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지제근 啓明大學校 醫科大學 1996 계명의대학술지 Vol.15 No.1
The eletron microscope has become an established and indispensable tool in diagnostic pathology. There is an increasing demand of ultrastructural studies for the cases that pathologists in making definite diagnosis. In this paper the author described representative cases that were experienced at the Seoul National University Hospital since 1985. Characteristic ultrastructural features of these diseases are presented along with electron micrographs. Among diseases involving parenchymal cells, several examples of abnormalities of organelles, metabolic disturbance, hair and ciliary anomaly and red cell anomaly are described. Among infectious agents 4 viruses, 2 fungi, 2 protozoa and 2 metazoa are described.
송계용,김숙이,서중석,지제근 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.3
To observe the developing process of human fetal eccrine sweat gland during the intrauterine life, an electron microscopic study was carried out based on 12 fetuses ranging from 20 to 42 weeks of gestation. These fetuses were the products of induced deliveries found to have not associated disease or congenital anomalies at the autopsy. Following observations were made. The various types of cell consisting coiled portion of eccrine sweat gland were recognized at the 20th weed of gestation and they were clear cells, undifferentiated dard cells, myoepithelial cells. clear cells were located in central central portion and dark or myoepithelial cells were in peripheral portion. While undifferentiated dark cells were randomly distributed in the straight portion of eccrine sweat gland. The differential points between clear cell and undifferentiated dark cell were its round nucleus and glycogen contents. Marked hydropic changes of clear cells were noted at the 30th week of gestation. Secretory granules were noted at the 31st week of gestation. Secretory cells in the coiled portion of eccrine sweat gland was not fully mature until the 42nd week of gestation. Clear cells showed clear cytoplasm, abundant free ribosomes and scanty organelles. Undifferentiated dark cells showed many mitochondria and few glycogen. Secretory granules were rarely seen. Myoepithelial cells showed a few mitochondria, glycogen and microfilaments. Among three portions of eccrine gland, duct lumen in the acral and coiled portion were formed through the intracellular canaliculus and in the straight portion were made through the intercellular canaliculus. The main basic morphological mechanism of the lumen formation were microvesicle formation and pinched off phenomenon.
신규 세파로스로린 항생제 DWC-751 합성과 물성연구
이재호,정종근,김명구,안상근,최영기,문치장,오세한,성무제,윤길중,신종만,김학형,김영도,박준우 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.1
The synthesis and physicochemical properties of a novel cephalosporin, DWC-751 are described. DWC-751, (6R, 7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(1-methylbenzotriazol-3-ium)methyl]-ceph-3-em-4-carboxylate monosulfate(IV_a) was conveniently obtained by the conversion of compound(IV) into the crystalline monosulfate. Adjusting pH 4.8-5.2 in aqeous solution of the crude crystalline, compound(IV) in the form of a crystalline pentahydrate was prepared with a high degree of purity. The influence of the various organic and inorganic acids on the solubility of compoud(IV) and its salts, was examined. Particularly, the solubility of DWC-751 was 92 ㎎/㎖ at pH 1.7 and 233 ㎎/㎖ at pH 3.0. DWC-751 showed a broad antimicrobial spectrum against gram-positive and negative bacteria.
지제근(Je Geun Chi),서정기(Jeong Kee Seo),황세희(Se Hee Hwang),박경희(Kyung Hee Park),신희영(Hee Young Shin),차한(Hann Tchah) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4
Arteriohepatic dysplasia is a disorder that is characterized by paucity of interlobular bile duct, neonatal hepatitis-like obstructve jaundice, characteristic facial profile, cardiovascular abnormalities and vertebral arch defect. We experienced 4 cases of Arteriohepatic dysplsia of a 1 year-old male, a 6 month-old female, a 3 year-old female and a 2 year 4 month-old male. L hey all showed persistent cholestasis and character- istic facies. The pulmonary artery stenosis was detected in three of them; vertebral arch defect, in one. The etiologic examnation of the liver showed pauctiy of interlobular bile ducts in all the cases.