Lower limb compartment syndrome by reperfusion injury after treatment of arterial thrombosis post-laparoscopic radical hysterectomy and pelvic lymph node dissection for cervical cancer

( Jihee Yeon ),( Ye Won Jung ),( Shin Seok Yang ),( Byung Hun Kang ),( Mina Lee ),( Young Bok Ko ),( Jung Bo Yang ),( Ki Hwan Lee ),( Heon Jong Yoo ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.2

Compartment syndrome is a clinical condition associated with decreased blood circulation that can lead to swelling of tissue in limited space. Several factors including lithotomy position, prolonged surgery, intermittent pneumatic compressor, and reperfusion after treatment of arterial thrombosis may contribute to compartment syndrome. However, compartment syndrome rarely occurs after gynecologic surgery. In this case, the patient was diagnosed as compartment syndrome due to reperfusion injury after treatment of arterial thrombosis, which occurred after laparoscopic radical hysterectomy and pelvic lymph node dissection for cervical cancer. Despite its rarity, prevention and identifying the risk factors of complication should be performed perioperatively; furthermore, gynecologist should be aware of the possibility of complications.

Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation

Choi, Ji-Yeon,Seo, Jeong Yeon,Yoon, Young-So,Lee, Ye-Ji,Kim, Hee-Sun,Kang, Jihee Lee AAAS 2015 Science signaling Vol.8 No.365

<P><B>Resolving inflammation with Mer</B></P><P>Unchecked inflammatory responses in the body can do more harm than good; thus, the body has mechanisms for resolving inflammation and restoring normal tissue function. Choi <I>et al</I>. found that mice with impaired signaling by the receptor tyrosine kinase Mer had exacerbated inflammation in response to acute sterile tissue damage, as well as decreased abundance of liver X receptor (LXR) transcription factors (which are implicated in inhibiting macrophage responses) in their macrophages, spleens, and lungs. Conversely, treating macrophages in culture with an agonist of Mer increased LXR abundance and activity. Furthermore, an LXR agonist reduced inflammation in mice even in the context of reduced Mer signaling. The finding that Mer-dependent increases in LXR abundance lead to the resolution of inflammation might be exploited therapeutically.</P><P>The receptor tyrosine kinase Mer plays a central role in inhibiting the inflammatory response of immune cells to pathogens. We aimed to understand the function of Mer signaling in the resolution of sterile inflammation in experiments with a Mer-neutralizing antibody or with Mer-deficient (<I>Mer</I><SUP>−/−</SUP>) mice in a model of sterile, zymosan-induced acute inflammation. We found that inhibition or deficiency of Mer enhanced local and systemic inflammatory responses. The exacerbated inflammatory responses induced by the lack of Mer signaling were associated with reduced abundance of the transcription factors liver X receptor α (LXRα) and LXRβ and decreased expression of their target genes in peritoneal macrophages, spleens, and lungs. Similarly, treatment of mice with a Mer/Fc fusion protein, which prevents the Mer ligand Gas6 (growth arrest–specific protein 6) from binding to Mer, exacerbated the inflammatory response and decreased the abundance of LXR. Coadministration of the LXR agonist T0901317 with the Mer-neutralizing antibody inhibited the aggravating effects of the antibody on inflammation in mice. In vitro exposure of RAW264.7 cells or primary peritoneal macrophages to Gas6 increased LXR abundance in an Akt-dependent manner. Thus, we have elucidated a previously uncharacterized pathway involved in the resolution of acute sterile inflammation: Enhanced Mer signaling during the recovery phase increases the abundance and activity of LXR to inactivate the inflammatory response in macrophages.</P>

Eccrine poromatosis associated with radiation therapy

( Jihee Kim ),( Mi Yeon Cho ),( Nu-ree Cha ),( Soo Chan Kim ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2

Anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation

Jeong, Yeon-Hui,Park, Jin-Sun,Kim, Dong-Hyun,Kang, Jihee Lee,Kim, Hee-Sun Elsevier 2017 PHARMACOLOGICAL RESEARCH Vol.119 No.-

<P><B>Abstract</B></P> <P>Neuroinflammation plays an important role in the progression of various neurodegenerative diseases. In this study, we investigated the anti-inflammatory effects of lonchocarpine, a natural compound isolated from <I>Abrus precatorius</I>, under <I>in vitro</I> and <I>in vivo</I> neuroinflammatory conditions induced by challenge with lipopolysaccharide (LPS)- or polyinosinic-polycytidylic acid (poly(I:C)). Lonchocarpine suppressed the expression of iNOS and proinflammatory cytokines in LPS or poly(I:C)-stimulated BV2 microglial cells. These anti-inflammatory effects were verified in brains of mice with systemic inflammation induced by administration of LPS or poly(I:C). Lonchocarpine reduced the number of Iba-1-positive activated microglia, and suppressed the mRNA expression of various proinflammatory markers in the cortex of LPS- or poly(I:C)-injected mice. Molecular mechanistic experiments showed that lonchocarpine inhibited NF-κB activity by reducing the phosphorylation and degradation of IκBα in LPS- or poly(I:C)-stimulated BV2 cells. Analysis of further upstream signaling pathways in LPS-stimulated microglia showed that lonchocarpine inhibited the phosphorylation of IκB kinase and TGFβ-activated kinase 1 (TAK1). Moreover, lonchocarpine suppressed the interaction of myeloid differentiation factor 88 (MyD88) and intereleukin-1 receptor-associated kinase 4 (IRAK4). These data suggest that toll-like receptor 4 downstream signals such as MyD88/IRAK4-TAK1-NF-κB are at least partly involved in the anti-inflammatory mechanism of lonchocarpine in LPS-stimulated microglia. Its strong anti-inflammatory effects may make lonchocarpine an effective preventative drug for neuroinflammatory disorders that are associated with systemic inflammation.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Digital pathology system for Mohs micrographic surgery

( Mi Yeon Cho ),( Soo Chan Kim ),( Yoon Jung Choi ),( Jihee Kim ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.74 No.1

A case of circumscribed plamar hypokeratosis in a 51-year-old female

( Mi Yeon Cho ),( Nu-ree Cha ),( Jihee Kim ),( Soo Chan Kim ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2

Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation.

Choi, Ji-Yeon,Park, Hyun-Jung,Lee, Ye-Ji,Byun, Jiyeon,Youn, Young-So,Choi, Ji Ha,Woo, So-Youn,Kang, Jihee Lee Williams Wilkins 2013 The Journal of pharmacology and experimental thera Vol.344 No.2

<P>Mer receptor tyrosine kinase (Mer) signaling plays a central role in the intrinsic inhibition of the inflammatory response to Toll-like receptor activation. Previously, we found that lung Mer protein expression decreased after lipopolysaccharide (LPS) treatment due to enhanced Mer cleavage. The purpose of the present study was to examine whether pharmacologically restored membrane-bound Mer expression upregulates the Mer signaling pathways and suppresses lung inflammatory responses. Pretreatment with the ADAM17 (a disintegrin and metalloproteinase-17) inhibitor TAPI-0 (tumor necrosis factor alpha protease inhibitor-0) reduced LPS-induced production of soluble Mer protein in bronchoalveolar lavage (BAL) fluid, restored membrane-bound Mer expression, and increased Mer activation in alveolar macrophages and lungs after LPS treatment. TAPI-0 also enhanced Mer downstream signaling, including phosphorylation of protein kinase b, focal adhesion kinase, and signal transducer and activator of transcription 1. As expected from enhanced Mer signaling, TAPI-0 also augmented suppressor of cytokine signaling-1 and -3 mRNA and protein levels and inhibited nuclear factor κB activation at 4 and 24 hours after LPS treatment. TAPI-0 suppressed LPS-induced inflammatory cell accumulation, total protein level elevation in BAL fluid, and production of inflammatory mediators, including tumor necrosis factor-α, interleukin-1β, and macrophage inflammatory protein-2. Additionally, the effects of TAPI-0 on the activation of Mer signaling and the production of inflammatory responses could be reversed by cotreatment with specific Mer-neutralizing antibody. Restored Mer protein expression by treatment with TAPI-0 efficiently prevents the inflammatory cascade during acute lung injury.</P>

Remarkably Efficient Photocurrent Generation Based on a [60]Fullerene–Triosmium Cluster/Zn–Porphyrin/Boron–Dipyrrin Triad SAM

Lee, Chang Yeon,Jang, Jae Kwon,Kim, Chul Hoon,Jung, Jaehoon,Park, Bo Keun,Park, Jihee,Choi, Wonyong,Han, Young-Kyu,Joo, Taiha,Park, Joon T. WILEY-VCH Verlag 2010 Chemistry Vol.16 No.19

<P>A new artificial photosynthetic triad array, a [60]fullerene–triosmium cluster/zinc–porphyrin/boron–dipyrrin complex (1, Os<SUB>3</SUB>C<SUB>60</SUB>/ZnP/Bodipy), has been prepared by decarbonylation of Os<SUB>3</SUB>(CO)<SUB>8</SUB>(CN(CH<SUB>2</SUB>)<SUB>3</SUB>Si(OEt)<SUB>3</SUB>)(μ<SUB>3</SUB>-η<SUP>2</SUP>:η<SUP>2</SUP>:η<SUP>2</SUP>-C<SUB>60</SUB>) (6) with Me<SUB>3</SUB>NO/MeCN and subsequent reaction with the isocyanide ligand CNZnP/Bodipy (5) containing zinc porphyrin (ZnP) and boron dipyrrin (Bodipy) moieties. Triad 1 has been characterized by various spectroscopic methods (MS, NMR, IR, UV/Vis, photoluminescence, and transient absorption spectroscopy). The electrochemical properties of 1 in chlorobenzene (CB) have been examined by cyclic voltammetry; the general feature of the cyclic voltammogram of 1 is nine reversible one-electron redox couples, that is, the sum of those of 5 and 6. DFT has been applied to study the molecular and electronic structures of 1. On the basis of fluorescence-lifetime measurements and transient absorption spectroscopic data, 1 undergoes an efficient energy transfer from Bodipy to ZnP and a fast electron transfer from ZnP to C<SUB>60</SUB>; the detailed kinetics involved in both events have been elucidated. The SAM of triad 1 (1/ITO; ITO=indium–tin oxide) has been prepared by immersion of an ITO electrode in a CB solution of 1 and diazabicyclo-octane (2:1 equiv), and characterized by UV/Vis absorption spectroscopy, water contact angle, X-ray photoelectron spectroscopy, and cyclic voltammetry. The photoelectrochemical properties of 1/ITO have been investigated by a standard three-electrode system in the presence of an ascorbic acid sacrificial electron donor. The quantum yield of the photoelectrochemical cell has been estimated to be 29 % based on the number of photons absorbed by the chromophores. Our triad 1 is unique when compared to previously reported photoinduced electron-transfer arrays, in that C<SUB>60</SUB> is linked by π bonding with little perturbation of the C<SUB>60</SUB> electron delocalization.</P> <B>Graphic Abstract</B> <P>Unique molecular characteristics of the cluster arrays of the title triad (see graphic, ITO=indium–tin oxide) give rise to a remarkably high quantum yield of the photoelectrochemical cell comprising a standard three-electrode system with an ascorbic acid sacrificial electron donor. It is hoped that similar SAMs may prove useful in molecular electronic devices. <img src='wiley_img_2010/09476539-2010-16-19-CHEM201000215-content.gif' alt='wiley_img_2010/09476539-2010-16-19-CHEM201000215-content'> </P>

Neighborhood Deprivation and Unmet Health Care Needs: A Multilevel Analysis of Older Individuals in South Korea

Seung Eun Lee,Miyeon Yeon,Chul-Woung Kim,Tae-Ho Yoon,Dongjin Kim,Jihee Choi 질병관리본부 2019 Osong Public Health and Research Persptectives Vol.10 No.5

Objectives: In this study the relationship between neighborhood deprivation and the unmet health care needs of elderly individuals (≥ 65 years) was examined. Some previous studies suggested that neighborhood characteristics affect access to health care, yet research on the unmet needs of older individuals is limited. Methods: Multilevel logistic regression analysis was used to assess the relationship of neighborhoodlevel factors with unmet health care needs due to costs, adjusting for individual-level factors, in individuals ≥ 65 years in the 2017 Korean Community Health Survey (n = 63,388). Results: There were 2.6% of elderly individuals who experienced unmet health care needs due to costs. Following adjustment for individual and neighborhood characteristics, the neighborhood deprivation in urban areas was found to have an inverse association with unmet needs (odds ratio = 0.50; 95% confidence interval = 0.24-1.06) for the most deprived quartile versus the least deprived quartile). However, in rural areas neighborhood deprivation was not a significant variable. Among the individuallevel variables, household income was one of the strongest correlates with unmet needs in both urban and rural areas. Conclusion: The present findings suggest that targeted policy interventions reflecting both neighborhood and individual characteristics, should be implemented to reduce the unmet health care needs of elderly individuals.

Diet composition of the Korean wild boar Sus scrofa coreanus (Suidae) at Mt. Jeombongsan, Korea

Shin, Hyung-Min,Kim, Jihee,Jin, Seon Deok,Won, Ho-Yeon,Park, Sangkyu The Ecological Society of Korea 2020 Journal of Ecology and Environment Vol.44 No.3

Background: Korean wild boars (Sus scrofa coreanus Heude), because of their adaptability, are a widespread large mammal; however, they sometimes cause problems by invading farms and eating the crops, creating insufficiencies of some foods in South Korea. To understand the diet composition of Korean wild boars according to sex and body size, we collected their feces from Mt. Jeombongsan, Seoraksan National Park, South Korea. The sizes of fecal samples were measured, and genomic DNA was extracted from the samples. We amplified specific loci targeting plants (rbcL and trnL) and animals (COI) to detect the food sources of this omnivore and amplified the ZF and SRY regions to determine the sex. Results: In the wild boar feces, Rosaceae and Bryophyte were the most frequently detected plant food sources at the family level and Diptera and Haplotaxida were the most frequently detected animal food sources at the order level. As a result of sex determination, the sex ratio of wild boars collected in the Mt. Jeombongsan area was approximately 1:1. Our result suggested that there is no significant difference between the diet composition of male and female boars. Based on the average cross-sectional area of the feces, the top 25% were classified into the large body size group and the bottom 25% were classified into the small body size group. The large body size group mainly preferred Actinidiaceae, and the small body size group most frequently consumed Fagaceae. The diet of the large body size group was more diverse than the small body size group. Conclusions: Our results showed that the wild boars preferred Rosaceae, especially Sanguisorba and Filipendula, as plant food sources, and Diptera and Coleoptera of Insecta as animal food sources. Based on the results, the dietary preferences of wild boar appear to be distinguished by not their sex but their body size. Our study could help to elucidate the feeding ecology and population structure of wild boar, as well as address conservation and management issues.