Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies

(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3

N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.

Binaural beat 훈련이 골프선수들의 생리적 변화 및 골프 퍼팅수행력에 미치는 영향

조현철,김성연,임성규 용인대학교 국제스포츠과학연구원 체육과학연구소 2008 體育科學硏究論叢 Vol.18 No.1

The purpose of this study was to increase a efficiency on physiological reaction and putting ability of golfer when they were used Binaural-beat. Participants were fourteen man aged 21-27 years in university golfer. They were tested both before and after Binaural-beat by EEG, EMG, Heart Rate and putting of three times at 4m range. The results as follow: 1. Alpha wave was a statistical significantly increased, beta and theta wave were not statistical significantly increased when it apply the Binural-beat. 2. EMG on apply the Binural-beat was lower than meditation. Especially, there were statistical significantly difference in Trapezius and Erector spinae, were not statistical significantly difference in Tibialis anterior. 3. There was no statistical significantly difference in heart rate when it apply the Binural-beat. As this results, We Binural-beat training was given a positive influence in brain alpha wave and lower of muscles activity. Therefore, we think that it can help to concentration elevation.

Cu-Al-Ni 合金에 있어서 마르텐사이트 變態에 따른 內部摩擦

趙顯麒,禹基道,金圭鎭 慶北大學校 1984 論文集 Vol.37 No.-

The internal friction measurement was carried out by the torsion pendulum method with automatic recording of the virbration patterns. The critical range of the martensitic transformation was checked by measuring the electrical resistance and by morphological observation. The extent of internal friction in the region of the peak depends on the previous rate of temperature change and decreases sharply during a few minutes of isothermal holding. The high level of internal friction found in Cu~Al-Ni alloy is likely to due to the reversible movement of interfacial and twin boundaries on exposure to alternating stresses.

Cycloheximide가 Mouse肝臟의 인산염 分解酵素의 活性에 미치는 影響

趙賢熙,鄭鎬三,李圭植 漢陽大學校 環境科學硏究所 1985 環境科學論文集 Vol.6 No.-

Cycloheximide는 Streptomyces griseus에서 추출한 항진균성 항생제로 진균의 성장을 저해하는 물질로 알려져 왔으며 포유동물의 세포에서 ribonucleic acid와 단백질 합성을 저해한다고 생화학적 방법에 의하여 보고되었다. 최근에 이르러 cycloheximide의 투여로 간세포내 소기관인 조면내형질세망 및 Golgi complex의 손상에 의해서 단백질합성이 저해된다고 형태학적으로 연구 보고된 바 있다. 이와같은 cycloheximide의 투여로 간세포가 손상을 입어 단백질합성이 저해될 때 간세포내 인산염분해효소로 분포되어 있는 acid phosphatase와 adenosine triphosphatase 활성을 추구하였다. 실험동물로는 실험실에서 사육한 건강한 ICR계 체중 20∼30gm의 mouse를 사용하였으며 정상대조군과 cycloheximide 투여군으로 구분하고 실험군은 다시 cycloheximide 투여 후 6시간군, 12시간군, 24시산군 및 36시간군으로 나누었고 각군에 10마리씩 배정하였다. Cycloheximide는 mouse의 체중 ㎏당 4㎎ 되게 생리적 식염수에 용해하여 0.1㎖를 복강내에 투여후 6시간, 12시간, 24시간 및 36시간 후에 희생시켜 간장을 적출하고 10% neutral formalin에 고정한 다음 cryostat로 두께 15㎛ 되게 동결절편을 만들어 Gomori법으로 acid phosphatase활성과 Wachstein 및 Meisel법으로 adenosine triphosphatase 활성을 관찰한 결과 다음과 같은 결과를 얻었다. 1. Cycloheximide 투여후 6시간, 12시간군 및 24시간군의 mouse 간소엽에서 중심 정맥부로 부터acid phosphatase 활성이 증가되기 시작하여 36시간군에서는 간소엽 전역에 중등도 이상의 강한 활성이 관찰되었다. 2. Cycloheximide 투여후 24시간군에서 부터 간소엽의 중심 정맥부에 ATPase 활성이 감소되기시작하여 36시간 경과군에서는 간소엽 전역에 음성반응을 나타내었다. 상기와 같은 결과는 cycloheximide 투여로 간장의 acid phosphatase는 간장이 손상을 입을 때 그 활성이 보다 강한 양성반응을 보이고 adenosine triphosphatase는 역으로 활성이 약해진다고 사료된다. It has been knwon that cycloheximide, an antifungal antibiotics extracted from streptomyces griseus, inhibits the growth of fungus. It has been reported by several investigators that this drug inhibits ribouncleic acid activity and protein synthesis of the mammalian cell. Recently, several reporters indicated that the cycloheximide causes the damage of hepatocyte. The observations by electron microscopic, histochemical and histological studies revealed that cycloheximide inhibits the RNA and protein synthesis by the injury of rough endoplasmic reticulum and the desocciation of polysome in hepatocyte. This study attempted, on the activities of acid phosphatase adenosine triphosphatase, phosphatelysis-enzymes distributed in the hepatocytes in the mouse liver. Healthy albino mice(ICR strain) of 20gm±in body weight were used as experimental animals which were divided into the control and cycloheximide treated groups. The animals of the cycloheximide treated groups were administered cycloheximide. (dissolved in physiological saline sol., by intraperitoneal injection in a dose of) 4mg per kg of body weight in a volume of 0.1ml, intraperitoneally. The experimental animals were sacrificed at intervals of 6, 12, 24 and 36 hours after administration of cycloheximide, respectively. The liver specimens were fixed with 10% neutral formalin, the sections of 15㎛ thickness were stained by Gomori, Wachstein and Meisel`s method for the detection of acid phosphatase and adenosine triphosphatase activities. The results were obtained as follows; 1. Acid phosphatase activity was increased in the central zone of liver lobule at the 6 hour and 24 hour period of the cycloheximide treated group, moderately positive activity was showed in the liver lobule at the 36 hour period group. 2. Adenosine triphosphatase activity was decressed in the centrol zone of liver lobule at the 24 hour period of the cycloheximide treated group. Negative reactions were showed in the whole liver lobules at the 36 hour period group. Consequently, it is supposed that cycloheximide caused increase of liver acid phosphatase result from liver damage, while adenosine phosphtase activity of the liver was decreased.

공동주택관리의 효율성 증대 방안 : 진주시 중심으로

조현화,김규 진주산업대학교 2000 論文集 Vol.39 No.-

This study is attempted to provide information that will be useful to the private managers of collective houses who intend to improve the collective house management. The objective of the study was an analytical survey on the improvement of the collective house management that would make every occupants' lives more convenient and safe, and minimize the costs of housing management. For this purpose a total of occupants of apartments in Chinju were put to questionnaire. The several facts that would make housing management improved were obtained from the survey. The alternatives for the effective management of the collective house were showed as follows : First, the effective management of the collective house has mainly been dependent on the laws and institutions related to it, and how to manage it such as flaw repair, maintenance, safety management, and so on. Second, if housing management is to be effective related laws are systematically and rationally improved. Laws and regulations have taken a negative effects on housing management. The law requires that adequate measure be devised if government concerned implement regulations that can influence the housing management. The occupants may manage the collective house for themselves instead of managers being licensed by the government to conduct their management. The laws and regulations suitable for direct management in actual must be revised and acted. These changes have improved the their existing system, and come into effect on the housing management. Third, there is no doubt that managers' ways of thinking and values have great influence on the housing management. There should, therefore, be established a institution so that the mangers may learn how to manage the housing management in a more professional way. Forth, if housing management is to be effective a comprehensive, positive participation of occupants is necessary. Occupants should maintain a high level of interest in housing management. Meaningful cooperative behaviors, from which every occupants could benefit, should be planned and pursued as well. Occupants's behaviors beneficial for housing management in actual are expected to produce significant results.

지역 이벤트 및 레져 스포츠에 대한 웹마케팅 욕구에 대한 소비행동

조충현,양재철,연규한 圓光大學校 附設 體力科學硏究所 2002 體力科學硏究 Vol.25 No.2

Recently are event and sport degree of satisfaction by sports consumer behavior is emerging as a alternative tourism in korea like other part of world. So many korean researchers are getting interested in this field. The central government and local government also have their interests in are event and sport for activating their economy. Because are event and sport has a advantage to enhance the national·local area's image, to attract visitors from other area or nations. But the study of are event and sport has been rarely accomplished, compared with the increasing importance of are event and sport. Futhermore, the studies has been primarily focused on commercialization of events for the sports information products. Now we need to lift our concern to are event and sports information user's satisfaction from that kinds of researchs. We have to regard are event and sports information user's as a consumer of our events. That's so important to get the high position in planning, marketing events, because the more we know about sports events and sports information user's mind, the more the possibility we have to succeed. As we know, the consumer satisfaction is the most important factor of the success of are sports events. So this study is done in the basic idea that are event and sports information user's is a kind of sports consumers behavior. The data analysis methods of this study are Frequency Analysis, Independent Group t Inspection, One-way ANOVA(Post Inspection: duncan', p<.05), Interrelation Analysis, Multiple Regression Analysis and use the SPSS WIN 10.0 program.

흉배혈관의 근피 천공분지에 기초한 유리피판의 임상적 이용

조규성,김대영,안호범,이삼용,조백현 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

The latissimus dorsi muscle or musculocutaneous flap is one of the most useful flaps in reconstructive surgery. This flap has many advantages, such as its reliable anatomy, long pedicle with large caliber vessels, minimal functional deficit of the donor site, and low incidence of donor site complications. However, the bulkiness of the flap has been considered a disadvantage, so various modifications of technique have been devised. The cutaneous portion of the flap can be safely elevated based on the cutaneous perforating branch of the thoracodorsal vessel. From March 1997 to February 1998, 10 patients underwent reconstructive procedures with thoracodorsal perforator-based free flaps. The composition of the flaps varied in accordance with the nature of the defect. The variances in the flaps were as follows; 3 were cutaneous, 6 musculocutaneous, and 1 osteomusculocutaneous including the rib. All flaps survived with good contour. We concluded that this thin and reliable flap was useful for reconstruction of various defects, and that the composition of the flap, such as subcutaneous, muscle and bone, gave it considerable flexibility as needed.

프로축구 선수들의 포지션별 유산소성 파워능력과 슬관절 등속성 근 기능의 특성

조현철,김준호,강민철,김종규 龍仁大學校 體育科學硏究所 2004 體育科學硏究論叢 Vol.14 No.1

The purpose this study was to investigate the aerobic power and isokinetic muscular function of knee joint for korea the pro-soccer players in field position. Data were obtained from thirty one pro-soccer players. They didn't have any medical problem. They performed exercise stress test and isokinetic muscular function on treadmill and Isomed 2000. The assessment of cardiorespiratory and isokinetic muscular function were VO2max, Maximal heart, ATVO2, AT heart rate, Total Work, Average Work, Maximum Torque, Maximum Work and Flex/Ext. A two-way analysis of variance with repeated measures(two-way(2x4)RM ANOVA) was used to compare group and field position differences aerobic power and isokinetic muscular function. A Tukey post hoc test was used when significant mean differences were observed. Statistical significance was accepted as p<O.05. Aerobic power do not showed any significant difference among in field position. Hamstring muscle power was significantly higher in Forward and Middle field than Defense and Goal keeper. Muscular endurance was higher Defense and Goal keeper than Forward and Middle field. Based on the facts that we have discussed, aerobic and anaerobic power in field position do not showed any difference. However, isokinetic muscular function was significant difference in field position. Ratios of conventional and functional for isokinetic Hamsting: Quadriceps muscle strength in soccer player for prediction and decision injures, it is thought that more researches on it should be required.

단시간 최대운동 방법이 유산소성 파워와 무산소성 파워에 미치는 상호관련성 연구

조현철,김종규 龍仁大學校 2004 용인대학교 논문집 Vol.22 No.-

The purpose of this study was to assess the interrelation of measuring both aerobic and anaerobic power at acute maximal exercise test protocols. It was hypothesized that oxygen consumption increases rapidly during maximal effort and maximal oxygen consumption(VO2 max) may be reached in one minute. subjects were male 11, female 7, performed the following test: 1) standard incremental workload VO2 max test. 2) 30, 45, 60sec wingate anaerobic test as VO2 measured maximal exertion test. All tests were performed on an electrically-braked lodeTM wingate sport ergometer. Peak oxygen consumption values for 30sec(male: 31.16±6.01 ml/min/kg; 62%, female: 27.45±4.68 ml/min/kg; 75%) and 45sec(male: 33.37±5.61 ml/min/kg; 66%, female: 29.14±5.41 ml/min/kg. 49%) tests were significantly lower than VO2 max(male: 50.54±6.29, female: 36.68±5.94). During the 60sec(male: 42.10±7.98 ml/min/kg 83%, female: 33.49±5.41 ml/min/kg; 91%)test, there was no significantly difference in VO2 max from standard incremental workload, demonstrating a plateau effect. There were no significant difference in peak power or peak power in time on 30sec, 45sec, 60sec wingate test, as expected, mean power were significantly difference these test. It was concluded that VO2 max was high interrelation during the 60sec test than 30sec and 45sec. Furthermore high correlation in peak power, peak power in time for 45sec and 60sec precludes the necessity for aerobic and anaerobic tests longer than the 30sec wingate test.

Cu-Al-Ni 합금에 있어서 시효에 따른 감쇠능의 변화

조현기,박철규 경북대학교 산업기술연구소 1987 産業技術硏究誌 Vol.14 No.-

The effects of ageing on specific damping capacity in Cu-Al-Ni alloy were carried out by the torsional pendulum testing method with the computer system. The critical range of the reverse martensitic transformation was checked by measuring adiabatic scanning calorimeter and the microstructure was observed by the optical microscope. The extent of specific damping capacity in the region of the reverse martensitic transformation increases with the amount of matrix and martensitic interface. The peak of specific damping capacity appears when the amount of martensites becomes 50% The peak of specific damping capacity decreases according to ageing due to the stabilization of martensites and the decreasing rate of specific damping capacity increases. Specific damping capacity depends on the strain amplitude and non-elastic additional strain is hysteresis type. The high level of specific damping capacity found in Cu-Al-Ni alloy is most likely to due to the reversible movement of interfacial and twin boundaries on exposure to alternating stresses.