Caerulein과 총담췌장관 결찰에 의한 급성췌장염 모델의 특징

심상수,김현준,이윤혜,박진형,이승준,김창종 중앙대학교 약학연구소 2000 약학 논총 Vol.14 No.-

To investigate the difference in acute pancreatitis experimentally induced by common bile-pancreatic duct (CBPD) ligation and caerulein iv infusion, we measured amylase activity, pancreatic edema and phospholipase A_2 activity in pancreatic tissue and serum. In acute pancreatitis induced by CBPD ligation and caerulein infusion, tissue edema and tissue phospholipase A_2 activity significantly increased as compared with normal group. Also experimental acute pancreatitis significantly increased the levels of serum protein, serum amylase activity and serum phospholipase A_2 activity. In the comparison of two experimental models, the symptom of acute pancreatitis induced by CBPD ligation was more severe than that induced by caerulein infusion. These results indicate that the increase of phospholipase A_2 activity in pancreatic tissue and serum may be one of the parameters for the diagnosis of acute pancreatitis.

대기압 플라즈마 처리와 접착력 강화 : 고무 소재의 접착력 향상

심동현,설수덕 東亞大學校附設 生産技術硏究所 2007 生産技術硏究所硏究論文集 Vol.12 No.-

An atmospheric plasma pre-treatment method was applied to Rubber material to improve its contact angle and adhesion. In order to investigate the optimum reaction condition of plasma treatment, type of reaction gas (nitrogen, argon, oxygen, air), rate of gas flow (30~100mL/min), and reaction time(0~30sec) were examined in a plate plasma reactor. The result of the surface modification with respect to the treatment procedure was characterized by using SEM and ATR-FTIR. Due to a decrease of the contact angle of polyurethane foam, the greatest adhesion strength was achieved at a flow rate of 100 mL/min and at a reaction time of 10s for N2 gas. Consequently, the atmospheric plasma treatment reduced the contact angle of the Rubber material and also resulted in the improvement of the peel strength.

저장기간에 따른 3개 수종의 종자 및 발아 특성 변화

한심희,김찬수,장석성,이현주,탁우식 한국농림기상학회 2004 한국농림기상학회지 Vol.6 No.3

This study was conducted to examine the changes in the seed physical characters and germinative properties of three tree species at three different storage times in order to determine the most suitable storage time and condition. Seed physical characters and germinative properties were examined from seeds of Fraxinus rhynchophylla, Zanthoxylum schinifolium and Staphylea bumalda that were stored at -18C for 1, 3 and 10 years, and the growth performance and physiological characters of their seedlings were analyzed. Seed physical characters and germinative properties showed significant differences between three storage times as well as three tree species. Seed moisture content of F. rhynchophylla and S. bumalda and seed fresh weight of Z. schinifolium decreased with increase of storage time. Storage time represented negative correlation with moisture content and fresh weight (r = -0.822, p < 0.01). Seed percent germination of Z. schinifolium and S. bumalda stored for 3 and 10 years decreased less than 15% and 10.7% respectively. Mean germination times for seed of F. rhynchophylla, Z. schinifolium and S. bumalda were delayed 11.9, 5.7 and 9.7 days after a storage time of 10 years, respectively. However the growth and viability of seedlings didn't show a special pattern for storage time and tree species.

후복막섬유증 5례의 임상적 고찰

정충식,김수현,안병수,심대성,박도영,김철성,장대수 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

Retroperitoneal fibrosis is a fibrotic process of the retroperitoneum that frequently produces ureteral obstruction. It can occur as an idiopathic disease or in association with various non-malignant and malignant condition. In the early phase of the retroperitoneal fibrosis ; symptoms originate from the disease process itself, while in the late state the clinical features represent the effect of obstructive uropathy and renal failure. Treatment consist of steroid therapy, urinary diversion and ureterolysis with jntraperitonealization or lateralization or wrapping with omentum. Herein we present 5 cases of retroperitoneal fibrosis.

Accessary nipple-like ectopic salivary gland in the anterior neck

( Hyun Bo Sim ),( Sun Young Moon ),( Soo Yuhl Chae ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Ectopic salivary gland is defined as the situation in which the salivary gland tissue develops at a site where it is not normally found. It occurs in various sites within the head and neck region and has even been found in other anatomical sites including anal mucosa. Though the origin of this entity still remains unclear, some reports insist about hypothesis to be a heteroplasia of the epithelium of the precervical sinus of His. A 13-year-old female presented nipple-like erythematous papule with fistula on her right anterior neck since birth. The lesion was mucoid discharge without other symptoms. Under the clinical impression of bronchogenic cyst, the lesion was totally excised. Histopathological examination revealed glandular elements and ducts in deep dermis and fat layer and the gland composed of multiple mucinous acini. Positive staining of mucinous acini with Periodic acid-Schiff(PAS). As accessary nipple-like ectopic salivary gland in the anterior neck is a rare disease with atypical clinical manifestation, it can be easily misdiagnosed as other conditions such as bronchogenic cyst. However ectopic salivary gland shows positive for PAS stain and has characteristic histopathological findings. So diagnosis of ectopic salivary gland can be easily done by histopathological and immunohistochemical examination. We report an informing case of an accessary nipple-like ectopic salivary gland which occurred on the anterior neck.

Subungual Verrucous Carcinoma of the Right Little Finger with Underlying Bony Invasion

( Hyun Bo Sim ),( Soo Yuhl Chae ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.5

FCP 6 : Sentinel lymph node biopsy of the 104 malignant melanoma of KNUH over 9 years (2006~2014)

( Hyun Bo Sim ),( Soo Yuhl Chae ),( Yong Hyun Jang ),( Weon Ju Lee ),( Do Won Kim ),( Seok Jong Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: In these days, Sentinel lymph node biopsy (SLNB) is used as the most sensitive and specific staging tool available for determination of disease status of regional lymph node and it also developed as a technique to surgically assess the regional lymph nodes i.e. sentinel lymph node(SLN) and allowed to spare node-negative patients unnecessary and potentially morbid complete lymphadenectomies. Objectives: To examine the clinical analysis of SLNB cases in Kyungpook national university hospital (KNUH) over 9 years. Methods: In the period from January 2006 to January 2014, a SLNB was performed in 104 patients under cooperation of the department of dermatology, general surgery or orthopedic surgery in KNUH. Data were collected from medical records and the melanoma registry of KNUH. Results: Of the 104 melanoma patients who underwent SLNB, 49 were males (47.1%), 55 were females (52.9%) and their ages ranged from 34~93 years (average: 60.9). Detection rate of SLN was 98.1% (102/104). Twenty nine patients had a tumor-positive SLNB (27.8%) and underwent completion regional lymph node dissection. The mean Breslow thickness of the primary tumors was 3.76 mm, and the proportion of ulcerated melanomas was 51.4%. Two side effects had been observed such as seroma (1case) and lymphocele (1case). Conclusion: Herein, we reviewed the importance of SLNB as prognostic and staging tools with minimal morbidity through our experience of 104 malignant melanoma cases during past 9 years.

Outcome and status of postcardiac arrest care in Korea: results from the Korean Hypothermia Network prospective registry

Soo-Hyun Kim,박규남,Chun Song Youn,Minjung Kathy Chae,김원영,이병국,Dong Hoon Lee,장태창,이재훈,최윤희,Je Sung You,In Soo Cho,Su Jin Kim,이종석,Yong Hwan Kim,Min Seob Sim,신종환,박유석,이영환,문형준,Won Jung Jeong,오주석,Seung Pill Choi 대한응급의학회 2020 Clinical and Experimental Emergency Medicine Vol.7 No.4

Objective High-quality intensive care, including targeted temperature management (TTM) for patients with postcardiac arrest syndrome, is a key element for improving outcomes after out-of-hospital cardiac arrest (OHCA). We aimed to assess the status of postcardiac arrest syndrome care, including TTM and 6-month survival with neurologically favorable outcomes, after adult OHCA patients were treated with TTM, using data from the Korean Hypothermia Network prospective registry. Methods We used the Korean Hypothermia Network prospective registry, a web-based multicenter registry that includes data from 22 participating hospitals throughout the Republic of Korea. Adult comatose OHCA survivors treated with TTM between October 2015 and December 2018 were included. The primary outcome was neurological outcome at 6 months. Results Of the 1,354 registered OHCA survivors treated with TTM, 550 (40.6%) survived 6 months, and 413 (30.5%) had good neurological outcomes. We identified 839 (62.0%) patients with presumed cardiac etiology. A total of 937 (69.2%) collapses were witnessed, shockable rhythms were demonstrated in 482 (35.6%) patients, and 421 (31.1%) patients arrived at the emergency department with prehospital return of spontaneous circulation. The most common target temperature was 33°C, and the most common target duration was 24 hours. Conclusion The survival and good neurologic outcome rates of this prospective registry show great improvements compared with those of an earlier registry. While the optimal target temperature and duration are still unknown, the most common target temperature was 33°C, and the most common target duration was 24 hours.

FCP 7 : Cutaneous foreign body reaction induced by retained bee sting

( Hyun Bo Sim ),( Soo Yuhl Chae ),( Kyung Hea Park ),( Hyun Wuk Cha ),( Weon Ju Lee ),( Seok Jong Lee ),( Do Won Kim ),( Yong Hyun Jang ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1

Reactions to a bee sting ranges from mild erythema to severe anaphylactic reactions. Occasionally, a sting may be retained in the skin and a foreign body reaction to the sting may persist. In traditional Korean medicine, bee sting therapy applies a bee sting directly into a lesion to treat various diseases. Although, some cases about foreign body reaction induced by bee sting were reported, there is no report showing bee sting in biopsy specimens. A 50-year-old woman presented mild pruritic grouped papules on both lip angles for 7 months. She had suffered from recurrent herpes simplex. As a treatment, multiple bee stings had been applied on the the skin lesions several months before. Interestingly, we found apparatuses suspected to be retained stings of bees, which were showed as yellow sticks with central cavity filled with eosinophilic venom in the biopsy specimen. The retained apparatuses were surrounded by hair follicle-like structure and a granulomatous inflammatory cell infiltrate. In H&E staining, that apparatuses were consistent with bee stings. Cutaneous reactions induced by long-standing retention of bee stings in the tissues may cause some difficulties in diagnosis, because of nonspecific, neoplasm-like changes in clinical and histopathological examination. Herein, we report an interesting case of a foreign body reaction induced by retained bee stings, demonstrated in comparison with live bee stings.

A case of lymphatic malformation with an unusual clinical presentation of evolving marginal polycyclic red induration

( Hyun Bo Sim ),( Dong Hyuk Eun ),( Sun Young Moon ),( Soo Yuhl Chae ),( Jin Hyup Lee ),( Myung Im ),( Yong Hyun Jang ),( Weon Ju Lee ),( Do Won Kim ),( Seok Jong Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Lymphatic malformations or lymphangiomas are congenital vascular anomalies characterized by progressive dilatation of anomalous lymphatic vessels. They are classified as microcystic versus macrocystic according to the diameter of the largest cystic cavity, or combined. Sclerotherapy, surgery or laser can be chosen for their management variably according to their subtype. Itscorrect differential diagnosis from other vascular tumors and malformations is mandatory before to decide therapeutic modalities. A 2-month-old female infant came to clinic presenting with large asymptomatic skin colored rubbery diffuse swelling with narrow marginal polycyclic red induration on left upper shoulder and axilla area since birth. As time went by, the lesion grew wider and more prominent marginal induration accordingly spreading. Vascular malformation with a slow flow on USG and lobulated, septated mass on MRI was revealed. Skin biopsy of the central and peripheral area to rule out vascular tumor or malformation revealed variably dilated thin walled vascular channels in whole dermis and subcutis. Diffuse positive reaction of lymphatic endothelial cell to D2-40 and Prox-1 staining was shown. Finally, she was diagnosed as lymphatic malformation with peculiar clinical feature of evolving marginal polycyclic red induration. To the best of our knowledge, there has been no report about lymphatic malformation with extraordinary clinical manifestation.