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Zhang, Shu Ling,Zhang, Zhen Xiu,Kim, Jin Kuk Wiley Subscription Services, Inc., A Wiley Company 2008 Journal of vinyl & additive technology Vol.14 No.1
<P>This work mainly introduces the recyclability of polypropylene (PP) modified by regenerated polyurethane (PU) that was obtained after partial thermochemical decomposition of waste PU. The influence of regenerated PU on the mechanical properties and thermal stability of PP during multiple processing cycles was evaluated by a universal testing machine, differential scanning calorimetry, and thermogravimetric analyses. The data showed that the mechanical properties of the modified PP were dependent on the content of regenerated PU with the increase in the number of processing cycles, whereas the thermal stability of the modified PP was almost independent of the content of regenerated PU. J. VINYL ADDIT. TECHNOL, 2008. © 2008 Society of Plastics Engineers</P>
Autophagy-associated Targeting Pathways of Natural Products during Cancer Treatment
Zhang, Shu-Fang,Wang, Xiao-Lu,Yang, Xiao-Qi,Chen, Ning Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
It is well known that conventional chemotherapy and radiation therapy can result in toxicity to both normal cells and tumor cells, which causes limitations in the application of these therapeutic strategies for cancer control. Novel and effective therapeutic strategies for cancers with no or low toxicity for normal cells are a high priority. Therefore, natural products with anticancer activity have gained more and more attention due to their favorable safety and efficacy profiles. Pre-clinical and clinical studies have demonstrated that several representative natural compounds such as resveratrol, epigallocatechin-3-gallate, curcumin, allicin and ginsenosides have obvious anticancer potential. In this article, we summarize autophagy-associated targeting pathways of such natural products for inducing the death of cancer cells, and discuss the core autophagic pathways involved in cancer treatments. Recent advances in the discovery, evaluation and exploitation of natural compounds as therapeutic agents for cancers will provide references and support in pre-clinical and clinical application of novel natural drugs for the treatment of primary and metastatic tumors in the future.
Cascade Selective Window for Fast and Accurate Object Detection
Zhang, Shu,Cai, Yong,Xie, Mei The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
Several works help make sliding window object detection fast, nevertheless, computational demands remain prohibitive for numerous applications. This paper proposes a fast object detection method based on three strategies: cascade classifier, selective window search and fast feature extraction. Experimental results show that the proposed method outperforms the compared methods and achieves both high detection precision and low computation cost. Our approach runs at 17ms per frame on 640×480 images while attaining state-of-the-art accuracy.
Zhang, Xiong,Jin, Fen-Shu,Zhang, Li-Guo,Chen, Rui-Xue,Zhao, Jin-Hui,Wang, Yan-Nan,Wang, En-Fu,Jiang, Zhen-Dong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Increasing scientific evidence suggests that ribonucleotide reductase M1 (RRM1) may be a powerful predictor of survival in patients with pancreatic cancer treated with adjuvant gemcitabine-based chemotherapy after operative resection, but many existing studies have yielded inconclusive results. This meta-analysis aimed to assess the prognostic role of RRM1 in predicting survival in patients with pancreatic cancer treated with gemcitabine. An extensive literature search for relevant studies was conducted on PubMed, Embase, Web of Science, Cochrane Library, and CBM databases from their inception through May 1st, 2013. This meta-analysis was performed using the STATA 12.0 software and crude hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated. Eight clinical studies were included in this meta-analysis with a total of 665 pancreatic cancer patients treated with adjuvant gemcitabine-based chemotherapy, including 373 patients in the high RRM1 expression group and 292 patients in the low RRM1 expression group. Our meta-analysis revealed that high RRM1 expression was associated with improved overall survival (OS) of pancreatic cancer patients (HR=1.56, 95%CI=0.95-2.17, P<0.001). High RRM1 expression also was linked to longer disease-free survival (DFS) than low RRM1 expression (HR=1.37, 95%CI=0.25-2.48, P=0.016). In conclusion, our meta-analysis suggests that high RRM1 expression may be associated with improved OS and DFS of pancreatic cancer patients treated with adjuvant gemcitabine-based chemotherapy. Detection of RRM1 expression may be a promising biomarker for gemcitabine response and prognosis in pancreatic cancer patients.
Zhang, Zhen Xiu,Lee, Sung-Hyo,Kim, Jin-Kuk,Zhang, Shu Ling,Xin, Zhen Xiang The Polymer Society of Korea 2008 Macromolecular Research Vol.16 No.5
In order to obtain 'value added products' from polypropylene (PP)/waste ground rubber tire powder (WGRT) composites, PP/WGRT microcellular foams were prepared via supercritical carbon dioxide. The effects of blend composition and processing condition on the cell size, cell density and relative density of PP/WGRT micro-cellular composites were studied. The results indicated that the microcellular structure was dependent on blend composition and processing condition. An increased content of waste ground rubber tire powder (WGRT) and maleic anhydride-grafted styrene-ethylene-butylene-styrene (SEBS-g-MA) reduced the cell size, and raised the cell density and relative density, whereas a higher saturation pressure increased the cell size, and reduced the cell density and relative density. With increasing saturation temperature, the cell size increased and the relative density decreased, whereas the cell density initially increased and then decreased.
Impact of Initial Moisture Content on the Shrinkage-Swelling Behavior of Heishan Bentonite
Shu-Cui Zhang,Kai Li,Ke-Ming Sun,Shuo Wang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.2
Bentonite is generally used as buffer or backfill material in geological repositories and its mechanical behavior is important to affect surrounding structures. In this paper, cyclic shrinkage-swelling tests are performed on Heishan bentonite taking into account the effect of initial moisture content. Results reveal that the shrinkage-swelling behavior of Heishan bentonite relies on initial moisture content and an obvious water retention property is obtainedwith the increases of initial moisture content. To investigate the accurate determination of aforementioned behavior of studied bentonite during drying and wetting cycle, the captured image of digital camera and the binary image processing technique are employed in this study. A simplified analytical model is proposed to simulate the shrinkage-swelling behavior at different initial moisture contents and the model parameters are calibrated by experimental results of Heishan bentonite. Based on the model performance, the model simulation agrees well with the tests and the proposed approach is able to predict the behavior of Heishan bentonite.
Zhang, Feng-Lin,Gao, Er-Yun,Shu, Rong-Bao,Wang, Hui,Zhang, Yan,Sun, Peng,Li, Min,Tang, Wei,Jiang, Bang-Qin,Chen, Shuang-Qi,Cui, Fang-Bo Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Aims: To study the effectiveness of human recombinant endostatin injection (Endostar(R)) combined with cisplatin doublets in treating advanced non-small cell lung cancer (NSCLC), and to evaluate outcome by CT perfusion imaging. Methods: From April 2011 to September 2014, 76 patients with advanced NSCLC who were treated with platinum-based doublets were divided into group A (36 patients) and group B (40 patients). Endostar(R) 15mg/day was administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A, and combined with chemotherapy from the first day in Group B. Endostar(R) in the two groups was injected intravenously for 14 days. Results: Treatment effectiveness in the two groups differed with statistical significance (p<0.05). Effectiveness evaluated by CT perfusion imaging, BF, BV, MTT and PS also demonstrated significant differences (all p<0.05). Adverse reactions in the two groups did not significantly vary (p> 0.05). Conclusions: The response rate with Endostar(R) administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A was better than Endostar(R) combined with chemotherapy from the first day, and CT perfusion imaging could be a reasonable method for evaluation of patient outcomes.
Zhang, Shu-Xiang,Yang, Shan,Xu, Chang-Qing,Hou, Rui-Ping,Zhang, Chuan-Zhen,Xu, Cui-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Aim: To study the contribution of genetic variation in RAD51 to risk of esophageal squamous cell carcinoma (ESCC). Methods: Three single nucleotide polymorphisms (SNPs) in RAD51 (rs1801320, rs4144242 and rs4417527) were genotyped in 316 ESCC patients and 316 healthy controls in Anyang area of China using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism). Demographic variables between cases and controls were statistically compared by T test and Chi-square test. Hardy-Weinberg equilibrium was evaluated by the Chi-square test. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure any association with ESCC. Haplotype frequencies were estimated by Phase 2.1. Result: The genotype frequencies of rs1801320, rs4144242 and rs4417527 in patients with ESCC demonstrated no significant differences from those in control group (P>0.05). When the haplotypes of these three SNPs were constructed and their relationships with ESCC risk investigated, however, CGG was observed to increase the risk (P=0.020, OR=2.289). Conclusions: There was no association between the three SNPs of RAD51 and ESCC susceptibility in our Chinese population. However, the CGG haplotype might be a risk factor.
Zhang, Hao,Huang, Meng-Shu,Zhang, Yi-Meng,Yoshihara, Tsutomu The Institute of Electronics and Information Engin 2014 Journal of semiconductor technology and science Vol.14 No.1
A nano-power CMOS voltage reference is proposed in this paper. Through a combination of switched-capacitor technology with the body effect in MOSFETs, the output voltage is defined as the difference between two gate-source voltages using only a single PMOS transistor operated in the subthreshold region, which has low sensitivity to the temperature and supply voltage. A low output, which breaks the threshold restriction, is produced without any subdivision of the components, and flexible trimming capability can be achieved with a composite transistor, such that the chip area is saved. The chip is implemented in $0.18{\mu}m$ standard CMOS technology. Measurements show that the output voltage is approximately 123.3 mV, the temperature coefficient is $17.6ppm/^{\circ}C$, and the line sensitivity is 0.15 %/V. When the supply voltage is 1 V, the supply current is less than 90 nA at room temperature. The area occupation is approximately $0.03mm^2$.