156 Mb/s Burst-Mode Operation of a PLC-Hybrid-Integrated Optical Module

T. Kurosaki,M. Nakamura,H. Kimura,N. Uchida,Y. Suzuki,T. Hashimoto,M. Yanagisawa,N. Ishihara,Y. Tohmori,K. Kato,Y. Inoue,Y. Yamada,H. Toba 한국통신학회 1997 OPTOELECTRONICS & COMMUNICATIONS CONFERENCE Vol.2 No.1

Conformation and Intermolecular Interaction Changes During Phase Transitions investigated by The Simultaneous DSC-FTIR Measurement

T.Baba,T.Yamada,H.Yoshida 한국고분자학회 2006 한국고분자학회 학술대회 연구논문 초록집 Vol.2006 No.10

Dislocation dynamics simulation on stability of high dense dislocation structure interacting with coarsening defects

Yamada, M.,Hasebe, T.,Tomita, Y.,Onizawa, T. Techno-Press 2008 Interaction and multiscale mechanics Vol.1 No.4

This paper examined the stability of high-dense dislocation substructures (HDDSs) associated with martensite laths in High Cr steels supposed to be used for FBR, based on a series of dislocation dynamics (DD) simulations. The DD simulations considered interactions of dislocations with impurity atoms and precipitates which substantially stabilize the structure. For simulating the dissociation processes, a point defect model is developed and implemented into a discrete DD code. Wall structure composed of high dense dislocations with and without small precipitates were artificially constructed in a simulation cell, and the stability/instability conditions of the walls were systematically investigated in the light of experimentally observed coarsening behavior of the precipitates, i.e., stress dependency of the coarsening rate and the effect of external stress. The effect of stress-dependent coarsening of the precipitates together with application of external stress on the subsequent behavior of initially stabilized dislocation structures was examined.

Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations

Yamada, Y.,Nishida, T.,Ichihara, S.,Sawabe, M.,Fuku, N.,Nishigaki, Y.,Aoyagi, Y.,Tanaka, M.,Fujiwara, Y.,Yoshida, H.,Shinkai, S.,Satoh, K.,Kato, K.,Fujimaki, T.,Yokoi, K.,Oguri, M.,Yoshida, T.,Watanab Elsevier Scientific Publ. Co 2011 Atherosclerosis Vol.215 No.1

Objective: We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations. Methods: A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. Results: Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0x10<SUP>-7</SUP>) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. Conclusion: BTN2A1 may be a susceptibility gene for MI in Japanese individuals.

Immunolocalization of laminin and integrin in regenerating junctional epithelium of mice after gingivectomy

Masaoka, T.,Hashimoto, S.,Kinumatsu, T.,Muramatsu, T.,Jung, H.-S.,Yamada, S.,Shimono, M. Blackwell Publishing Ltd 2009 Journal of periodontal research Vol.44 No.4

<P>Background and Objective: </P><P>The expression patterns of adhesive proteins and extracellular matrix proteins in regenerating gingival epithelium after gingivectomy are unknown. The aim of this study was to examine the expression of laminin 1, laminin &ggr;<SUB>2</SUB> (a specific component of laminin 5), integrin &bgr;<SUB>4</SUB> and integrin &agr;<SUB>3</SUB> in the regenerating gingival epithelium in order to understand the mechanism of wound healing during reconstitution of the sulcular environment.</P><P>Material and Methods: </P><P>The palatal gingivae of the maxillary molars of Institute of Cancer Research mice were excised, and the regenerating tissues were examined 1, 3, 5, 7 and 14 days later. Fresh, non-fixed and non-decalcified frozen sections were prepared and stained using immunofluorescence.</P><P>Results: </P><P>At 1 day post-surgery, intense expression of laminin &ggr;<SUB>2</SUB>, integrin &bgr;<SUB>4</SUB> and integrin &agr;<SUB>3</SUB> was distinct in the frontal margin of the regenerating oral epithelium. Laminin &ggr;<SUB>2</SUB> was diffusely detected on the root surface and in connective tissues beneath the regenerating oral epithelium at 3 and 5 days. At 7 days, laminin &ggr;<SUB>2</SUB> was intermittently recognizable in the internal basal lamina (IBL) close to tooth-facing cells, while laminin &ggr;<SUB>2</SUB>, integrin &bgr;<SUB>4</SUB> and integrin &agr;<SUB>3</SUB> were observed in the IBL and in the external basal lamina (EBL) of the regenerating junctional epithelium at 14 days.</P><P>Conclusion: </P><P>These results suggest that secretion of laminin 5 in the connective tissue may induce epithelial cell migration, and that binding of laminin 5 to integrin &agr;<SUB>6</SUB>&bgr;<SUB>4</SUB> and integrin &agr;<SUB>3</SUB>&bgr;<SUB>1</SUB> in the IBL may provoke cell adhesion and migration of cells facing the tooth on the enamel surface of the regenerating junctional epithelium.</P>

Involvement of laminin and integrins in adhesion and migration of junctional epithelium cells

Kinumatsu, T.,Hashimoto, S.,Muramatsu, T.,Sasaki, H.,Jung, H-S,Yamada, S.,Shimono, M. Blackwell Publishing Ltd 2009 Journal of periodontal research Vol.44 No.1

<P>Background and Objective: </P><P>The junctional epithelium attaches to the enamel surface with hemidesmosomes (of which laminin-5 and integrin-&agr;<SUB>6</SUB>&bgr;<SUB>4</SUB> are the main components) in the internal basal lamina. Laminin-5 is also involved in cell motility with integrin-&agr;<SUB>3</SUB>&bgr;<SUB>1</SUB>, although their functions have not yet been clarified. The purpose of this study was to determine the functions of those adhesive components between the tooth and the junctional epithelium during cell migration. Because an idea has been proposed that directly attached to tooth cells (DAT cells) may not contribute to cell migration, 5-bromo-2-deoxyuridine staining was performed to confirm cell migration.</P><P>Material and Methods: </P><P>We investigated laminin-&ggr;<SUB>2</SUB> (contained only in laminin-5), integrin-&bgr;<SUB>4</SUB> (involved in cell–extracellular matrix contact) and integrin-&agr;<SUB>3</SUB> (inducing cell migration) in the junctional epithelium, oral gingival epithelium and gingival sulcus epithelium of 6-wk-old ICR mice using laser microdissection, quantitative real-time reverse transcription-polymerase chain reaction, immunofluorescence and 5-bromo-2-deoxyuridine staining.</P><P>Results: </P><P>Laminin and integrins were clearly immunolocalized in the basal lamina of all epithelium. Quantitative analysis of laminin and integrin mRNAs by laser microdissection showed that they were more highly expressed in DAT cells than in basal cells in the oral gingival epithelium. In particular, a 12-fold higher expression of laminin-5 was observed in the junctional epithelium compared with the oral gingival epithelium. 5-Bromo-2-deoxyuridine staining showed rapid coronal migration of DAT cells.</P><P>Conclusion: </P><P>These results suggest that the abundant expression of laminin-5 and integrin-&agr;<SUB>6</SUB>&bgr;<SUB>4</SUB> is involved in the attachment of DAT cells to teeth by hemidesmosomes. Abundant expression of laminin-5 and integrin-&agr;<SUB>3</SUB>&bgr;<SUB>1</SUB> might assist in DAT cell migration, confirmed by 5-bromo-2-deoxyuridine staining during the turnover of junctional epithelium.</P>

Distribution of stress state in the Nankai subduction zone, southwest Japan and a comparison with Japan Trench

Lin, W.,Byrne, T.B.,Kinoshita, M.,McNeill, L.C.,Chang, C.,Lewis, J.C.,Yamamoto, Y.,Saffer, D.M.,Casey Moore, J.,Wu, H.Y.,Tsuji, T.,Yamada, Y.,Conin, M.,Saito, S.,Ito, T.,Tobin, H.J.,Kimura, G.,Kanagaw Elsevier Scientific Publishing Co 2016 Tectonophysics Vol.692 No.2

<P>To better understand the distribution of three dimensional stress states in the Nankai subduction zone, southwest Japan, we review various stress-related investigations carried out in the first and second stage expeditions of the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) by the Integrated Ocean Drilling Program (IODP) and compile the stress data. Overall, the maximum principal stress sigma(l) in the shallower levels (<similar to 1 km) is vertical from near the center of forearc basin to near the trench and; the maximum horizontal stress S-Hmax (interpreted to be the intermediate principal stress sigma(2)) is generally parallel to the plate convergence vector. The exception to this generalization occurs along the shelf edge of the Nankai margin where S-Hmax, is along strike rather than parallel to the plate convergence vector. Reorientation of the principal stresses at deeper levels (e.g., >similar to 1 km below seafloor or in underlying accretionary prism) with sigma(1) becoming horizontal is also suggested at all deeper drilling sites. We also make a comparison of the stress state in the hanging wall of the frontal plate-interface between Site C0066 in the Nankai and Site C0019 in the Japan Trench subduction zone drilled after the 2011 Mw 9.0 Tohoku-Oki earthquake. In the Japan Trench, a comparison between stress state before and after the 2011 mega-earthquake shows that the stress changed from compression before the earthquake to extension after the earthquake. As a result of the comparison between the Nankai Trough and Japan Trench, a similar current stress state with trench parallel extension was recognized at both C0006 and C0019 sites. Hypothetically, this may indicate that in Nankai Trough it is still in an early stage of the interseismic cycle of a great earthquake which occurs on the decollement and propagates to the toe (around site C0006). (C) 2015 Elsevier B.V. All rights reserved.</P>

The Release of Hepatic Triglyceride Lipase from Rat Monolayered Hepatocytes in Primary Culture

윤대헌(Tai Heon Yoon),Yamada N(Nobuhiro Yamada),Ishibashi S(Shun Ishibashi),Shimano H(Hitoshi Shimano),Gotohda T(Takanari Gotohda),Harada K(Kenji Harada),OAkanuma Y(Yasuo Akanuma),Murase T(Toshio Murase) 한국식품영양과학회 1991 한국식품영양과학회지 Vol.20 No.1

쥐간세포 배양시 간트리글리세리드 lipase의 유리 및 호르몬 조절에 관하여 연구하였다. 배양 2일째 헤파린 첨가구 배양액에 유리된 lipase 활성은 24시간 동안 계속 증가하였다. 반면에 헤파린 무첨가의 lipase활성은 헤파린 첨가가우에 비하여 10%에 지나지 않았다. 간세포를 anti-hepatic triglyceride lipase IgG와 배양시 lipase 활성이 92%까지 저해되었다. Monensin 첨가시 lipase활성 저해는 61%였다. 인슐린은 lipase활성을 20% 상승시켰으며 dexamethasone은 44% 저해시켰다. 이상의 결과로 미루어 보아 간트리글리세리드 lipase는 헤파린 존재하에 분비 및 유리되며 그 분비는 호르몬에 의해 조절됨을 시사한다. The release of hepatic triglyceride lipase from cultured rat hepatocytes and its hormonal regulation were studied. The activity of lipase released into the medium in the presence of heparin was increasing during 24 hours on the 2nd day of culture, while this was 10% in the absence of heparin as compared with the lipase activity in the presense of heparin. When hepatocytes were cultured with anti-hepatic triglyceride lipase IgG, the lipase activity was suppressed by 92%. The results suggest that the enzyme released into culture medium is identical to hepatic triglyceride lipase which can be released only in the presence of heparin, the model of release being similar to that of lipoprotein lipase from adipocytes. The addition of monensin to the medium resulted in the inhibition of lipase secretion by 61%. Insulin enhanced lipase activity only 20%, whereas dexamethasone suppressed the activity by 44%. These data indicated that hepatic triglyceride lipase is secreted and released from hepatocytes in the presence of heparin and its secretion is regulated by hormones.

MODELING OF A REPULSIVE TYPE MAGNETIC BEARING FOR FIVE AXIS CONTROL INCLUDING EDDY CURRENT EFFECT

T.Ohji,S.C.Mukhopadhyay,M.I wahara,S.Yamada 전력전자학회 1998 ICPE(ISPE)논문집 Vol.- No.-

So far a single-axis controlled repulsive type magnetic bearing system have been designed and fabricated in our laboratory employing the repulsive forces operating between the stator and rotor permanent magnet for levitation. The radial axis is uncontrolled passive one The higher speed of operation is limited due to the vibration along the uncontrolled axis and the increase of control current due to eddy current interference. This paper will discuss a detailed modeling of the repulsive type magnetic bearing system for five axis control including the eddy current effect and the method of reduction of eddy current effect Simulation results using Matlab will be presented.<br/>

Second-harmonic generation in a silicon-carbide-based photonic crystal nanocavity

Yamada, S.,Song, B.-S.,Jeon, S.,Upham, J.,Tanaka, Y.,Asano, T.,Noda, S. OPTICAL SOCIETY OF AMERICA 2014 Optics letters Vol.39 No.7