유방통을 호소하는 한국 여성에서 Gamma Linolenic acid의 임상적인 효과

정재헌,김권천,조현진,민영돈,김성환,김정용,장정환 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background and Objectives : Recently, the incidence of breast cancer is gradually increasing in korea. Many patients visit the hospital with a fear of breast cancer, if she had the pain in her breast. But Breast pain is not a cardinal sign of breast cancer. Only 7% of patient in breast cancer has breast pain. Materials and Method : To know the clinical effects of gamma-linolenic acid(GLA), we analyzed the medical records of 55 cases with breast pain, who visited the outpatient clinic of Chosun university hospital, between July of 1999 to December of 1999. Of the 55cases of breast pain, we analyzed 26 cases of patient with breast pain who was treated with GLA for 2 month and we excluded patients of breast pain who had breast mass or were treated with other drug. Results : 2 Patients we are dropped out because nausea and vomiting were developed, 4 Patient with breast pain were treated with GLA for 1 month, and relieved completely from mastalgia and 8 patients with breast pain were treated with GLA for 2 months and breast pain was relieved completelys. 4 patient had treatment for 2 months, were relieved slightly. But 8 patients with breast pain didn't reveal the relief of symptom after the intake of GLA. Conclusion : We conclude that GLA could be considered a first line drug in patients with mastalgia.

여고생의 의복착용과 구매행동

권수애,이진희,서정은,차윤숙,김은영 충북대학교 교육생활연구소 2001 생활과학연구논총 Vol.4 No.-

The purpose of this study was to investigate the wearing and purchase behavior of clothing among girls' high school students. The subjects of this study were 393 girls' high school students in Chongju. The data were collected by questionnaires and analyzed by frequencies and χ2 -test. The results were as follows: 1)Most of girls' high school students wore plain clothes 2-4 days per a week when they went out after school, and the seventy percents of them tended to exchange their clothing each other and to modify their school uniform. 2)In a purchase behavior, they use the display in stores to seek for information regarding clothing products and they were supported by their parents for buying their clothes. Also, most of them purchased their clothes once or twice a season. About thirty five percents of them, purchased their clothes in famous brand stores. 3)The frequency of purchasing clothing products was related with the variables of allowance. self-perceived economic state, the frequency of wearing plain clothes, and the exchange of clothes.

XML 저장 관리 시스템에서 효율적인 버전 관리 및 문서 저장 방안

정현주,김권양,최재혁 한국컴퓨터교육학회 2003 컴퓨터교육학회 논문지 Vol.6 No.4

빠르게 변하는 정보화 사회에서 방대한 양의 문서 정보를 전자 문서로 만들고 관리하는 것은 필수적이다. 이러한 전자 문서를 표현하는 데 있어서 사용하는 문서 내에 포함된 모든 정보를 손실 없이 저장하고 관리하는데 적합한 언어가 전자 문서의 표준인 XML이다. 본 논문에서는 문서의 변경이 발행한 경우에 문서 전체가 아닌 변경이 발행한 내용만 버전을 부여하고 저장함으로써 저장 공간을 절약하였다. 그리고 문서의 변경 내용이 일정한 크기 이하이면 JOIN 연산을 생략할 수 있도록 시스템을 설계함으로써 JOIN연산으로 인한 시스템의 성능 저하를 줄여 효율적인 XML 문서 저장과 빠른 검색 및 버전 관리가 가능한 방안을 제시하고, 이를 적용한 문서 저장 관리 시스템을 구현하였다. In rapidly changing an information=oriented society, it is essential to control massive document information by electronic file, In relation to these electronic document, it is also important to keep and maintain all kinds of information without any losses. It should be allowed to trace previous contents as well as recently updated contents by controlling updated contents with version. For these, XML is recommendable. In this thesis, we intend to save the document storing space by saving only updated contents with version without saving whole documentation, when document is updated. In case of controlling the history of document update by version, we designed system so as to omit “JOIN operation” if document size is under a certainspecific size. Therefore, we implemented a new XML document repository system which is possible for quick search and efficient XML document saving by reducing perfomance deterioration caused by JOIN operation.

Schiff Base 리간드의 몰리브덴 착물 합성과 그 성질

구본권,김정숙 대구효성가톨릭대학교 자연과학연구소 1992 基礎科學硏究論集 Vol.1992 No.1

Six-coordinate molybdenum(V) complexes [MoOCl(L)(MeOH)], where L = the tridentate schiff base dianions derived from the condensation reaction beween various salicylaldehydes and 2-aminophenol have been synthesized. The structures of the complexes have been determined by elemental analysis, conductivity, U.V.-visible, I.R., and ^1H n.m.r.. The coordination around the molybdenum is distorted octahedral. A tridentate ligand containing the ONO donor atoms occupies meridional positions with the N atom trans to the terminal oxo group. The electrochemical behaviors for the complexes have been also investigated by cyclic voltammetry in dimethylsulfoxide.

위암의 근치절제술 후 생존율과 예후인자

차윤정,박진영,장정환,김성환,김권천,조현진,민영돈 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Background and Objectives: Gastric cancer is still the leading cause of cancer death in Korea, and surgery remains the only method of treatment that offers the potential for a cure. Purpose: The aims of this study are to examine the outcome of the patients with gastric adenocarcinoma who underwent curative resection and to identify the prognostic factors leading to improved survival rates in these patients. Materials and Methods: The medical records of 278 patients with gastric adenocarcinoma, treated curatively at the Chosun University Hospital between January 1990 and December 1994, were reviewed retrospectively from January 2000 to March 2000. Follow-up was obtained for 250 patients(89.9%). The survival rates were calculated by the Kaplan-Meier method, and the significance of differences between patient factors(age and sex), tumor factors(location, size, gross type, tumor depth, lymph node metastasis, and stage) and treatment factors(operation method and reconstruction type) were evaluated statistically by the log-rank test. Results: The overall five-year survival probability was 59.6%. There was no survival difference according to age and sex. The 5-year survival rates according to the tumor depth were 97.0% for Tl, 74.5% for T2, 39.6% for T3, and 23.1% for T4(p=0.0000); to the lymph node metastasis were 81,4% for N0, 51.9% for N1, and 21.2% for N2(p=0.0000); to the TNM stage were 96.7% for stage I a, 79.5% for stage I b, 68.8% for stage II, 52.9% for stage III a, 25.9% for stage III b, and 7.5% for stage IV(p=0.0000). Other statistically significant differences were shown in tumor location, size, gross type, operation method, and reconstruction type after subtotal gastrectomy. Conclusion: The most definitive prognostic factors affecting the survival rate of gastric adenocarcinoma were tumor depth, lymph node metastasis, and tumor stage. The keys to successful outcome includes early diagnosis and curative resection with radical lymph node dissection at early stage as possible.

Schiff Base 리간드의 몰리브덴 착물 합성과 그 성질

구본권,김정숙 대구효성가톨릭대학교 1992 연구논문집 Vol.45 No.1

Six-coordinate molybdenum(V) complexes [MoOCI(L)(MeOH)], where L=the tridentate schiff base dianions derived from the condensation reaction between various salicylaldehydes and 2-aminophenol have been synthesized. The structures of the complexes have been determined by elemental analysis, conductivity, U.V.-visible, I.R., and ¹H n.m.r.. The coordination around the molybdenum is distorted octahedral. A tridentate ligand containing the ONO donor atoms occupies meridional positions with the N atom trans to the terminal oxo group. The electrochemical behaviors for the complexes have been also investigated by cyclic voltammetry in dimethylsulfoxide.

자발성 뇌지주막하출혈 환자에서 Cardiac Troponin Ⅰ를 이용한 심근손상의 발생율

김용권,류진호,소정일,문원식,전병조,허탁,민용일 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Background : More than 90% of acute stroke patients have measurable cardiovascular sequelae, but we have been often overlooked in formal discussions of treatment. If we estimate the incidence of myocardial injury in patients with spontaneous SAH, we may figure the possibility of cardiac dysfunction in such patients. This study was designed to investigate the incidence of myocardial injury in patients with spontaneous SAH using cardiac troponin I(cTnI). Methods : A prospective single emergency center study was performed to determined preoperative incidence of unrecognized cardiac injury in patients suffering spontaneous SAH. We include the spontaneous SAH patients who underwent serum measurements of the cardic troponin I immediately upon admission last six month period. ECG, CK, CK-MB and myoglobin were also performed at admission. We excluded the spontaneous SAH patients who had past history of myocardial ischemia and ECG abnormality. Results : Fifty-two patients(34 females, 18 males) with spontaneous SAH were studied prospectively. 18 patients(34.6% of the total study population) had cTnI level above 0.5ng/ml. ECG was performed in 52 patients and was abnormal in 15 of the 52 patients(28.8%). Conclusion : The measurement of cTnI has provided physicians with a myocardial marker that has a cardiac sensitivity for cardiac injury equal to that of CK-MB yet with greater specificity. So, cardiac troponin I is useful to estimate the incidence of myocardial injury in patients with spontaneous SAH. And we may estimate the possibility of cardiac dysfunction in such patients. This knowledge will hopefully aid in the care and improve the outcome.

뇌졸중 환자에 동반된 환측 요신경총병증 1예

김권영,강정훈,박진우 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

The majority of stroke patients present that upper extremity of hemiplegic limb is weaker than lower extremity. So rehabilitation of hemiplegic upper extremity shows multiple problems. Peripheral nerve injuries included brachial plexopathy in hemiplegic upper extremity is more common reported than lower problem. Moreover, lumbar plexopathy in hemiplegic lower extremity is rarely reported. A 56-year old woman of acute hemiplegic stroke presented with back pain and proximal weakness of the hemiplegic leg. Neurologic examination and electrophysiologic studies show upper lumbar plexopathy. We report a stroke patient with lumbar plexopathy which leads to proximal weaknesss on hemiplegic leg.

한국인의 심근 조직내 카드뮴 농도의 참고치

박정덕,임헌방,최병선,권일훈,이상연,강은용,홍연표,장임원 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

Cadmium(Cd) is an ubiquitous, toxic and nonessential metal which is controversial about the association with a cardiovascular disease. In this study, we investigated the reference level of Cd in myocardium in Korean general population. The level of Cd and zinc(Zn) concentration in myocardium of 252 cases of "sudden and unexpected death" autopsies (male: 172, female : 60) aged 0 to 87 years was analyzed. The concentration of Cd and Zn was determined with atomic absorption spectrophotometer(Perkin-Elmer Model 5100) by flameless and flame method, respectively. The content of Cd and Zn in myocardium showed the log-normal distribution rather than normal distribution. Geometric mean concentration of Cd was 0.19 ㎍/g wet weight in myocardium. The level of Cd in myocardium was not significantly different between male (0.18㎍/g wet weight) and female (0.22㎍/g wet weight). Geometric mean concentration of Zn in myocardium was 25.25 ㎍/g wet weight. The level of Zn between male (25.13 ㎍/g wet weight) and female (25.57㎍/g wet weight) was not different. The deposit of Cd in myocardium was age-dependent of biphasic pattern, but the Zn level by age was not significantly different. The level of Cd in myocardium was increased to the fifties of age, thereafter a leveling-off was shown. The regression model of Cd deposit in myocardium by age was predicted as the following equation: Log Heart-Cd= -1.2726 + 0.0234 ·Age -0.0002 ·Age². The maximum Cd deposit in myocardium was estimated to be 0.26 ㎍/g wet weight at the age of 58.5 in Korean general population. In addition, the total Cd burden in heart by age was predicted as a following equation: Total Cd burden in Heart= -10.165+2.891 ·Age -0.0258 ·Age². The maximum heart burden of Cd was estimated to be 70.7㎍ at age of 55.4. The positive correlation between Cd and Zn was observed in myocardium. The linear regression equation was Log Heart-Zn = 1.4195+0.0262 ·Log Heart-Cd.

한국인의 신장과 간장조직내 카드뮴함유량의 참고치

박정덕,최병선,권일훈,홍연표,장임원 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.3

목 적 : 카드뮴은 인체의 물질대사에는 불필요하며 사람에게 발암작용이 있는 유해금속 물질로서체 내에서 축적되는 경향이 있다. 신장과 간장은 카드뮴의 주요 축적 장기로서 일반 인구집단에서 생활환경을 통해 미량의 카드윰에 만성적으로 폭로량을 가장 잘 반영한다. 방 법 : 이번 연구에서는 특별히 카드윰에 폭로된 적이 없는 0∼87세 범위의 부검체 254예(남자:188예, 여자 : 66예)를 대상으로 신장피질과 간장조직내 카드윰량을 분석하여 한국인에 있어서 신장과 간장내 카드윰 함유량의 참고치를 제시하였고, 체내카드뮴 총 부하량을 추정하였다. 결 과 : 한국인의 신장피질과 간장내 카드윰 농도의 기하평균치는 각각 27.4 ㎍/g wet weight와 3.1 ㎍/g wet weight 이었고, 아연의 기하평균치는 신장피질 35.4 ㎍/g wet weight, 간장 42.6 ㎍/g wet weight 이었다. 신장피질내 카드윰 축적량은 간장의 약 9배로서 미량 만성적 폭로시 신장이 주요 축적장기이었다. 한국인에 있어서 연령에 따른 신장피질내 카드윰 축적량은 50대 까지는 증가하다가 이후 감소되는 양상을 나타내었다. 신장피질내 카드뮴 축적량과 연령과는 2차 함수적인 관계를 나타내어 연령별 신장피질내 카드윰 축적량을 추정할 수 있는 예측식이 Log KCd=0.2325+0.0553 · Age-0.0005 · Age2으로 산출되어, 한국인에 있어 신장피질내 카드윰 축적량의 최고 농도는 50.8세에서 43.4 ㎍/g wet weight로 추정되었다. 또한, 신장 피질과 간장내 카드윰 축적량으로부터 산출된 연령에 따른 체내 카드윰 총 부하량의 예측식이 Total Cd Body Burden=-4.5948+1.2278 · Age-0.0121 · Age2로 산출되어, 체내 카드윰 총 부하량은 50.7 세에서 가장 높았으며 이때 26.5mg의 카드뮴이 체내에 축적되는 것으로 추정되었다. 신장피질과 간장에서 아연과 카드윰은 양의 상관이 있어 각각 Log KZn=1.1410+0.2841· Log KCd, Log LBn=1.5016+0.2396 · Log LCd 의 직선회귀관계가 성립되었으며, Cu/Zn비는 조직내 연령별 카드뮴농도와 비슷한 양상을 나타내었다. 결 론 : 이상의 결과에서 나타난 한국인의 카드뮴 폭로량은 일본인에 비해서는 낮았으나, 미국이나 서구지역에 비해서는 비슷하거나 다소 높은 수준으로 평가되었다. Objectives : Cadmium (Cd), a toxic and non-essential metal, is recognized as a human carcinogen, which has a tendency to accumulate In the human body. The levels of Cd in renal cortex and liver are good indicators as an index of Cd exposure in the general popelation. In this study, we present an estimation of reference Cd levels in tissue (renal cortex and liver) and total body burden in the general population of Korea. Methods : Cd and zinc (Zn) were analyzed in renal cortex and liver from 254 autopsies(male : 188 cases, female : 66 cases) aged 0 to 87 years. Results : Geometric mean concentration of Cd was 27.4 and 3.1 ㎍/g wet weight in renal cortex and liver, respectively. The level of Zn in renal cortex and liver was 35.4 and 42.6 ㎍/g wet weight, respectively. The result suggests that kidney is the target organ for Cd accumulation. The accumulation of Cd in renal cortex was age-dependent with a biphasic pattern. The level of Cd in renal cortex increased with age up to the fifties, and then level설 off thereafter. Based on the data, the regression model for Cd accumulation In renal cortex by age is predicted by : Log KCd = 0.2325 + 0.0553 · Age -0.0005 · Age2. The highest Cd accumulation in renal cortex of Koreans was estimated at 43.3 ㎍/g wet weight at 50.8 years old. In addition, the total Cd body burden by age was estimated by the fellowing equation'Total Cd Body Burden = -4.5948 + 1.2278 · Age - 0.0121 Age2. The highest body burden of Cd was estimated at 26.5 mg at age 50.7 years in the Korean general population. The positive correlation between Zn and Cd was observed In renal cortex and liver. Conclusions The level of Cd exposure in Korean was found to be lower than In Japanese, but same as or higher than in American and Europeans.