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Md Ariful Hoque,김기석 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.8
Two bimetallic Pd-Pt catalysts were prepared by wash-coating the composites of Pd-Pt/CeZrO2-Al2O3 ontocordierite monolith and they were evaluated in a tubular reactor for stability in combustion of SOFC stack flue gas atGHSV 29,280 h−1 and 1 atm. The Pd-rich catalyst showed better stability than the Pt-rich catalyst for combustion of thewet feed. Water vapor in the stack flue gas affected the catalyst activity adversely via the formation of inactive Pd(OH)2species at the reaction temperatures of 723 and 823 K, but this effect was eliminated by raising the temperature to 923 Kor above. Catalyst properties such as specific surface area, pore size and metal dispersion did not deteriorate significantlyafter combustion of the wet feed in the temperature range of 723-1,023 K. The presence of CeZrO2 in Al2O3 materialwas considered to affect the support properties favorably, leading to a kind of metal-support interaction beneficial forthe combustion of the wet feed. This interaction helped to enable the Pd-Pt catalysts to maintain good stability for combustingthe wet SOFC stack flue gas with the stoichiometric air-to-fuel ratio at 923 K or above.
Hasan, Md. Mahmudul,Islam, Md. Shihabul,Hoque, Kazi Md. Faisal,Haque, Ariful,Reza, Md Abu Korean Society of ToxicologyKorea Environmental Mu 2019 Toxicological Research Vol.35 No.3
Citrus macroptera (Rutaceae) has long been used in folk medicine in Bangladesh. Considering the folkloric context, this study was aimed to scrutinize anti-proliferative activity of C. macroptera fruit pulp juice (CMFPJ) against Ehrlich's ascites carcinoma (EAC). The anti-proliferative capacity of CMFPJ was investigated and confirmed primarily using MTT assay. In vivo anti-proliferative aptitude of CMFPJ was investigated with 25, 50, and 100 mg/kg/day intraperitoneal (i.p.) treatment. Anti-proliferative efficacy of CMFPJ was assessed based on EAC growth inhibition. CMFPJ inhibited EAC growth in vitro in a dose-dependent manner. And the percentages of in vivo EAC growth inhibition were 19.53, 49.2, and 68.9% at 25, 50, and 100 mg/kg CMFPJ respectively. CMFPJ significantly induced expression of apoptosis regulatory genes caspase-8, caspase-9, cytochrome-c, and caspase-3. This considerable anti-cancer activity was perhaps due to combinatorial effect of lectin, polyphenols, and flavonoids present in CMFPJ.
Md Abu Sayem Khan,Rifat Parveen,Sheikh Ariful Hoque,Md Firoz Ahmed,Abu Shara Shamsur Rouf,Sabita Rezwana Rahman 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.3
Emergence of antiviral drug resistance in influenza virus remains a major public health concern worldwide. Nowadays, different herbs receive renewed attention because of their enormous antiviral potential. In this study, we investigated the antiviral activity of Camellia sinensis, Persicaria hydropiper, Persicaria orientale, Persicaria lapathifolia, Persicaria stagnina, Mucuna pruriens and Chenopodium album against different influenza strains using both in vitro and in silico approaches. Antiviral effect of plant extracts was evaluated by cytopathic effect (CPE) inhibition assay on influenza infected MDCK (Madin Darby Canine Kidney) cell line. Later, the herb demonstrating antiviral activity was virtually screened for their available bioactive compounds and multiple in silico tools were performed to prioritize and establish these compounds as potential inhibitor. The methanol, but not the n-hexane and ethyl acetate extracts of C. sinensis, P. hydropiper, M. pruriens and C. album exhibited anti-influenza effect with EC50 values within 32–46 μg/ml. Importantly, the extracts remained effective against both amantadine-resistant and -sensitive influenza isolates. The molecular docking analysis showed that flavonoids, steroid and derivatives had strong binding affinity to the target proteins which may remain responsible for the anti-influenza characteristics of plant extracts. Pharmacokinetic properties, bioavailability and drug-likeness score revealed that ferulic acid, sinapic acid, campesterol, cryptomeridiol, eupatin and genistein could be attractive leads as potential influenza inhibitors. Taken together, the botanical ingredients of these herbs could be used as valuable candidates for developing novel therapeutics to control influenza related illnesses.
Md. Mahmudul Hasan,Md. Shihabul Islam,Kazi Md. Faisal Hoque,Ariful Haque,Md Abu Reza 한국독성학회 2019 Toxicological Research Vol.35 No.3
Citrus macroptera (Rutaceae) has long been used in folk medicine in Bangladesh. Considering the folkloric context, this study was aimed to scrutinize anti-proliferative activity of C. macroptera fruit pulp juice (CMFPJ) against Ehrlich’s ascites carcinoma (EAC). The anti-proliferative capacity of CMFPJ was investigated and confirmed primarily using MTT assay. In vivo anti-proliferative aptitude of CMFPJ was investigated with 25, 50, and 100 mg/kg/day intraperitoneal (i.p.) treatment. Anti-proliferative efficacy of CMFPJ was assessed based on EAC growth inhibition. CMFPJ inhibited EAC growth in vitro in a dose-dependent manner. And the percentages of in vivo EAC growth inhibition were 19.53, 49.2, and 68.9% at 25, 50, and 100 mg/kg CMFPJ respectively. CMFPJ significantly induced expression of apoptosis regulatory genes caspase-8, caspase-9, cytochrome-c, and caspase-3. This considerable anti-cancer activity was perhaps due to combinatorial effect of lectin, polyphenols, and flavonoids present in CMFPJ.