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노화 쥐 해마에서 미토콘드리아 칼슘 유니포터 발현 및 미토콘드리아 기능장애에 대한 운동의 효과
박세환 ( Park¸ Se-hwan ) 한국융합과학회(구 한국시큐리티융합경영학회) 2020 한국융합과학회지 Vol.9 No.4
연구목적: 노화는 다양한 조직 내 미토콘드리아 기능장애 및 결함을 초래한다. 중추신경계에서 미토콘드리아 기능장애는 다양한 신경퇴행성 질환의 발생 기전에 핵심적인 역할을 한다. 본 연구는 노화과정에서 해마 영역의 미토콘드리아 칼슘 유니포터 발현, 미토콘드리아 기능장애 및 세포사멸에 대한 유산소 운동의 효과를 규명하고자 하였다. 연구방법: 총 32마리 Sprague-Dawley rat을 이용하여 연령별(16주령 / 42주령) 대조군과 운동군으로 총 4 그룹으로 구분하였다. 운동그룹은 동물용 소형 트레드밀 기기를 이용하여 총 8주간 1일 4회, 30분씩, 분당 20m 속도로 운동을 실시하였다. 결과: 본 연구의 결과, 노화 쥐 해마에서 미토콘드리아 칼슘 유입 및 항상성 유지를 위한 주요 경로 칼슘 유니포터 단백질은 높은 발현량을 나타내었으며, 또한 미토콘드리아 기능장애 및 세포사멸이 증가가 관찰되었다. 반면, 규칙적인 유산소 운동은 노화로 유도된 주요 변인들에 대한 긍정적 개선 효과를 나타내었다. 결론: 따라서, 노화 과정 동안 운동에 매개된 미토콘드리아 칼슘 항상성 조절 요인들은 신경퇴행성 질환의 예방 및 개선을 위한 새로운 치료적 전략으로 제안될 수 있을 것으로 사료된다. Purpose: This study was to investigate the effects of aerobic exercise on mitochondria dysfunction, mitochondria calcium uniporter (MCU) and apoptosis factors (Bax and Bcl-2) expression in the hippocampus of aged rats. Methods: Thirty-two male Sprague-Dawley rats were randomly divided into four groups: 16 weeks control (16W-CON, n=8), 16 weeks exercise (16W-EXE, n=8), 42 weeks control (42W-CON, n=8), 42 weeks exercise (42W-EXE). The rats in the exercise groups were forced to run on a treadmill for 30 min 4 times per week for 8 weeks. Results: In the present study, aging increased MCU protein expression and induced mitochondrial dysfunction with apoptosis. Compared with the 42W-CON group, in the 42W-EXE group MCU and Bax protein expression were significantly decreased and mitochondrial function showed a significant improvement(p<.05). Conclusion: The findings of the present study indicate that aerobic exercise may assist in preventing overexpression of MUC proteins during brain aging, which leading to alteration of mitochondrial dysfunction and increased apoptosis factors. Therefore, MCU is thought to be a new potential target for the prevention and improvement of neurodegenerative diseases.
Industrial Trends of 3D Printing Technology
Sehwan Park,Jongkyu Park 국제문화기술진흥원 2013 International Journal of Advanced Culture Technolo Vol.1 No.1
The basic principle of the product manufacturing technology using the 3D printing technique materializes the material including the high molecular substance or plastic and metallic dust, and etc. the product into the laminate additive manufacturing according to the design diagram gradually. It is applied to the various industrial field including the field of food division, field of home appliances, field of medicine, field of mechanical department and construction, etc.. The global development case of 3D printing technique is the next. This study described global technology and market trends. Afterward, 3D printing technique manages the important role when it exceeds the product manufacturing view just and is grafted with the various technology including the biotechnology, nanotechnology, and etc. and it improves the quality of the human life.
Sehwan Park 국제문화기술진흥원 2014 International Journal of Advanced Culture Technolo Vol.2 No.1
3D printing technology polymeric material or plastic and metallic powder to suit the drafting of additive manufacturing would gradually products soars. 3D printing technologyapplication of a wide variety of industrial sectors. 3D printing technology enables raw materials consumption is less, the supply chain are shorter depending on the load and reduce the use of fossil fuels.Emergence of 3D printing technology so called the third industrial revolution in ICT market, quickly spread worldwide.In the future, 3D printing technology is simply beyond bio-technology, Nano-engineering, the manufacture of the product, incorporating a variety of technologies to improve the quality of life of human beings have played an important role will be.
Smart AI Textile System for Injury Prevention During Exercise
( Sehwan Chun ),( Jooyong Kim ) 한국감성과학회 2023 한국감성과학회 국제학술대회(ICES) Vol.2023 No.-
The significance of resistance training is on the rise, particularly in the context of measuring exercise intensity, or perceived exertion, which is crucial for injury prevention and personalized exercise programs. Thus far, exercise intensity has primarily been assessed subjectively using Likert scales and observational methods, presenting inherent limitations. In this study, we addressed this challenge by attaching textile sensors around the biceps area of a sleeve to collect data on barbell weight and repetitions as variables. Using the Epley formula, we calculated 1RM and extrapolated 1, 3, 5, 8, 12, 15, and 20RM values. Subsequently, we quantified the degree of exercise intensity based on weight and repetitions using Fuzzy Logic. Through the implementation of an artificial intelligence LSTM model, we achieved a high prediction accuracy of 87.35% for classifying exercise intensity into Intense and Moderate categories with new data. This achievement has practical implications for injury prevention and tailoring individual exercise programs.
Experimental Study on a Conduction Cooling System for an HTS NMR Magnet
Sehwan In,Yong-Ju Hong,Hankil Yeom,Junseok Ko,Hyobong Kim,Seong-Je Park,Sangwon Yoon,Kyekeun Cheon,Jae Young Jang,Young Jin Hwang,SangGap Lee IEEE 2017 IEEE transactions on applied superconductivity Vol.27 No.4
<P>A nuclear magnetic resonance (NMR) magnet composed of a high-temperature superconductor (HTS) is expected to contribute to a smaller size and a higher magnetic field (>1 GHz) of the NMR magnet due to its high critical current density under high magnetic field and better mechanical properties. The high operating temperature of HTS NMR magnets also makes conduction cooling by a cryocooler available. The conduction cooling system combined with a cryocooler is compact and user-friendly but has critical issues about the design of conduction cooling passages and the mechanical vibration. The small-scale HTS magnet with the conduction cooling system is fabricated and tested to check the issues and establish the design basis as a preliminary step for the development of a 400-MHz HTS NMR magnet. Thermal analysis for heat loads and thermal resistances at main joints is performed from the temperature distribution of the cooling system. The vibration levels at the crycooler and the vacuum chamber are discussed in comparison to the vibration criterion of NMR magnets. In addition, the design approach to the conduction cooling system for the HTS NMR magnet is discussed.</P>
SeHwan Kim,Jul-Ki Seok IEEE 2013 IEEE TRANSACTIONS ON POWER ELECTRONICS - Vol.28 No.12
<P>A hybrid maximum voltage utilization controller is developed for interior permanent-magnet synchronous motors over a wide operating range. The structure of the controller combines the current vector control (CVC)-type maximum torque per ampere controller and the modulating voltage-scaled controller (MVSC). The hybrid structure provides a smooth transition from the CVC to the proposed MVSC mode by deactivating the current regulator in the flux weakening region. A seamless transition to a full six-step modulation can be realized by adjusting the scaling gain, which is a significant merit in terms of power utilization for wide flux weakening applications. This paper also examines the torque control accuracy under motor parameter drifts to determine how to decouple its effect using a voltage disturbance state-filter design.</P>