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( Bin Xiao ),( Dan-dan Li ),( Ying Wang ),( Eun La Kim ),( Na Zhao ),( Shang-wu Jin ),( Dong-hao Bai ),( Li-dong Sun ),( Jee H. Jung ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.5
In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib to the ligand-binding domain of PPAR-γ showed high binding affinity and relevant binding conformation compared with the PPAR-γ ligand/antidiabetic drug rosiglitazone. Per the docking result, parecoxib showed the best PPAR-γ transactivation in Ac2F rat liver cells. Further docking simulation and a luciferase assay suggested parecoxib would be a selective (and partial) PPAR-γ agonist. PPAR-γ activation by parecoxib induced adipocyte differentiation in 3T3-L1 murine preadipocytes. Parecoxib promoted adipogenesis in a dose-dependent manner and enhanced the expression of adipogenesis transcription factors PPAR-γ, C/EBPα, and C/EBPβ. These data indicated that parecoxib might be utilized as a partial PPAR-γ agonist for drug repositioning study.
Huang, Bin,Chen, Haoshuo,Fontaine, Nicolas K.,Jin, Cang,Shang, Kuanping,Ryf, Roland,Essiambre, Rene-Jean,Ung, Bora,Messaddeq, Younes,LaRochelle, Sophie,Li, Guifang IEEE 2017 Journal of Lightwave Technology Vol.35 No.4
<P>We directly measure the spatially and spectrally resolved gain of erbium doped multicore and few mode fiber amplifiers using a coherent swept wavelength interferometer operated in the reflection mode. It greatly simplifies the characterization of multispatial mode amplifiers because it enables characterization of the mode-dependent gain with only a single mode-selective multiplexer at the input. The gains for both multicore fiber amplifier and three spatial modes (LP<SUB>01</SUB> and <TEX>${\rm{LP}}_{{11}}$</TEX>) amplifier are measured. Measurements for multicore fiber amplifier are conducted using two pump schemes, core pump and cladding pump. Also, the comparison with the cutback experiments shows the validity of this technique.</P>
Closed T-Spline Surface Reconstruction from Medical Image Data
Ce Shang,Jianzhong Fu,Zhiwei Lin,Jiawei Feng,Bin Li 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.11
The reconstruction from medical image data to CAD model is an essential process of Bio-medical engineering. So far, it is still challenging to create medical model which is suitable for both design and manufacturing. This paper introduces a process of constructing a single-patched closed T-spline surface model based on medical image data. The image data is first converted into triangular mesh and then parameterized onto a rectangular domain. An iterative least-squares fitting process is proposed to finally obtain the T-spline surface model with a user-specified tolerance. In this fitting process, the smoothing part of the algorithm is redesigned, considering the flexible structure of T-mesh and the geometric complexity of the T-spline surface. Local smoothness weighting factors are introduced to the fitting formula to locally adjust the smoothness of the surface. An adaptive smoothness checking points distribution method is proposed to reduce the computational cost. These algorithms are easy to implement and the obtained model is simple in form. Compared with the STL and NURBS model, the T-spline surface model requires less storage space and can be easily modified. The obtained model is suitable for Bio-medical engineering applications like bone scaffolds design, surgical planning and related manufacturing process.
Xiaoxiang Han,Shang-Bin Liu,Wei Yan,Chin-Te Hung,Yanfei He,Pei-Hao Wu,Li-Li Liu,Shing-Jong Huang 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.7
A series of Brønsted-Lewis acidic ionic liquid (BLAIL) catalysts consisting of sulfonated ionic liquid [SO3H-pmim]Cl and Sn(II) chloride have been synthesized and exploited for catalytic transesterification of soybean oil with methanol to biodiesel. The structural and chemical properties of these [SO3H-pmim]Cl-xSnCl2 (x=0-0.8) catalysts were characterized by different analytical and spectroscopic techniques, such as FT-IR, TGA, and NMR. In particular, their acid properties were studied by solid-state 31P NMR using trimethylphosphine oxide as the probe molecule. The BLAIL catalysts were found highly efficient for transesterification reaction due to the introduction of Lewis acidity by SnCl2 in the initially Brønsted acidic [SO3H-pmim]Cl catalyst. The effects of three independent process variables on biodiesel yield were optimized by response surface methodology (RSM). Consequently, an excellent biodiesel yield of 98.6% was achieved under optimized reaction conditions over the BLAIL catalyst with SnCl2 loading (x) of 0.7.
Yang, Yong-Bin,Shang, Yan-Hong,Tan, Yan-Li,Kang, Xian-Jiang,Meng, Ming,Zhao, Zhan-Xue Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Although many epidemiologic studies investigated the methylenetetrahydrofolate reductase (MTHFR) polymorphisms and their associations with esophageal cancer, definite conclusions could not be drawn. To clarify the effects of MTHFR polymorphisms on the risk of esophageal cancer, a meta-analysis was here performed in Chinese populations. A total of 16 studies including 3,040 cases and 4,127 controls were involved in this metaanalysis. Overall, significant associations were found between the MTHFR C677T polymorphism and esophageal cancer risk when all studies in Chinese populations were pooled into the meta-analysis (T vs. C, OR = 1.19, 95% CI = 1.06-1.34; TT vs. CC, OR = 1.35, 95% CI = 1.07-1.70; TT+ CT vs. CC, OR = 1.29, 95% CI = 1.08-1.54; TT vs. CC + CT, OR = 1.19, 95% CI = 1.03-1.37). In subgroup analyses stratified by ethnicity and source of controls, the same results were found in Kazakh (TT vs. CC, OR = 1.38, 95% CI = 1.02-1.87; TT + CT vs. CC, OR = 1.50, 95% CI = 1.03-2.18), in not stated populations (T vs. C, OR = 1.24, 95% CI = 1.08-1.42; TT vs. CC, OR = 1.47, 95% CI = 1.10-1.96; TT + CT vs. CC, OR = 1.30, 95% CI = 1.05-1.60; TT vs. CC + CT, OR = 1.32, 95% CI = 1.12-1.56), and in hospital-based studies (T vs. C, OR = 1.34, 95% CI = 1.19-1.51; TT vs. CC, OR = 1.81, 95% CI = 1.37-2.39; TT + CT vs. CC, OR = 1.51, 95% CI = 1.26-1.83; and TT vs. CC + CT, OR = 1.39, 95% CI = 1.13-1.70). In conclusion, this meta-analysis provides evidence that the MTHFR C677T polymorphism contributes to esophageal cancer development in Chinese populations.
Li, Xiao-Ming,Di, Bin,Shang, Yao-Dong,Tao, Zhen-Feng,Cheng, Ji-Min,He, Zhan-Guo Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Objective: We aimed to define clinicopathologic risk factors associated with regional recurrence (RR) and thus the effectiveness of postoperative radiotherapy (PORT) for neck control for head and neck squamous cell carcinomas (HNSCCs) with differing cervical lymph node status. Methods: A retrospective study was performed in 196 HNSCC patients with pathologically positive neck node (N+) to evaluate the high-risk factors for RR and to define the role of PORT in control after neck dissection and postoperative radiotherapy (PORT). Results: Overall, the RR rate after neck dissection and PORT was 29%. Extracapsular spread (ECS) was confirmed to be the only independent risk factor for RR. There were no significant risk factors associated with RR in the ECS- group. The 5-year disease-specific survival rate was 45%, which descended to 10% with the emergence of RR. Conclusions: ECS remains a determined risk factor for RR after neck dissection and PORT in patients with N+. PORT alone is not adequate for preventing RR in the neck with ECS after neck dissection. More intensive postoperative adjuvant therapies, especially combined chemotherapy and radiotherapy, are needed to prevent regional failure in HNSCC patients with ECS.
박종열,김기웅,Ke Shang,김상원,최유리,Cheng-Dong Yu,Ji-Eun Son,Gyeong-Jun Kim,Won-Bin Jeon,김인환,Bai Wei,Min Kang,장형관,차세연 한국가금학회 2023 韓國家禽學會誌 Vol.50 No.4
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive disease in young chickens, and causes considerable economic losses to the poultry industry. More than 30 years ago, an antigenic variant IBDV (avIBDV) was reported in chicken farms in the United States. Recently, a novel avIBDV exhibited clear differences in molecular characteristics compared with previous variant strains. This study investigated the molecular characteristics of recently isolated avIBDV strains in Korea. Strains of avIBDV were confirmed by reverse transcription PCR (RT-PCR) and were propagated in 10-day-old specific-pathogen-free (SPF) embryonated chicken eggs through chorioallantoic membrane (CAM) inoculation. Multiple sequence alignment and phylogenetic analyses of hypervariable regions VP2 gene revealed that the strains originated from two different avIBDV lineages (G2a and G2d). In our results, we confirmed the co-existence and prevalence of avIBDV genogroup G2a and G2d in chicken farms. It is necessary to study the protective efficacy of current vaccines against avIBDVs.