Life Science : Pinusolide Isolated from Biotu orientalis Inhibits 5-Lipoxygenase Dependent Leukotriene C4 Generation by Blocking c-Jun N-Terminal Kinase Pathway in Mast Cells

( Ye Jin ),( Hyun Ok Yang ),( Jong Keun Son ),( Hyeun Wook Chang ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

Pinusolide, an herbal medicine isolated from Biota orientalis L. (B. orientalis), inhibited 5-lipoxygenase(5-LO)-dependent leukotriene C4 (LTC4) generation in immunoglobulin E (IgE)/Ag-induced bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To clarify the action mechanism of pinusolide on the inhibition of LTC4 generation, we examined the effect of pinusolide on phosphorylation of cytosolic phospholipase A2 (cPLA2), as well as translocation phospho-cPLA2 and 5-LO to nucleus. Inhibition of LTC4 generation by pinusolide was accompanied by a decrease in cPLA2 phosphorylation which occurred via a decrease in intracellular Ca2+ influx and blocking the c-Jun N-terminal kinase (JNK) pathways. However, pinusolide had no effect on extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein (MAP) kinas phosphorylation. Taken together, the present results suggest that potent inhibition of 5-LO dependent LTC4 generation bypinusolide requires both suppression of calcium influx and JNK phosphorylation.

퍼놀로지 기반 디지털 캠페인 참여형 UI 디자인 연구

신예진 ( Sin¸ Ye-jin ),김성훈 ( Kim¸ Sung-hoon ) 커뮤니케이션디자인학회 2021 커뮤니케이션 디자인학연구 Vol.77 No.-

현대 사회는 기술의 발전으로 일상생활에서 접하는 모든 것들이 디지털화되고 이와 연대적으로 현대 사회의 사용자들은 정서적 감정에 민감하게 반응하고 있다. 이러한 시대의 퍼놀로지 기반의 디지털 캠페인은 신속하게 진보하는 기술과 펀(Fun) 아이디어의 융합으로 다양한 디지털 공간에서 감각적인 서비스를 원하는 사용자들의 니즈와 가치를 충족시키는 마케팅으로 적합하며 디지털 공간에서 사용자들의 원활한 상호작용을 위해서는 참여형 UI 디자인이 요구된다. 따라서 본 연구에서는 사용자들이 퍼놀로지 기반 디지털 캠페인에 참여할 때 디지털 공간에서 유희적 감성 유발과 적극적 참여를 위한 퍼놀로지 기반의 디지털 캠페인의 참여형 UI 디자인 발전 방안을 제시하는 것이 목적이다. 먼저 퍼놀로지의 이론적 배경과 개념에 대해 고찰하고 디지털 캠페인의 정의와 유형에 대해 살펴보았다. 또한 선행연구를 통해 참여형 UI디자인의 요소들을 정리하고 공통된 요소를 도출하였다. 이를 통해 연구에 적용할 퍼놀로지 기반 디지털 캠페인을 사용자 체험유형(수용적 체험/참여적 체험/주도적 체험)으로 나누어 참여형 UI디자인 3가지 요소로 디자인 요소(레이아웃/컬러/그래픽/텍스트), 기술 요소(일관성/가시성/단순성), 사용자 요소(흥미성/정보성/관계성)를 분석유형을 도출하였다. 도출된 내용을 통해 사용자 체험유형에 따른 국내외 실시된 퍼놀로지 기반 디지털 캠페인의 3개 사례를 선정하여 분석하였으며 그 결과는 다음과 같다. 첫 번째, 모든 체험유형에서 디자인 요소인 ‘텍스트’를 이용하여 참여 독려와 행동을 유도하였고 캠페인 체험 시 사용방법, 맥락에 있어서 일관되게 나타나는 기술 요소인 ‘일관성’, 캠페인의 의도나 아이덴티티의 구축하는 사용자 요소인 ‘정보성’이 강하게 나타났다. 두 번째, 사용자가 캠페인을 수용적 체험일수록 디자인 요소가 강하게 나타났고 반면에 사용자 요소는 약하게 나타난 것을 확인할 수 있었다. 특히 수용적 체험에서 사용자 요소인 ‘관계성’과 주도적 체험에서 ‘레이아웃’이 가장 낮게 나타났다. 세 번째, 디자인과 기술의 질(quality)과 보상(Feedback)을 나타내는 ‘가시성’이 모든 유형에서 미미하게 나타났다. 따라서 디지털 공간에서 사용자의 능동적이고 자발적인 참여와 다양한 체험을 제공하고 사용자의 유희적 감성을 유발시키고 의미 있는 경험을 창출을 위해선 퍼놀로지 기반 디지털 캠페인의 활용성 향상을 위한 참여형 UI디자인에 대한 지속적인 연구가 진행되어야 한다. With the development of technology in modern society, everything we encounter in our daily life is being digitalized, and users in modern society respond sensitively to how they feel emotionally. The funology-based digital campaign of that era is suitable as a marketing that meets the needs and values of users who want to receive a sensible service in a variety of digital spaces due to the convergence of the rapidly advancing technology and the fun idea, and the participatory UI design is required for smooth interaction of users in those digital spaces. Therefore, this study aimed to suggest a development plan for the funology-based digital campaign’s participatory UI design to induce users’ enjoyable emotions and encourage their active participation in the digital spaces when they participate in the funology-based digital campaign. First of all, it considered the theoretical background and concept of funology and examined the definitions and types of the digital campaign. In addition, it derived common elements by organizing the elements of the participatory UI design. Based on this, it divided the funology-based digital campaign to be applied in the study into some user experience types (receptive experience/ participatory experience/ proactive experience) and derived analysis types such as design elements (layout/ color/ graphic/ text), descriptive elements (consistency/ visibility/ simplicity), and user elements (interest/ informativeness/ relatedness) as three elements of the participatory UI design. Based on the derived contents, it selected and analyzed three cases of the funology-based digital campaign performed both in the country and abroad according to the user experience types, and the results were as follows. First, it encouraged participation and induced actions by using the ‘text’, one of the design elements, among all experience types, and ‘consistency’, one of the descriptive elements, that is consistent in terms of the usage and context at the time of experiencing the campaign, and ‘informativeness’, one of the user elements that builds the intention or identity of the campaign, were strongly observed. Second, the more receptive the users’ experiences with the campaign, the stronger the design elements and the weaker the user elements. In particular, ‘relatedness’, a user element in the receptive experience, and ‘layout’ in the proactive experience were found to be the lowest. Third, it was confirmed that ‘visibility’, which represents the quality and feedback of the design and technology, appeared insignificantly in all the types. Therefore, a study on the participatory UI design to improve the usability of the funology-based digital campaign should continue to be carried out in order to attract active and voluntary participation of users, provide them with various experiences, induce their enjoyable emotions, and create meaningful experiences for them in digital spaces.

Effect of Flow Rate on Smoke Control System for Railway Tunnel Fire

Yejin Ha(Yejin Ha),Joonho Jeon(Joonho Jeon) 한국화재소방학회 2023 International Journal of Fire Science and Engineer Vol.37 No.2

Tunnel is a semi-closed structure with a high risk of fire becuse of difficulty of smoke exhaust and restricted evacuation route in fire. No specific guidelines on smoke control systems have been developed for railway tunnels. Therefore, in the railway tunnel design, an average airflow velocity of 2.5 m/s inside a tunnel for the entry and exit of workers has been used as a reference. In this study, a fire simulation conducted to examine whether the average flow velocity can sufficiently apply on smoke control system in railway tunnel design. An 870-m-long railway tunnel with a single track and double track was modeled, and fire scenarios for light rail cars were simulated. It was found that the reference flow velocity showed sufficient smoke control performance, even at a maximum fire source of 60 MW. However, evacuees might be exposed to smoke due to the backlayer formed immediately. Furthermore, the smoke control performance for the reference velocity does not reflect the influence of the tunnel length. It is necessary to conduct a study on standard for appropriate smoke control performance to reduce fire risk in a railway tunnel fire.

A bio-inspired superhydrophobic electrospun Silicon nanofiber coating for Improvement of oil Purification

Yejin Liang(LIANG YEJIN),Heechul Choi(최희철),Minbeom Kim(김민범),Eunmok Yang(양은목),Soyoung Kim(김소영) 대한환경공학회 2021 대한환경공학회 학술발표논문집 Vol.2021 No.11

Hepatotoxicity and liver disease induced by exposure of butylparaben in liver organoids

Yejin Kim,Jong Hun Lee 한국산업식품공학회 2023 학술대회 및 심포지엄 Vol.2023 No.04

Analysis of Endophytic Bacterial Communities and Investigation of Core Taxa in Apple Trees

Yejin Lee,Gyeongjun Cho,김다란,곽연식 한국식물병리학회 2023 Plant Pathology Journal Vol.39 No.4

Fire blight disease, caused by Erwinia amylovora, is a devastating affliction in apple cultivation worldwide. Chemical pesticides have exhibited limited effectiveness in controlling the disease, and biological control options for treating fruit trees are limited. Therefore, a relatively large-scale survey is necessary to develop microbial agents for apple trees. Here we collected healthy apple trees from across the country to identify common and core bacterial taxa. We analyzed the endophytic bacterial communities in leaves and twigs and discovered that the twig bacterial communities were more conserved than those in the leaves, regardless of the origin of the sample. This finding indicates that specific endophytic taxa are consistently present in healthy apple trees and may be involved in vital functions such as disease prevention and growth. Furthermore, we compared the community metabolite pathway expression rates of these endophyte communities with those of E. amylovora infected apple trees and discovered that the endophyte communities in healthy apple trees not only had similar community structures but also similar metabolite pathway expression rates. Additionally, Pseudomonas and Methylobacterium-Methylorobrum were the dominant taxa in all healthy apple trees. Our findings provide valuable insights into the potential roles of endophytes in healthy apple trees and inform the development of strategies for enhancing apple growth and resilience. Moreover, the similarity in cluster structure and pathway analysis between healthy orchards was mutually reinforcing, demonstrating the power of microbiome analysis as a tool for identifying factors that contribute to plant health.

Pharmacokinetic change of flunitrazepam caused by ethanol in rats

Yejin Kim,Eun Gyu Lee,Seong Eun Cho,Hye Hyun Yoo 한국분석과학회 2023 학술대회논문집 Vol.2023 No.5

직장 네트워크 데이터에 대한 통계적 ERGM 분석

Yejin Park,Jungmin Um,Subeen Hong,Yujin Han,김재희 한국통계학회 2022 응용통계연구 Vol.35 No.4

회사는 영리 등의 공동 목표를 달성하는 조직으로, 더 나은 성과를 도출해내기 위해 함께 노력하는 수많은 개인으로 구성된 사회 집단이다. 이에 따라 개인의 의사소통 능력을 비롯한 구성원 간의 네트워크 형성이 중요해지고 있다. 이러한 배경으로부터 본 연구는 직원 간 조언 관계 형성에 어떠한 요인이 영향을 미치는지 알아보고자 수행되었다. 이를 위해 미국과 유럽에 지사를 둔 컨설팅 회사 내 직원 44명의 네트워크 데이터를 ERGM (Exponential Random Graph Model) 방법으로 분석하였다. 분석 결과로 첫째, 연결을 비롯해 네트워크의 구조와 관련한 변수들이 유의하였다. 둘째, 서로 조언을 구할 확률에 성별 속성이 가장 큰 주효과로 나타났다. 셋째, 지역별 동질성은 성별 주효과보다 더 큰 연결 확률을 유도하였다. 이러한 결과로부터 직장 내 네트워크가 조금 더 효율적으로 활발하게 이루어질 수 있는 방법을 제시하였다.

Omni-Directional Protected Nanofiber Membranes by Surface Segregation of PDMS-Terminated Triblock Copolymer for High-Efficiency Oil/Water Emulsion Separation

Yejin Liang,Soyoung Kim,Eunmok Yang,Heechul Choi 대한환경공학회 2020 대한환경공학회 학술발표논문집 Vol.2020 No.11

Proposal for a Sensory Integration Self-system based on an Artificial Intelligence Speaker for Children with Developmental Disabilities: Pilot Study

YeJin Wee,Onseok Lee 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.4

Conventional occupational therapy (OT) is conducted under the observation of an occupational therapist, and there are limitations in measuring and analyzing details such as degree of hand tremor and movement tendency, so this important information may be lost. It is therefore difficult to identify quantitative performance indicators, and the presence of observers during performance sometimes makes the subjects feel that they have to achieve good results. In this study, by using the Unity3D and artificial intelligence (AI) speaker, we propose a system that allows the subjects to steadily use it by themselves and helps the occupational therapist objectively evaluate through quantitative data. This system is based on the OT of the sensory integration approach. And the purpose of this system is to improve children’s activities of daily living by providing various feedback to induce sensory integration, which allows them to develop the ability to effectively use their bodies. A dynamic OT cognitive assessment tool for children used in clinical practice was implemented in Unity3D to create an OT environment of virtual space. The Leap Motion Controller allows users to track and record hand motion data in real time. Occupational therapists can control the user’s performance environment remotely by connecting Unity3D and AI speaker. The experiment with the conventional OT tool and the system we proposed was conducted. As a result, it was found that when the system was performed without an observer, users can perform spontaneously and several times feeling ease and active mind.