plants compared to wild type. The pollen development was greatly impaired in mutant plants, resulting in reduced and deformed pollens with grains inviable. Our fndings indicate that iPGAM is critical for pollen vitality, chlorophyll synthesis and chloroplast morphogenesis in N. tabacum.
-
Mingyu Fu,Dan Bai,Hanbo Deng,Lijing Dong 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.4
In this paper, a novel global sliding mode controller (GSMC) with a comprehensive observer is used to solve the problems of time-varying coefficients, modeling errors and disturbance with unknown upper bound in the trajectory tracking control of the air-cushion vehicle (ACV). Considering the multiple resistance coefficients that change with the motion state in the ACV’s dynamic model, a comprehensive observer is used to estimate and compensate for the model uncertainty in real time. An adaptive disturbance estimation law without disturbance upper bound is given to compensate for the total disturbance. On the basis of real-time compensation of model uncertainty by adaptive estimation law, a new GSMC with hyperbolic tangent function is proposed to track the ACV’s trajectory. The interconnected system of observer and trajectory tracking controller is shown to have enhanced robustness. Finally, simulations verify the effectiveness of the proposed control approaches.
ScienceON
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
