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數 種 韓藥의 아세틸콜린에스터레이즈 酵素活性에 대한 효과
최재환,김미영,김현미,최훈,전훈,김대근,임종필,임강현 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1
아세틸콜린에스터레이즈(AChE)는 신경조직에 분포하는 효소로 신경전달물질 중 아세틸콜린(ACh)을 분해하는 효소로 시냅스 신호전달체계에 있어 중요한 역할을 하는 효소이다. 현재 알츠하이머병과 치매치료에 사용하는 서양약물은 AChE의 활성을 저해하는 작용기전을 가진다. 목적 : 전통적으로 기억력 감퇴, 치매 등 치료에 사용되어 온 한약의 AChE에 대한 작용을 밝히기 위해 본 실험이 구상되었다. 방법 : 생쥐 대뇌신경세포의 균질 혼합액으로부터 효소의 활성을 Ellman 방법을 개선한 엘리자(ELISA)법을 이용하여 측정하였다. 결과 : 실험결과 天花? 의 6종이 2.5㎎/㎖의 농도에서 우수한 효소활성저해력을 보였고, 50% 효소활성 저해농도(ID_50)를 구한 결과, 天花?의 ID_50은 1.5㎎/㎖이었고, ??? 1.2 ㎎/㎖, ?? 2.0 ㎎/㎖, ??草 1.2 ㎎/㎖, ??? 1.0 ㎎/㎖, ??生 1.7㎎/㎖, 및 大?皮 2.0 ㎎/㎖를 나타내어 忍冬?의 저해력이 가장 우수하였다. 결론 : 치매 및 기억력감퇴 증상을 치료하는 한약의 작용기전 중 AChE 효소활성억제효과는 忍冬? 의 6종에서 나타났으며, 이는 전통적인 한방치료에 과학적인 기초자료를 제공할 것으로 생각한다.
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Jeon, Jae-Pil,Hwang, Jae-Sam,Lee, Jeong-Hae,Lee, Sang-Mong,Kang, Hyun-Ah,Uik Sohn Korean Society of Applied Entomology 2000 Journal of Asia-Pacific Entomology Vol.3 No.1
Gene discovery from highly specialized tissues is important for understanding of development and tissue-dependent gene regulation in organism. To identify highly active genes from the posterior silk gland of the oak silkworm, Antheraea yamamai, which is specialized for the production of silk proteins, we constructed an oligo(dT) primed directional cDNA library from the posterior silk gland of the final star larvae. One hundred and three expressed sequence tags(ESTs) were generated by single-run partial sequencing from the primary cDNA library. Their sequence analysis indicated that 59 clones exhibited a significant homology to known genes, and 6 clones to ESTs of unknown functions, and 33 clones were novel transcripts. In the expression profile, the most abundant gene was found to be fibroin(25.2%), followed by TAXREB107(5.8%) and ribosomal protein S9(2.9%). Northern blot analyses confirmed that fibroin and TAXREB107 genes are actively expressed in the posterior silk gland of the final instar larvae of the oak silk worm. This study demonstrated that the expression profile of the silk gland ESTs could be a useful tool for isolating the highly active genes in insect tissues.
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Anti-collision Method for AGV Using RFID and ZigBee Network
Jae Pil Ko,Jung Won Jung,Jae Wook Jeon 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10
This work presents an anti-collision method for an automated guided vehicle (AGV). In this study, we show three ways to obtain the position of AGVs, determine the priority when two or more AGVs enter the areas of collision, and control a route of AGVs on a ZigBee network. First, an AGV easily obtains its position and direction data from the inexpensive, reliable, and flexible radio frequency (RF) tag. Second, the control tower, the Coordinator, determines the AGV’s priority and route by combining various data acquired through other AGVs on the basis of a first-in-first-out algorithm and the shared memory architecture. Third, the AGVs transmit their status data to the Coordinator, and receive the driving data from the Coordinator on the ZigBee network which is a specification for wireless communication protocols using small, inexpensive, low-power digital radios.
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Proton Irradiation and Hydrogen Diusion in Quasicrystals
Jae-Kyun Jeon,Jeonggil Lee,Euikwoun Kim,Yun-Man Lee,Sang-Hwa Lee,신혜민,Soo-Bin Choi,Sang-Pil Youn,Kyeryung Kim,Jae-Yong Kim 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.5
Ti-Zr-Ni quasicrystals are new candidates for hydrogen storage applications due to their capabil- ity of loading a large amount of hydrogen at reasonable temperature and hydrogen pressure. The technical applications, however, have been limited because of the presence of a thick oxygen layer, which must be eliminated prior to introducing hydrogen into a sample. To effectively remove the oxygen barrier and to enhance the capability of hydrogen absorption, we irradiated Ti39.5Zr39.5Ni21 quasicrystal ingots by using a proton beam at energy of 20 MeV, 15 mA for 30 minutes. The proton-beam-treated samples were exposed to a hydrogen pressure of 650 psi at 200℃ and the results were analyzed by monitoring the pressure change of the chamber. The main concerns were a careful measurement of the weight gain after hydrogenation and an estimate of the peak shifts in X-ray diffraction. An absorption of hydrogen was observed for the proton-beam-irradiated samples while little hydrogen loading was noticed for unirradiated ones. Our results demonstrate that proton irradiation may be used as a new technique that can effectively eliminate the oxygen barrier and enhance the rates of hydrogen diffusion. However, more systematic investigations regarding the role of the proton are required before applying the technique for practical applications. Ti-Zr-Ni quasicrystals are new candidates for hydrogen storage applications due to their capabil- ity of loading a large amount of hydrogen at reasonable temperature and hydrogen pressure. The technical applications, however, have been limited because of the presence of a thick oxygen layer, which must be eliminated prior to introducing hydrogen into a sample. To effectively remove the oxygen barrier and to enhance the capability of hydrogen absorption, we irradiated Ti39.5Zr39.5Ni21 quasicrystal ingots by using a proton beam at energy of 20 MeV, 15 mA for 30 minutes. The proton-beam-treated samples were exposed to a hydrogen pressure of 650 psi at 200℃ and the results were analyzed by monitoring the pressure change of the chamber. The main concerns were a careful measurement of the weight gain after hydrogenation and an estimate of the peak shifts in X-ray diffraction. An absorption of hydrogen was observed for the proton-beam-irradiated samples while little hydrogen loading was noticed for unirradiated ones. Our results demonstrate that proton irradiation may be used as a new technique that can effectively eliminate the oxygen barrier and enhance the rates of hydrogen diffusion. However, more systematic investigations regarding the role of the proton are required before applying the technique for practical applications.
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Jae-Pil Jeon,Hye-Young Nam,Sung-Mi Shim,Bok-Ghee Han 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.2
EBV-transformed lymphoblastoid cell lines (LCLs) are used as a resource for human genetic, immunological, and pharmacogenomic studies. We investigated the biological activity of 20 LCL strains during continuous long-term subculture up to a passage number of 160. Out of 20 LCL strains, 17 proliferated up to a passage number of 160, at which point LCLs are generally considered as “immortalized”. The other three LCL strains lost the ability to proliferate at an average passage number of 41, during which these LCLs may have undergone cellular crisis. These non-immortal LCL strains exhibited no telomerase activity, decreased EBV gene expression, and a lower copy number of the EBV genome and mitochondrial DNA when compared with immortal LCLs. Thus, this study suggests that sustained EBV viral activity as well as telomerase activity may be required for complete LCL immortalization.
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Jae-Pil Jeon,Sung-Mi Shim,Jongsun Jung,Hye-Young Nam,Hye-Jin Lee,Bermseok Oh,Kuchan Kimm,김형래,Bok-Ghee Han 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.9
To examine copy number variations among the Korean population, we compared individual genomes with the Korean reference genome assembly using the publicly available Korean HapMap SNP 50 k chip data from 90 individuals. Korean individuals exhibited 123 copy number variation regions (CNVRs) covering 27.2 mb, equivalent to 1.0% of the genome in the copy number variation (CNV) analysis using the combined criteria of P value (P < 0.01) and standard deviation of copy numbers (SD ≥ 0.25) among study subjects. In contrast, when compared to the Affymetrix reference genome assembly from multiple ethnic groups, considerably more CNVRs (n = 643) were detected in larger proportions (5.0%) of the genome covering 135.1 mb even by more stringent criteria (P < 0.001 and SD ≥ 0.25), reflecting ethnic diversity of structural variations between Korean and other populations. Some CNVRs were validated by the quantitative multiplex PCR of short fluorescent fragment (QMPSF) method, and then copy number invariant regions were detected among the study subjects. These copy number invariant regions would be used as good internal controls for further CNV studies. Lastly, we demonstrated that the CNV information could stratify even a single ethnic population with a proper reference genome assembly from multiple heterogeneous populations.
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Shin, Jae Kook,Cheon, Jae Hee,Lim, Joon Seok,Park, Jae Jun,Moon, Chang Mo,Jeon, Soung Min,Lee, Jin Ha,Hong, Sung Pil,Kim, Tae Il,Kim, Won Ho Blackwell Publishing Asia 2011 Journal of gastroenterology and hepatology Vol.26 No.5
<P><B>Abstract</B></P><P><B>Background and Aim: </B> Computed tomography enterography (CTE) is a promising modality for small bowel imaging. However, the role of CTE in the evaluation of obscure gastrointestinal bleeding (OGIB) has not been established. We investigated the efficacy of CTE in diagnosing OGIB and the long‐term outcomes based on CTE findings, with special reference to negative CTE.</P><P><B>Methods: </B> A total of 63 consecutive patients who had undergone CTE for OGIB were enrolled, and their pre‐ and post‐CTE clinical data were collected. “Specific treatments” were defined as treatments directly aimed at resolving presumed bleeding causes, including hemostasis and operation, while “non‐specific treatments” were defined as symptomatic treatments for anemia.</P><P><B>Results: </B> Among 60 patients for whom long‐term follow‐up data were available, positive lesions were found in 16 patients (26.7%). The overall rebleeding rate was 21.7% during a mean follow up of 17.6 ± 4.7 months. There was no significant difference in the cumulative rebleeding rates between patients with positive and negative CTE results (<I>P</I> = 0.241). All patients who received specific treatments after CTE did not rebleed (0/8). In positive CTE patients, specific treatments significantly reduced the rebleeding rate (<I>P</I> = 0.023).</P><P><B>Conclusions: </B> CTE has a high rate of detecting overt OGIB. However, negative CTE results do not predict lower long‐term rebleeding, and such patients with OGIB should be closely observed. In patients with positive CTE, more vigorous management significantly reduces the incidence of rebleeding.</P>
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Shin, Jae Kook,Cheon, Jae Hee,Kim, Eun Sook,Yoon, Jin Young,Lee, Jin Ha,Jeon, Soung Min,Bok, Hyun Jung,Park, Jae Jun,Moon, Chang Mo,Hong, Sung Pil,Lee, Yong Chan,Kim, Won Ho The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.7
<P>The purpose of this study is to evaluate the predictive capability of anorectal physiologic tests for unfavorable outcomes prior to the initiation of biofeedback therapy in patients with dyssynergic defecation. We analyzed a total of 80 consecutive patients who received biofeedback therapy for chronic idiopathic functional constipation with dyssynergic defecation. After classifying the patients into two groups (responders and non-responders), univariate and multivariate analyses were performed to determine the predictors associated with the responsiveness to biofeedback therapy. Of the 80 patients, 63 (78.7%) responded to biofeedback therapy and 17 (21.3%) did not. On univariate analysis, the inability to evacuate an intrarectal balloon (<I>P</I>=0.028), higher rectal volume for first, urgent, and maximal sensation (<I>P</I>=0.023, <I>P</I>=0.008, <I>P</I>=0.007, respectively), and increased anorectal angle during squeeze (<I>P</I>=0.020) were associated with poor outcomes. On multivariate analysis, the inability to evacuate an intrarectal balloon (<I>P</I>=0.018) and increased anorectal angle during squeeze (<I>P</I>=0.029) were both found to be independently associated with a lack of response to biofeedback therapy. Our data show that the two anorectal physiologic test factors are associated with poor response to biofeedback therapy for patients with dyssynergic defecation. These findings may assist physicians in predicting the responsiveness to therapy for this patient population.</P>
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