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신현철,윤철호,김종대,정지천,신억섭,허근 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
In convulsion state by PTZ in rat, anticonvulsive effect and some γ-aminobutyric acid (GABA)-related mechanisms of Bythus extract in brain was experimented. It was ingibited GABA-T activity, lipid peroxide generation and xanthine oxidase activity as scheduled administration in vitro and vivo. And the content of brain gutathione was increased as scheduled administration in rat. In convulsion state by PTZ of previously managed rat by Buthus extract, onset eime and duration were non-specific changes but recovery time and severity was remarkably reduced. In conclusion speculated that Buthus extract inhibits convulsion by control of GABA content in brain.
무궁화 위성방송 수신용 고이득 마이크로스트립 배열안테나의 설계
김진생,신현철,이문수 慶尙大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.12 No.-
In this paper, a microstrip array antenna for receiving KOREASAT broadcasting is designed, which has left-handed circularly polarization property with the gain of 29dB at 11.84GHz. An antenna using a single feed point is chosen as an array element because of its simplicity and low feeding loss. The 2 X 2 array is a basic array element to achieve the overall 16 X 16 array antenna. All the elements of the array are fed in phase using the parallel feed method for broadside beam radiation. The actual dimension of array is about 30 X 30cm. The measured return loss and VSWR is in a good agreement with the calculations. The measured results are as follows ; SLL of -15dB below, gain of 27dB, directivity of 31.9dBi, and axial ratio of 0.74dB at 11.84GHz.
S-211 : Biventricular tachycardia induced by herbal medicine containing ephedra sinica
( Cheol Won Hyeon ),( Young Hwan Choi ),( Jun Hwan Cho ),( Kyung Joon Kim ),( Sharath Kumar ),( Seong Hyeop Hyeon ),( Jee Eun Kwon ),( Eun Young Kim ),( Seung Yong Shin ),( Wang Soo Lee ),( Kwang Je L 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Ephedra is a potent sympathomimetic agent with cardiovascular effects including tachyardia, positive inotropy, arterial vasoconstriction and hypertension. We report 1 case of biventricular tachycardia after taking herbal medicine containing ephedra sinica. A 77-year-old male with a 30-year-history of COPD prsented with acute onset chest discomfort and dyspnea. He was precribed herbal medicines containing ephedra sinica for abdominal discomfort 2 days ago. Initial electrocardiography (ECG, Fig. A) showed hemodynamically unstable monomorphic ventricular tachycardia with RBBB pattern in percordial leads, which was terminated by electrical cardioversion. ECG after cardioversion, atrial fibrillation was observed (Fig. B). About 1 hour later, hemodynamically unstable fast monomorphic ventricular tachycardia with LBBB pattern was spontaneously induced (Fig. C). Because of hemodynamic instability, additional electrical cardioversion was performed and sinus rhythm was restored (Fig.D). Electrolytes and arterial blood gas analyses were normal. To rule out structural heart disease, echocardiography was done and it revealed normal ejection fraction and no significant abnormalities. Coronary angiography showed a 80% stenosis in the proximal circumflex coronary artery and a 70% stenosis in the posterior descending artery. Percutanous coronary intervention was done to left circumflex artery. The patient was discharged on clopidogrel, warfarin, ACE inhibitor, beta-blocker, statin. His follow up was uneventful.
S-224 : The Early Repolarization Pattern EKG in patients with Acute Coronary Syndrome: IVUS study
( Cheol Won Hyeon ),( Young Hwan Choi ),( Jun Hwan Cho ),( Kyung Joon Kim ),( Sharath Kumar ),( Seong Hyeop Hyeon ),( Jee Eun Kwon ),( Eun Young Kim ),( Seung Yong Shin ),( Wang Soo Lee ),( Kwang Je L 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Background: Early repolarization pattern (ERP) has been considered as benign condition in great majority of cases. Recently, the presence of ERP can be an index of poor prognosis in various heart diseases. Method: We analyzed 59 consecutive patients with acute coronary syndrome underwent primary coronary intervention and virtual histology intravascular ultrasonography (VH-IVUS). Thin cap fibroatheroma (TCFA) was defined as necrotic core (NC) >10% of plaque area with a plaque burden of >40% and NC in contact with the lumen for >3 image slices. Positive remodeling was a remodeling index (lesion/reference vessel area) >1.05. The diagnostic criterion of ERP was defined when there is J-point elevation of ≥0.1 mV in two adjacent leads. Results: The presence of ERP was observed in 27 patients (45.8%). Although there was no significant difference in lesion length and remodeling index at minimal lumen area between the 2 groups, reference diameter and minimal luminal area were significantly smaller in patients with ERP (p=0.033, p=0.048, respectively). The lesion characteristics of patients with ERP demonstrated (1) more necrotic core (p<0.001), (2) lesser calcium component (p=0.028). Although the incidence of plaque rupture failed to demonstrate significant differences, TCFA was more frequently observed in patients with ERP (p=0.038). Conclusion: We report, for the first time, that the ERP in ACS might distinguish patients with more vulnerable plaque.
Shin Hyeon-Cheol,Hwang Hye Jeong,Kang Kee Jung,Lee Bong Ho The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.2
Osteoarthritis is thought to be induced by the ageing-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to overproduction under undesirable physiological conditions. Phlorotannins are unique polyphenolic compounds bearing dibenzo-1,4-dioxin skeleton which are not found in terrestrial plants but found only in some brown algal species such as Ecklonia and Eisenia families. Phlorotanninrich extracts of Ecklonia cava including LAD103 showed significant antioxidant activities such as DPPH radical scavenging, ferric ion reduction, peroxynitrite scavenging, and inhibition of LDL oxidation, indicating their possible antioxidative interference both in onset and downstream consequences of osteoarthritis. LAD103 also showed significant down regulation of $PGE_2$ generation in LPS-treated RAW 246.7 cells, and significant inhibition of human recombinant interleukin-$1{\alpha}$-induced proteoglycan degradation, indicating its beneficial involvement in pathophysiological consequences of osteoarthritis, the mechanism of which needs further investigation. Since LAD103 showed strong therapeutic potentials in arthritic treatment through several in vitro experiments, it is highly encouraged to perform further mechanistic and efficacy studies.
종설(綜說) : 재발성(再發性) 방광염(膀胱炎) 및 하부뇨로감염(下部尿路感炎)의 침술(針術) 치료(治療)에 관한 고찰
신현철 ( Hyeon Cheol Shin ) 대구한의대학교 제한동의학술원 2010 東西醫學 Vol.35 No.4
Objectives: Frequently recurrent acute uncomplicated lower urinary tract infection(cystitis), defined as acute cystitis in otherwise healthy adult women is common. Usually even though they use prophylactic antibacterial treatment, long-term antibacterial treatment can lead to unintended increased bacterial resistance, which is a medical problem of increasing concern. The main purpose of this study is to evaluate the effect of acupuncture in the treatment and prevention of recurrent cystitis and lower urinary tract infection. Methods and Materials: Writer ran a computer literature search in Pubmed. The search terms were 「cystitis acupuncture」 and 「lower urinary tract infection acupuncture」, and selected 5 literatures. Results Recurrent cystitis and lower urinary tract infection frequently occurred in the middle generation women in the latter half of their thirties. In Zang-Fu they were connected with Spleen, Kidney and Liver. In the frequency of use, Sanyinjiao and P`angkuangshu in the Jing-Points and Spleen-Channel and Urinary Bladder-Channel in the Meridians were most. The difference of the incidence rate between acupuncture treated group and nontreated group was more than twice. Especially in the nontreated group the residual urine was unchanged, but in the treated group reduced to a half at least. Conclusions: In the treatment and prevention of recurrent cystitis and lower urinary tract infection acupuncture-therapy seems to be effective, but in many ways it is likely that further research is need.