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Farias, Rut,Sepulveda, Alejandro,Chamorro, Rodrigo Occupational Safety and Health Research Institute 2020 Safety and health at work Vol.11 No.3
We evaluated the eating pattern, physical activity, and daytime sleepiness level in Chilean shift workers. Fifty, middle-aged adult health workers from a public hospital in Santiago, Chile, were included: a group undergoing shift work (shift workers, including at least one "night shift" and one "long day", n = 33), and day workers under traditional schedule (from 8:00 to 17:00h, n = 17). Body composition, physical activity, and daytime sleepiness levels, and diet characteristics (diet composition, meals' timing, and diet quality) were assessed. Despite similar total energy intake, shift worker showed lower carbohydrate (% of energy) and higher protein intake (both P < 0.01), decreased diet quality, an irregular eating pattern, and delayed meal timing (all P < 0.05). Physical activity and daytime sleepiness levels did not differ between groups. Findings from this first Chilean study in healthcare shift workers support the fact that meal timing and diet quality appear as critical factors for upcoming intervention studies in this group.
SYNERGISTIC EFFECTS OF COCONUT OIL WITH ATORVASTATIN ON THE CHOLESTEROL LEVELS OF GUINEA PIGS
Maxine Helga Pinpin,Gian Paolo B. Sepulveda,Marian Camille C. Obrero,Ms. Rose Butaran 국제과학영재학회 2012 APEC Youth Scientist Journal Vol.4 No.-
Most cardiovascular diseases (CVD) are caused by high levels of cholesterol and lipoproteins, specifically Low Density Lipoproteins (LDL), in the blood, heart and liver. In response to the growing number of patients with heart-related diseases, this study was conducted to determine the synergistic effects of coconut oil with the leading cholesterollowering medicine, atorvastatin on the lipid profile of guinea pigs (Cavia percellus), particularly the Total Cholesterol to high-density lipoprotein (TC: HDL) ratio, which is considered one of the best markers in determining CVD risk. After blood samples were taken for initial lipid analysis, the guinea pigs were subjected to four treatments: coconut oil, statins, statins with coconut, oil and a control group. After two weeks of administering the treatments, blood was extracted again for the new lipoprotein levels. Data was analyzed using two-way ANOVA (α = 0.05). Results show that decrease in the TC:HDL ratio induced by coconut oil was lower than the decrease induced by atorvastatin. Interestingly, the group with coconut oil and statins, yielded the greatest decrease in the TC: HCL ratio. This shows the positive synergy of coconut oil and statins in decreasing CVD risk. The information provided in this study will aid in the improvement of current medicine.
Sanchez, Cesar,Camus, Mauricio,Medina, Lidia,Oddo, David,Artigas, Rocio,Sepulveda, Alejandra Perez,Domainguez, Francisco,Razmilic, Dravna,Navarro, Maria Elena,Galindo, Hector,Acevedo, Francisco Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Background: Pathological factors, based mainly on immunohistochemistry (IHC) and histological differentiation, are mostly used to differentiate breast cancer (BC) subtypes. Our present aim was to describe the characteristics and survival of a relapsing BC patient cohort based on clinico-pathologic subtypes determined for the primary tumors. Methods: We used a clinico- pathological definition of BC subtypes based on histological grade (HG), estrogen receptor (ER), progesterone receptor (PgR),and epidermal growth factor receptor type 2 (HER2) expression assessed by IHC. We determined variables associated with loco-regional recurrence (LRR), second primaries (SP), systemic recurrence (SR) and post-recurrence survival (PRS). Results: Out of 1,702 patients, 240 (14%) had an event defined as recurrence. Those with recurrent disease were significantly younger than those without,and were initially diagnosed at more advanced stages, with larger tumors, greater lymph nodal involvement and higher HG. With a median follow up of 61 months (1-250), 4.6% of patients without recurrence and 56.6% of patients with an event defined as recurrence had died. The median PRS for the LRR group was 77 months; 75 months for those who developed a SP and 22 months for patients with an SR (p <0.0001). In SR cases, the median PRS was shorter for ER- tumors than for ER+ tumors (15 vs. 26 months, respectively; p = 0.0019, HR 0.44; CI: 0.25-0.44). Conclusions: Subtype, defined through classic histopathologic parameters determined for primary tumors, was found to eb related to type of recurrence and also to prognosis after relapse.
Thurner, Kensey,Goforth, Reuben R.,Chen, Shuai,Amberg, Jon,Leis, Eric,Kinsella, John M.,Mahapatra, Cecon,Sepulveda, Maria S. The Korean Society of Fish Pathology 2017 한국어병학회지 Vol.30 No.2
Pathogen introductions associated with aquatic invasive species threaten ecosystems and biodiversity worldwide. Bigheaded carps (BHC), including Silver Carp Hypophthalmichthys molitrix, Bighead Carp H. nobilis, and their hybrids, are prolific, invasive pests in central US rivers. However, little is known about pathogen effects on invading BHC or how BHC affect the disease risk profile for native fishes in receiving ecosystems. We therefore conducted, from May 2013-December 2014, a systematic pathogen survey for BHC and native fishes in the Wabash River watershed, Indiana, USA. We found Pseudomonas fluorescens, P. putida, and Salmonella enterica DNA in BHC as well as native fishes, although none of these bacteria were exclusively present in BHC. DNA from other bacterial taxa was detected only in native fishes and Common Carp Cyprinus carpio. No gastrointestinal helminths were detected in BHC, although they were common in most native fishes examined. We also conducted in vitro studies on BHC tissues (skin, gill, fin, and fry) and found high sensitivity to Largemouth Bass virus, viral hemorrhagic septicemia virus, and infectious pancreatic necrosis virus. We conclude that BHC are not heavily burdened by bacteria, viruses and parasites in the invaded study ecosystems, although they do harbor native bacteria and show potential for high sensitivity to endemic viruses.
Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies
Kaneko, Kimihiko,Sato, Douglas Kazutoshi,Nakashima, Ichiro,Nishiyama, Shuhei,Tanaka, Satoru,Marignier, Romain,Hyun, Jae-Won,Oliveira, Luana Michelli de,Reindl, Markus,Seifert-Held, Thomas,Sepulveda, M BMJ 2016 Journal of neurology, neurosurgery and psychiatry Vol.87 No.11