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Fotemustine, Teniposide and Dexamethasone in Treating Patients with CNS Lymphoma
Wu, Jing-Jing,Wang, Xin-Hua,Li, Ling,Li, Xin,Zhang, Lei,Sun, Zhen-Chang,Fu, Xiao-Rui,Ma, Wang,Chang, Yu,Zhang, Xu-Dong,Han, Li-Juan,Zhang, Ming-Zhi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Purpose: We developed and evaluated a regimen including fotemustine, teniposide and dexamethasone (FTD) for treating patients with central nervous system (CNS) lymphoma based on pharmacokinetic properties of individual agents and in combination. Patients and Methods: In a comparison study, 8 patients with primary CNS lymphoma (PCNSL) and 8 with secondary CNS lymphoma (SCNSL) were treated with FTD (comprising fotemustine 100 mg/m2, 1h infusion, day 1; teniposide 60 mg/m2, >0.5 h infusion, on day 2, 3, 4; dexamethasone 40 mg, 1h infusion, on day 1, 2, 3, 4 and 5; and methotrexate 12 mg, cytosine arabinoside 50 mg plus dexamethasone 5 mg intrathecally, on day 2 and 7). Cycles were repeated every 3 weeks. After response assessment, patients received whole brain radiotherapy. Results: Of the 8 PCNSL patients, 4 (50%) achieved CR and 3 (38%) PR, an overall response rate of 88%. Four patients (50%) were in continuing remission at the end of this study after a median follow-up of 30 months (range 10 to 56 months). Of the 8 SCNSL patients the overall response rate was 63% (CR+PR: 38%+25%). All responses were achievable with predictable toxicity mainly reflecting reversible myelosuppression. Conclusion: This study suggests that FTD could be an effective treatment for CNS lymphoma, and is worthy of further evaluation.
Naturally Occurring Lactic Acid Bacteria Isolated from Tomato Pomace Silage
Wu, Jing-Jing,Du, Rui-Ping,Gao, Min,Sui, Yao-Qiang,Xiu, Lei,Wang, Xiao Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.5
Silage making has become a significant method of forage conservation worldwide. To determine how tomato pomace (TP) may be used effectively as animal feed, it was ensilaged for 90 days and microbiology counts, fermentation characteristics and chemical composition of tomato pomace silage (TPS) were evaluated at the 30th, 60th, and 90th days, respectively. In addition, 103 lactic acid bacteria were isolated from TPS. Based on the phenotypic and chemotaxonomic characteristics, 16S rDNA sequence and carbohydrate fermentation tests, the isolates were identified as 17 species namely: Lactobacillus coryniformis subsp. torquens (0.97%), Lactobacillus pontis (0.97%), Lactobacillus hilgardii (0.97%), Lactobacillus pantheris (0.97%), Lactobacillus amylovorus (1.9%), Lactobacillus panis (1.9%), Lactobacillus vaginalis (1.9%), Lactobacillus rapi (1.9%), Lactobacillus buchneri (2.9%), Lactobacillus parafarraginis (2.9%), Lactobacillus helveticus (3.9%), Lactobacillus camelliae (3.9%), Lactobacillus fermentum (5.8%), Lactobacillus manihotivorans (6.8%), Lactobacillus plantarum (10.7%), Lactobacillus harbinensis (16.5%) and Lactobacillus paracasei subsp. paracasei (35.0%). This study has shown that TP can be well preserved for 90 days by ensilaging and that TPS is not only rich in essential nutrients, but that physiological and biochemical properties of the isolates could provide a platform for future design of lactic acid bacteria (LAB) inoculants aimed at improving the fermentation quality of silage.
태권도 선수들이 인지하는 지도자-선수 상호작용이 자기효능감, 운동몰입, 인지된 경기력 간의 관계
WU JINGE,최천(Choi, Chun) 한국무예학회 2023 무예연구 Vol.17 No.1
본 연구는 한국 대학 태권도 선수들이 인지하는 지도자-선수 상호작용, 자기효능감, 운동몰입, 인지된 경기력 간의 관계를 규명하는데 목적이 있다. 이러한 목적을 달성하기 위하여 한국대학에서 태권도 겨루기와 품새 선수를 모집단으로 선정하여 비확률표본추출법 중 편의표본추출법을 실시하여, 총 289부 설문지를 사용하였다. 수집된 자료는 SPSS 23.0과 AMOS 23.0을 통해 분석되었으며, 연구결과는 다음과 같다. 첫째, 상호작용의 하위요인 중 믿음과 노하우는 자기효능감에 긍정적인 영향을 미치는 것으로 나타났다. 둘째, 상호작용의 하위요인 중 믿음은 운동몰입에 긍정적인 영향을 미치는 것으로 나타났다. 셋째, 상호작용의 하위요인 중 노하우는 인지된 경기력에 긍정적인 영향을 미치는 것으로 나타났으며, 기술은 인지된 경기력에 부정적인 영향을 미치는 것으로 나타났다. 넷째, 자기효능감은 인지된 경기력에 긍정적인 영향을 미치는 것으로 나타났다. 다섯째, 운동몰입은 인지된 경기력에 긍정적인 영향을 미치는 것으로 나타났다. 결론적으로 현대 태권도의 발전에 따라 경기규칙, 시합전략은 계속 변화•발전될 것이며, 지도자들은 이러한 전문성 신장을 위해 지속적인 노력을 해야 할 것이다. 따라서 현재 대학 태권도 지도자들은 필요한 전문지식을 갖추기 위해서 워크숍, 세미나 등에 적극적으로 참여할 필요성이 있다. The purpose of this study is, therefore, to examine the effect of the coach-athlete interaction perceived by Taekwondo athletes on the self-efficacy. To this end, it conducted the convenience sampling among the non-probability sampling, by recruiting Taekwondo sparring and Poomsae athletes from the Korean university, and used a total of 289 questionnaires. data were conducted by using SPSS 23.0 and AMOS 23.0. The findings are as follows: First, the belief and the know-how among the sub-factors of the coach-athlete interaction perceived have positive effects of the self-efficacy. Second, the belief among the sub-factors of the coach-athlete interaction perceived has a positive effect on the exercise flow. Third, the know-how among the sub-factors of the coach-athlete interaction perceived has a positive effect on the perceived performance. Fourth, the self-efficacy has a positive effect on the perceived performance. Fifth, the exercise flow has a positive effect on the perceived performance. In conclusion, The game rules, game strategies and training methods would be changed and developed, and coaches should make continuous effort to increase their professionalism, along with the development of the modern Taekwondo. Hence the current Taekwondo coaches need to actively participate in workshops, seminars, etc., to acquire professional knowledge necessary for them.
Wu, Jing,Tan, Xinyu,Peng, Xiaozhong,Yuan, Jiangang,Qiang, Boqin Korean Society for Biochemistry and Molecular Biol 2003 Journal of biochemistry and molecular biology Vol.36 No.4
For better understanding of functions of the Calcyclin Binding Protein (CacyBP) and exploring its possible roles in neuronal differentiation, the subcellular localization of human CacyBP was examined in retinoic acid(RA)-induced and uninduced neuroblastoma SH-SY5Y cells. Immunostaining indicated that CacyBP was present in the cytoplasm of uninduced SH-SY5Y cells, in which the resting $Ca^{2+}$ concentration was relatively lower than that of RA-induced cells. After the RA induction, immunostaining was seen in both the nucleus and cytoplasm. In the RA-induced differentiated SH-SY5Y cells, CacyBP was phosphorylated on serine residue(s), while it existed in a dephosphorylated form in normal (uninduced) cells. Thus, the phosphorylation of CacyBP occurs when it is translocated to the nuclear region. The translocation of CacyBP during the RA-induced differentiation of SH-SY5Y cells suggested that this protein might play a role in neuronal differentiation.
Jing-Ren Wu,Luigi Di Sarno,Steve Hesketh,Nigel Phan 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.6
The practical application of cold-formed high strength steel is becoming increasingly popular in structural engineering due to its great effi ciency and cost eff ectiveness. However, cold-formed steel sections are usually associated with high slenderness, hence are susceptible to buckling failure. Consequently, the buckling resistance of steel struts made of cold-formed high strength steel must be determined with carefulness, particularly for complex compound sections. To this end, the present paper aims at investigating the behaviour of back-to-back channel sections made of S700 steel with a characteristic yield strength of 700 MPa. Compressive tests on such members are conducted for the purpose of validating the fi nite element models. Subsequently, a numerical parametric analysis is carried out on the buckling resistance of axially loaded cold-formed steel back-to-back channel sections, using the previously validated numerical modelling approach. In particular, the eff ects of stiff eners and number of bolts on the buckling resistance are investigated. Furthermore, the results of the parametric analysis are also compared with the codifi ed buckling resistance determined based on the eff ective width method adopted in Eurocode 3 Part 1–3, in order to evaluate the reliability of the standardised design method for buckling resistance.