An Analysis on the Research Trends on Online Learning Engagement Using CiteSpace

( Chen¸ Yuanyuan ),( Kim¸ Gina ) 한국현대영어영문학회 2021 현대영어영문학 Vol.65 No.3

Online learning engagement is a network application that places the homepage and related materials of a course on the Web to form a shared virtual learning space, so as to achieve a face-to-face(FTF) learning effect. Based on the studies published from 2000 to 2020 in influential international and Chinese journals in the field of online learning engagement including the core databases of Web of Science, this paper conducts co-citation and co-occurrence analysis of the literature, subjects, and keywords with the use of CiteSpace. In other words, the study tries to draw the knowledge map of the international research in the field in comparison with China by using CiteSpace which is a software designed to analyze existing literature by co-citation networks. The researchers aimed to reveal the general situation and development trends of the research on online learning engagement. It was found that the number of publications in the field increased and the numbers are given according to year. The most cited journals and articles are revealed. The paper is concluded with some implications for future related research. (Hoseo University)

Culture Dimension of Sports Management : Chinese Australians' Adaptation to a New Culture

Yuan Yuan,Timothy Jeonglyeol Lee 한국엔터테인먼트산업연구원 2007 ceri 엔터테인먼트연구 Vol.8 No.-

Data Fusion-based Resilient Control System under DoS Attacks: A Game Theoretic Approach

Yuan Yuan,Fuchun Sun 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.3

In this paper, the resilient control under the Denial-of-Service (DoS) attack is rebuilt within the framework of Joint Directors of Laboratories (JDL) data fusion model. The JDL data fusion process is characterized by the so-called Game-in-Game approach, where decisions are made at different layers. The interactions between different JDL levels are considered which take the form of Packet Delivery Rate of the communication channel. Some criterions to judge whether the cyber defense system is able to protect the underlying control system is provided. Finally, a numerical example is proposed to verify the validity of the proposed method.

The Loading–Unloading Model of Contact Between Fractal Rough Surfaces

Yuan Yuan,Kuo Xu,Ke Zhao 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.6

A loading–unloading elastic–plastic model of contact between three dimensional fractal rough surfaces has been presented in this paper. During loading process, the mechanical properties of a single asperity follow Hertzian theory. During unloading process, the load-area relationships of a single asperity are obtained by EK model. The truncation size distribution functions for diff erent levels of asperities are deduced. And total true contact area and total contact load are obtained during a loading–unloading process. The results show as the rough surface is in elastic deformation, the load-area relationships during loading and unloading process are identical. As the rough surface is in inelastic deformation, the total true contact area during unloading process is greater than that during loading process. An experiment is designed to verify the validity of the present model.

Liposome-mediated Induction of Apoptosis of Human Hepatoma Cells by C-Myc Antisense Phosphorothioate Oligodeoxynucleotide and 5-Fluorouracil

Yuan, Yuan,Cai, Hui,Yang, Xiao-Jun,Li, Wei,He, Jin,Guo, Tian-Kang,Chen, Yi-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Background: The aim of this study was to investigate the effect of a c-myc antisense oligodeoxynucleotide and 5-fluorouracil on the expression of c-myc, invasion and proliferation of HEPG-2 liver cancer cells. Materials and Methods: HEPG-2 cells were treated with lipiosome-mediated c-myc ADSON and 5-fluorouracil. The proliferation inhibition rate and invasion were measured by MTT and invasion assay, respectively. Cell apoptosis was detected by flow cytometry and expression of c-myc by RT-PCR and immunohistochemistry. Results: The proliferation inhibition rate was significantly higher in the antisense oligodeoxynucleotide added-5-fluorouracil group than single antisense oligodeoxynucleotide or 5-fluorouracil group (p<0.05). G0/G1 cells in the antisense oligodeoxynucleotide group and S cells in the 5-fluorouracil groups were significantly increased than that in the control group, respectively (P<0.01). The amplification strips of PCR products in 5-FU, ASODN and combination groups were significantly weaker than that in the control group (P<0.01). The percentage of c-myc-protein-positive cells were significantly lower in antisense oligodeoxynucleotide, 5-fluorouracil and combination groups than that in the control group (P<0.01). Conclusions: A liposome-mediated c-myc antisense oligodeoxynucleotide and 5-fluorouracil can inhibit the proliferation and invasion of liver cancer cells by reducing the expression of c-myc. A c-myc antisense oligodeoxynucleotide can increase the sensitivity of liver cancer cells to 5-fluorouracil and decrease the dosage of the agent necessary for efficacy, providing an experimental basis for the clinical therapy of liver cancer.

The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells

Yuan Yuan,Caihua Xue,Qiang Wu,Mengjie Wang,Jiahua Liu,Longfei Zhang,Qianwen Xing,Jingyan Liang,Hua Wu,Zhi Chen 한국유전학회 2021 Genes & Genomics Vol.43 No.2

Background Procyanidin B2 (PCB2) can increase the levels of anti-infammatory and immune mediators. Objectives However, its molecular mechanism in human breast cancer remains unclear. This study aimed to investigate the antitumor efect of PCB2 on MCF-7 cells and to examine the underlying mechanism. Methods The fow cytometry and EdU incorporation assays were measured the PCB2-induced BMECs. The expression levels of infammatory factors and immune response genes were upregulated in MCF-7 cells, high-throughput sequencing was used to detect diferentially expressed genes in blank and PCB2-treated MCF-7 cells. Results The results showed that PCB2 induced the apoptosis of MCF-7 cells. CD36 profles were afected in MCF-7 cells. Additionally, prediction software identifed a miR-145-5p binding site in the CD36 sequence. Luciferase reporter assays and Western blot analysis were used to verify the regulatory relationships between the diferentially expressed miRNA miR145-5p and CD36. MiR-145-5p and its key target (CD36) constitute a potential miRNA-mRNA regulatory pair. Functional studies in MCF-7 cells revealed that CD36 promotes but miR-145-5p inhibits apoptosis. Conclusion Overall, these data suggest that miR-145-5p inhibits the enhancing efect of PCB2 on CD36 expression by binding CD36 and subsequently regulating apoptosis, the immune response and anti-infammatory pathways. These results provide theoretical and experimental support for the treatment of breast cancer.

Resilient Control in the Presence of DoS Attack: Switched System Approach

Yuan Yuan,Fuchun Sun,Quanyan Zhu 제어·로봇·시스템학회 2015 International Journal of Control, Automation, and Vol.13 No.6

This paper studies the switched resilient control of the Cyber-Physical Systems (CPSs) under Denial-of-Service (DoS) attack. We interpret the term ‘resilience’ as the ability to be both robust to the external disturbances in the physical layer, and defending against DoS attacks in the cyber layer. A hybrid-theoretical framework is proposed which is comprised of a physical control subsystem, a cyber security subsystem, and an interface which integrates the control design with the security configuration. Within this framework, the controller will switch in accordance with the competing result of the cyber attacker and defender. Our approach highlights the interaction between the physical control layer and cyber security layer and achieves the goal of coupled design. Some algorithms are provided to obtain the so-called joint defense strategies. Finally, the proposed method is applied to the voltage regulation of the Uninterrupted Power System (UPS).

Nonlocal-integro-vibro analysis of vertically aligned monolayered nonuniform FGM nanorods

Yuan Yuan,Ke Zhao,Yafei Zhao,Keivan Kiani 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.37 No.5

Vibration of vertically aligned-monolayered-nonuniform nanorods consist of functionally graded materials with elastic supports has not been investigated yet. To fill this gap, the problem is examined using the elasticity theories of Eringen and Gurtin-Murdoch. The geometrical and mechanical properties of the surface layer and the bulk are allowed to vary arbitrarily across the length. The nonlocal-surface energy-based governing equations are established using differential-type and integro-type formulations, and solved by employing the Galerkin method by exploiting admissible modes approach and element-free Galerkin (EFG). Through various comparison studies, the effectiveness of the EFG in capturing both nonlocal-differential/integro-based frequencies is proved. A constructive parametric study is also conducted, and the roles of nanorods’ diameter, length, stiffness of both inter-rod’s elastic layer and elastic supports, power-law index of both constituent materials and geometry, nonlocal and surface effects on the dominant frequencies are revealed.

Enhancing the static behavior of laminated composite plates using a porous layer

Yuan Yuan,Ke Zhao,Kuo Xu 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.72 No.6

The main aim of this paper is enhancing design of traditional laminated composite plates subjected to static loads. In this regard, this paper suggests embedding a lightweight porous layer in the middle of laminated composite as the core layer of the resulted sandwich plate. The static responses of the suggested structures with uniform, symmetric and non-symmetric porosity distributions are compared to optimize their design. Using the first order shear deformation theories, the static governing equations of the suggested laminated composite plates with a porous layer (LCPPL) rested on two-parameter foundation are obtained. A finite element method is also utilized to solve the governing equations of LCPPLs. Effects of laminated composite and porosity characteristics as well as geometry dimension, edges’ boundary conditions and foundation coefficients on the static deflection and stress distribution of the suggested composite plates have been investigated. The results reveal that the use of core between the layers of laminated composites leads to a sharp reduction in the static deflections of LCPPLs. Furthermore, in compare with perfect cores, the use of porous core between the layers of laminated composite plates can offer a considerable reduction in structural weight without a significant difference in their static responses.

Clinical Research on Albumin-Bound Paclitaxel-Based Chemotherapy for Advanced Esophageal Cancer

Yuan, Yuan,Zhang, Yan,Shi, Lin,Mei, Jing-Feng,Feng, Jif-Eng,Shen, Bo Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

Background: To evaluate the efficacy and safety of albumin-bound paclitaxel-based chemotherapy in treatment for patients with advanced esophageal cancer who failed in first-line chemotherapy. Materials and Methods: We collected29 advanced esophageal cancer patients who received albumin-bound paclitaxel-based chemotherapy fromJune 2009 to September 2013, and the efficacy and safety of the compound were evaluated. These patients were treated with $100-150mg/m^2$ nab-paclitaxel on days 1,8. The cycle was repeated every 3 weeks. Clinical efficacy was evaluated every two cycles. Results: Of the 29 patients, two persons interrupted treatment because of adverse reactions, failed to evaluate efficacy effect. The rest of 27 patients who could be evaluated for short-term response, 10 patients (37%) achieved partial response, 2 (7.4%) remained stable disease, and 15 (55.6%) had progressivedisease. The objective response rate was 37%, and the disease control rate was 44.4%.The median time to progression was 6.6 months.The major adverse reactions includedalopecia (62.07%), neutropenia (65.5%), gastrointestinalreaction (10.3%) andsensory neuropathy(6.8%). Conclusions: The albumin-bound paclitaxel-based chemotherapy is efficacy and safety in treatment for patients with advanced esophageal cancer who failed in first-line chemotherapy.