http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Jee Yea Choi ),( Joonkyung Kim ),( Min Ju Jo ),( Sung Jun Chung ),( Yoomi Yeo ),( Tai Sun Park ),( Dong Won Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae Hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoo 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Most posterior mediastinal malignancies in adults are of neurogenic origin. Accordingly, metastatic posterior mediastinal tumors are very rare. We report a case where a metastatic endometrial cancer developed in the posterior mediastinum and compress the lower trachea and both main bronchi. A 71-year-old woman who had received concurrent chemoradiation for stage IV endometrial cancer 13 years ago was admitted for progressive dyspnea. A 10 cm-sized posterior mediastinal tumor compressing the lower trachea and both main bronchi was found on the chest computed tomography. Positron tomography showed no metastasis to organs other than the posterior mediastinum. For pathologic confirmation, we performed bronchoscopy and EBUS-TBNA. After the procedure, the patient developed respiratory failure and received mechanical ventilation. The patient was diagnosed with metastatic endometrial adenocarcinoma based on pathologic findings (positive for p16 and TTF-1). She received concurrent chemoradiotherapy to treat metastatic endometrial cancer compressing the airways while receiving mechanical ventilator treatment. Thereafter, the patient can be successfully weaned from the ventilator. To the best of our knowledge, this is the first case in which previous endometrial cancer recurred as a posterior mediastinal tumor without the involvement of other abdominal organs or lungs. Although it is very rare, clinicians should be aware that metastatic cancer can manifest as a single posterior mediastinal tumor and can cause respiratory failure by compressing large airways.
( Joonkyung Kim ),( Jee Yea Choi ),( Min Ju Jo ),( Sung Jun Chung ),( Yoomi Yeo ),( Hyun Lee ),( Tai Sun Park ),( Dong Won Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Jang Won Sohn ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Cough is frequently caused by drugs. However, little is known about the epidemiology and causative drugs leading to cough. We analyzed causative drugs and clinical features of drug-induced cough based on 10-year real-world data. Methods We used the database of the Korea Adverse Events Reporting System (KAERS) from January 2009 to December 2018. Cases of drug-induced cough were identified by selecting cases with a cough code of WHO-Adverse Response Terminology without any other adverse events. Causative drugs were compared between acute (<3 weeks) and delayed onset (≥3 weeks). Results In the study period of 10 years, there were 3,021 cases of drug-induced cough. Cough was most frequently caused by cardiovascular drugs (43.8%), followed by respiratory system drugs (14.9 %), including angiotensin-converting enzyme (ACE) inhibitors, antineoplastic and immune-modulating drugs (14.4 %), and anti-infective drug (8.3 %). In acute onset cough, perindopril, docetaxel, ramipril, paclitaxel, and acetylcysteine were found to be frequent causes, while delayed onset cough was commonly caused by perindopril, ramipril, indacaterol, captopril, and imidapril. Conclusion In this analysis of real-world data from a nationwide spontaneous reporting system, various drugs were found to cause cough, while cardiovascular drugs including ACE inhibitors were the most common cause. [This study was funded by the Korea Ministry of Environment (MOE) as ‘‘the Environmental Health Action Program (2016001360003)" and a research grant from the Korea Institute of Drug Safety & Risk Management].
Effects of Early Operation in Patients Who Diagnosed Complicated Parapneumonic Effusion
( Sung Jun Chung ),( Hyo Jun Jang ),( Jee Yea Choi ),( Joonkyung Kim ),( Jun Ho Lee ),( Hyun Lee ),( Dong Won Park ),( Sang-heon Kim ),( Jang Won Sohn ),( Hyuck Kim ),( Ho Joo Yoon ),( Won Sang Chung 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose Thoracic empyema is defined as active suppuration within the pleural space and its treatment is controversial. Recently treatment of empyema is changing observation of empyema formation to early invasive treatment with the operation. This study compared the outcomes of early surgery and delayed surgery Method We retrospectively reviewed 40 patients who underwent surgery for complicated parapneumonic effusion from January of 2013 to May of 2020. The early group was defined as operation with empyema diagnosed within 1 week. Results Among 40 patients, 22 patients received early surgery, and 18 patients received delayed surgery. Stage III empyema was prevalent in the delayed group (27.3% vs 76.9%, p=0.004). Operative time was longer in the delayed group (87.5 vs 132.5 min, p=0.004). Intraoperative blood loss was more in the delayed group (200ml vs 750ml, p=0.009). The hospital stay was longer in the delayed group (18.5 days vs 30.0 days, p<0.001). The complication rate was not different between groups (31.8% vs 33.3%, p=0.919). The mortality rate was no significance between the two groups (4.5% vs 5.6%, p=0.884). Conclusion Delayed surgical treatment make operation difficult. Although inactive infected phase, early surgical treatment did not increase postoperative morbidity and mortality.
( Yun Hee Lee ),( Hui-Ji Choi ),( Ji Yea Kim ),( Ji-eun Kim ),( Jee-hyun Lee ),( So-Hyun Cho ),( Mi-Young Yun ),( Sungkwan An ),( Gyu Yong Song ),( Seunghee Bae ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.7
Ginsenoside Rg4 is a rare ginsenoside that is naturally found in ginseng, and exhibits a wide range of biological activities including antioxidant and anti-inflammatory properties in several cell types. The purpose of this study was to use an in vivo model of hair follicle (HF)-mimic based on a human dermal papilla (DP) spheroid system prepared by three-dimensional (3D) culture and to investigate the effect of Rg4 on the hair-inductive properties of DP cells. Treatment of the DP spheroids with Rg4 (20 to 50 μg/ml) significantly increased the viability and size of the DP spheres in a dose-dependent manner. Rg4 also increased the mRNA and protein expression of DP signature genes that are related to hair growth including ALP, BMP2, and VCAN in the DP spheres. Analysis of the signaling molecules and luciferase reporter assays further revealed that Rg4 induces the activation of phosphoinositide 3-kinase (PI3K)/AKT and the inhibitory phosphorylation of GSK3β, which activates the WNT/β-catenin signaling pathway. These results correlated with not only the increased nuclear translocation of β-catenin following the treatment of the DP spheres with Rg4 but also the significant elevation of mRNA expression of the downstream target genes of the WNT/β-catenin pathway including WNT5A, β-catenin, and LEF1. In conclusion, these results demonstrated that ginsenoside Rg4 promotes the hair-inductive properties of DP cells by activating the AKT/GSK3β/β-catenin signaling pathway in DP spheres, suggesting that Rg4 could be a potential natural therapy for hair growth.