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Intracranial Involvement of Systemic Hodgkin Lymphoma: A Case Report and Literature Review
( Hwanhee Lee ),( Sangjun Ahn ),( Seung Heon Cha ),( Won Ho Cho ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2024 Brain Tumor Research and Treatment Vol.12 No.1
A 27-year-old male patient, previously diagnosed with Hodgkin lymphoma (HL), presented with gait disturbance. Brain MRI showed a 4.5 cm mass lesion in the right occipital lobe, suggesting either intracranial involvement of HL or a potential meningioma. Despite high-dose methotrexate and steroid treatment, the patient’s symptoms persisted, and imaging showed an enlarging mass, leading to surgical intervention. Histopathological examination confirmed central nervous system (CNS) involvement of HL. Postoperatively, the patient underwent whole-brain radiotherapy and demonstrated marked clinical improvement. Our literature review from 1980 to 2023 identified only 46 cases of intracranial HL (IC-HL), underscoring its rarity. Lymphomas represent 2.2% of brain tumors, with 90%-95% being diffuse large B-cell lymphoma (DLBCL). In contrast, the incidence of CNS-HL patients is a mere 0.02%. Notably, IC-HL and intracranial DLBCL have differences in their typical locations and treatment strategies. Unlike DLBCL, which predominantly appears in the supratentorial region (87%), IC-HL is found there in 61.5% of cases. Additionally, 33.3% of IC-HL cases occur in the cerebellum, with 43.5% associated with posterior circulation regions. Furthermore, while biopsy followed by chemotherapy induction is a common strategy for DLBCL, 81.8% of IC-HL cases underwent surgical resection, and only 18.1% had a biopsy alone. The distinct characteristics of IC-HL tumors, including their larger size, attachment to the dura, and fibrotic nature with clear boundaries, might account for the preference for surgical intervention. The unique features of IC-HL compared to DLBCL highlight the need for distinct considerations in diagnosis and management.
Fast, Lightweight, and Robust Path Planning for Low-power Embedded Environments
Hwanhee Lee,Ilyong Yoon,Sangwoo Kim,Dong Jin Hyun 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
A fast, lightweight, and robust path planning algorithm is proposed for single agent robot navigation environments varying every moments, and its feasibility for low-power embedded environments are verified. Main objective of this paper is to find path immediately avoiding obstacles in unstructured environments for safe robot navigation on low-power embedded environments. Several experiments are conducted to evaluate the path planning performance and the long-term operation and to verify the consistency of performance and the feasibility for low-power embedded environments.
Lee, Hwanhee,Magara, Tetsuya American Astronomical Society 2018 The Astrophysical journal Vol.859 No.2
<P>We present a magnetohydrodynamic model of solar eruption based on the dynamic state transition from the quasi-static state to the eruptive state of an active region (AR) magnetic field. For the quasi-static state before an eruption, we consider the existence of a slow solar wind originating from an AR, which may continuously make the AR magnetic field deviate from mechanical equilibrium. In this model, we perform a three-dimensional magnetohydrodynamic simulation of AR 12158 producing a coronal mass ejection, where the initial magnetic structure of the simulation is given by a nonlinear force-free field derived from an observed photospheric vector magnetic field. We then apply a pressure-driven outflow to the upper part of the magnetic structure to achieve a quasi-static pre-eruptive state. The simulation shows that the eruptive process observed in this AR may be caused by the dynamic state transition of an AR magnetic field, which is essentially different from the destabilization of a static magnetic field. The dynamic state transition is determined from the shape evolution of the magnetic field line according to the kappa H-mechanism. This work demonstrates how the mechanism works to produce a solar eruption in the dynamic solar corona governed by the gravitational field and the continuous outflows of solar wind.</P>
Mental disease-related emergency admissions attributable to hot temperatures
Lee, Suji,Lee, Hwanhee,Myung, Woojae,Kim, E. Jin,Kim, Ho Elsevier 2018 Science of the Total Environment Vol.616 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>The association between high temperature and mental disease has been the focus of several studies worldwide. However, no studies have focused on the mental disease burden attributable to hot temperature. Here, we aim to quantify the risk attributed to hot temperatures based on the exposure-lag-response relationship between temperature and mental diseases.</P> <P><B>Method</B></P> <P>From data on daily temperature and emergency admissions (EA) for mental diseases collected from 6 major cities (Seoul, Incheon, Daejeon, Daegu, Busan, and Gwangju in South Korea) over a period of 11years (2003–2013), we estimated temperature-disease associations using a distributed lag non-linear model, and we pooled the data by city through multivariate meta-analysis. Cumulative relative risk and attributable risks were calculated for extreme hot temperatures, defined as the 99th percentile relative to the 50th percentile of temperatures.</P> <P><B>Results</B></P> <P>The strongest association between mental disease and high temperature was seen within a period of 0–4days of high temperature exposure. Our results reveal that 14.6% of EA for mental disease were due to extreme hot temperatures, and the elderly were more susceptible (19.1%). Specific mental diseases, including anxiety, dementia, schizophrenia, and depression, also showed significant risk attributed to hot temperatures. Of all EA for anxiety, 31.6% were attributed to extremely hot temperatures.</P> <P><B>Conclusions</B></P> <P>High temperature was responsible for an attributable risk for mental disease, and the burden was higher in the elderly. This finding has important implications for designing appropriate public health policies to minimize the impact of high temperature on mental health.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We quantified the burden of mental disease due to hot temperatures. </LI> <LI> Elderly were more susceptible than young group to hot temperatures. </LI> <LI> The risks for specific mental diseases attributed to hot temperatures were also high. </LI> <LI> 14.6% of EA for mental disease can be attributed to extreme hot temperatures. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>This graphical abstract indicates the overall cumulative relative risk and attributable fractions attributed to extreme hot temperature by subgroup.</P> <P>[DISPLAY OMISSION]</P>
Dynamic response of coupled shaft torsion and blade bending in rotor blade system
Hwanhee Lee,송지석,장석주,나성수 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.9
This study develops a computational model for the dynamic characteristics of a rotor-blade system. The rotor-blade coupled model with pre-twisted blade attached to a rigid disk driven by a shaft is developed using the Lagrange equation in conjunction with the assumed mode method to discretize the blade deformation. The effects of axial shortening due to blade lagging deformation, centripetal force caused by the rotating blade, and gravity are included in the model. The coupled equation of motion is formulated based on the small deformation theory for the blade and shaft torsional deformation to obtain the dynamic characteristics of the system for various system parameters. Numerical simulations show that the pre-twist angle of the blade and the shaft torsional flexibility strongly influence the dynamic behavior of the rotor-blade system.