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The Benefit of Lekodepleted PRC Transfusion for Biliary Patient after Kasai Procedure
( Adika Zhulhi Arjana ),( Ninda Devita ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Patients with choledochal tract problems often needed surgery. The common procedure for this problem is Kasai portoenterostomy. However, some problems arising after surgery. Many patients encounter the bleeding problem that needed packed red cell (PRC) transfusion. This transfusion, which may increase the risk of transfusion reaction mediated by inflammatory cytokine. Accumulation of interleukin-8, one of the inflammatory cytokines produced by leukocyte contain in PRC, has been known to contribute to increasing transfusion reaction risk. Lekodepletion is an effort to decrease leukocyte number in PRC, give expectation to decrease IL-8 accumulation in PRC. Methods: The study is a quasi-experimental study. Subjects were biliary patients after Kasai Procedure who need PRC transfusion in Dr. Sardjito General Hospital Yogyakarta. The interleukin-8 level is measured using the ELISA sandwich method. Delta IL-8 is obtained from the subtraction of IL-8 level one hour after transfusion with before transfusion. Statistical analysis was performed using the difference test to know significant differences of delta IL-8 mean value between lekodepleted and non-lekodepleted PRC. Results: Total study subjects were 77 persons, most were women 52 (67,5%). There was no significant differences between group received lekodepleted with non-lekodepleted PRC transfusion based on age (P=0.484), gender (P=0.410). There was a statistically significant median difference in delta interleukin 8 between groups. Increased level of IL-8 value for group received lekodepleted PRC transfusion is less than group received non-lekodepleted PRC transfusion. Conclusions: Lekodepletion PRC have potential benefit for biliary patients after Kasai procedure.
Laboratory Healthcare Gap of Hepatitis B Care in Yogyakarta, Indonesia
( Arum Tri Wahyuningsih ),( Osman Sianipar ),( Adika Zhulhi Arjana ),( Rhaina Khairani ),( Romi Ade Selsata ),( Fadhilah Khairuna Larasati ),( Alfin Herjuno Dwiputro ),( Intan Susmita Rafsanjani ),( B 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1
Laboratory healthcare gap of hepatitis B care in Yogyakarta, Indonesia
Arum Tri WAHYUNINGSIH,Osman SIANIPAR,Adika Zhulhi ARJANA,Rhaina KHAIRANI,Romi Ade SELSATA,Fadhilah Khairuna LARASATI,Alfin Herjuno DWIPUTRO,Intan Susmita RAFSANJANI,Budi MULYONO 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-