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Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma
( Hyerim Ha ),( Bhumsuk Keam ),( Chan-young Ock ),( Tae Min Kim ),( Jin Ho Kim ),( Eun-jae Chung ),( Seong Keun Kwon ),( Soon-hyun Ahn ),( Hong-gyun Wu ),( Myung-whun Sung ),( Dae Seog Heo ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1
Background/Aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC. Methods: We retrospectively analyzed clinical data from 10 patients with pathologically confirmed ACC of the head and neck who received CCRT with cisplatin in Seoul National University Hospital between 2013 and 2018. Results: Ten patients with unresectable disease at the time of diagnosis or with positive margins after surgical resection received CCRT with weekly cisplatin. Eight patients (80%) achieved complete remission, of which three later developed distant metastases without local relapse; one patient developed distant metastasis and local relapse. Two patient achieved partial remission without progression. Patients experienced several toxicities, including dry mouth, radiation dermatitis, nausea, and salivary gland inflammation of mostly grade 1 to 2. Only one patient showed grade 3 oral mucositis. Median relapse-free survival was 34.5 months (95% confidence interval, 22.8 months to not reached). Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC.
FPGA 기반 AES-256 CTR 모듈의 Text Length 별 사양 비교
장혜림(Hyerim Jang),정성훈(Sunghun Jung),하지석(Jiseok Ha),문병인(Byungin Moon) 한국정보기술학회 2021 Proceedings of KIIT Conference Vol.2021 No.11
IT 분야의 발전을 통해 더욱더 많은 데이터를 처리함으로써 얻는 이점도 많지만, 이와 동시에 정보유출의 위험 또한 증가하게 되었다. 정보유출 문제를 막기 위해 데이터를 암호화하는 방법이 적용되고 있으나, 막대한 데이터들을 실시간으로 암호화해야 하는 분야에서는 적용하기 어려운 문제가 있다. 이에 본 논문에서는 암호화 연산을 실시간으로 수행하기에 적절한 하드웨어 가속기의 구조를 제시하기 위해 AES-256 CTR 모듈의 text length 별 하드웨어 리소스와 전력의 사용량, 그리고 연산의 소요 시간을 비교분석 한다. There are many advantages to be gained by processing a lot of data through the development of information technology, but the risk of information leakage has also increased. Data encryption method is applied to prevent information leakage problem, but there is a problem that it is difficult to apply in the field where huge amount of data needs to be encrypted in real time. Therefore, in this paper, in order to present the architecture of a hardware accelerator suitable for real-time encryption, we compare and analyze the hardware resource usage, power consumption, and the processing time of AES-256 CTR modules by text length.
PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay
Yi, Hyerim,Park, Joha,Ha, Minju,Lim, Jaechul,Chang, Hyeshik,Kim, V. Narry Elsevier 2018 Molecular cell Vol.70 No.6
<P><B>Summary</B></P> <P>Multiple deadenylases are known in vertebrates, the PAN2-PAN3 (PAN2/3) and CCR4-NOT (CNOT) complexes, and PARN, yet their differential functions remain ambiguous. Moreover, the role of poly(A) binding protein (PABP) is obscure, limiting our understanding of the deadenylation mechanism. Here, we show that CNOT serves as a predominant nonspecific deadenylase for cytoplasmic poly(A)<SUP>+</SUP> RNAs, and PABP promotes deadenylation while preventing premature uridylation and decay. PAN2/3 selectively trims long tails (>∼150 nt) with minimal effect on transcriptome, whereas PARN does not affect mRNA deadenylation. CAF1 and CCR4, catalytic subunits of CNOT, display distinct activities: CAF1 trims naked poly(A) segments and is blocked by PABPC, whereas CCR4 is activated by PABPC to shorten PABPC-protected sequences. Concerted actions of CAF1 and CCR4 delineate the ∼27 nt periodic PABPC footprints along shortening tail. Our study unveils distinct functions of deadenylases and PABPC, re-drawing the view on mRNA deadenylation and regulation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The human CCR4-NOT complex is a predominant nonspecific deadenylase </LI> <LI> PAN2/3 trims excessively long tails with minimal impact on mRNA stability </LI> <LI> CAF1 trims PABPC-free A tails while CCR4 removes PABPC-bound A tails </LI> <LI> PABPC facilitates mRNA deadenylation while preventing precocious uridylation and decay </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim Do Yeun,Ha Hyerim,Bae SeungJin,Kang Jin-Hyoung 대한의학회 2021 Journal of Korean medical science Vol.36 No.29
Background: As the role of immunotherapies and personalized medicine grow, cancer patients have faced many choices in treatments and have suffered financial toxicity. These challenges brought the need for the value framework (VF) to guide treatment decision making. Methods: A survey was taken to 102 oncologists about perception for VF. They were asked about priorities among several considerations when they prescribe cancer drugs. Their views on the need for development and potential implications of VF in Korea were assessed, also. Results: The survey shows that 90% of the respondents choose clinical efficacy as the most important value in cancer drugs selection, and the cost of drug was more weighted value in immune checkpoint inhibitors (13.7%). Approximately half (53.9%) answered that they were aware of the existing VFs. Over 90% of respondents agreed with the need for development of a VF for cancer drugs based on Korean healthcare system and further usefulness for decisions about reimbursement issues. Seventy-one percent answered that two representative VFs (American Society Clinical Oncology-VF and European Society for Medical OncologyMagnitude of Clinical Benefit Scale) should be reflected in value measurement of cancer drugs in Korea. Conclusion: The Korean oncologists recognized the necessity for the clinical application of VF. Further discussion between the stakeholders should be followed to alleviate the financial burden through the value-based decision making of cancer drugs.
Lee Yo Han,Oh Namkee,Kim Hyerim,Ha Shin 대한의학회 2021 Journal of Korean medical science Vol.36 No.12
Background: Little is known about the surgical discipline in North Korea from the perspective of the outside world. This study aimed to examine the disease entities covered by articles published in the major medical journal in North Korea, “Surgery.” Methods: Content and frequency analyses of 2,132 articles published in “Surgery” from 2006 to 2017 were conducted. Two medical doctors who majored in surgery and anesthesiology perused the articles and compiled the diseases being elucidated in each article. The diseases described in each article were stratified into 13 surgical subspecialties. Results: Articles from “Surgery,” similar to articles from the Western surgical community, also covered a wide variety of surgical diseases from different subspecialties, and the number of publications continued to grow consistently. Moreover, a number of studies focused on the fields of orthopedics and general surgery dealing with benign diseases. Some articles focused on minimally invasive surgeries using laparoscopy. Conclusion: The studies published in the North Korean journal “Surgery” encompass various clinical areas, but their quality is unclear.