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Resveratrol blunts tumor necrosis factor-α-induced monocyte adhesion and transmigration
Dong Shoo Kim,Hyang-Mi Kwon,Jung-Suk Choi,Sang-Wook Kang,Geun-Eog Ji,Young-Hee Kang 대한지역사회영양학회 2007 Nutrition Research and Practice Vol.1 No.4
The leukocyte recruitment and transmigration across the endothelial barrier into the vessel wall are crucial steps in atherosclerosis. Leukocyte trafficking on the endothelium is elicited by induction of endothelial adhesion molecules, and its transmigration is mediated by degradation of basement membrane proteins through enzymatic activity of matrix metalloproteinases (MMP). The current study investigated whether resveratrol, a polyphenol present in grapes and red wine, was capable of inhibiting leukocyte adhesion to tumor necrosis factor (TNF)-α-activated endothelium. It was found that resveratrol inhibited the TNF-α-activated endothelial expression of vascular cell adhesion molecule-1 in a dose-dependent manner. In addition, resveratrol hampered THP-1 monocyte adhesion to activated endothelial cells. This study further examined whether resveratrol interfered with transendothelial migration of leukocytes. The MMP-2 gelatinolytic activity of endothelial cells was enhanced by TNF-α, which was attenuated by an addition of ≥25 μM resveratrol. In addition, 25 μM resveratrol mitigated the MMP-9 activity of THP-1 cells, followed by a marked inhibition of transendothelial migration. These results demonstrated that resveratrol suppressed monocyte adhesion and migration induced by TNF-α through modulating expression of adhesion molecules and gelatinolytic activity of MMP. These findings suggest that dietary resveratrol may be therapeutic agent for inhibiting leukocyte recruitment into the subendothelium during inflammatory atherosclerosis.
Chae, Shoo-Geun,Eom, Young-Geun Korea Furniture Society 2006 한국가구학회지 Vol.17 No.2
Control particleboards were significantly higher in thickness swelling than wood particle-polypropylene fiber composites and their thickness swelling increased with the increase of target density. In the composites, thickness swelling did not vary significantly with the increase of target density but increased with the increase of wood particle content. And the composites with fine wood particles were significantly lower in thickness swelling than those with coarse wood particles irrespective of target density and formulation. In the scanning electron microscopy, significantly higher thickness swelling in the composites with coarse wood particles was thought to be the result of more interfacial separations by higher swelling stresses.
韓國閨房作家의 具象的表現 硏究 : 直喩와 色彩語를 中心하여 Focusing on Similes and Color Terms
朴甲洙 淑明女子大學校 亞細亞女性問題硏究所 1974 아시아여성연구 Vol.13 No.-
This paper is an attempt to identify the difference between women writers and their male counterparts in ways of concrete literary expression through comparing mainly their way of using simile and color terms. It is found out that women writers use more simile and less color terms in general, but less simile and more color terms in medium and mode. The characteristics of women writers in their way of using simile and color terms are summarized as follows: 1. Women writers prefer simple and open simile, and the combined forms of these two types as well. This implies that they tend to be idiomatic, implicit, descriptive in their way of concrete literary expression. 2. In types and word order women writers prefer adverbials and vehicle preposited more than their male counterparts. 3. In terms of tenor, women writers seem to put emphasis on the concreteness of the background, but in terms of vehicle they do not indicate any difference from male writers. 4. Color terms which are frequently used do not reveal the difference of sex. But the variety of color term is characteristic of women writers, whereas repeatedness of male writers. 5. In terms of parts of speech, nouns and adjectives are most prevalent, indicating the expression of women writers being more concrete and sensuous. 6. In case of women writers color terms are found to be associated with parts of human body more than male writers. The use of such colors as red, yellow and white is most frequent.