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Ramí,rez-Lugo, Juan S,Yoo, Hae Yong,Yoon, Su Jin,Dunphy, William G Landes Bioscience 2011 Cell cycle Vol.10 No.3
<P>In the presence of double-stranded DNA breaks (DSBs), the activation of ATR is achieved by the ability of ATM to phosphorylate TopBP1 on serine 1131, which leads to an enhancement of the interaction between ATR and TopBP1. In Xenopus egg extracts, the Mre11-Rad50-Nbs1 (MRN) complex is additionally required to bridge ATM and TopBP1 together. In this report, we show that CtIP, which is recruited to DSB-containing chromatin, interacts with both TopBP1 and Nbs1 in a damage-dependent manner. An N-terminal region containing the first two BRCT repeats of TopBP1 is essential for the interaction with CtIP. Furthermore, two distinct regions in the N-terminus of CtIP participate in establishing the association between CtIP and TopBP1. The first region includes two adjacent putative ATM/ATR phosphorylation sites on serines 273 and 275. Secondly, binding is diminished when an MRN-binding region spanning residues 25-48 is deleted, indicative of a role for the MRN complex in mediating this interaction. This was further evidenced by a decrease in the interaction between CtIP and TopBP1 in Nbs1-depleted extracts and a reciprocal decrease in the binding of Nbs1 to TopBP1 in the absence of CtIP, suggestive of the formation of a complex containing CtIP, TopBP1, and the MRN complex. When CtIP is immunodepleted from egg extracts, the activation of the response to DSBs is compromised and the levels of ATR, TopBP1, and Nbs1 on damaged chromatin are reduced. Thus, CtIP interacts with TopBP1 in a damage-stimulated, MRN-dependent manner during the activation of ATR in response to DSBs.</P>
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Yoon, Jung Hee,Lee, Woo Ram,Ryu, Dae Won,Lee, Jin Wuk,Yoon, Sung Won,Suh, Byoung Jin,Kim, Hyoung Chan,Hong, Chang Seop American Chemical Society 2011 Inorganic Chemistry Vol.50 No.21
<P>Three one-dimensional coordination polymers [Mn(L)(N<SUB>3</SUB>)]<SUB><I>n</I></SUB> [L = L1 (<B>1</B>), L2 (<B>2</B>), L3 (<B>3</B>); L1H<SUB>2</SUB> = <I>N</I>,<I>N</I>′-bis(5-chlorosalicylideneiminato)-1,3-diaminopentane, L2H<SUB>2</SUB> = <I>N</I>,<I>N</I>′-bis(5-bromosalicylideneiminato)-1,3-diaminopentane, L3H<SUB>2</SUB> = <I>N</I>,<I>N</I>′-bis(5-bromosalicylideneiminato)-1,3-diamino-2-dimethylpropane] bridged by end-to-end azides were prepared. The crystal systems differ according to the Schiff bases used. Each Mn atom adopts a typical Jahn–Teller distortion. The helicity of the chains occurs in a racemic manner only for <B>2</B>. No noncovalent forces are relevant in <B>2</B>, while π–π contacts are visible in <B>1</B> and <B>3</B>. Magnetic measurements show the presence of apparent spin canting. Complexes <B>1</B> and <B>3</B> exhibit a field-induced metamagnetic transition from an antiferromagnetic state to a weak ferromagnetic phase, whereas <B>2</B> embraces a field-induced two-step magnetic phase transition. The critical temperature is observed at 38 K for <B>2</B>, which is relatively higher than those for <B>1</B> (11 K) and <B>3</B> (10 K). The pronounced long-range order may contribute from intrachain exchange couplings and through-space dipolar interactions between adjacent chains.</P><P>Three azide-linked Mn<SUP>III</SUP> coordination chains with different tetradentate Schiff bases were prepared. Magnetic properties show that spin canting is operating in these complexes. A long-range order occurs in <B>2</B> with a relatively high <I>T</I><SUB>C</SUB> of 38 K, which is compared with <B>1</B> (11 K) and <B>3</B> (10 K). The enhanced critical temperature in <B>2</B> may be associated with stronger intrachain magnetic coupling and through-space dipolar interaction.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2011/inocaj.2011.50.issue-21/ic2013232/production/images/medium/ic-2011-013232_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic2013232'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic2013232'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic2013232'>ACS Electronic Supporting Info</A></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic2013232'>ACS Electronic Supporting Info</A></P>
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Effect of the Extract of Herbal Drugs Mixture on Brain Function in Rats
Yoon Jo Oh,Ah-ram Lee,Jin-Joo Hue,Yea Eun Lee,Lan Li,Jung-Su Lee,Min-hang Cho,Sang Yoon Nam,Young Won Yun,Byungwoo Ahn,Jae-Hwang Jeong,Sang-Hwa Lee,Beom Jun Lee 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.4
Green tea, Crataegus oxycantha fruit, gingko leaves and tangleweed were known to increase blood circulation and improve brain function. The mixture containing green tea (50 g), Crataegus oxycantha fruit (50 g), gingko leaves (20 g), and tangleweed (20 g) was water-extracted and freeze-dried to powder. The pharmacological effect of the extract of herbal drugs on acetylcholinesterase (AChE) in an in vitro enzyme system and in rats was investigated. The extract of herbal drugs at the doses of 10, 25, 50 and 100 ㎍/㎖ decreased activity of AChE by 8.8, 22.1, 43.1 and 63.0%, respectively. The treatment of the extract of herbal drugs at the dose of 0.1 g/㎏ b.w. to rats for 5 and 10 consecutive days reduced AChE activity in the brain by 12.8 and 26.9 %, respectively, corresponding to increases by 26.4 and 59.7% in the concentration of acetylcholine (ACh) in the brain of rats, compared with the control rats. The levels of ATP in the brain also increased in treatment group in a time-dependent manner. The liver toxicity was not shown as determined by serum biochemistry. These results suggest that a composition of these herbal drugs may improve brain function by increasing the levels of acetylcholine and ATP.
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Yoon, Jung Hee,Lim, Kwang Soo,Ryu, Dae Won,Lee, Woo Ram,Yoon, Sung Won,Suh, Byoung Jin,Hong, Chang Seop American Chemical Society 2014 Inorganic Chemistry Vol.53 No.19
<P>Two trimetallic coordination complexes were prepared by self-assembly of [W(CN)<SUB>8</SUB>]<SUP>3–</SUP> and the Mn(III) Schiff base followed by the addition of a Zn(II) or Fe(II) cationic unit. The octacyanotungstate connects neighboring Mn(III) centers to form a one-dimensional chain. The anionic chain requires cationic units of Zn(II) or Fe(II) to maintain charge balance in the structure. The Zn-containing complex shows ferrimagnetic behavior originating from the antiparallel alignment of W(V) and Mn(III) spins within the chain, which leads to slow magnetic relaxation at low temperatures. For the Fe(II)-containing compound, Fe(II) moieties are integrated into the ferrimagnetic chains, altering their spin states depending on the temperature. It appears that the coexistence of high- and low-spin states in the low temperature regime is responsible for the slower and faster relaxations of the magnetization.</P><P>Trimetallic complexes were prepared by self-assembly of [W(CN)<SUB>8</SUB>]<SUP>3−</SUP> and the Mn(III) Schiff base, followed by the addition of a Zn(II) or Fe(II) cationic unit. The W<SUP>V</SUP>Mn<SUP>III</SUP> anionic chains were separated by the cationic moieties, which causes the slow magnetization relaxation. The Fe(II)-containing compound showed a distinct single-chain magnet behavior at low temperatures and spin crossover at high temperatures.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2014/inocaj.2014.53.issue-19/ic501506s/production/images/medium/ic-2014-01506s_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic501506s'>ACS Electronic Supporting Info</A></P>
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Yoon, Bo-Ram,Lee, Seung-Sin THE KOREAN FIBER SOCIETY 2011 FIBERS AND POLYMERS Vol.12 No.1
To develop waterproof breathable materials for diverse consumer applications, we used electrospinning to fabricate layered fabric systems with varying composite structures. Specifically, we developed layered fabric structures based on electrospun nanofiber webs with different levels of nanofiber web density, as well as different substrates and layer structures, and then examined the breathability and waterproofness of the material. The breathability and waterproofness of the layered fabric systems were compared with those of traditional waterproof breathable fabrics, including densely woven fabric, microporous membrane laminated fabric, and hydrophilic nonporous polyurethane coated fabric. Different breathability and barrier performance levels were achieved by varying the layer structure and substrates in the electrospun nanofiber web layered fabric systems. The uniformity of the nanofiber web and lamination process also affected the barrier and comfort performances. The comparison of waterproofness and breathability performances between the new materials and the traditional waterproof breathable materials revealed that the layered structures based on electrospun nanofiber webs provide a higher level of resistance to water penetration than densely woven fabrics and a higher degree of moisture vapor and air permeability than microporous membrane laminates and coated fabrics, with a proper selection of layer structure, substrate fabric, and lamination process.
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( Woo Ram Yoon ),( Sang Heon Park ),( Chan Hyeok Jeong ),( Ji Ho Park ),( Suk-hoon Yoon ) 한국운동역학회 2018 한국운동역학회지 Vol.28 No.1
Objective: The aim of this study was to analyze muscle activation of the lower extremities as a function of changes of the center of pressure (CoP) of the foot during squats in order to provide quantitative information to trainers who would like to teach correct movements for developing muscles. Method: Ten men with over three years of weight training experience participated in this study (age: 26.1 ± 0.8 yrs, height: 171.2 ± 3.9 cm, body mass: 71.1 ± 5.7 kg, 60%RM: 84 ± 9 kg, career: 4.0 ± 0.7 yrs). The participants were instructed to perform a squat in each of 3 conditions, with different CoP's (the front, middle, and rear of the foot). Results: The position of the CoP showed significant differences according to instructions in both the eccentric and concentric contraction phases (p < .05). The range of movement of the hip and ankle joints showed significant differences corresponding to changes of the CoP position (p < .05). The rectus femoris and gluteus maximus muscle showed significant differences for different CoP positions only in the concentric contraction phase, while the gastrocnemius and anterior tibialis were significantly different in both the concentric and eccentric contraction phase (p < .05). Conclusion: When the target muscle of squat training is the gastrocnemius, the CoP should be located in the front of the foot for effective muscle training. When the target muscles of squat training are the gluteus maximus and quadriceps femoris, the CoP should be located on the rear of the foot.
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Bo Ram Kim,So Hyun Kim,JaeSang Ko,Seung Woon Baek,Yung Kyung Park,Yoon Jung Kim,Jin Sook Yoon 대한안과학회 2021 Korean Journal of Ophthalmology Vol.35 No.1
Purpose: We sought to evaluate the safety and effectiveness of patient-specific ocular prostheses produced by three-dimensional(3D) printing and the sublimation technique. A comparison with prostheses produced using manual manufacturingmethods was then performed. Methods: To confirm the biological and physiochemical safety, cytotoxicity, systemic acute toxicity, intradermal reaction,and skin sensitization tests were conducted according to the International Organization for Standardization guidelines. Thecompressive strength of the prostheses was also tested. Further, a case series of three patients who wore the 3D printedprostheses for more than eight hours daily for 4 weeks was executed. Self-assessments by these individuals using a questionnaireand safety evaluations focusing on the occurrence of conjunctival inflammation or allergic reactions according to theCornea and Contact Lens Research Unit criteria by slit-lamp examination and similarity assessment were completed. Results: The 3D printed ocular prostheses met the necessary qualifications per the biological and physiochemical safety tests,showing the absence of cytotoxicity, acute systemic toxicity, intradermal reactivity, and skin-sensitizing potency. Also, therewas no difference in strength test results between previous ocular prostheses and the 3D printed ones. Self-assessment bythe patients yielded satisfactory results, with no significant difference in the level of satisfaction reported for the 3D printedand previous handmade ocular prostheses. The 3D printed prosthesis did not trigger any side effects in the conjunctival sacand showed similar objective findings with respect to the color of the iris, sclera, and vessel patterns. Conclusions: Our study confirms the biologic and physiochemical safety of 3D-printed ocular prostheses created using computer-aided design technology and a sublimation technique. The patients’ questionnaires and the judgment of the ophthalmologists/ocularists showed that the 3D printed ocular prosthesis was acceptable in function and appearance through a caseseries report.
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A-Ram Kim,Hyemin Lim,Hyun-So Ji,Ung-Han Yoon,Tae-Ho Kim,Gang-Seob Lee 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Crops are exposed to various environmental stresses. These have been affecting the growth of crops, resulting in the severe loss of agronomic production in many countries. Therefore, development of new varieties of resistant crops is required to assure the desired productivity of crops in stress conditions. In this study, a putatively stress-related gene BrTSR53 was isolated from Brassica rapa. The BrTSR53 is 481 bp long and contains ORF region of 234 bp. The expression of BrTSR53 was determined by quantitative real-time PCR analysis. After 3 hr, the highest quantities of mRNA were revealed in cold and salt stress treatments. In drought stress treatments, there was the highest expression after 36 hr. Therefore, it was confirmed that the ORF in BrTSR53 should be a gene that confer increased resistance to B. rapa growing in different stress conditions. The ORF region of BrTSR53 gene was cloned into an expression vector, pYES-DEST52, and a new protein with molecular weight of 13 kDa was detected by western blot analysis. Also, stress tolerance tests showed that BrTSR53-ORF transgenic yeast exhibited increased resistance to the salt stresses compared with the control. In conclusion, the present data predicts that novel ORF in BrTSR53 can serve as an important genetic resource for abiotic stress resistance.
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