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RISS 인기검색어
- 검색키워드
- 저자 : Shu-Bo Wan (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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He, Bo,Zhang, Hui-Qing,Xiong, Shu-Ping,Lu, Shan,Wan, Yi-Ye,Song, Rong-Feng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: This study was designed to investigate the value of CEA and CA199 in predicting the treatment response to palliative chemotherapy for advanced gastric cancer. Materials and Methods: We studied 189 patients with advanced gastric cancer who received first-line chemotherapy, measured the serum CEA and CA199 levels, used RECIST1.1 as the gold standard and analyzed the value of CEA and CA199 levels changes in predicting the treatment efficacy of chemotherapy. Results: Among the 189 patients, 80 and 94 cases had increases of baseline CEA (${\geq}5ng/ml$) and CA199 levels (${\geq}27U/ml$), respectively. After two cycles of chemotherapy, 42.9% patients showed partial remission, 33.3% stable disease, and 23.8% progressive disease. The area under the ROC curve (AUC) for CEA and CA199 reduction in predicting effective chemotherapy were 0.828 (95%CI 0.740-0.916) and 0.897 (95%CI 0.832-0.961). The AUCs for CEA and CA199 increase in predicting progression after chemotherapy were 0.923 (95%CI 0.865-0.980) and 0.896 (95%CI 0.834-0.959), respectively. Patients who exhibited a CEA decline ${\geq}24%$ and a CA199 decline ${\geq}29%$ had significantly longer PFS (log rank p=0.001, p<0.001). With the exception of patients who presented with abnormal levels after chemotherapy, changes of CEA and CA199 levels had limited value for evaluating the chemotherapy efficacy in patients with normal baseline tumor markers. Conclusions: Changes in serum CEA and CA199 levels can accurately predict the efficacy of first-line chemotherapy in advanced gastric cancer. Patients with levels decreasing beyond the optimal critical values after chemotherapy have longer PFS.
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정상인의 혈중 및 뇨중 Extracellular Phospholipase A_2 활성도
황윤근,서영익,강문수,최영환,이종명,김보완,김능수,서장수,이주형,배현혜,김경호,이중기,백석환,장현욱 慶北大學校 醫科大學 1993 慶北醫大誌 Vol.34 No.3
Extracellular phospholipase A_2(PLA_2) is known to be secreted by the mononucleocytes, granulocytes, platelet, and chondrocytes in the joint, and it is also reported that this enzyme is increased in inflammatory conditions, such as acute panceratitis, sepsis, ARDS and arthritis. It was proposed that the extracellular release of phospholipase A_2 in response to inflammatory stimuli might represent an amplification mechanism for the generation of high levels of lipid mediators such as eicosanoids. To establish the normal value of PLA_2 in the healthy individuals we measured extracellular PLAz of healthy individuals of 84 males and 85 females in their serum and urine. The levels of PLA_2 activity in serum were 170.85±79.92 (U/㎖) in under 29 years old (20 males), 160.68±109.61 in 30 to 39 years old (19 males), 226.58±130.47 in 40 to 49 years old (19 males), 231.10±82.32 in 50 to 59 years old(17 males), 228.21±102.46 in over 60 years old(6 males), 168.21±62.11(U/㎖) in under 29 years old(6 females), 125.85±101.64 in 30 to 39 years old(20 females), 86.70±31.03 in 40 to 49 years old(20 females), 79.00±35.51 in 50 to 59 years old(20 females), 104.74±46.97 in over 60 years old(19 females). The levels of PLA_2 activity in urine were 142.61±141.86(U/㎖) in under 29 years old(18 males), 377.85±273.01 in 30 to 39 years old(20 males), 406.16±318.07 in 40 to 49 years old(19 males), 84.34±56.12(U/㎖) in under 29 years old(6 females), 17.20±9.94 in 30 to 39 years old(15 females), 54.98±86.24 in 40 to 49 years old(15 females), 14.78±11.38 in 50 to 59 years old(18 females), 43.00±40.29 in over 60 years old(19 females).
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The K+/H+ antiporter AhNHX1 improved tobacco tolerance to NaCl stress by enhancing K+ retention
Wei-Wei Zhang,Jing-Jing Meng,Jin-Yi Xing,Sha Yang,Feng Guo,Xin-Guo Li,Shu-Bo Wan 한국식물학회 2017 Journal of Plant Biology Vol.60 No.3
High salinity is the one of important factors limiting plant growth and crop production. Many NHX-type antiporters have been reported to catalyze K+/H+ exchange to mediate salt stress. This study shows that an NHX gene from Arachis hypogaea L. has an important role in K+ uptake and transport, which affects K+ accumulation and plant salt tolerance. When overexpressing AhNHX1, the growth of tobacco seedlings is improved with longer roots and a higher fresh weight than the wild type (WT) under NaCl treatment. Meanwhile, when exposed to NaCl stress, the transgenic seedlings had higher K+/H+ antiporter activity and their roots got more K+ uptake. NaCl stress could induce higher K+ accumulation in the roots, stems, and leaves of transgenic tobacco seedlings but not Na+ accumulation, thus, leading to a higher K+/Na+ ratio in the transgenic seedlings. Additionally, the AKT1, HAK1, SKOR, and KEA genes, which are involved in K+ uptake or transport, were induced by NaCl stress and kept higher expression levels in transgenic seedlings than in WT seedlings. The H+-ATPase and H+-PPase activities were also higher in transgenic seedlings than in the WT seedlings under NaCl stress. Simultaneously, overexpression of AhNHX1 increased the relative distribution of K+ in the aerial parts of the seedlings under NaCl stress. These results showed that AhNHX1 catalyzed the K+/H+ antiporter and enhanced tobacco tolerance to salt stress by increasing K+ uptake and transport.
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