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( Jihee Sung ),( Nayoung Kim ),( Jongchan Lee ),( Young-jae Hwang ),( Hyoung Woo Kim ),( Jung Wha Chung ),( Jin-wook Kim ),( Dong Ho Lee ) 대한간학회 2018 Gut and Liver Vol.12 No.2
Background/Aims: Gastric juice plays a crucial role in the physiology of the stomach. The aim of this study is to evaluate associations among the pH of gastric juice, atrophic gastritis (AG), intestinal metaplasia (IM), pepsinogen, and Helicobacter pylori infection. Methods: Gastric biopsies and juice were collected from 46 subjects who underwent endoscopies at Seoul National University Bundang Hospital between November 2011 and March 2013. H. pylori, AG and IM were evaluated, and pepsinogen I or II, I/II ratio, and interleukin (IL)-1β levels were measured. Results: The mean pH of gastric juice was higher in the H. pylori-positive group (n=17) than that in the H. pylori-negative group (n=29) (4.54 vs 2.46, p=0.002). When patients were divided into pH <3 (n=28) and pH ≥3 (n=18) groups, H. pylori was lower in the pH <3 group (21.4%) than in the pH ≥3 group (61.1%) (p=0.007). The pH ≥3 group demonstrated AG and IM more frequently than the pH <3 group in the body (p=0.047 and p=0.051, respectively) but not in the antrum. There were no differences in pepsinogen I or II, I/II ratio, and IL-1β levels between the two groups. Conclusions: There is a relationship between chronic H. pylori infection and gastric juice pH ≥3, which may originate from AG and IM in the body. (Gut Liver 2018;12:158-164)
Growth and Migration of BALB/3T3 Fibroblast Cells on Nano-engineered Silica Beads Surface
Jihee Kim,Prakash Chandra,Jiyoon Yang,Seog Woo Rhee 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
In this study, the behavior of cells on the modified surface, and the correlation between the modified substrates and the response of cells is described. A close-packed layer of nano-sized silica beads was prepared on a coverslip, and the adhesion, proliferation, and migration of BALB/3T3 fibroblast cells on the silica layer was monitered. The 550 nm silica beads were synthesized by the hydrolysis and condensation reaction of tetraethylorthosilicate in basic solution. The amine groups were introduced onto the surfaces of silica particles by treatment with 3-aminopropyltrimethoxysilane. The close-packed layer of silica beads on the coverslip was obtained by the reaction of the amine-functionalized silica beads and the (3-triethoxysilyl)propylsuccinic anhydride treated coverslip. BALB/3T3 fibroblast cells were loaded on bare glass, APTMS coated glass, and silica bead coated glass with the same initial cell density, and the migration and proliferation of cells on the substrates was investigated. The cells were fixed and stained with antibodies in order to analyze the changes in the actin filaments and nuclei after culture on the different surfaces. The motility of cells on the silica bead coated glass was greater than that of the cells cultured on the control substrate. The growth rate of cells on the silica bead coated glass was slower than that of the control. Because the close-packed layer of silica beads gave an embossed surface, the adhesion of cells was very weak compared to the smooth surfaces. These results indicate that the adhesion of cells on the substrates is very important, and the actin filaments might play key roles in the migration and proliferation of cells. The nuclei of the cells were shrunk on the weakly adhered surfaces, and the S1 stage in which DNA is duplicated in the cell dividing processes might be retarded. As a result, the rate of proliferation of cells was decreased compared to the smooth surface of the control. In conclusion, the results described here are very important in the understanding of the interaction between implanted materials and biosystems.
Jihee Kang,Shin-Young Woo,Shin-Seok Yang,Yang-Jin Park,Dong-Ik Kim,Pyoung Jeon,Gyeong-Moon Kim,Young-Wook Kim 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.103 No.2
Purpose: Exposure to ionizing radiation over the head and neck accelerates atherosclerotic changes in the carotid arteries. Owing to the characteristics of radiation-induced carotid stenosis (RICS), the results regarding the optimal revascularization method for RICS vary. This study compared treatment outcomes between carotid endarterectomy (CEA) and carotid artery stenting (CAS) in RICS. Methods: This was a single-center retrospective review of consecutive patients who underwent CEA or CAS for carotid stenosis. RICS was defined as carotid stenosis (>50%) with the prior neck irradiation for cancer treatment on either side. For the analyses, demographics, comorbid conditions, carotid lesion characteristics based on imaging studies, surgical complications, neurologic outcomes, and mortality during the follow-up period were reviewed. To compare CEA and CAS results in RICS, a 1:1 propensity score matching was applied. Results: Between November 1994 and June 2021, 43 patients with RICS and 2,407 patients with non-RICS underwent carotid revascularization with CEA or CAS. RICS had fewer atherosclerotic risk factors and more frequent severe carotid stenosis and contralateral carotid occlusions than non-RICS. CAS was more commonly performed than CEA (22.9% . 77.1%) for RICS due to more frequent unfavorable carotid anatomy (0 . 16.2%). Procedure-related complications were more common in the CEA than in the CAS. However, there was no significant difference in neurologic outcomes and restenosis rates between CEA and CAS in RICS. Conclusion: Considering its lesion characteristics and cumulative incidence, RICS requires more attention than non-RICS. Although CAS has broader indications for RICS, CEA has shown acceptable results if selectively performed.
Jihee Yoon,Yang-Hoon Kim,Ji-Young Ahn,Hyun-Cheol Lee,Suk-Jung Oh,Bong-Woo Chung,Jiho Min,B.-W. Chung 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.4
Although melanin plays a biological role in the protection of underlying tissues from harmful ultraviolet radiations, yet large amounts of melanin in light-skinned individuals can make them susceptible to skin cancer. In this study, lysosome-related organelles extracts (LOE) from hen egg whites, HeLa cells, and Saccharomyces cerevisiae have been used to lower melanin color intensity. The results show 80% reduction in melanin upon daily treatment with 100 μg LOE for a period of 19 days. Additionally, the treatment with S. cerevisiae LOE showed the best melanin color reduction, which is consistent with the level of peroxidase activity. The treatment of LOE from S. cerevisiae with NH4Cl decreases melanin reduction activity and peroxidase activity compare to LOE from normal S. cerevisiae. Meanwhile, in contrast, the treatment with H2O2 showed a completely contrary pattern. The above results thus indicate that LOEs can be promising agents for use in cosmeceutical skin lightening as well as for the treatment of hyper pigmentation disorders.
이지희(Jihee Lee),안지송(Jisong An),김종우(Zong Woo Geem) 적정기술학회 2018 적정기술학회지(Journal of Appropriate Technology) Vol.4 No.1
아프리카의 전력 부족 문제는 이 지역의 발전을 가로막는 큰 장애요인이다. 아프리카 농촌지역은 인구밀도가 낮기 때문에 전력망 연결이 쉽지 않고 높은 투자비용, 높은 전력 요금이 발생한다. 따라서 전력난 해결을 위해 대규모 그리드계통에 연결하는 대신 마이크로 그리드가 효과적이다. 본 연구는 전력에너지 분야에서 공적개발협력이 필요한 개발도상국에 신재생 마이크로 그리드를 구축할 경우 그 최적의 용량을 산정하는 모형을 제시한다. 마이크로 그리드 실증사이트에 대하여 기후환경분석, 분산 전원 운영환경분석 및 예측을 통하여 마이크로 그리드의 경제성을 평가하고, 마이크로그리드의 구성 및 최적 전원구성방안을 수립한다. 여기서 최적화라는 것은 가장 경제적(초기 투자비 및 운영비용측면)으로 연계된 신재생에너지원의 이용률을 극대화하는 것이다. 마이크로 그리드는 주 전력인 신재생발전원과 예비전력인 디젤로 구성된다. 또한 신재생 발전시스템은 크게 태양광발전부와 풍력발전부, 에너지저장시스템(ESS)으로 구성된다. 이를 설치할 지역의 기후 조건과 인프라 상황을 분석하여 신재생발전원의 발전량을 계산하며, 경제성 분석을 통해 가장 최적의 태양광 패널 개수와 풍력터빈의 개수를 구하게 된다. 또한 에너지 수지 누적 곡선을 이용하여 ESS의 소요 용량을 계산하고 이를 통해 ESS의 총 개수를 구하게 된다. Electric power shortage in Africa prevents the region from better development. Especially for rural area, grid-connected power cannot be easily supplied due to low population density and high investment cost. Thus, micro grid system instead of big grid is appropriate for the area. This study proposes an optimal design model for micro grid renewable energy system including PV panel, wind generator, energy storage system, and backup generator in official development assistance program. Computational results showed that it was effective and efficient model. Thus, we hope other researchers and engineers in this field to utilize the model when they cope with the situation of renewable system design in the future.
박지희 ( Jihee Park ),우지민 ( Jimin Woo ),조민지 ( Minji Cho ),김명주 ( Myuhng-joo Kim ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.1
정보화시대로 넘어오면서 코딩 역시 중요한 교육으로 자리 잡고 있다. 초등학교는 물론 중, 고등학교도 교육적인 측면에서 프로그래밍을 중요시하고 있으며 C언어나 Java는 더이상 개발자만을 위한 언어로 인지되지 않는다. 하지만 코딩의 결과만 의존할 경우 정보보호를 하는 시큐어 코딩의 요소를 중요하게 여기지 않을 수 있다. 그 결과 DB는 물론 서버 에러를 비롯해 개인정보는 많은 위험에 노출될 수 있다. 기본적인 프로그래밍을 숙지한 개발자를 위해 더욱 안전한 코딩을 교육하고자 시큐어 C 코딩 앱을 기획하게 되었고, 정보보호를 코딩의 중요한 요소로 인지하기를 기대한다.