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RISS 인기검색어
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- 저자 : ( Anupam Guleria ) (검색결과 3 건)
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( Anupam Guleria ),( Arun Karyampudi ),( Rajan Singh ),( Chunni L Khetrapal ),( Abhai Verma ),( Uday C Ghoshal ),( Dinesh Kumar ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.3
Background/Aims Irritable bowel syndrome (IBS) is associated with exaggerated cerebral response including emotional processing following visceral stimulation; though data on this issue is available in female IBS patients, it is scanty among males. Hence, we aimed to study brain response of male IBS patients following rectal balloon distension as compared to healthy controls using functional magnetic resonance imaging (fMRI). Data between diarrhea and constipation predominant IBS (IBS-D and IBS-C) were also compared. Methods Rectal balloon distension threshold was assessed in 20 male IBS patients (10 IBS-C and 10 IBS-D) and 10 age-matched male healthy controls. Subsequently, fMRI on all the participants was performed at their respective rectal pain threshold. The fMRI data were analysed using the Statistical Parametric Mapping software. Results IBS patients showed greater cerebral activations in insula, middle temporal gyrus, and cerebellum in the left hemisphere compared to healthy controls. Neural activation was found in bilateral precuneus/superior parietal lobules in controls but not in patients with IBS. The brain activation differed among IBS-C and IBS-D patients; while the right mid-cingulate cortex was activated in IBS-C, the left inferior orbito-frontal cortex, left calcarine, and bilateral fusiform gyri were activated among patients with IBS-D following rectal balloon distension. Conclusions Brain response to rectal balloon distension differed among male patients with IBS and controls and among patients with IBS-C and IBS-D. Differential activation among patients with IBS-C and IBS-D was seen in the brain regions controlling affective motivation, homeostatic emotions, and autonomic responses to pain. (J Neurogastroenterol Motil 2017;23:415-427)
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Kashmiri Deka,Anupam Guleria,Dinesh Kumar,Jayeeta Biswas,Saurabh Lodha,Som Datta Kaushik,Suman Dasgupta,PRITAM DEB 한국물리학회 2020 Current Applied Physics Vol.20 No.1
Single mode (either T1 or T2) contrast agents employed during magnetic resonance imaging owe their advantage over their dual counterparts to the fact that they do not involve any quenching caused by interference between the two modes. The chemistry involving oxides of manganese is highly significant due to their applicability as MRI contrast agents. Manganese oxides are usually known to display a dominant T1 relaxation enhancement. But, in this work, an engineered structure of manganese oxide (Mn2O3) nanoparticles encapsulated within mesoporous carbon frameworks was developed which exhibited dominant T2 contrast enhancement, through regulation of contact between the magnetic ion and water. Microstructural characterization revealed that the mesoporous carbon frameworks were spherical in shape and the nanoparticles within them had an average size of 40–50 nm. Relaxivity measurement, MRI experiments and cell viability assay convincingly established the system as a new class of biocompatible T2 based magnetic resonance imaging agent.
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Sejal Chauhan,Raghu Solanki,Ashok Kumar Jangid,Poonam Jain,Pranjali Pranjali,Sunita Patel,Anupam Guleria,Deep Pooja,Hitesh Kulhari 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Enzyme responsive nanocarriers are reactive or sensitive towards a specific enzyme and, therefore, havethe advantages of low systemic toxicity, targeted delivery, and superior therapeutic effect with high efficiency. In this study, we have developed a matrix metalloproteinase 9 (MMP9) enzyme responsive manganesenanocarrier for the site-specific delivery of anticancer drugs. Manganese nanoparticles werecoated with G5 PAMAM dendrimers and loaded with irinotecan hydrochloride (IRI). The drug loadednanoparticles were further coated with collagen-IV (Col-IV) peptide, an MMP9 substrate, to make themMMP9 responsive (Col-IV@IRI-G5MNP). The developed nanoparticles were monodispersed with size ofabout 12 nm and high IRI encapsulation efficiency (80%). A faster but controlled IRI release was observedfrom Col-IV@IRI-G5MNP in HEPES buffer containing MMP9 enzyme. When incubated with human redblood cells, the nanoformulation was hemocompatible and caused <2% hemolysis. The anticancer activityof Col-IV@IRI-G5MNP against HCT116 human colon cancer cells was better than free IRI. The cell viability ofHCT116 cells incubated with 25 lg/mL Col-IV@IRI-G5MNP was significantly lower (p < 0.001) than the cellsincubated with free IRI. Further, Col-IV@IRI-G5MNP showed paramagnetic nature and good T2 relaxivity ata very low concentration, suggesting its potential use for diagnosis through magnetic resonance imaging.
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