정상임신중 양수내 Amylase치 변동에 관한 연구

장준홍(JH Jang),장윤석(YS Chang) 대한산부인과학회 1980 Obstetrics & Gynecology Science Vol.23 No.11

There has been known that the fetus is the source of the amylase in amniotic fluid. Amylase activity of amniotic fluid was determined by the modified Caraway method in 26 samples obtained from normal pregnant women admitted to the Seoul National University Hospital during the period from March 1980 to August 1980 in order to elucidate the relationship between amylase activity in amniotic fluid and gestational age and fetal weight. The results obtained were as follows: 1. No amylase activity was detectable in amniotic fluid before or during the 23rd week of pregnancy. 2. A progressive rise in amylase activity of amniotic fluid commencing from the 32nd week was noted, followed by an abrupt increase during the last month of pregnancy. There was significant positive relationship between amylase activity of amniotic fluid and gestational age(r=0.94, P<0.001). 3. Amylase activity of amniotic fluid was also increased as fetal weight increased, and there was a significant positive relationship between amylase activity and fetal weight(r=0.81, P<0.001). 4. The standard value determining fetal maturity was 250 I.U./l of amylase activity in amniotic fluid. 5. Using 250 I.U./l of amylase activity as the standard value for determining fetal maturity(38 weeks or more in gestational age) gave false positive rate of 6 percent and false negative rate of 33 percent. 6. Using 250 I.U./l of amylase activity as the standard value for determining fetal maturity(2,500gm or more in fetal weight) gave false positive rate of 11 percent and false negative rate of 43 percent.

과배란 유도시 내인성 LH surge에 관한 연구

장준홍(JH Jang),장윤석(YS Chang) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.5

1. LH surge occured in 38(44.7%) out of 85 cycles studied. 2. Occurence rate of LH surge was not influenced by serum estradiol levels or serum estradiol patterns. 3. Serum LH/FSH ratio on the third day of the menstraul cycle did not significantly after the occurrence rate of LH surge 4. Occurrence rate of LH surge increased significantly as serum progesterone level or rising rate of serum progesterone increased. 5. Number of oocytes retrieved in cycels with LH surge did not differe significantly from those without LH surge. 6. Cleavage rate and pregnancy rate after IVF in cycle with LH surge did not differ significantly from those without LH surge 7. Cleavage rate of oocytes retrieved in cycles with LH surge on the day prior to hCG administration differed significantly from those LH surge on the day of hCG administraion. In conclusion, LH surge occurs in a significantly number of controlled ovarian hyperstimulation cycles with gonadotropins. because the increment of serum progestereone level is followed by LH surge, the rising level of serum progesterone might be used as a predictor of the occurrence of LH surge in cotrolled ovarian hyperstimulation

Development of Molecular Markers Specific to Samdeok Zoysiagrass

Park JH,Jang YM,Kim DY,Jung JH,Jung SH,Seo YW 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

Inhibitory Action of Thimerosal, a Sulfhydryl Oxidant, on Sodium Channels in Rat Dorsal Root Ganglion Neurons

JH Song,YY Jang,YK Shin,MY Lee,CS Lee 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

Amitriptyline Modulation of Sodium Channels in Rat Dorsal Root Ganglion Neurons

JH Song,SS Ham,H Ha,YY Jang,YK Shin,CS Lee 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

만삭 전 조기양막파수 임산부에서의 CRP 측정에 관한 연구

장호성,박학열,이흥관,채진호,신해수,박준철 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.7

1996년 6월 1일부터 1996년 12월 31일까지 7개월간 대구 파티마병원 산부인과에 입원한 임신 24주에서 36주 사이의 조기양막파수 임산부 70예를 실험군으로, 같은 재태 기간의 임산부 20예를 대조군으로 하여 만삭전 조기양막파수 임산부에서의 CRP 측정의 의의를 조사하여, 연구한 결과 다음과 같은 결론을 얻었다. 1. 조기양막 파수군에서는 CRP 음성이 74.3% CRP 양성이 25.7%, 대조군에서는 CRP 음성이 95% CRP 양성이 5%로 나타났다. 2. 연령, 분만 횟수, 내원시 임신 주수에서는 group I, group II와 대조군 사이의 유의한 차이가 없었으나, Bishop score에서는 group I 5.5±1.6, group II 6.6±1.7 로 서 두군 모두에서 대조군 3.6±1.0보다 유의하게 높았다. 3. 입원 당시 임산부 혈색소치는 group II에서만 10.6 ±1.3 g/dl로 대조군 11.8±1.1g/dl 보다 유의하게 낮았으며, 백혈구 수치는 group I 11,417.1±2,419.0/ mm3, group II 14,016.7±3,077.1/mm3로 대조군 10,484.5±1,827.2/mm3 보다 모두 유의하게 높게 측정되었다. 4. 임신 지연기간 또한 group I 12.8±10.3일, group II 6.8±7.2일로 대조군의 54.8±17.0일보다 모두 유의하게 짧았다. 5. 분만 형태로는 조기양막파수군에서 질식분만 77.1%, 제왕절개분만 22.9%이었고, 대조군에서는 질식분 만 85%, 제왕절개분만이 15%이었다. 6. 신생아 평균체중은 group I, group II에서 각각 2,245.8±451.6 g, 2,017.8±558.0 g으로 대조군 3,332.0± 394.8 g에 비해 모두 유의하게 적었으며, 분만시 Apgar 점수에서도 1분 Apgar점수는 group I, group II 모두 대조 군보다 낮았지만, 5분 Apgar 점수는 CRP 양성인 group II 에서만 대조군보다 유의하게 낮게 나타났다. 주산기 이환 및 사망률은 group I이 9.62%, 7.69%, group II가 22.2%, 16.7%로 대조군의 5%, 0%보다 유의하 게 높았다. 7. CRP의 융모양막염의 진단에 있어서의 민감도 및 특이도는 각각 83%, 80%이었다. Objective: To evaluate the role of C-reactive protein as a predictor of infectious morbidity with premature rupture of membranes. Study Design: The study group was comprised of seventy patients who presented to the Taegu Fatima Hospital between 24∼36 gestational weeks who had a diagnosis of ruptured membranes. The study group underwent assay of C-reactive protein in the maternal serum, and divided into two groups by the results of CRP, that is 52 cases of CRP negative PROM patients (group I), 18 cases of CRP positive PROM patients (group II), and 20 cases of intact membranes women as a control group. Outcome measures were the occurrence of preterm delivery, the admission-to-delivery interval, maternal characteristics, fetal body weight, 1min & 5min Apgar score, perinatal morbidity and mortality etc. Statistical analyses were performed by means of ANOVA test and Dunnett`s T-test. Results: 1. The prevalence of positive C-reactive protein in premature rupture of membranes was 74.3%. 2. There were no significant differences of age, parity, gestational weeks at admission between group I, II and control group. 3. White blood cell count of group I, II were significantly higher than that of control group. 4. The delay of time from admission to delivery in group I, II were significantly shorter than that of control group. 5. In perinatal outcomes, the mean birth weight, 1 min/5 min Apgar score of group I, II were significantly lower than those of control group, and perinatal morbidity and mortality of group I, II were significantly higher than those of control group. 6. Chorioamnionitis was found in 6 cases of premature rupture of membranes and the sensitivity and specificity of CRP as a test to predict of pathological placental infection were 83% and 80%. Conclusion: C-reactive protein level is a very sensitive predictor of infectious morbidity in premature rupture of membranes.

Immunohistochemical expression of matrix metalloproteinases in the granulomatous rosacea compared with the non‐granulomatous rosacea

Jang, YH,Sim, JH,Kang, HY,Kim, YC,Lee, E‐,S Blackwell Publishing Ltd 2011 Journal of the European Academy of Dermatology and Vol.25 No.5

<P><B>Abstract</B></P><P><B>Background </B> There is a granulomatous variant which is recognized in the rosacea spectrum. However, the pathogenesis of granuloma formation in rosacea has not been clearly demonstrated. Matrix metalloproteinases (MMPs) are required for recruitment of inflammatory cells and for tissue remodelling, making way for the development of well‐organized granuloma.</P><P><B>Objective </B> The aim of this study was to investigate the expression of transforming growth factor (TGF)‐β, TGF‐β type II receptor (TβRII), Tumour necrosis factor (TNF)‐α, MMP‐1, 2 and 9 in the granulomatous rosacea (GR) compared with the non‐granulomatous rosacea (NGR) and test the hypothesis that the changes of these profiles in GR would be related with chronic ultraviolet radiation (UVR)‐exposure.</P><P><B>Methods </B> Facial skin samples were obtained from 20 patients with GR and NGR (control group). The sections were stained using haematoxylin and eosin, Verhoeff’s elastic stain, and antibodies to TGF‐β, TβRII, TNF‐α, MMP‐1, ‐2 and ‐9.</P><P><B>Results </B> The amount of elastotic material was significantly increased in the dermis of GR lesions. Expression of TGF‐β was significantly decreased in the epidermis of GR lesions compared with NGR lesions. In addition, the expression of MMP‐9 was significantly increased in the dermis of GR lesions compared with NGR lesions, especially at the centre of the granuloma on a semi‐quantitative analysis. MMP‐2 expression was also increased in GR lesions, although the difference between the two groups was not statistically significant.</P><P><B>Conclusions </B> The results of this study suggest that the increased expression of MMPs in the dermis may participate in granuloma formation of GR in association with UVR.</P>

Hair-growth Effect of chrysin 7-0-cyclopropanecarboxylate

Jang JM,Kim KS,Lee SH,Jung JH,KIM YB,KIM BK 대한약학회 2000 大韓藥學會 總會 및 學術大會 Vol.49 No.-

Characterization of Components from Aerial part of Artemisia mongolica

SP Jang,MK Inn,JH Jeong,CS Yook 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.2004 No.1

임신 중기에 발견된 전이성 융모상피암 1예

남주현,목정은,이주학,김영신,전대준,장현정 대한부인종양 콜포스코피학회 1994 Journal of Gynecologic Oncology Vol.5 No.1

This is the third reported case of choriomrcinoma during pregnancy in Korea. A 28-years-old gravida 2 patient with an intrauterine pregnancy of 29 weeks had a coexisting vaginal metastatic choricareinorna. After termination of pregnancy, treatment with triple combination chemotherapy (methotrexate, actinomycin-D,cytaxen) was successfully done.