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Hahn, Bum-Soo,Jo, You-Young,Yang, Kyung-Youl,Wu, Song-Ji,Pyo, Mi-Kyung,Yunchoi, Hye-Sook,Kim, Yeong-Shik The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.1
A saline suspension of Lumbricus rubellus earthworm powder (EWP) was administered to rats (1 g/kg/day) orally for 15 days to evaluate an oral effectiveness for thrombotic disorders. Blood was drawn at 2-day interval after the administration. Several parameters for antithrombotic, anticoagulant and fibrinolytic activities were measured, including platelet aggregation, clotting time, plasmin activity and the levels of FDP (fibrin/fibrinogen degradation products), D-dimer, and t-PA antigen. It did not affect platelet aggregation induced by ADP and collagen but anticoagulant activity (aPTT and TT) was gradually increased to two-folds for the first 5 days of administration and back to normal. Fibrinolytic activity of euglobulin fraction was highest on the 11 th day after the administration. The level of FDP was elevated to be comparable to the positve control$ (5-10 {\mu}g/ml)$ after 9-day treatment. Oral administration of the EWP could also reduce the formation of venous thrombus induced with viper venom. Complete blood count (CBC) profiles were within normal ranges except for a slight increase in white blood cells after the oral administration for 15 days. These results suggested that the EWP may be valuable for the prevention and/or treatment of thrombotic diseases.
Quantitative analysis of anthraquinone compounds from Senna tora seeds at different ripening stages
Joon-Soo Sim,Soo-Ji Choi,Ji-Seon Kim,In-Jin Ha,Chang-Muk Lee,Bum-Soo Hahn 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.07
Senna tora (Cassia tora), a member of Leguminosae, is widely distributed in south-east Asian countries. The dried or roasted seed of Senna tora has been used as one of Oriental medicines for centuries for vision-improving, anti-asthenia and diuretic. Furthermore, many reports related to various biological and pharmacological activities of Senna tora have been published such as anti-inflammatory, anti-hepatotoxic, radical scavenging, anti-allergic, anti-mutagenic, antipyretic, hypoglycemic, anti-fungal and anti-bacterial effects. In this study, we have focused on characterizing and quantifying of anthraquinone compounds from Senna tora seeds during different ripening stages. Ultra-high performance liquid chromatography coupled with diode array detector and electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC-DAD-ESI-Q-TOF-MS) was used to investigate the compositional changes of anthraquinone compounds that were involved in ripening of Senna tora seeds. Furthermore, non-targeted UHPLC-ESI-Q-TOF-MS data were subjected to principal component analysis and discriminant analysis to find the potential characteristic components from different ripening stages of Senna tora seeds.