Clinical efficacies of topical agents for the treatment of seborrheic dermatitis of the scalp: A comparative study

SHIN, Hyoseung,KWON, Oh Sang,WON, Chong Hyun,KIM, Beom Joon,LEE, Yang Won,CHOE, Yong Beom,AHN, Kyu Joong,EUN, Hee Chul Wiley (Blackwell Publishing) 2009 The Journal of dermatology Vol.36 No.3

<P>Previous studies have shown that topical steroid and shampoo containing zinc pyrithione provide clinical benefits for treatment of scalp seborrheic dermatitis. But the clinical efficacy of topical tacrolimus, a newly developed calcineurin inhibitor on seborrheic dermatitis, is not well investigated yet. We wanted to compare the clinical efficacy of topical tacrolimus with that of conventional treatment (zinc pyrithione shampoo and topical betamethasone) for treatment of seborrheic dermatitis of the scalp. Patients with seborrheic dermatitis of the scalp were randomly allocated to receive topical betamethasone, topical tacrolimus or zinc pyrithione shampoo. Some patients were instructed to continue the treatments for 8 weeks and the others to discontinue the treatments at week 4. We evaluated the efficacy using a clinical severity score, dandruff score and sebum secretion at baseline, week 4 and week 8. All treatment groups showed significant improvements in clinical assessment after 4 weeks. While the patients treated by zinc pyrithione improved continuously even after cessation of the treatment, the patients treated by betamethasone lotion or tacrolimus ointment were aggravated clinically. Topical tacrolimus was as effective as topical betamethasone, and showed more prolonged remission than topical betamethasone. To treat seborrheic dermatitis of the scalp, we think that the combination therapy of topical steroid or topical tacrolimus, and zinc pyrithione is recommended.</P>

FC 2-6 : Risk factors for premature hair graying: family history, smoking, and obesity

( Hyoseung Shin ),( Hyeong Ho Ryu ),( Junghee Yoon ),( Seongmoon Jo ),( Sihyeok Jang ),( Mira Choi ),( Ohsang Kwon ),( Seong Jin Jo ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: The risk factors for premature hair graying (PHG) have not been the focus of research. Objectives: This study aimed to identify risk factors for PHG in healthy young Korean males. Methods: We conducted a cross-sectional study using questionnaires in males younger than 30 years. After a pilot study that included 1,069 males, we surveyed 6,390 males about their gray hair status and various socio-clinical characteristics. Results: In the pilot study, body mass index, family history of PHG, and emotional stress were associated with PHG. The age of participants in the main survey was 20.2 ± 1.3 years (mean ± standard deviation). Of the 6,390 participants, 1,618 (25.3%) presented with PHG. Family history of PHG (odds ratio [OR], 12.82), obesity (OR, 2.61), and >5 pack-years history of smoking (OR, 1.61) were significantly associated with the development of PHG. A paternal history of PHG (OR, 14.84; CI, 10.10-21.81) (P <0.001) had a greater association with PHG than a maternal history (OR, 2.92; CI, 1.57-5.43) (P = 0.001). In the multivariate analysis, family history of PHG (OR, 2.63) and obesity (OR, 2.22) correlated with the severity of PHG. Conclusion: Family history of PHG, obesity, and smoking were significantly associated with the incidence of PHG. Smoking and obesity are independently associated with systemic oxidative stress. Our findings imply that hair graying is affected by oxidative stress, which may provide an approach for health education against obesity and smoking.

FC 2-7 : Efficacy of Interventions for prevention of chemotherapy-induced alopecia: A systematic review and meta-analysis

( Hyoseung Shin ),( Seong Jin Jo ),( Do Hun Kim ),( Seung Kwon Myung ),( Oh Sang Kwon ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Chemotherapy-induced alopecia (CIA) is a highly distressing event for cancer patients. Objectives: We here aimed to assess the efficacy of various interventions in the prevention of CIA Methods: We searched PubMed, EMBASE, and the Cochrane Library, from 20 June 2013 through 31 August 2013. Two of the authors independently reviewed and selected clinical trials that reported the efficacy of any intervention for prevention of CIA compared with that of controls. Relative risks (RRs) and 95% confidential intervals (CIs) were calculated for efficacy of CIA prevention by using random-effect or fixed-effect models. Results: Out of 691 articles retrieved, a total of 8 randomized controlled trials and 9 controlled clinical trials involving 1098 participants (616 interventions and 482 controls), were included in the final analyses. Scalp cooling, scalp compression, a combination of cooling and compression, topical minoxidil, and Panicum miliaceum were used as interventions. The participants were mainly breast cancer patients receiving doxorubicin- or epirubicin-containing chemotherapy. Scalp cooling, which is the most popular preventive method, significantly reduced the risk of CIA (RR = 0.38, 95% CI = 0.32-0.45), whereas topical 2% minoxidil and other interventions did not significantly reduce the risk of CIA. No serious adverse effects associated with scalp cooling were reported. Conclusion: Our results suggest that scalp cooling can prevent CIA in patients receiving chemotherapy.

Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols

( Hyoseung Shin ),( A Ri Cho ),( Dong Young Kim ),( Semchin Munkhbayer ),( Soon Jin Choi ),( Sunhyae Jang ),( Seong Ho Kim ),( Hyeon Cheol Shin ),( Oh Sang Kwon ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.1

Background: Ecklonia cava is a brown alga that contains various compounds, including carotenoids, fucoidans, and phlorotannins. E. cava polyphenols (ECPs) are known to increase fibroblast survival. The human dermal papilla cell (hDPC) has the properties of mesenchymal-origin fibroblasts. Objective: This study aims to investigate the effect of ECPs on human hair growth promotion in vitro and ex vivo. Methods:MTT assays were conducted to examine the effect of ECPs on hDPC proliferation. Hair growth was measured using ex-vivo hair follicle cultures. Real-time polymerase chain reaction was performed to evaluate the mRNA expression of various growth factors in ECP-treated hDPCs. Results: Treatment with 10 μg/ml purified polyphenols from E. cava (PPE) enhanced the proliferation of hDPCs 30. 3% more than in the negative control (p<0. 001). Furthermore, 0. 1 μg/ml PPE extended the human hair shaft 30. 8% longer than the negative control over 9 days (p<0. 05). Insulin-like growth factor-1 (IGF-1) mRNA expression increased 3. 2-fold in hDPCs following treatment with 6 μg/ml PPE (p<0. 05). Vascular endothelial growth factor (VEGF) mRNA expression was also increased 2. 0-fold by 3 μg/ml PPE (p<0. 05). Treatment with 10 μg/ml PPE reduced oxidative stress in hDPCs (p<0. 05). Conclusion: These results suggest that PPE could enhance human hair growth. This can be explained by hDPC proliferation coupled with increases in growth factors such as IGF-1 and VEGF. Reducing oxidative stress is also thought to help increase hDPCs. These favorable results suggest that PPE is a promising therapeutic candidate for hair loss.

Laser therapy

( Hyoseung Shin ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1

Laser therapy

( Hyoseung Shin ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-

Acute Stress-Induced Changes in Follicular Dermal Papilla Cells and Mobilization of Mast Cells: Implications for Hair Growth

( Hyoseung Shin ),( Soon Jin Choi ),( A Ri Cho ),( Dong Young Kim ),( Kyu Han Kim ),( Ohsang Kwon ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.5

Background: Stress is a known cause of hair loss in many species. Objective: In this study, we investigated the role of acute stress on hair growth using a rat model. Methods: Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of rat and human dermal papilla cells (hDPCs), as well as serum cortisol and corticotropin-releasing hormone levels, were measured. Mast cell staining was performed on the biopsied tissue. In addition, Western blot and quantitative real time polymerase chain reaction were used to assess mast cell tryptase and cytokine expression, respectively in rat skin biopsies. Results: Stress-serum treatment reduced significantly the number of viable hDPCs and arrested the cell cycle in the G1 phase, compared to serum from unrestrained rats (p<0.05, respectively). Moreover, restrained rats had significantly higher levels of cortisol in serum than unrestrained rats (p<0.01). Acute stress serum increased mast cell numbers and mast cell tryptase expression, as well as inducing interleukin (IL)-6 and IL-1β up-regulation. Conclusion: These results suggest that acute stress also has an inhibitory effect on hair growth via cortisol release in addition to substance P-mast cell pathway. (Ann Dermatol 28(5) 600∼606, 2016)

Chronic spontaneous urticaria: treatment guidelines and non-biologic therapy

신효승 ( Hyoseung Shin ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

·Avoidance of triggers and aggravating factors ·European Academy of Allergy and Clinical Immunology recommends the following stepwise approach. . First line treatment includes non-sedating, second-generation H1 antihistamines . Second-line therapy involves up-dosing the second-generation H1 antihistamine (up to fourfold dosage) . Third-line treatment includes adding leukotriene receptor antagonist, cyclosporine, or omalizumab. . Corticosteroids may be used as rescue therapy as rescue therapy for a maximum of 10 days. . First generation H1 antihistamines are not included based on the benefit-to-risk ratio of these agents. ·However, American Academy of Allergy, Asthma, and Immunology guidelines consider the options of up-dosing second-generation H1 antihistamines, adding other second-generation H1 antihistamines, and adding H2 antagonists, leukotriene receptor antagonists or first-generation H1 antihistamines at bedtime to all be equally weighted second-line options. ·The expected response rate by antihistamines is about 45% based on the literature. The response rate of omalizumab was 65% of reminder. And then, the response rate of cyclosporine was 65% of reminder. Calculated total response rate was 92%. (Ref> Ann Allergy Asthma Immunol. 2014;112:419-25) ·Miscellaneous treatments: dapsone, hydroxychloroquine, sulfasalazine, colchicine, methotrexate, intravenous gamma-globulin, and phototherapy have all been used to treat chronic spontaneous urticaria.

Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis

( Ye Eun Kim ),( Hyoseung Shin ),( Young Gull Kim ),( Hyunsun Park ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Phakomatosis pigmentovascularis(PPV) is a rare congenital cutaneous condition. It is associated with widespread capillary malformation and pigmented nevus. Objectives: This study aims to evaluate the characteristics and treatment of PPV. Methods: We retrospectively reviewed PPV patients visited our special clinic between 2003 and 2017. Treatment outcome of cutaneous lesions was scored using a 4-point scale. Results: 52 patients (19M/33F) were involved in this study. Type IIa was the most common type and 17.3% patients have systemic involvement. Significantly more systemic involvement was observed in patients with nevus of Ota and in patients with pigmented nevus on head and neck (P = 0.004 and P = 0.035, respectively). 28.6% of the patients’ capillary malformation was almost cleared by pulsed dye laser, whereas 23.7% of the patients’ pigmented nevus was almost cleared and 42.1% of the patients’ pigmented nevus was completely cleared by Q-switched Nd:yttrium-aluminum-garnet laser. The treatment outcome shows significant negative correlation with the extent of port-wine stain or pigmented nevus (P=0.047 and P=0.011, respectively). Conclusion: In PPV patients, pigmented nevus rather than capillary malformation showed better treatment response to lasers. In both capillary malformation and pigmented nevus, smaller lesions likely to have better treatment outcomes.

The Pattern of Hair Dyeing in Koreans with Gray Hair

( Seong Jin Jo ),( Hyoseung Shin ),( Seung Hwan Paik ),( Jae Woo Choi ),( Jong Hee Lee ),( Soyun Cho ),( Ohsang Kwon ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.4

Background: Hair graying is considered as a part of normal ageing process. Nonetheless, this process raises a significant cosmetic concern, especially among ethnic Korean elderly whose baseline hair color is black. For this reason, Korean elderly dye their hair with frequency despite the risk of dermatologic problems such as allergic contact dermatitis. Objective: In this study, the authors investigate the prevalence and pattern of hair dyeing and its relation with scalp diseases in Korea. Methods: Six hundred twenty subjects (330 men and 290 women) with graying hair were given a questionnaire survery and underwent a physical examination. Results: Of the 620 total, 272 subjects (43.9%) dyed their hair. Hair dyeing was significantly more frequent among women than among men (p<0.001). Subjects from 50 to 69 years of age showed higher prevalence of hair dyeing when compared to either younger or older groups. Subjective self-assessment of the extent of hair graying was associated with increased prevalence of hair dyeing, that is, individuals who feel graying has advanced by more than 20% of the overall hair were much more likely to dye their hair (p<0.001). Hair dyeing did not correlate with either alopecia or scalp disease. Conclusion: Our survey has found that the prevalence of hair dyeing is higher among Korean women than men. People in their fifties and sixties and people with more than 20% extent of grayness were more likely to dye their hair than otherwise. Hair dyeing was not associated with any increase in the prevalence of scalp diseases. (Ann Dermatol 25(4) 401∼404, 2013)