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      • KCI등재후보

        INVESTIGATION OF HOMOLOGOUS SERIES AS PRECURSORY HYDROCARBONS FOR ALIGNED CARBON NANOTUBE FORMATION BY THE SPRAY PYROLYSIS METHOD

        ZHI YANG,HUAGUI NIE,XUEMEI ZHOU,ZHEN YAO,SHAOMING HUANG,XIAOHUA CHEN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.3

        The precursory carbon source is one of the key parameters which govern the formation of carbon nanotubes (CNTs). In this work, by selecting four homologous series, namely n-pentane, n-hexane, n-heptane and n-octane, as investigated targets, we comparatively study the relationship between thermodynamic properties of the precursory carbon source and formation of aligned CNTs. We find that all of these alkanes are favored for the growth of aligned CNTs in a suitable growth environment. But only n-heptane can yield the aligned CNTs with relatively high quality, high yield and narrow diameter distribution. Furthermore, after considering the link between thermodynamic properties of the precursory carbon source and the morphology characteristic of the nanotube samples, we find that the Gibbs free energy and formation enthalpy of precursory carbon sources play critical roles in the nanotube formation. In additions some possible explanations are proposed to better understand these phenomena. These rules will be very helpful in making clearer the formation mechanism from the precursory carbon sources to the CNTs, and preparing large-scale aligned CNTs with diameter control at low cost.

      • KCI등재후보

        SYNTHESIZING A WELL-ALIGNED CARBON NANOTUBE FOREST WITH HIGH QUALITY VIA THE NEBULIZED SPRAY PYROLYSIS METHOD BY OPTIMIZING ULTRASONIC FREQUENCY

        ZHI YANG,HUAGUI NIE,XUEMEI ZHOU,ZHEN YAO,SHAOMING HUANG,XIAOHUA CHEN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.4

        Nebulized spray pyrolysis (NSP) offers ease of scaling into an industrial scale process method for large-scale CNT synthesis. In the method, ultrasonic frequency plays an important role in the formation of well-aligned carbon nanotubes (CNTs). In this work, we obtain well-aligned CNTs with high quality by optimizing ultrasonic frequency via the NSP method. SEM, TEM and HRTEM results show that the aligned CNTs obtained under an ultrasonic frequency of 1.8 MHz have good alignment, uniform nanotube length (~200 μm), high density and no trace of other carbon nanoparticles. The Raman spectra result further confirms that the aligned CNTs have a high graphitization degree. Furthermore, we find that ultrasonic frequency is an important factor in determining the nanotube diameter. The higher the ultrasonic frequency, the smaller the nanotube diameter. This rule may be very helpful in the preparation of large-scale well-aligned CNTs with high quality and diameter-controlled at low cost.

      • Plasmonic colorimetric sensors based on etching and growth of noble metal nanoparticles: Strategies and applications

        Zhang, Zhiyang,Wang, Han,Chen, Zhaopeng,Wang, Xiaoyan,Choo, Jaebum,Chen, Lingxin Elsevier 2018 Biosensors & bioelectronics Vol.114 No.-

        <P><B>Abstract</B></P> <P>Plasmonic colorimetric sensors have emerged as a powerful tool in chemical and biological sensing applications due to the localized surface plasmon resonance (LSPR) extinction in the visible range. Among the plasmonic sensors, the most famous sensing mode is the “aggregation” plasmonic colorimetric sensor which is based on plasmon coupling due to nanoparticle aggregation. Herein, this review focuses on the newly-developing plasmonic colorimetric sensing mode – the etching or the growth of metal nanoparticles induces plasmon changes, namely, “non-aggregation” plasmonic colorimetric sensor. This type of sensors has attracted increasing interest because of their exciting properties of high sensitivity, multi-color changes, and applicability to make a test strip. Of particular interest, the test strip by immobilization of nanoparticles on the substrate can avoid the influence of nanoparticle auto-aggregation and increase the simplicity in storage and use. Although there are many excellent reviews available that describe the advance of plasmonic sensors, limited attention has been paid to the plasmonic colorimetric sensors based on etching or growth of metal nanoparticles. This review highlights recent progress on strategies and application of “non-aggregation” plasmonic colorimetric sensors. We also provide some personal insights into current challenges associated with “non-aggregation” plasmonic colorimetric sensors and propose future research directions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The strategies for plasmonic colorimetric sensors based on nanoparticles etching/growth are reviewed. </LI> <LI> Highlighted applications in environmental as well as biological analysis are provided. </LI> <LI> The advantages and future directions of this kind of sensing platforms are detailed discussed. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Plasmonic colorimetric sensors based on etching and growth of noble metal nanoparticles.</P> <P>[DISPLAY OMISSION]</P>

      • KCI등재

        Metastatic pattern of ovarian cancer delineated by tracing the evolution of mitochondrial DNA mutations

        Xu Zhiyang,Zhou Kaixiang,Wang Zhenni,Liu Yang,Wang Xingguo,Gao Tian,Xie Fanfan,Yuan Qing,Gu Xiwen,Liu Shujuan,Xing Jinliang 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

        Ovarian cancer (OC) is the most lethal gynecologic tumor and is characterized by a high rate of metastasis. Challenges in accurately delineating the metastatic pattern have greatly restricted the improvement of treatment in OC patients. An increasing number of studies have leveraged mitochondrial DNA (mtDNA) mutations as efficient lineage-tracing markers of tumor clonality. We applied multiregional sampling and high-depth mtDNA sequencing to determine the metastatic patterns in advanced-stage OC patients. Somatic mtDNA mutations were profiled from a total of 195 primary and 200 metastatic tumor tissue samples from 35 OC patients. Our results revealed remarkable sample-level and patient-level heterogeneity. In addition, distinct mtDNA mutational patterns were observed between primary and metastatic OC tissues. Further analysis identified the different mutational spectra between shared and private mutations among primary and metastatic OC tissues. Analysis of the clonality index calculated based on mtDNA mutations supported a monoclonal tumor origin in 14 of 16 patients with bilateral ovarian cancers. Notably, mtDNA-based spatial phylogenetic analysis revealed distinct patterns of OC metastasis, in which a linear metastatic pattern exhibited a low degree of mtDNA mutation heterogeneity and a short evolutionary distance, whereas a parallel metastatic pattern showed the opposite trend. Moreover, a mtDNA-based tumor evolutionary score (MTEs) related to different metastatic patterns was defined. Our data showed that patients with different MTESs responded differently to combined debulking surgery and chemotherapy. Finally, we observed that tumor-derived mtDNA mutations were more likely to be detected in ascitic fluid than in plasma samples. Our study presents an explicit view of the OC metastatic pattern, which sheds light on efficient treatment for OC patients.

      • Combining different forms of statistical energy analysis to predict vibrations in a steel box girder comprising periodic stiffening ribs

        Hao Luo,Zhiyang Cao,Xun Zhang,Cong Li,Derui Kong 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.45 No.1

        Due to the complexity of the structure and the limits of classical SEA, a combined SEA approach is employed, with angle-dependent SEA in the low- and mid-frequency ranges and advanced SEA (ASEA) considering indirect coupling in the high-frequency range. As an important component of the steel box girder, the dynamic response of an L-junction periodic ribbed plate is calculated first by the combined SEA and validated by the impact hammer test and finite element method (FEM). Results show that the indirect coupling due to the periodicity of stiffened plate is significant at high frequencies and may cause the error to reach 38.4 dB. Hence, the incident bending wave angle cannot be ignored in comparison to classical SEA. The combined SEA is then extended to investigate the vibration properties of the steel box girder. The bending wave transmission study is likewise carried out to gain further physical insight into indirect coupling. By comparison with FEM and classical SEA, this approach yields good accuracy for calculating the dynamic responses of the steel box girder made of periodic ribbed plates in a wide frequency range. Furthermore, the influences of some important parameters are discussed, and suggestions for vibration and noise control are provided.

      • KCI등재

        Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice

        Qi Guo,Zhiyang Shen,Hongxia Yu,Gaofeng Lu,Yong Yu,Xia Liu,Pengyuan Zheng 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1

        Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment significantly ameliorated APAP-induced hepatic necrosis. The levels of both alanine aminotransferase (ALT) and aspartate transaminase (AST) in serum were reduced by CA treatment. Moreover, CA treatment significantly inhibited APAP-induced hepatocytes necrosis and lactate dehydrogenase (LDH) releasing. Western blot analysis showed that CA abrogated APAP-induced cleaved caspase-3, Bax and phosphorylated JNK protein expression. Further results showed that CA treatment markedly inhibited APAP-induced pro-inflammatory cytokines TNF-a, IL-1b, IL-6 and MCP-1 mRNA expression and the levels of phosphorylated IkBa and p65 protein in the liver. In addition, CA treatment reduced APAP- induced hepatic malondialdehyde (MDA) contents and reactive oxygen species (ROS) accumulation. Conversely, hepatic glutathione (GSH) level was increased by administration of CA in APAP-treated mice. Mechanistically, CA facilitated Nrf2 translocation into nuclear through blocking the interaction between Nrf2 and Keap1, which, in turn, upregulated anti-oxidant genes mRNA expression. Taken together, our results indicate that CA facilitates Nrf2 nuclear translocation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity.

      • SCIESCOPUSKCI등재

        Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice

        Guo, Qi,Shen, Zhiyang,Yu, Hongxia,Lu, Gaofeng,Yu, Yong,Liu, Xia,Zheng, Pengyuan The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1

        Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment significantly ameliorated APAP-induced hepatic necrosis. The levels of both alanine aminotransferase (ALT) and aspartate transaminase (AST) in serum were reduced by CA treatment. Moreover, CA treatment significantly inhibited APAP-induced hepatocytes necrosis and lactate dehydrogenase (LDH) releasing. Western blot analysis showed that CA abrogated APAP-induced cleaved caspase-3, Bax and phosphorylated JNK protein expression. Further results showed that CA treatment markedly inhibited APAP-induced pro-inflammatory cytokines TNF-${\alpha}$, IL-$1{\beta}$, IL-6 and MCP-1 mRNA expression and the levels of phosphorylated $I{\kappa}B{\alpha}$ and p65 protein in the liver. In addition, CA treatment reduced APAP- induced hepatic malondialdehyde (MDA) contents and reactive oxygen species (ROS) accumulation. Conversely, hepatic glutathione (GSH) level was increased by administration of CA in APAP-treated mice. Mechanistically, CA facilitated Nrf2 translocation into nuclear through blocking the interaction between Nrf2 and Keap1, which, in turn, upregulated anti-oxidant genes mRNA expression. Taken together, our results indicate that CA facilitates Nrf2 nuclear translocation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity.

      • KCI등재

        Dynamic Response of High Strength Steel Beams Subjected to Explosion Induced Blast Load

        Xinchang Feng,Xiyue Liu,Zhiyang He,Shuxin Bai,Shun Li,Yu Tang 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.6

        A series of anti-explosion tests were performed on H-type high strength steels (Q460JSC and HQ600) and ordinary steels (Q345B) to address the problem of anti-explosion in the technical application of high strength steel. The dynamic behavior of steel beams during explosion and the propagation of shock waves were analyzed. The effects of proportionate distance, steel strength, high-span ratio, section shapes were investigated. The finite element software (ANSYS/LS-DYNA) was used to analyze the anti-explosion performance of high strength steel beams. The finite element models which adopted modified Johnson–Cook constitutive model and damage criterion were validated by comparing with the experimental results. The influence factors of anti-explosion performance of high strength steel were explored by numerical simulation as well. The results reveal that under near-explosion conditions, the peak values of overpressure predicted by empirical formulas are often less than the experimental outcomes. As the scaled distance reduces, the damage to the steel beam increases, making it more prone to local fracture. By decreasing the scaled distance, increasing the high-span ratio, and strengthening the constraint of H-type steel beam, the deformation and damage of steel beams can reduce. The results provide an effective basis to evaluate the safety of high strength steel beams applied in practical engineering when subjected to explosion.

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