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Po-Wei Lee,Tzu-Yun Wang,Yun-Hsuan Chang,Sheng-Yu Lee,Shiou-Lan Chen,Ze-Cheng Wang,Po See Chen,Chun-Hsien Chu,San-Yuan Huang,Nian-Sheng Tzeng,I Hui Lee,Kao Chin Chen,Yen Kuang Yang,Jau-Shyong Hong,Ru-B 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1
Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2 ) gene has been associated with OUD and ALDH2 gene polymorphisms may affect aldehyde metabolism and cognitive function in other substance use disorder. Therefore, we aimed to investigate whether ALDH2 genotypes have significant effects on neuropsychological functions in OUD patients undergoing methadone maintenance therapy (MMT). Methods: OUD patients undergoing MMT were investigated and followed-up for 12 weeks. ALDH2 gene polymorphisms were genotyped. Connors’ Continuous Performance Test (CPT) and the Wechsler Memory Scale-Revised (WMS-R) were administered at baseline and after 12 weeks of MMT. Multivariate linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the ALDH2 genotypes and performance on the CPTs and WMS-R. Results: We enrolled 86 patients at baseline; 61 patients completed the end-of-study assessments. The GEE analysis showed that, after the 12 weeks of MMT, OUD patients with the ALDH2 *1/*2+*2/*2 (ALDH2 inactive) genotypes had significantly higher commission error T-scores (p = 0.03), significantly lower hit reaction time T-scores (p = 0.04), and significantly lower WMS-R visual memory index scores (p = 0.03) than did patients with the ALDH2 1 */*1 (ALDH2 active) genotype. Conclusion: OUD patients with the ALDH2 inactive genotypes performed worse in cognitive domains of attention, impulse control, and memory than did those with the ALDH2 active genotype. We conclude that the ALDH2 gene is important in OUD and is associated with neuropsychological performance after MMT.
Impact Assessments of High Oil Prices on the Agro-Food System and the Role of Bioenergy Crops
Lee, Duu-Hwa,Lin, Hsin-Chun,Chang, Ching-Cheng,Hsu, Shih-Hsun,Chen, Chi-Chun,Sun, Jenny Chin-Hwa Korean Resource Economics Association 2007 자원·환경경제연구 Vol.16 No.3
In this study, multi-sectoral partial equilibrium and computable general equilibrium models of Taiwan are used to investigate the direct and indirect effects of energy price increases on overall economies and agro-food sector in Taiwan. The results suggest that agricultural prices, production cost would increase between 0.27% to 1.88%, and a reduction in GDP around 0.39% to 0.54 %. The negative impact on livestock sector is slightly higher than that on the crop sector. Negative impacts are also observed in the employment and wages. The rising oil price has the potential to discourage production of energy-intensive activity because of the possibility of substitution and adaptations. The growth rate of real GDP will shrink by 0.64% to 1.06% and CPI will increase by 1.17% to 1,95%. Both the agriculture and non-agricultural sector also respond by raising output prices by 0.80% to 1.33%. The rising international oil price has urged the government to take policy actions like using alternative fuels such as biodiesel, bioethanol, and adopting measures to cut down on energy consumptions mainly in transportation sectors in response to public concern over economic shocks.
Hepatocyte and mesenchymal stem cell co-transplantation in rats with acute liver failure
Cheng-Maw Ho,Ya-Hui Chen,Chin-Sung Chien,Shu-Li Ho,Hui-Ling Chen,Rey-Heng Hu,Po-Huang Lee 대한이식학회 2020 Korean Journal of Transplantation Vol.34 No.2
Background: Cell therapy is considered a potential alternative to liver transplantation in acute liver failure (ALF). We aimed to evaluate the add-on therapeutic benefit of hepatocyte and mesenchymal stem cell (MSC) cotransplantation over hepatocyte-only transplantations in a rat model of ALF. Methods: ALF was induced by D-galactosamine in Sprague-Dawley rats. Freshly isolated donor hepatocytes were derived from Tg (UBC-emGFP) rats and MSCs were collected from the bone marrow cells of DsRed rats. Donor hepatocytes (1×107/mL) were intraportally transplanted 24 hours after treatment with D-galactosamine over a 70-second interval, and donor MSCs (0.5, 1, or 2×106/0.5 mL) were intraportally transplanted 1 hour after the hepatocyte transplantation was complete. Animals were sacrificed after 7 and 14 days and subjected to donor cell identification, liver histology, serologic testing, and immunohistopathological examination. Results: MSCs were observed in the periportal area, 1 and 2 weeks after transplantation. Transplanted hepatocytes did not actively proliferate when compared to hepatocyte-only transplantation. Morphologically, transplanted MSCs did not appear to differentiate into hepatocytes even 2 weeks after transplantation. Cotransplantation of MSCs was associated with lower macrophage infiltration, and reduced type I collagen, hepatocyte growth factor, tumor necrosis factor-α, and interleukin 10 expression, with similar gene expression profiles for epidermal growth factor and interleukin 6, when compared to hepatocyte-only transplantation. Conclusions: Hepatocyte and MSC cotransplantation is feasible and safe in rat models of ALF. MSCs were found to survive the process and could be located within the periportal niches 2 weeks after treatment, without enhancing transplanted hepatocyte proliferation or differentiating into hepatocytes, while ameliorating the inflammatory response.
( Cheng-maw Ho ),( Shu-li Ho ),( Chia-tung Shun ),( Po-huang Lee ),( Ya-hui Chen ),( Chin-sung Chien ),( Hui-ling Chen ),( Rey-heng Hu ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Primary liver progenitor cell cancer is a rare disease entity without definite evidence and characterization. Current nomenclature of primary liver cancer with prominent progenitor features is not comprehensive. This study was aimed to investigate the existence of this kind of primary liver cancer and characterize it immunohistopathologically based on the emerging understanding of cancer stem cell pathobiology. Methods: Surgical specimens from primary liver cancer which posed diagnostic difficulty fitting within current WHO classification of combined hepatocellular-cholangiocellular carcinoma with stem-cell features according to the growth morphology and its suggested immunohistochemical features, were stained with antibodies against well-defined markers of progenitor cells, stemness, and differentiation toward hepatocytes or cholangiocytes. Comparative interpretation of images was processed considering the histological morphology and characteristic markers. Results: The primary liver cancer consisted of CD24+ cancer progenitor cells and CD90+ mesenchymal stromal cells, which were intimately mixed. CD24+ cancer cells demonstrated bi-directional trends of differentiation: bile ductule transformation (cytokeratin 19+, epithelial cell adhesion molecule [EpCAM]+, neural cell adhesion molecule [NCAM]+, CD133+, and delta-like 1 homolog [DLK1]+); and trabecular or nested cell clusters toward hepatic lineage (hepatocyte nuclear factor-4 alpha [HNF-4α]+, Hep Par1+ and negative for CK19, EpCAM, CD133, and DLK1). Moderate lymphocyte (mostly CD4+ and CD8+ T cells) infiltrated in the CD90+ cancer- associated stroma. Conclusions: We provided the corroboration that liver progenitor cells can form primary liver cancer, not just presented as few side population of cancer stem cells. Its existence might pose significance for future stem cell therapeutic intervention targeting liver diseases, albeit the disease is rare.
Range Aggregation With Set Selection
Yufei Tao,Cheng Sheng,Chin-Wan Chung,Jong-Ryul Lee IEEE 2014 IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERIN Vol.26 No.5
<P>In the classic range aggregation problem, we have a set S of objects such that, given an interval I, a query counts how many objects of S are covered by I. Besides COUNT, the problem can also be defined with other aggregate functions, e.g., SUM, MIN, MAX and AVERAGE. This paper studies a novel variant of range aggregation, where an object can belong to multiple sets. A query (at runtime) picks any two sets, and aggregates on their intersection. More formally, let S<SUB>1</SUB>,...,S<SUB>m</SUB> be m sets of objects. Given distinct set ids i, j and an interval I, a query reports how many objects in S<SUB>i</SUB> ∩ S<SUB>j</SUB> are covered by I. We call this problem range aggregation with set selection (RASS). Its hardness lies in that the pair (i, j) can have (<SUB>2</SUB><SUP>m</SUP>) choices, rendering effective indexing a non-trivial task. 2 The RASS problem can also be defined with other aggregate functions, and generalized so that a query chooses more than 2 sets. We develop a system called RASS to power this type of queries. Our system has excellent efficiency in both theory and practice. Theoretically, it consumes linear space, and achieves nearly-optimal query time. Practically, it outperforms existing solutions on real datasets by a factor up to an order of magnitude. The paper also features a rigorous theoretical analysis on the hardness of the RASS problem, which reveals invaluable insight into its characteristics.</P>
Fusion of hydrologic and geophysical tomographic surveys
Tian-Chyi Jim Yeh,Cheng-Haw Lee,Kuo-Chin Hsu,Jet-Chau Wen 한국지질과학협의회 2008 Geosciences Journal Vol.12 No.2
In this paper, we argue the need for high-resolution characterization of the subsurface and discuss difficulties of traditional characterization approaches to meet this need. Necessary and sufficient conditions are then presented for well-posedness of groundwater inverse problems associated with identifying spatially distributed parameters. Non-uniqueness and large uncertainty in model calibration are subsequently attributed to difficulties in collecting information to meet these conditions. Using an example, we show that a tomographic survey can make problems of identification of spatially distributed parameters better posed. We subsequently present some recent advances in hydrologic/geophysical characterization of the subsurface using information fusion based on tomographic survey concepts. This paper includes hydraulic and electrical resistivity tomographic surveys as well as fusion of hydraulic and resistivity tomography and fusion of hydraulic and tracer tomography
( Shih Sen Lin ),( Chin Cheng Lee ),( Tsrang Neng Jang ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.2
Non-tubecrulosis mycobacterium infections were increasinglyreported either pulmonary or extrapulmonary in thepast decades. In Taiwan, we noticed several reports aboutthe soft tissue infections caused by rapid growing mycobacteriumsuch as Mycobacterium abscessus, Mycobacteriumchelonae, on newspaper, magazines, or the multimedia. Most of them occurred after a plastic surgery, andmedical or non-medical procedures. Here, we reported twocases of these infections following medical procedures. Wealso discussed common features and the clinical course ofthe disease, the characteristics of the infected site, and thetreatment strategy. The literatures were also reviewed, andthe necessity of the treatment guidelines was discussed.