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RKO 대장암세포에서 3-헵틸아미노-6-알릴티오피리다진과 3-디펜틸아미노-6-알릴티오피리다진의 항암기전
임현경,권유미,송지윤,김경미,김채원,박명숙,정주희,Lim, Hyun Kyung,Kwon, Yumi,Song, Jiyun,Kim, Kyoung Mee,Kim, Chaewon,Park, Myung-Sook,Jung, Joohee 대한약학회 2016 약학회지 Vol.60 No.3
Allylthiopyridazine derivatives were synthesized and evaluated for anti-proliferative activities in the previous study. In this study, selected two allylthiopyridazine derivatives (compound I, 3-heptylamino-6-allylthiopyridazine and compound II, 3-dipentylamino-6-allylthiopyridazine) were assessed for cytotoxicity and chronic proliferation in human colon carcinoma RKO cells. Two derivatives dose-dependently inhibited cell viability and proliferation. To elucidate the anticancer mechanism of two derivatives, we investigated the expression level of apoptosis-related proteins in RKO cells. Compound I induced the activation of JNK and expression of p53 and p21. On the other hand, compound II showed no change of p53 level. Interestingly, compound II inhibited the nuclear translocation of NF-${\kappa}B$. This result suggested that compound II suppressed cell proliferation. These different mechanisms of these compounds might have occurred through different steric conformation.
Visual MRI Grading System to Evaluate Atrophy of the Supraspinatus Muscle
임현경,홍성환,류혜진,최자영,김세훈,최정아,강흥식 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.4
Objective: To investigate the interobserver reproducibility and diagnostic feasibility of a visual grading system for assessing atrophy of the supraspinatus muscle on magnetic resonance imaging (MRI). Materials and Methods: Three independent radiologists retrospectively evaluated the occupying ratio of the supraspinatus muscle in the supraspinatus fossa on 192 shoulder MRI examinations in 188 patients using a 3-point visual grading system (1, ≥ 60%; 2, 30–59%; 3, < 30%) on oblique sagittal T1-weighted images. The inter-reader agreement and the agreement with the reference standard (3-point grades according to absolute occupying ratio values quantitatively measured by directly contouring the muscles on MRI) were analyzed using weighted kappa. The visual grading was applied by a single reader to a group of 100 consecutive patients who had undergone rotator cuff repair to retrospectively determine the association between the visual grades at preoperative state and postsurgical occurrences of retear. Results: The inter-reader weighted kappa value for the visual grading was 0.74 when averaged across three reader pairs (0.70–0.77 for individual reader pairs). The weighted kappa value between the visual grading and the reference standard ranged from 0.75 to 0.83. There was a significant difference in retear rates of the rotator cuff between the 3 visual grades of supraspinatus muscle atrophy on MRI in univariable analysis (p < 0.001), but not in multivariable analysis (p = 0.026). Conclusion: The 3-point visual grading system may be a feasible method to assess the severity of supraspinatus muscle atrophy on MRI and assist in the clinical management of patients with rotator cuff tear.
국내 공공분야 전문용어 표준화를 위한 해외 선진사례 조사 및 제언
임현경 한국통역번역학회 2015 통역과 번역 Vol.17 No.2
This paper highlights the importance of multilingual terminological standardization, especially in the context of quality control for public translation as an attempt to ensure efficient multinational communication in the public sector. Historical efforts for terminological standardization in Korea have been structured around (a) multilingual standardization primarily in science and technology, and (b) monolingual standardization in the public sector as part of language planning, while much remains to be done in terms of multilingual terminological standardization for the purpose of efficient communication in the public sector. This paper explains why multilingual terminological standardization is needed and explores best practices abroad, centering on the international guidelines and norms from Infoterm and ISO/TC37, the use of IATE and other terminology databases in the context of public translation, and the roles of public agencies in terminological standardization. With these as the basis, this paper describes the current status of and problems with terminological standardization in Korea before providing suggestions for its successful standardization of public-sector terminology.
I-gel과 굴곡성 기관지경을 이용한 기관내 삽관 경험 -증례 보고-
임현경,최춘길,신혜란,이춘수,황성일,이성묵,송장호 대한마취통증의학회 2012 Anesthesia and pain medicine Vol.7 No.2
Most anesthesiologists, at one point or another, are faced with a difficult airway. We came upon an unexpected difficult airway and a failed intubation using a direct laryngoscope and lightwand. At this point, we decided to insert an i-gel which is quick and simple. This allowed us to maintain oxygenation and ventilation. After checking for the location of the laryngeal inlet with a flexible fiber optic bronchoscope, a 5.5 mm internal diameter endotracheal tube was inserted into the trachea over the flexible fiber optic bronchoscope. Finally, a suitable a 7.0 mm internal diameter endotracheal tube was inserted using an exchange catheter technique. With respect to this case, we conclused that the i-gel is a very helpful device for endotracheal intubation in patients with difficult airways.
Asymptomatic pneumomediastinum resulting from air in the epidural space -a case report-
임현경,차영덕,송장호,박지웅,이미현 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.65 No.3
There are no reports regarding pneumomediastinum caused by thoracic epidural block complications. We believe that it is possible to experience an occurrence of pneumomediastinum caused by air in the epidural space after performing a thoracic epidural block using the loss of resistance (LOR) technique with air. We report a witnessed case where pneumomediastinum appeared after a thoracic epidural block. Pneumorrrhachis, paravertebral muscle emphysema, and pneumomediastinum were diagnosed by Positron Emission Tomography-Computed Tomography. Although extremely rare, pneumomediastinum can be caused by an epidural block using LOR technique with air. In order to avoid the above danger, the use of saline or very minimal amount of air is required during a careful LOR technique.