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Inae Jeong,송자영,Song Yi Bae,Sang Kook Lee 대한암예방학회 2019 Journal of cancer prevention Vol.24 No.4
Background: Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, is a limited factor in the treatment of non-small-cell lung cancer (NSCLC) patients. Therefore, ongoing studies are trying to identify EGFR-TKIs-resistant mechanisms and to discover novel therapeutic strategies and targets for NSCLC treatment. Methods: In the present study, the possibility of overcoming intrinsic gefitinib-resistance was examined by regulating the expression of AXL. A natural product-derived antitumor agent, yuanhuadine (YD) was employed to modulate the expression of AXL in the cells. Results: Treatment with YD effectively downregulated AXL expression in AXL-overexpressed gefitinib-resistant H1299 cells. The combination of gefitinib and YD exhibited a synergistic grwoth-inhibitory activity in H1299 cells by downregulation of AXL expression. Conclusions: Based on these findings, AXL was found to be a promising therapeutic target to overcome the intrinsic resistance to gefitinib in NSCLC. Furthermore, YD is able to effectively regulate the expression of AXL and thus it may be applicable as a potential lead compound for the treatment of gefitinib-resistant NSCLC. (J Cancer Prev 2019;24:217-223)
Adipose Tissue-Derived Exosomes Regulate Proliferation of Pancreatic Cancer Cells during Obesity
Inae Jeong,Ok-Kyung Kim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
It is well known that the risk of pancreatic cancer is increased among those who are obese or have a high body mass index. However, the complex molecular mechanisms underlying the pancreatic cancer-obesity link are not fully understood. Recent accumulating evidence has demonstrated the role of exosomes in promoting tumor progression and survival. Here, we investigated the function of adipose tissue-derived exosome from obese mice in pancreatic cancer cells. Level of HB-EGF, ligand of epidermal growth factor receptor, was increased in the adipose tissue-derived exosome from the high fat diet-induced obese mice compared to the normal mice. The adipose tissue-derived exosome from the high fat diet-induced obese mice stimulated ERK and cell proliferation in Panc02 cells. In addition, it suppressed the activation of splenocytes on pancreatic cancer cells. Here, we suggest that exosomes-derived from adipose tissue affects the molecular mechanisms underlying the pancreatic cancer-obesity link.
Jeong, Ina,Chae, Sangmin,Yi, Ahra,Kim, Juae,Chun, Ho Hwan,Cho, Jung Hyeong,Kim, Hyo Jung,Suh, Hongsuk Elsevier 2017 Polymer Vol.109 No.-
<P><B>Abstract</B></P> <P>In this report, a series of copolymers based on 6-(2-thienyl)-4<I>H</I>-thieno[3,2-<I>b</I>]indole (TTI) as an electron-rich unit and fluorinated DTBT as an electron-deficient unit were synthesized, namely <B>PTTIF1</B> and <B>PTTIF2</B>, and applied to photovoltaic devices. TTI unit was coupled with fluorinated DTBT to utilize the merit of introduction of fluorine atom leading to the lowering of the HOMO energy level while keeping high planarity of the conjugated backbone.</P> <P>The synthesized copolymers show a noticeable change in HOMO energy levels as compared with non-fluorinated polymer (PTTIDTBT-<I>h</I>). Optimized photovoltaic devices of <B>PTTIF2</B> exhibited power conversion efficiency of 4.36% with decent <I>J</I> <SUB>SC</SUB> and <I>FF</I> values, which can be explained by the higher charge transporting ability of <B>PTTIF2</B> with preferable face-on crystallite population than <B>PTTIF1</B> in grazing incident wide-angle X-ray scattering (GIWAXS).</P> <P><B>Highlights</B></P> <P> <UL> <LI> The series of 6-(2-Thienyl)-4<I>H</I>-thieno[3,2-<I>b</I>]indole -based polymers were synthesized. </LI> <LI> The polymers exhibited deep HOMO energy levels due to the strong electron-withdrawing ability of fluorine atom. </LI> <LI> The optimal device performance reached a power conversion efficiency of 4.36%. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Tau energy loss and ultrahigh energy skimming tau neutrinos
Jeong, Yu Seon,Luu, Minh Vu,Reno, Mary Hall,Sarcevic, Ina American Physical Society 2017 Physical Review D Vol.96 No.4
<P>We consider propagation of high-energy earth-skimming taus produced in interactions of astrophysical tau neutrinos. For astrophysical tau neutrinos, we take generic power-law flux, E-2 and the cosmogenic flux initiated by the protons. We calculate tau energy loss in several approaches, such as dipole models and the phenomenological approach in which parametrization of the F-2 is used. We evaluate the tau neutrino charged-current cross section using the same approaches for consistency. We find that uncertainty in the neutrino cross section and in the tau energy loss partially compensate giving very small theoretical uncertainty in the emerging tau flux for distances ranging from 2 to 100 km and for the energy range between 10(6) and 10(11) GeV, focusing on energies above 10(8) GeV. When we consider uncertainties in the neutrino cross section, inelasticity in neutrino interactions and the tau energy loss, which are not correlated, i.e. they are not all calculated in the same approach, theoretical uncertainty ranges from about 30% and 60% at 10(8) GeV to about factors of 3.3 and 3.8 at 10(11) GeV for the E-2 flux and the cosmogenic flux, respectively, for the distance of 10 km rock. The spread in predictions significantly increases for much larger distances, e.g., similar to 1, 000 km. Most of the uncertainty comes from the treatment of photonuclear interactions of the tau in transit through large distances. We also consider Monte Carlo calculation of the tau propagation and we find that the result for the emerging tau flux is in agreement with the result obtained using analytic approach. Our results are relevant to several experiments that are looking for skimming astrophysical taus, such as the Pierre Auger Observatory, HAWC and Ashra. We evaluate the aperture for the Auger and discuss briefly application to the other two experiments.</P>
Jeong, Seung Jae,Kim, Jong Hyun,Lim, Beom Jin,Yoon, Ina,Song, Ji-Ae,Moon, Hee-sun,Kim, Doyeun,Lee, Dong Ki,Kim, Sunghoon Nature Publishing Group 2018 Experimental and molecular medicine Vol.50 No.1
<P>Mucin1 (MUC1), a heterodimeric oncoprotein, containing tandem repeat structures with a high proportion of threonine, is aberrantly overexpressed in many human cancers including pancreatic cancer. Since the overall survival rate of pancreatic cancer patients has remained low for several decades, novel therapeutic approaches are highly needed. Intestinal mucin has been known to be affected by dietary threonine supply since <I>de novo</I> synthesis of mucin proteins is sensitive to luminal threonine concentration. However, it is unknown whether biosynthesis of MUC1 is regulated by threonine in human cancers. In this study, data provided suggests that threonine starvation reduces the level of MUC1 and inhibits the migration of MUC1-expressing pancreatic cancer cells. Interestingly, knockdown of threonyl-tRNA synthetase (TRS), an enzyme that catalyzes the ligation of threonine to its cognate tRNA, also suppresses MUC1 levels but not mRNA levels. The inhibitors of TRS decrease the level of MUC1 protein and prohibit the migration of MUC1-expressing pancreatic cancer cells. In addition, a positive correlation between TRS and MUC1 levels is observed in human pancreatic cancer cells. Concurrent with these results, the bioinformatics data indicate that co-expression of both TRS and MUC1 is correlated with the poor survival of pancreatic cancer patients. Taken together, these findings suggest a role for TRS in controlling MUC1-mediated cancer cell migration and provide insight into targeting TRS as a novel therapeutic approach to pancreatic cancer treatment.</P>