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Effect of miRNAs on Pain related Genes in Endometriosis
( Jae Yen Song ),( Mee Ran Kim ),( Hugh Taylor ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Two of the problems with endometriosis are pain and infertility. The objectives is to show how endometriosis controls pain-related gene in humans. Methods: I selected up or down-expressed genes more than two fold differences between mice brain of endometriosis and those of control. I search the number of valid gene found in the four parts of the brain. I found a reported gene associated with pain, mainly in humans or mice, and another condition was to see target gene of microRNA related to endometriosis through two database. At first, I confined to microRNA 125, 150, 342, 451, 3613, Let7b as microRNA associated with Endometriosis. I transfected those miRNAs into human SH-SY5Y cell line, which is human BM neuroblast. Using RNA from the cell line, create a cDNA and evaluate the Candidate gene by the RT-PCR. And then using protein extracted from cell line, western blot was performed to check out candidate genes. Results: The most commonly found lesion is the insula area among amygdala, cerebral cortex, hippocampus and insula. Among these genes, 14 pain-related gene could be extracted. The RT-PCR repeated in several batches resulted in a significant increase in the DRD2 in the group treated with microRNA 125 and a significant decrease in TAC1. As with the RT-PCR results, the group that transfected microRNA 125 mimc increased the Western blot density and the group that transfected microRNA 125 inhibitor decreased the Western blot density. And also microRNA 150 inhibitor decreased the Western blot density. But it is not shown from the RT-PCR results. Conclusion: We confined two target genes which interact with endometriosis-related microRNAs. Also we showed how to control those genes. We could use microRNAs as pain regulator caused by endometriosis.
You, Yizhi,Cho, Gil Young,Hughes, Taylor L. American Physical Society 2016 Physical review. B Vol.94 No.8
<P>In this paper, we investigate the theory of dynamical axion strings emerging from chiral symmetry breaking in three-dimensional Weyl semimetals. The chiral symmetry is spontaneously broken by a charge density wave (CDW) order which opens an energy gap and converts the Weyl semimetal into an axion insulator. Indeed, the phase fluctuations of the CDW order parameter act as a dynamical axion field theta((x) over right arrow ,t) and couple to electromagnetic field via L-theta = theta((x) over right arrow ,t)/32 pi(2) epsilon(sigma tau nu mu) F-sigma tau F-nu mu. Additionally, when the axion insulator is coupled to deformations of the background geometry/strain fields via torsional defects, e.g., screw dislocations, there is interesting interplay between the crystal dislocations and dynamical axion strings. For example, the screw dislocation traps axial charge, and there is a Berry phase accumulation when an axion string (which carries axial flux) is braided with a screw dislocation. In addition, a cubic coupling between the axial current and the geometry fields is nonvanishing and indicates a Berry phase accumulation during a particular three-loop braiding procedure where a dislocation loop is braided with another dislocation and they are both threaded by an axion string. We also observe a chiral magnetic effect induced by a screw dislocation density in the absence of a nodal energy imbalance between Weyl points and describe an additional chiral geometric effect and a geometric Witten effect.</P>