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정미선,김영록 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.1
The purposes of this study were to investigate risk factors of low back pain in civil airmen and to use this information as basis far the back rehabilitation. Subjects of this study were randomly selected 276 civil airmen who had been employed at four airports in Seoul. These data were analyzed by χ2 test, t-test, ANOVA, and multiple logistic regression using SAS. The results were as follows: 1) The prevalence of low back pain among 276 civil airmen was 64.9%. 2) The most common cause of low back pain was load lifting (stewardess), long sitting (aircrew A), and long sitting plus training (aircrew B), 3) There were no statistically significant associations among age, height, body weight, and low back pain, 4) No statistically significant relationships were found among the average monthly working time, total working time, average monthly rest time, working year and low back pain. 5) There was statistically significant relationship between abnormal posture and low back pain (p〈.01). 6) There was statistically significant relationship between fatigue and low back pain among stewardess and aircrew B. 7) There was a statistically significant relationship between job satisfaction and job-related stress (p〈.05). 8) In stewardess, higher satisfaction score was associated with less likelihood of low back pain (odds ratio = .80). The results of this study indicate that civil airmen developed chronicity of low back pain due to unfit seat, poor habitual posture, fatigue symptom, and stress or other risk factors. Therefore, there is a need to improve the working environment for the prevention of posture-related low back pain.
Structural Studies on IRES 4-2 Domain of Foot-and-mouth Disease Virus
Kim, Young-Mee,Yoo, Jun-Seok,Cheong, Hae-Kap,Lee, Chul-Hyun,Cheong, Chae-Joon Korean Magnetic Resonance Society 2003 Journal of the Korean Magnetic Resonance Society Vol.7 No.2
Foot-and-mouth disease virus (FMDV) belongs to the aphthovirus genus within the picornavirus which has a single copy of a positive sense RNA. The translation initiation process of FMDV occurs by a cap-independent mechanism directed by a highly structured element (∼435 nt) termed an internal ribosome entry site (IRES). We have designed and prepared FMDV 4-2 RNA (28nt) by in vitro transcription. The 2D NMR data revealed that FMDV 4-2 IRES domain RNA has a flexible loop and bulge conformation. In further study, we need to make an isotope labeled RNA sample and conduct 3D NMR experiments to completely determine the 3D structure. This study may establish a new drug design strategy to treat foot-and mouth disease.
Cheong, Sun-Hee,Kim, Mi-Yeon,Son, Chan-Wok,Kim, Min-Hee,Lee, Yun-Jin,Kim, Mee-Ree Korean Society of Food Culture 2008 Food Quality and Culture Vol.2 No.2
The principal objective of this study was to assess the anti oxidative activities of Petasites japonicus against oxidative stress in bovine brain tissue. Petasites japonicus is found with a relatively widespread distribution, and is cultivated as a culinary vegetable in Korea. Petasites japonicus samples were dried either by freeze-drying or by hot air-convection drying ($80^{\circ}C$), then evaluated for their anti oxidative activity by measuring 1-dipheny-1,2-picrylhydrazyl (DPPH) radical scavenging, and by measuring thiobarbituric acid-reactive substances (TBARS) in brain homogenates subjected to $Fe^{2+}$-mediated lipids with or without the addition of botanical extract. Hot air convection-drying resulted in a slight increase in the extraction yield as compared with freeze-drying. However, total phenol and flavonoid contents in freeze-dried Petasites japonicas were significantly higher than those of hot air convection-drying. Freeze-drying increased the free radical scavenging activity of Petasites japonicas, leaves, and stems by 52.6, 28.6, and 248.0%, as compared with hot air convection-drying. Additionally, the $IC_{50}$ values measured by TBARS in hot air convection-dried Petasites japonicas, leaves, and stems were increased by 36.0, 31.6, and 15.9%, as compared to those of freeze-drying. Although anti oxidative activity was reduced slightly by heat processing in Petasites japonicas, freeze-drying for each portion of Petasites japonicus was the most appropriate for use as a functional food and pharmaceutical material.
CHEONG, Sun Hee,KIM, Mi Yeon,SOK, Dai-Eun,HWANG, Seock-Yeon,KIM, Jin Hee,KIM, Hye Ran,LEE, Jeung Hee,KIM, Yun-Bae,KIM, Mee Ree Center for Academic Publications Japan 2010 JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY Vol.56 No.1
<P>The anti-atherogenic effects of spirulina (<I>Spirulina platensis</I>) were investigated in the New Zealand White (NZW) rabbit model. The animal had hypercholesterolemia induced by being fed a high cholesterol diet (HCD) containing 0.5% cholesterol for 4 wk, and then fed a HCD supplemented with 1 or 5% spirulina (SP1 or SP5) for an additional 8 wk. Spirulina supplementation lowered intimal surface of the aorta by 32.2 to 48.3%, compared to HCD. Serum triglyceride (TG) and total cholesterol (TC) significantly were reduced in SP groups. After 8 wk, serum low density lipoprotein cholesterol (LDL-C) remarkably decreased by 26.4% in SP1 and 41.2% in SP5, compared to HCD. On the other hand, high density lipoprotein cholesterol (HDL-C) was markedly increased in SP1 and SP5 compared with that in the HCD group from 2 to 8 wk. These results suggest that spirulina intake can cause the reduction of hypercholesterolemic atherosclerosis, associated with a decrease in levels of serum TC, TG and LDL-C, and an elevation of HDL-C level. Spirulina may, therefore, be beneficial in preventing atherosclerosis and reducing risk factors for cardiovascular diseases.</P>
Kim, Mi-Yeon,Cheong, Sun-Hee,Kim, Min-Hee,Son, Chan-Wok,Yook, Hong-Sun,Sok, Dai-Eun,Kim, Jin-Hee,Cho, Yong-Sik,Chun, Hye-Kyung,Kim, Mee-Ree The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.4
Daily consumption of an antioxidant-rich leafy vegetable mix (LVM) was assessed for beneficial effects on plasma lipid profiles, tissue lipid peroxidation, and oxidative DNA damage in C57BL/6J mice fed a high fat and high cholesterol diet (20% fat and 1% cholesterol, wt/wt) for 4 weeks. The LVM contained beet leaf, angelica, red leaf lettuce, dandelion, green cos lettuce, lollo rosso, romaine lettuce (12.5%, respectively), scotch kale, and red kale (6.25%, respectively). The mice (n=16) were randomly divided into either the control (high fat and cholesterol diet without LVM) or the LVM (high fat and cholesterol diet with 8% LVM supplement) groups after a 1-week acclimation. Lipid peroxidation as measured by thiobarbituric acid-reactive substances in the plasma, liver, heart, and kidney was significantly lower. Antioxidants (glutathione and $\beta$-carotene) and antioxidant enzyme activities (glutathione peroxidase, glutathione reductase, and superoxide dismutase) were improved in mice fed LVM diet. In the comet assay, tail extent moment, olive tail moment, and tail length were significantly less in the hepatocyte and lymphocyte DNA of the LVM group, indicating the beneficial effect of LVM on the resistance of hepatocytes and lymphocytes DNA to oxidative damage. Findings from the present study suggest that dietary supplementation with LVM may be useful for protecting cells from lipid peroxidation and oxidative DNA damage.
Sun Hee Cheong,MiYeon Kim,ChanWok Son,Min Hee Kim,Yun Jin Lee,Mee Ree Kim 한국식생활문화학회 2008 Food Quality and Culture Vol.2 No.2
The principal objective of this study was to assess the antioxidative activities of Petasites japonicus against oxidative stress in bovine brain tissue . Petasites japonicus is found with a relatively widespread distribution, and is cultivated as a culinary vegetable in Korea. Petasites japonicus samples were dried either by freeze-drying or by hot air-convection drying (80℃), then evaluated for their antioxidative activity by measuring 1-dipheny-1,2-picrylhydrazyl (DPPH) radical scavenging, and by measuring thiobarbituric acid-reactive substances (TBARS) in brain homogenates subjected to Fe2+ -mediated lipids with or without the addition of botanical extract. Hot air convection-drying resulted in a slight increase in the extraction yie1d as compared with freeze-drying. However, total phenol and flavonoid contents in freeze-dried Petasites japonicas were significantly higher than those of hot air convection-drying. Freeze-drying increased the free radical scavenging activity of Petasites japonicas, leaves, and stems by 52.6, 28.6, and 248.0%, as compared with hot air convection-drying. Additionally, the IC50 values measured by TBARS in hot air convection-dried Petasites japonicas, leaves, and stems were increased by 36.0, 31.6, and 15.9%, as compared to those of freeze-drying. Although antioxidative activity was reduced slightly by heat processing in Petasites japonicas, freeze-drying for each portion of Petasites japonicus was the most appropriate for use as a functional food and pharmaceutical material.
김지영 ( Ji Young Kim ),오승종 ( Seung Jong Oh ),오정아 ( Cheong Ah Oh ),김대훈 ( Dae Hoon Kim ),배영식 ( Young Sik Bae ),최민규 ( Min Gew Choi ),김경미 ( Kyoung Mee Kim ),노재형 ( Jae Hyung Noh ),손태성 ( Tae Sung Sohn ),배재문 ( 대한임상종양학회 2010 Korean Journal of Clinical Oncology Vol.6 No.2
목적: 위 악성 종양으로 위절제술을 시행 받은 환자에서 Epstein-Barr 바이러스 감염 여부에 따른 임상병리학적 특성에 대해 알아보고자 하였다. 대상 및 방법: 2009년 9월부터 2010년 1월까지 위암으로 위절제술을 시행 받은 환자 640명을 대상으로 in situ hydridization 방식으로 EBV를 검출하고 EBV 양성군과 음성군간의 임상병리학적 특성을 비교 분석하였다. 결과: 본 연구의 대상자 640명 중 남자는 408명, 여자는 232명이었고, 평균 연령은 55.3(26-82)세였다. EBV 양성위암환자에서 남자가 39명 (90.7%)으로 여자 4명 (9.3%) 보다 통계적으로 유의하게 많았으며 (p<0.001), 종양이 위의 상부 1/3에 위치한 경우와 (p<0.001) Lauren 분류에서 혼합형이 경우가 통계적으로 유의하게 빈도가 높았다. (P=0.010). 그러나, 연령, 종양의 침윤 정도, 종양의 크기와 모양, 분화도, 림프절 전이 여부 등의 인자들과 EBV 감염여부 사이에 통계학적으로 의미 있는 결과를 보이지 않았다. 결론: EBV 양성 위암은 남자, Lauren 분류에서 혼합형, 상부에 발생한 위암과 관련이 있는 것으로 나타났다. 이후 EBV 와 관련된 위암이 환자의 생존율에 미치는 영향에 대한 추가적인 연구가 필요할 것으로 판단된다. Purpose: The purpose of this retrospective study is to examine the clinical and pathological features of Epstein-Barr virus (EBV) infection in patients with gastric cancer who underwent gastric resection. Subject and Method: Six hundred and forty patients with gastric cancer underwent gastric resection at Samsung Medical Center (Sungkyunkwan University School of Medicine) from September 2009 to January 2010. EBV was detected through in situ hydridization in these patients. Subsequent clinical and pathological features of EBV infection were analyzed and compared between the EBV-positive group and EBV-negative group. Results: Of the 640 patients, 408 patients were male and 232 patients were female. The average age was 55.3 years of age (range 26-82). In the EBV-positive group, 39 patients were male (90.7%) and 4 patients were female (9.3%) (p<0.001). Tumors were located in the upper one-third of the stomach (p<0.001) and had a mixed Lauren classification (p=0.010). Age, depth of tumor, size and shape of the tumor, degree of cancer differentiation, and lymph node metastasis were not statistically significant. Conclusion: EBV-positive gastric cancer may be more prevalent in males with a predominance of a mixed intestinal and diffuse carcinomas of the Lauren classification (a mixed Lauren classification) that are located in the upper third of the stomach. However, additional factors that may influence the overall survival should be investigated in this specific group of patient population.