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Temmy Pegarro Vales,지준필,이원영,Ilgi Min,조성,김호중 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.4
Herein, the preparation of the cross-linked copolymer hydrogels composed of various weight ratios of 2-methacryloyloxyethyl phosphorylcholine (MPC) and 2-hydroxyethyl methacrylate (HEMA) monomers employing free-radical polymerization was reported. The integration of the MPC monomer into HEMA-based hydrogels showed good transmittance (>90%) and enhanced the water content retention (79?202%) relative to those of pure HEMA-based hydrogel. Notably, the MPC-containing hydrogels (MPC-H) exhibited the improved anti-biofouling properties due to the formation of a compact hydration layer produced by the biomimetic MPC units at the hydrogel surface. MPC-H exhibited a decrease in the bovine serum albumin (BSA) and lysozyme adsorption of approximately 40?70% and 44?65%, respectively, relative to those of control hydrogel without MPC monomer. The results presented herein demonstrate the potential of expending biocompatible monomers such as HEMA and MPC to efficiently generate a biomaterial that possesses both bio-membrane mimicking character and protein and bacterial resistant properties for various industrial and biomedical applications.
김보람,강병만,Temmy Pegarro Vales,양시경,이주민,김호중 한국고분자학회 2018 Macromolecular Research Vol.26 No.1
In this work, polyphenol-modified hydrogels were prepared and their antioxidant activities were investigated. Poly(2-hydroxyethyl methacrylate) (pHEMA)- based hydrogels were first synthesized and subsequently functionalized with an interpenetrating polymer network (IPN) structure comprising crosslinked chitosans and p(HEMA) networks. The resulting hydrogels were further modified with polyphenols such as gallic acid and dopamine through amide coupling reactions to afford the antioxidant hydrogels. The antioxidant activity of the prepared hydrogels were evaluated using 2,2-diphenyl-1-picrylhydrazyl and 2,2’-azino-bis(3-ethyl-benzothiazoline- 6-sulfonic acid) radical scavenging assays. The gallic-acid-modified hydrogels exhibited superior antioxidant activity when compared to their dopamine-functionalized counterparts; this was correlated to the number of hydroxyl groups in the benzene ring. Moreover, longer chitosan moieties afforded larger amounts of polyphenols. Thus, hydrogels containing the same polyphenols but longer chitosan moieties exhibited stronger antioxidant activity. This work demonstrates that the development of antioxidant hydrogels based on chitosan-IPN structures shows great potential for application in biomedical devices and ophthalmic materials.
Barriers to Pain Management among Older Adults in Rural Areas
Hyunjin Noh,Temmy Aladeokin 한국노인복지학회 2018 한국노인복지학회 학술발표논문집 Vol.2018 No.11
This study explored health or senior care service providers’views of barriers to optimal pain management among chronically ill older adults in rural communities in the United States. An exploratory, qualitative research design was used to capture service providers’ perceptions of barriers through individual, face-to-face interviews. Thematic analysis of the interview data revealed 5barriers: lack of transportation, lack of alternative pain treatments, difficulties with assessment of pain, hesitance to pain medicine, and lack of trained professionals. Findings of this study suggest need for increased resources at federal and state level and more education on pain and its management.
Lee, Seung Hwan,Bui, Hoa Thi,Vales, Temmy Pegarro,Cho, Sung,Kim, Ho-Joong Applied Science Publishers 2017 Dyes and pigments Vol.145 No.-
<P><B>Abstract</B></P> <P>We report the modulation of the dual photo/thermo-responsive multicolor fluorescence from poly(<I>N</I>-isopropyl acrylate) pNIPAM-based nanogels. The thermo-responsive pNIPAM-crosslinked matrix was covalently copolymerized with nitrobenzoxadiazole (NBD) monomers as a Förster resonance energy transfer (FRET) donor and electrostatically conjugated with photochromic spiropyran (SP) dyes as a FRET acceptor. The pristine nanogel emits green fluorescence derived from the NBD moieties; however, the irradiation of the nanogels with UV light led to the transformation of the ring-closed colorless SP moieties to the ring-opened coral-red merocyanine (MC) moieties, resulting in light-pink fluorescent nanogels. Notably, at higher temperatures, the fluorescence of the nanogels was red-shifted and enhanced by the more efficient FRET process. The nanogels were well-distributed in the cellular cytoplasm and showed excellent photochromic function in the subcellular environment for applications as photo-switchable bio-imaging agents and nanothermometers.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Selective fluorescence intensity of the nanogels was modulated by thermo-responsive FRET processes. </LI> <LI> Multicolor fluorescent nanogels consist of nitrobenzoxadiazole and spiropyran dyes. </LI> <LI> Nanogels showed a photochromic property upon specific light irradiations. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Thermo‐sensitive nanogel‐laden bicontinuous microemulsion drug‐eluting contact lenses
Lee, Se‐,Hee,Kim, Ho‐,Joong,Kim, Duck‐,Hyun,Chang, Won‐,Seok,Vales, Temmy Pegarro,Kim, Jae‐,Woo,Kim, Ki‐,Hong,Kim, Jong‐,Ki John Wiley Sons, Inc. 2019 Journal of Biomedical Materials Research Part B Vol.107 No.4
<P><B>Abstract</B></P><P>The bicontinuous microemulsion contact lens (BMCL) has nanoporous biphasic structures (100–250 nm) that are interconnected via multiple nano‐channels, providing suitable retention of various drugs for glaucoma. Timolol maleate (TM)‐carried thermosensitive poly(<I>N</I>‐isopropylacrylamide) (PNIPAM) nanogel (30–50 nm) was incorporated into BMCLs by soaking or by centrifuging plus soaking. Here, we present drug‐loading and release in silicon‐ or polyethylene oxide‐microemulsion BMCLs under various conditions. Nanoporous BMCLs containing thermosensitive TM‐laden nanogel were capable of potent body‐temperature‐triggered release of TM. Daily drug release was controllable according to the initial volume of drug‐loaded (VDL) and loading method for sustained drug release, making them reduce drug‐loss during transportation or storage. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1159–1169, 2019.</P>