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Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies
Kaneko, Kimihiko,Sato, Douglas Kazutoshi,Nakashima, Ichiro,Nishiyama, Shuhei,Tanaka, Satoru,Marignier, Romain,Hyun, Jae-Won,Oliveira, Luana Michelli de,Reindl, Markus,Seifert-Held, Thomas,Sepulveda, M BMJ 2016 Journal of neurology, neurosurgery and psychiatry Vol.87 No.11
STUDY ON X-RAYS AND NEUTRONS LEAKED FROM A 45 MeV ELECTRON LINAC FACILITY
Sadashi, Sawamura,Masatoshi, Kitaichi,Ichiro, Nojiri,Takuma Yamada,Junichi, Kaneko,Teruko, Sawamura 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.3
Spatial and time distributions of x-rays and neutrons from Hokkaido University 45 MeV electron linac facility were measured and compared with the calculation. In the calculation, x-rays in a Pb-target were evaluated using the EGS-code. The x-rays and the neutrons from the target to the facility building boundary and skyshine processs outside the facility building were simulated with the EGS and the MCNP respectively.
Humanoid Robot Arm Performance Optimization using Multi Objective Evolutionary Algorithm
Zulkifli Mohamed,Mitsuki Kitani,Genci Capi,Shin-ichiro Kaneko 제어·로봇·시스템학회 2014 International Journal of Control, Automation, and Vol.12 No.4
As humanoid robots are expected to operate in human environments they are expected to perform a wide range of tasks. Therefore, the robot arm motion must be generated based on the specific task. In this paper we propose an optimal arm motion generation satisfying multiple criteria. In our method, we evolved neural controllers that generate the humanoid robot arm motion satisfying three different criteria; minimum time, minimum distance and minimum acceleration. The robot hand is required to move from the initial to the final goal position. In order to compare the performance, single objective GA is also considered as an optimization tool. Selected neural controllers from the Pareto solution are implemented and their performance is evaluated. Experimental investigation shows that the evolved neural controllers performed well in the real hardware of the mobile humanoid robot platform.
( Christopher M Dussik ),( Maryam Hockley ),( Aleksandra Grozi ),( Ichiro Kaneko ),( Lin Zhang ),( Marya S Sabir ),( Jin Park ),( Jie Wang ),( Cheryl A Nickerson ),( Steven H Yale ),( Christopher J Ra 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.1
Background/Aims Irritable bowel syndrome (IBS) is a multifaceted disorder that afflicts millions of individuals worldwide. IBS is currently diagnosed based on the presence/duration of symptoms and systematic exclusion of other conditions. A more direct manner to identify IBS is needed to reduce healthcare costs and the time required for accurate diagnosis. The overarching objective of this work is to identify gene expression-based biological signatures and biomarkers of IBS. Methods Gene transcripts from 24 tissue biopsy samples were hybridized to microarrays for gene expression profiling. A combination of multiple statistical analyses was utilized to narrow the raw microarray data to the top 200 differentially expressed genes between IBS versus control subjects. In addition, quantitative polymerase chain reaction was employed for validation of the DNA microarray data. Gene ontology/pathway enrichment analysis was performed to investigate gene expression patterns in biochemical pathways. Finally, since vitamin D has been shown to modulate serotonin production in some models, the relationship between serum vitamin D and IBS was investigated via 25-hydroxyvitamin D (25[OH]D) chemiluminescence immunoassay. Results A total of 858 genetic features were identified with differential expression levels between IBS and asymptomatic populations. Gene ontology enrichment analysis revealed the serotonergic pathway as most prevalent among the differentially expressed genes. Further analysis via real-time polymerase chain reaction suggested that IBS patient-derived RNA exhibited lower levels of tryptophan hydroxylase-1 expression, the enzyme that catalyzes the rate-limiting step in serotonin biosynthesis. Finally, mean values for 25(OH)D were lower in IBS patients relative to non-IBS controls. Conclusions Values for serum 25(OH)D concentrations exhibited a trend towards lower vitamin D levels within the IBS cohort. In addition, the expression of select IBS genetic biomarkers, including tryptophan hydroxylase 1, was modulated by vitamin D. Strikingly, the direction of gene regulation elicited by vitamin D in colonic cells is “opposite” to the gene expression profile observed in IBS patients, suggesting that vitamin D may help “reverse” the pathological direction of biomarker gene expression in IBS. Thus, our results intimate that IBS pathogenesis and pathophysiology may involve dysregulated serotonin production and/or vitamin D insufficiency. (J Neurogastroenterol Motil 2018;24:96-106)
STUDY ON X-RAYS AND NEUTRONS LEAKED FROM A 45 MeV ELECTRON LINAC FACILITY
Sawamura, Sadashi,Kitaichi, Masatoshi,Nojiri, Ichiro,Yamada, Takuma,Kaneko, Junichi,Sawamura, Teruko Korean Association for Radiation Protection 2001 방사선방어학회지 Vol.26 No.3
Spatial and time distributions of x-rays and neutrons from Hokkaido University 45 MeV electron linac facility were measured and compared with the calculation. In the calculation, x-rays in a Pb-target were evaluated using the EGS-code. The x-rays and the neutrons from the target to the facility building boundary and skyshine process outside the facility building were simulated with the EGS and the MCNP respectively.