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Wooram Park,Chanik Park 한국정보과학회 2011 Journal of Computing Science and Engineering Vol.5 No.4
Recently, Virtual Desktop Infrastructure (VDl) has been widely adopted to ensure secure protection of enterprise data and provide users with a centrally managed execution environment. However, user experiences may be restricted due to the limited functionalities of thin clients in VDI. If thick client devices like laptops are used, then data leakage may be possible due to malicious software installed in thick client mobile devices. In this paper, we present Data Firewall, a security framework to manage and protect security-sensitive data in thick client mobile devices. Data Firewall consists of three components: Virtual Machine (VM) image management, client VM integrity attestation, and key management for Protected Storage. There are two types of execution VMs managed by Data Firewall: Normal YM and Secure VM. In Normal VM, a user can execute any applications installed in the laptop in the same manner as before. A user can access security-sensitive data only in the Secure VM, for which the integrity should be checked prior to access being granted. All the security-sensitive data are stored in the space called Protected Storage for which the access keys are managed by Data Firewall. Key management and exchange between client and server are handled via Trusted Platform Module (TPM) in the framework. We have analyzed the security characteristics and built a prototype to show the performance overhead of the proposed framework.
Frequency detuning effects in a loop-back WDM-PON employing gain-saturated RSOAs
Wooram Lee,Seung Hyun Cho,Mahn Yong Park,Jie Hyun Lee,Kim, C.,Geon Jeong,Byoung Whi Kim IEEE 2006 IEEE photonics technology letters Vol.18 No.13-16
<P>We report that, in a loop-back wavelength-division-multiplexed passive optical network link with gain-saturated reflective semiconductor optical amplifiers, the upstream performance is strongly affected not only by the gain saturation but also by the selective spectral filtering caused by the frequency difference between the optical downstream signal and the cascaded filter's passband. We experimentally investigate these effects and propose to use an additional negatively detuned optical filter at an optical network terminal to improve the upstream transmission performance</P>
Dermatan Sulfate as a Stabilizer for Protein Stability in Poly(lactide-co-glycolide) Depot
Wooram Park,나건 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.5
Dermatan sulfate (DS), a glycosaminoglycan family, was investigated as a additive to enhance the stability of therapeutic protein with low pf value loaded in poly(lactide-co-glycolide) (PLGA) microspheres prepared by water-in-oil-in-water (W1/O/W2) method. DS maintains negative charge below pH 3.0 because of its sulfate groups, while most anionic polymer with carboxyl groups becomes neutral charge at that pH. Thus, at pH 3.0 DS can form a polyelectrolyte complex with a protein with lower pf=such as exendin-4, insulin, and human growth hormone. In order to complex with DS, bovine serum albumin (BSA) was employed as a model protein, which has low pf value (pf== 4.8). The complex prepared at pH 3.0 showed a nano-size in the range of 100~200 nm with a mono distribution. During the preparation of PLGA depot, DS concentration in water phase increases with decreasing the formation of non-covalent BSA aggregates and enhancing BSA loading efficiency. It means that DS/BSA complex system enabled to keep a stability of BSA at the water/organic interface. In an in vitro BSA release test, PLGA depot with DS exhibited a lower initial burst kinetic than only PLGA depot and continuous BSA release in almost 100% for 23 days. From the results, it was concluded that DS as an additive in PLGA depot, has a potential for the long-term delivery of therapeutic proteins with lower pf value Dermatan sulfate (DS), a glycosaminoglycan family, was investigated as a additive to enhance the stability of therapeutic protein with low pf value loaded in poly(lactide-co-glycolide) (PLGA) microspheres prepared by water-in-oil-in-water (W1/O/W2) method. DS maintains negative charge below pH 3.0 because of its sulfate groups, while most anionic polymer with carboxyl groups becomes neutral charge at that pH. Thus, at pH 3.0 DS can form a polyelectrolyte complex with a protein with lower pf=such as exendin-4, insulin, and human growth hormone. In order to complex with DS, bovine serum albumin (BSA) was employed as a model protein, which has low pf value (pf== 4.8). The complex prepared at pH 3.0 showed a nano-size in the range of 100~200 nm with a mono distribution. During the preparation of PLGA depot, DS concentration in water phase increases with decreasing the formation of non-covalent BSA aggregates and enhancing BSA loading efficiency. It means that DS/BSA complex system enabled to keep a stability of BSA at the water/organic interface. In an in vitro BSA release test, PLGA depot with DS exhibited a lower initial burst kinetic than only PLGA depot and continuous BSA release in almost 100% for 23 days. From the results, it was concluded that DS as an additive in PLGA depot, has a potential for the long-term delivery of therapeutic proteins with lower pf value
Wooram Choi,Jeong Hun Cho,Sang Hee Park,Dong Seon Kim,Hwa Pyoung Lee,Donghyun Kim,Hyun Soo Kim,Ji Hye Kim,Jae Youl Cho The Korean Society of Ginseng 2024 Journal of Ginseng Research Vol.48 No.2
Background: Recently, plant-derived exosome-like nanoparticles (PDENs) have been isolated, and active research was focusing on understanding their properties and functions. In this study, the characteristics and molecular properties of ginseng root-derived exosome-like nanoparticles (GrDENs) were examined in terms of skin protection. Methods: HPLC-MS protocols were used to analyze the ginsenoside contents in GrDENs. To investigate the beneficial effect of GrDENs on skin, HaCaT cells were pre-treated with GrDENs (0-2 × 10<sup>9</sup> particles/mL), and followed by UVB irradiation or H<sub>2</sub>O<sub>2</sub> exposure. In addition, the antioxidant activity of GrDENs was measured using a fluorescence microscope or flow cytometry. Finally, molecular mechanisms were examined with immunoblotting analysis. Results: GrDENs contained detectable levels of ginsenosides (Re, Rg1, Rb1, Rf, Rg2 (S), Gyp17, Rd, C-Mc1, C-O, and F2). In UVB-irradiated HaCaT cells, GrDENs protected cells from death and reduced ROS production. GrDENs downregulated the mRNA expression of proapoptotic genes, including BAX, caspase-1, -3, -6, -7, and -8 and the ratio of cleaved caspase-8, -9, and -3 in a dose-dependent manner. In addition, GrDENs reduced the mRNA levels of aging-related genes (MMP2 and 3), proinflammatory genes (COX-2 and IL-6), and cellular senescence biomarker p21, possibly by suppressing activator protein-1 signaling. Conclusions: This study demonstrates the protective effects of GrDENs against skin damage caused by UV and oxidative stress, providing new insights into beneficial uses of ginseng. In particular, our results suggest GrDENs as a potential active ingredient in cosmeceuticals to promote skin health.
Wooram Shin,Ju Hwan Oh,A Young Cho,In Sup Song,Young Suk Kim,Kwang Young Lee,In O Sun 대한가정의학회 2022 Korean Journal of Family Medicine Vol.43 No.2
Spinal epidural abscess (SEA) caused by Escherichia coli is an uncommon condition. It usually occurs secondary to urinary tract infection (UTI), following hematogenous propagation. Disruption of spinal anatomic barriers in-creases susceptibility to SEA. Although rarely, such disruption can take the form of lumbar spine stress fractures, which can result from even innocuous activity. Here, we describe a case of SEA secondary to UTI in a patient with pre-existing stress fractures of the lumbar spine, following use of an automated massage chair. Successful treatment of SEA consisted of surgical debridement and a six-month course of antibiotic therapy.
Design and Layout of CMOS interface circuit for measuring photoplethysmogram
WooRam Lee,WanJik Lee,ChangSoo Won,SangHee Son,WonSup Chung,KyoungRok Cho 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
A CMOS interface circuit for measuring PPG(Photoplethysmogram) is proposed and designed by using current-control Schmitt trigger in this paper,. This circuit detects the blood beat using PPG which occurs in bloodbeat sensor and composed of analog and digital parts. Current signal of sensor is converted into voltage in analog parts and then converted into digital signal in digital parts. Compared to the conventional method, operation speed is increased and linear error is diminished by applying OTA(Operational transconductance amplifier) to Schmitt trigger circuit and oscillator. Also, proposed and designed circuit has some features of low power consumption, simple structure and high resolution compared with previous method.