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A New ent-Kaurane type Diterpenoid Glycoside from Inula japonica Thunb
Jiang Jiang Qin,Jia Xian Zhu,Wei Dong Zhang1,2,Yan Zhu,Jian Jun Fu,Xiao Hua Liu,Hui Zi Jin 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
A new ent-kaurane type diterpenoid glycoside, 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid (1), together with 17-hydroxy-16α-ent-kauran-19-oic acid (2), 16α,17-dihydroxyl-ent-kauran-19-oic acid (3), and 16α-hydroxy-17-acetoxy-ent- kauran-19-oic acid (4) were isolated from the aerial parts of Inula japonica Thunb. The structure of 1 was determined mainly by use of 1D and 2D NMR spectroscopic techniques including HSQC, 1H-1H COSY, HMBC, and NOESY. In addition, 4 exhibited significant inhibitory activity on NO production in LPS-stimulated RAW264.7 cells with IC50 value of 14.3 μg/mL.
Zhang, Xinxin,Cheng, Shiyang,Zhang, Wei,Zhang, Cai,Drewett, Nicholas E.,Wang, Xiyang,Wang, Dong,Yoo, Seung Jo,Kim, Jin-Gyu,Zheng, Weitao American Chemical Society 2017 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.56 No.39
<P>Ag/Pr<SUB>6</SUB>O<SUB>11</SUB> catalysts supported by either Pr<SUB>6</SUB>O<SUB>11</SUB> nanorods (Pr<SUB>6</SUB>O<SUB>11</SUB>-NRs) or nanoparticles (Pr<SUB>6</SUB>O<SUB>11</SUB>-NPs) were prepared by conventional incipient wetness impregnation. The nanocomposite of Ag/Pr<SUB>6</SUB>O<SUB>11</SUB>-NRs demonstrated a higher catalytic activity for CO oxidation than Ag/Pr<SUB>6</SUB>O<SUB>11</SUB>-NPs at lower temperatures. This improved performance may be ascribed to the mesoporous features and resultant oxygen vacancies of the Pr<SUB>6</SUB>O<SUB>11</SUB> nanorods support, as well as the large surface area and homogeneous loading of Ag species. As a result, 98.7 and 100% CO conversions were achieved at 210 and 240 °C for Ag/Pr<SUB>6</SUB>O<SUB>11</SUB>-NRs, while Ag/Pr<SUB>6</SUB>O<SUB>11</SUB>-NPs require a temperature of 320 °C to obtain the 100% CO conversion rate. These findings reveal that Pr<SUB>6</SUB>O<SUB>11</SUB>-NRs is the preferable support, comparative to Pr<SUB>6</SUB>O<SUB>11</SUB>-NPs, for Ag/Pr<SUB>6</SUB>O<SUB>11</SUB> catalysts, for CO oxidation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/iecred/2017/iecred.2017.56.issue-39/acs.iecr.7b02530/production/images/medium/ie-2017-02530c_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ie7b02530'>ACS Electronic Supporting Info</A></P>
The K+/H+ antiporter AhNHX1 improved tobacco tolerance to NaCl stress by enhancing K+ retention
Wei-Wei Zhang,Jing-Jing Meng,Jin-Yi Xing,Sha Yang,Feng Guo,Xin-Guo Li,Shu-Bo Wan 한국식물학회 2017 Journal of Plant Biology Vol.60 No.3
High salinity is the one of important factors limiting plant growth and crop production. Many NHX-type antiporters have been reported to catalyze K+/H+ exchange to mediate salt stress. This study shows that an NHX gene from Arachis hypogaea L. has an important role in K+ uptake and transport, which affects K+ accumulation and plant salt tolerance. When overexpressing AhNHX1, the growth of tobacco seedlings is improved with longer roots and a higher fresh weight than the wild type (WT) under NaCl treatment. Meanwhile, when exposed to NaCl stress, the transgenic seedlings had higher K+/H+ antiporter activity and their roots got more K+ uptake. NaCl stress could induce higher K+ accumulation in the roots, stems, and leaves of transgenic tobacco seedlings but not Na+ accumulation, thus, leading to a higher K+/Na+ ratio in the transgenic seedlings. Additionally, the AKT1, HAK1, SKOR, and KEA genes, which are involved in K+ uptake or transport, were induced by NaCl stress and kept higher expression levels in transgenic seedlings than in WT seedlings. The H+-ATPase and H+-PPase activities were also higher in transgenic seedlings than in the WT seedlings under NaCl stress. Simultaneously, overexpression of AhNHX1 increased the relative distribution of K+ in the aerial parts of the seedlings under NaCl stress. These results showed that AhNHX1 catalyzed the K+/H+ antiporter and enhanced tobacco tolerance to salt stress by increasing K+ uptake and transport.
Comprehensive Evaluation of Impacts of Connecting Distributed Generation to the Distribution Network
Jin, Wei,Shi, Xuemei,Ge, Fei,Zhang, Wei,Wu, Hongbin,Zhong, Chengyuan The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
In this paper, we study the various impacts of connecting distributed generation (DG) to the distribution network. The comprehensive evaluation index system (CEIS) of four hierarchies is established, considering economy, reliability and voltage quality, and the calculation methods of different indexes are presented. This paper puts forward an improved triangular fuzzy number analytic hierarchy process (ITFNAHP) to weight the second level indexes (SLI) and the third level indexes (TLI), and calculates the variation coefficient to weight the fourth level indexes (FLI). We calculate the comprehensive weight coefficients based on the weight coefficients of the SLI, TLI and FLI, and then calculate the comprehensive evaluation of satisfaction (CES) of different access schemes. On the basis of the IEEE 33-bus example system, simulations of the calculation methods and the comprehensive evaluation method are carried out under different DG access schemes according to the same total investment cost and the same permeability, respectively, and the simulation results are analyzed and discussed.
Zhang, Wei,Shin, Eun‐,Joo,Wang, Tongguang,Lee, Phil Ho,Pang, Hao,Wie, Myung‐,Bok,Kim, Won‐,Ki,Kim, Seong‐,Jin,Huang, Wen‐,Hsin,Wang, Yongjun,Zhang, Wanqin,Hong, Jauȁ Federation of American Society for Experimental Bi 2006 The FASEB Journal Vol.20 No.14
<P>We investigated the neuroprotective property of analogs of dextromethorphan (DM) in lipopolysaccharide (LPS) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models to identify neuroprotective drugs for Parkinson's disease (PD). In vivo studies showed that daily injections with DM analogs protected dopamine (DA) neurons in substantia nigra pars compacta and restored DA levels in striatum using two different models for PD. Of the five analogs studied, 3-hydroxymorphinan (3-HM), a metabolite of DM, was the most potent, and restored DA neuronal loss and DA depletion up to 90% of the controls. Behavioral studies showed an excellent correlation between potency for preventing toxin-induced decrease in motor activities and neuroprotective effects among the DM analogs studied, of which 3-HM was the most potent in attenuating behavioral damage. In vitro studies revealed two glia-dependent mechanisms for the neuroprotection by 3-HM. First, astroglia mediated the 3-HM-induced neurotrophic effect by increasing the gene expression of neurotrophic factors, which was associated with the increased acetylation of histone H3. Second, microglia participated in 3-HM-mediated neuroprotection by reducing MPTP-elicited reactive microgliosis as evidenced by the decreased production of reactive oxygen species. In summary, we show the potent neuroprotection by 3-HM in LPS and MPTP PD models investigated. With its high efficacy and low toxicity, 3-HM may be a novel therapy for PD.</P>
Jin-Wei Yang,Cui Li,Xiao-Peng He,Hong Zhao,Li-Xin Gao,Wei Zhang,Xiao-Xin Shi,Yun Tang,Jia Li,Guo-Rong Chen 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
The incorporation of microwave irradiation with the prevalent “click chemistry” is currently of considerable synthetic interest. We describe here the introduction of such laboratorial shortcut into carbohydrate-based drug discovery,resulting in the rapid formation of a series of triazole-linked salicylic β-D-O-glycosides with biological activities. All “clicked” products were achieved in excellent yields (≈ 90%) within only a quarter. In addition, based on the structural characteristics of the afforded glycomimetics, their inhibitory activities were evaluated toward protein tyrosine phosphatases 1B (PTP1B) and a panel of homologous protein tyrosine phosphatases (PTPs). Docking simulation was also conducted to plausibly propose binding modes of this glycosyl salicylate series with the enzymatic target.
Comprehensive Evaluation of Impacts of Connecting Distributed Generation to the Distribution Network
Wei Jin,Xuemei Shi,Fei Ge,Wei Zhang,Hongbin Wu,Chengyuan Zhong 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
In this paper, we study the various impacts of connecting distributed generation (DG) to the distribution network. The comprehensive evaluation index system (CEIS) of four hierarchies is established, considering economy, reliability and voltage quality, and the calculation methods of different indexes are presented. This paper puts forward an improved triangular fuzzy number analytic hierarchy process (ITFNAHP) to weight the second level indexes (SLI) and the third level indexes (TLI), and calculates the variation coefficient to weight the fourth level indexes (FLI). We calculate the comprehensive weight coefficients based on the weight coefficients of the SLI, TLI and FLI, and then calculate the comprehensive evaluation of satisfaction (CES) of different access schemes. On the basis of the IEEE 33-bus example system, simulations of the calculation methods and the comprehensive evaluation method are carried out under different DG access schemes according to the same total investment cost and the same permeability, respectively, and the simulation results are analyzed and discussed.