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Additions to the Knowledge of the Fungal Order Eurotiales in Korea: Eight Undescribed Species
Thuong T. T. Nguyen,Ki Hyun Kang,Dong Hee Kim,Su Jin Kim,Hye Yeon Mun,Wonsu Cheon,Hyang Burm Lee 한국균학회 2023 Mycobiology Vol.51 No.6
Eurotiales is a relatively large order of Ascomycetes, well-known for their ability to producesecondary metabolites with potential beneficial applications. To understand their diversity anddistribution, different environmental sources including soil, freshwater, insect, and indoor airwere investigated. Eight strains of Eurotiales were isolated and identified based on theirmorphological characters and a multi-gene phylogenetic analysis of the ITS , BenA, CaM, andRPB2 regions. We identified eight taxa that were previously not reported from Korea: Aspergillusbaeticus, A. griseoaurantiacus, A. spinulosporus, Penicillium anthracinoglaciei, P. labradorum, P. nalgiovense, Talaromyces atroroseus, and T. georgiensis. Detailed descriptions, illustrations, andphylogenetic tree for the eight new records species are presented, and information regardingthe records is also discussed.
Hoang Thai Hoa,Nguyen Thi Thu,Nguyen Thuong Dong,Tran Thi Oanh,Tran Thi Hien,Do Thi Ha 한국생약학회 2020 Natural Product Sciences Vol.26 No.3
The ability of the total extract from Physalis angulata; three fractions after partitioning with n-hexane, ethyl acetate (TBE), and water; and four withanolides (compounds 1 – 4) to phosphorylate 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in HepG2 cells was evaluated. The TBE fraction (50 μg/mL) activated p-ACC and p-AMPK expression most strongly. Compounds 1 – 4 (10 μM) upregulated p-ACC expression at different levels. Compound 4 induced the most significant changes in p-AMPK expression, followed by 1 and 2. Sterol regulatory element-binding proteins (SREBPs) play a functional role in the transcriptional regulation of the lipogenic pathway, including fatty acid synthase (FAS) and ACC. The effects of compounds 2 and 4 (10 μM) on FAS and SREBP-1c expression under high glucose conditions (30 mM) in HepG2 cells were evaluated further. Both dose-dependently inhibited FAS and SREBP-1c expression as well as lipid accumulation (1 – 10 μM) were compared to high-concentration glucose control, which upregulated FAS and SREBP-1c. These results suggest that compounds 2 and 4 upregulate AMPK, suppress FAS and SREBP-1c, and have potential effects on glucose and lipid metabolism.