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The Revised Edition of Korean Calendar for Allergenic Pollens
Oh, Jae-Won,Lee, Ha-Baik,Kang, Im-Joo,Kim, Seong-Won,Park, Kang-Seo,Kook, Myung-Hee,Kim, Bong-Seong,Baek, Hey-Sung,Kim, Joo-Hwa,Kim, Ja-Kyung,Lee, Dong-Jin,Kim, Kyu-Rang,Choi, Young-Jin The Korean Academy of Asthma, Allergy and Clinical 2012 Allergy, Asthma & Immunology Research Vol.4 No.1
<P>The old calendar of pollens did not reflect current pollen distribution and concentrations that can be influenced by changes of weather and environment of each region in South Korea. A new pollen calendar of allergenic pollens was made based on the data on pollen concentrations obtained in eight regions nationwide between 1997 and 2009. The distribution of pollen was assessed every day at 8 areas (Seoul, Guri, Busan, Daegu, Jeonju, Kwangju, Kangneung, and Jeju) for 12 years between July 1, 1997 and June 30, 2009. Pollens were collected by using Burkard 7-day sampler (Burkard Manufacturing Co Ltd, UK). Pollens which were stained with Calberla's fuchsin staining solution were identified and counted. Pine became the highest pollen in May, and the pollen concentrations of oak and birch also became high. Ragweed appeared in the middle of August and showed the highest pollen concentration in the middles of September. Japanese hop showed a high concentration between the middle of August and the end of September, and mugwort appeared in the middles of August and its concentration increased up until early September. In Kangneung, birch appeared earlier, pine showed a higher pollen concentration than in the other areas. In Daegu, Oriental thuja and alder produced a large concentration of pollens. Pine produced a large concentration of pollens between the middle of April and the end of May. Weeds showed higher concentrations in September and mugwort appeared earlier than ragweed. In Busan the time of flowering is relatively early, and alder and Oriental thuja appeared earliest among all areas. In Kwangju, Oriental thuja and hazelnut appeared in early February. Japanese cedar showed the highest pollen concentration in March in Jeju. In conclusion, update information on pollen calendar in South Korea should be provided for allergic patients through the website to manage and prevent the pollinosis.</P>
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Nu Ri Oh,Ae Rang Hwang,Ja In Jeong,Sung Hyun Park,Jin Seok Yang,Yong-Ho Lee 대한의생명과학회 2012 Biomedical Science Letters Vol.18 No.1
This study was to investigate the effects of high-fat diet feeding for a very long period of time on gene expression of inflammatory cytokines in mouse adipose tissue and to determine whether caloric restriction (CR) or insulin sensitizer treatment changes the cytokine gene expressions even in obese mice fed a high-fat diet for a very long term-period. Gene expression levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) were examined by real-time PCR in subcutaneous abdominal adipose tissue (SubQ) from obese and non-obese male C57BL/6 mice at 16, 26, 36, 47, and 77 weeks of age on either normal diet (ND) or high-fat diet (HFD) after starting at 6 weeks of age. In addition, gene expression levels of TNF-α, IL-6 and MCP-1 were determined in SubQ before and after rosiglitazone treatment or CR on 47-week-old obese mice. The results demonstrated that gene expression levels of TNF-α, IL-6 and MCP-1 were significantly increased with aging in SubQ of mice in both groups of diet. MCP-1 gene expression of SubQ in all ages tested was significantly or marginally increased in mice on HFD compared with ND. While TNF-α expression was significantly reduced by rosiglitazone, IL-6 and MCP-1 were significantly decreased by CR. The basic data in this study will be useful for characterizing the C57BL/6 mouse as an animal model of obesity induced by high-fat diet feeding for a very long period of time, and a better understanding of inflammatory cytokine regulation in diet induced obesity which may facilitate the development of new therapeutic strategies to prevent the complications of obesity.
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Prediction Model for Annual Variation in Total Pollen by Allergenic Trees in Korean Cities
Kim Kyu Rang,Han Mae Ja,Han Young Jong,Lee Yong Hee,Oh Jae-Won 대한천식알레르기학회 2024 Allergy, Asthma & Immunology Research Vol.16 No.1
Purpose: Pollen forecasting systems can provide information for coping with respiratory allergies. They estimate daily pollen production, dispersal, deposition, and removal based on daily weather conditions to predict daily pollen concentrations and provide allergy warnings. As of 2023, the Korea Meteorological Administration (KMA) provides 2-day forecast of allergenic pollens. However, unlike these models, long-term analysis of annual observations of tree pollen reveal annual variations. Therefore, in this study, we aimed to develop annual prediction models for allergenic tree pollens based on long-term multi-site pollen and meteorological data. Methods: Daily pollen concentrations were observed using Hirst-type volumetric spore traps at nine sites in Korea from 1998 to 2021, and daily weather data from the closest KMA stations were utilized. Models were developed to predict the seasonal pollen integral of seven tree species based on monthly mean temperature, wind speed, and total precipitation using three variable selection methods: 1) the t-test based key variable screening followed by linear regression with stepwise procedure (TM), 2) direct linear regression with stepwise procedure from the full variable model (FM), and 3) LASSO regression from the full variable model (LM). Results: Data obtained during 1998–2017 and 2018=2021 were utilized for model development and validation, respectively. The root mean squared error, mean absolute error, mean error, and coefficient of determination (R2) revealed that the TM models were best suited for actual forecasting, even though R2 in the TM model was lower than those of the FM and LM models. Conclusions: The annual variation model in this study can be integrated with the daily pollen forecast model by controlling the annual pollen potential, and the accuracy of the daily forecast can be improved accordingly.
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Eun Na Lee,Jin Kyeong Park,Ja-Rang Lee,Sae-Ock Oh,Sun-Yong Baek,Bong-Seon Kim,Sik Yoon 대한해부학회 2010 Anatomy & Cell Biology Vol.43 No.1
The thymus is a central lymphoid organ for T cell development. Thymic epithelial cells (TECs) constitute a major component of the thymic stroma, which provides a specialized microenvironment for survival, proliferation, and differentiation of immature T cells. In this study, subsets of TECs were examined immunohistochemically to investigate their cytokeratin (CK) expression patterns during thymus regeneration following thymic involution induced by cyclophosphamide treatment. The results demonstrated that both normal and regenerating mouse thymuses showed a similar CK expression pattern. The major medullary TECs (mTEC) subset, which is stellate in appearance, exhibited CK5 and CK14 staining, and the minor mTEC subset, which is globular in appearance, exhibited CK8 staining, whereas the vast majority of cortical TECs (cTECs) expressed CK8 during thymus regeneration. Remarkably, the levels of CK5 and CK14 expression were enhanced in mTECs, and CK8 expression was upregulated in cTECs during mouse thymus regeneration after cyclophosphamide-induced acute thymic involution. Of special interest, a relatively high number of CK5+CK8+ TEC progenitors occurred in the thymic cortex during thymus regeneration. Taken together, these findings shed more light on the role of CK5, CK8, and CK14 in the physiology of TECs during mouse thymus regeneration, and on the characterization of TEC progenitors for restoration of the epithelial network and for concomitant regeneration of the adult thymus.
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조시현 ( Si Hyun Cho ),오자랑 ( Ja Rang Oh ),윤덕경 ( Duk Kyoung Yoon ),채용현 ( Yong Hyun Chae ),이미범 ( Mi Bum Lee ),이경은 ( Kyung Eun Lee ),이혜선 ( Hye Sun Lee ),전영은 ( Young Eun Chun ),황주연 ( Ju Youn Hwang ),김재훈 ( Ja 대한주산의학회 2008 大韓周産醫學會雜誌 Vol.19 No.1
목적: 최근 연도별 태아 빛 신생아의 질적 관리를 평가하고자 주산기 통계를 제공하고, 출생체중, 임신주수, 임신부 연령, 영아의 성, 산전 진찰 횟수와 사망원인별 주산기 사망을 분석하고자 하였다. 방법: 1998년부터 2003년까지 본원에서 출생한 단태아 4910예의 전자의무기록을 검토하였다. 주산기는 WHO정의에 따랐고 임상적 사망원인은 Aberdeen 분류를 기준으로 하였다. 결과: 조(교정) 주산기 사망률은 22.8 (13.4)였다. 임신 중단이나 중중기형아를 제외한 4.862예의 출생아 중 (1) 태아사망이 주산기 사망의 78% (51/65)였다. (2) 신생아(4,811예) 출생체중 1,000 g 미만, 1,000~1,499 g, 1,500~2,499 g의 빈도는 각각 0.3%. 0.7%. 5.6%로 생존율은 각각 73.7%, 86.1%, 99.6%였다. (3) 36주 이하의 조산아 사망은 총 신생아 사망의 약 86%(12/14)를 차지하였다. (4) 35세 이상의 고령 임신부(494예)의 주산기 사망률이 20.2로 다른 연령군의 경우보다 높았으나, 의미 있는 차이는 없었다(p=0.273). (5) 남아(2,616예)와 여아(2,245예)의 주산기 사망 시 성비는 173:100으로 남아의 주산기 사망이 의미 있게 높았다(p=0.03l). (6) 산전진찰 2번 미만의 출생아(204예)의 주산기 사망률이 152.0으로 2회 이상의 경우 7.3 보다 의미 있게 높았다(p<0.00l). 조 주산기 사망 112예의 원인을 보면 기형 31.3% 원인 모르는 미숙아 28.6%, 모성질환 10.7% 순이었다. 결론: 출생아 수가 매년 감소하나, 연도별 주산기 사망의 개선된 변화가 없어 특히 조산, 기형, 모성질환에 대한 주산기 관리가 더욱 요구된다. Objective: The aim of this study was to analyze the perinatal mortality rate (PMR) and to evaluate the risk factors of perinatal deaths such as birth weight, gestational age maternal age, fetal sex, number of antenatal visits, and cause of deaths. Methods: Review of electronic medical records of 4,910 cases of singleton deliveries from 1998 to 2003 at Yongdong Severance Hospital was done. The perinatal period was defined according to the WHO definition and the cause of mortality was determined according to Aberdeen Classification. Results: Crude (corrected) PMR was 22.8 (13.4). Among 4862 deliveries excluding termination of pregnancy and severe congenital anomalies, (1) stillbirths accounted for 78% (51/65) of perinatal deaths. (2) Distribution of neonatal birth weights less than 1,000 g, 1,000~1,499 g, 1,500 g~2,499 g were 0.3%, 0.7%, 5.6% with survival rates of 73.7%, 86.1%, and 99.6% respectively. (3) Deaths of preterm births accounted for 86% (12/14) of total neonatal deaths. (4) PMR of 494 cases of advanced maternal age was higher (20.2) than those of other age groups without statistical significance (p=0.273). (5) PMR of male-to-female ratio was 173:100 with statistical significance (p=0.031). (6) PMR of infants with less than 2 antenatal visits was 152.0, in comparison with the rate (7.3) of infants with more than 2 antenatal visits (P<0.001). Among 112 cases of crude perinatal deaths, the leading causes were congenital anomalies (31.3%), prematurity cause unknown (28.6%), and maternal disease (10.7%). Conclusions: The number of births is decreasing, but no significant decrease of PMR was observed. Therefore, intensive care of preterm infants and congenital anomalous babies should be improved.
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Eun Na Lee,Jin Kyeong Park,Ja-Rang Lee,Sae-Ock Oh,Sun-Yong Baek,Bong-Seon Kim,Sik Yoon 대한해부학회 2011 Anatomy & Cell Biology Vol.44 No.1
The thymus is a central lymphoid organ for T cell development. Thymic epithelial cells (TECs) constitute a major component of the thymic stroma, which provides a specialized microenvironment for survival, proliferation, and differentiation of immature T cells. In this study, subsets of TECs were examined immunohistochemically to investigate their cytokeratin (CK) expression patterns during thymus regeneration following thymic involution induced by cyclophosphamide treatment. The results demonstrated that both normal and regenerating mouse thymuses showed a similar CK expression pattern. The major medullary TECs (mTEC) subset, which is stellate in appearance, exhibited CK5 and CK14 staining, and the minor mTEC subset, which is globular in appearance, exhibited CK8 staining, whereas the vast majority of cortical TECs (cTECs) expressed CK8 during thymus regeneration. Remarkably, the levels of CK5 and CK14 expression were enhanced in mTECs, and CK8 expression was upregulated in cTECs during mouse thymus regeneration after cyclophosphamide-induced acute thymic involution. Of special interest, a relatively high number of CK5+CK8+ TEC progenitors occurred in the thymic cortex during thymus regeneration. Taken together, these findings shed more light on the role of CK5, CK8, and CK14 in the physiology of TECs during mouse thymus regeneration, and on the characterization of TEC progenitors for restoration of the epithelial network and for concomitant regeneration of the adult thymus.
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Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro
( Ji Wook Jung ),( Su Jin Kim ),( Eun Mi Ahn ),( Sa Rang Oh ),( Hye Ja Lee ),( Ji Ahn Jeong ),( Ju Young Lee ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.6
However, the exact mechanism that accounts for the anti-inflammatory effect of R. fasciculatum is not completely understood. We aimed to ascertain the pharmacological effects of R. fasciculatum on both compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice. Additionally, to find a possible explanation for the anti-inflammatory effects of R. fasciculatum, we evaluated the effects of R. fasciculatum on the production of inflammatory mediators in LPS-stimulated macrophage cells. Treatment of R. fasciculatum significantly reduced compound 48/80- or histamine-induced the pruritus in mice. R. fasciculatum attenuated the AD symptoms such as eczematous, erythema and dryness and serum IgE levels in AD model. Additionally, R. fasciculatum inhibited the production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The maximal rates of TNF-α and IL-6 inhibition by R. fasciculatum (1 mg/ml) were approximately 32.12% and 46.24%, respectively. We also showed that R. fasciculatum inhibited the activation of nuclear factor-kappa B in LPS-stimulated macrophages. Collectively, the findings of this study provide us with novel insights into the pharmacological actions of R. fasciculatum as a potential molecule for use in the treatment of allergic inflammatory diseases.
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